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MD, Harbin Medical University
PhD, Shanghai Institute of Materia Medica
MS, Harbin Medical University

BU Research
BMC Research

Nox4 Oxidizes SERCA and Induces Vasculature Dysfunction in a Prediabetic Model
01/01/2010 - 12/31/2012 (PI)
American Diabetes Association

The effects of WuQing on Vascular function and atherosclerosis in LDLR deficient mice
05/01/2013 - 04/30/2014 (PI)
Zhimingde International Group

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Goodman JB, Qin F, Morgan RJ, Chambers JM, Croteau D, Siwik DA, Hobai I, Panagia M, Luptak I, Bachschmid M, Tong X, Pimentel DR, Cohen RA, Colucci WS. Redox-Resistant SERCA [Sarco(endo)plasmic Reticulum Calcium ATPase] Attenuates Oxidant-Stimulated Mitochondrial Calcium and Apoptosis in Cardiac Myocytes and Pressure Overload-Induced Myocardial Failure in Mice. Circulation. 2020 12 22; 142(25):2459-2469.View Related Profiles.

Pimentel, David
Siwik, Deborah
Qin, Fuzhong
Luptak, Ivan
Goodman, Jena
Chambers, Jordan
Panagia, Marcello
Cohen, Richard
Morgan, Robert
Colucci, Wilson
Tong, XiaoYong

PMID: 33076678; PMCID: PMC7752816; DOI: 10.1161/CIRCULATIONAHA.120.048183;

Tong X, Hou X, Wason C, Kopel T, Cohen RA, Dember LM. Smooth Muscle Nitric Oxide Responsiveness and Clinical Maturation of Hemodialysis Arteriovenous Fistulae. Am J Pathol. 2017 Sep; 187(9):2095-2101.View Related Profiles.

Cohen, Richard
Tong, XiaoYong

PMID: 28822538; PMCID: PMC5809333; DOI: 10.1016/j.ajpath.2017.05.006;

Cohen RA, Murdoch CE, Watanabe Y, Bolotina VM, Evangelista AM, Haeussler DJ, Smith MD, Mei Y, Tong X, Han J, Behring JB, Bachschmid MM, Matsui R. Endothelial Cell Redox Regulation of Ischemic Angiogenesis. J Cardiovasc Pharmacol. 2016 Jun; 67(6):458-64.View Related Profiles.

Murdoch, Colin
Haeussler, Dagmar
Behring, Jessica
Han, Jingyan
Bachschmid, Markus
Matsui, Reiko
Cohen, Richard
Bolotina, Victoria
Tong, XiaoYong

PMID: 26927696; PMCID: PMC4899292; DOI: 10.1097/FJC.0000000000000381;

Tong X, Khandelwal AR, Qin Z, Wu X, Chen L, Ago T, Sadoshima J, Cohen RA. Role of smooth muscle Nox4-based NADPH oxidase in neointimal hyperplasia. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):185-94.View Related Profiles.

Chen, Lili
Cohen, Richard
Tong, XiaoYong

PMID: 26582463; DOI: 10.1016/j.yjmcc.2015.11.013;

Mei Y, Thompson MD, Shiraishi Y, Cohen RA, Tong X. Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 promotes ischemia- and hypoxia-induced angiogenesis via coordinated endothelial cell and macrophage function. J Mol Cell Cardiol. 2014 Nov; 76:275-82.View Related Profiles.

Cohen, Richard
Tong, XiaoYong

PMID: 25260714; PMCID: PMC4250384; DOI: 10.1016/j.yjmcc.2014.09.018;

Thompson MD, Mei Y, Weisbrod RM, Silver M, Shukla PC, Bolotina VM, Cohen RA, Tong X. Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase Cys-674 regulate endothelial cell calcium stores and angiogenic function as well as promote ischemic blood flow recovery. J Biol Chem. 2014 Jul 18; 289(29):19907-16.View Related Profiles.

Cohen, Richard
Bolotina, Victoria
Tong, XiaoYong

PMID: 24920669; PMCID: PMC4106311; DOI: 10.1074/jbc.M114.554451;

Mei Y, Thompson MD, Cohen RA, Tong X. Autophagy and oxidative stress in cardiovascular diseases. Biochim Biophys Acta. 2015 Feb; 1852(2):243-51.View Related Profiles.

Cohen, Richard
Tong, XiaoYong

PMID: 24834848; PMCID: PMC4231019; DOI: 10.1016/j.bbadis.2014.05.005;

Qin Z, Hou X, Weisbrod RM, Seta F, Cohen RA, Tong X. Nox2 mediates high fat high sucrose diet-induced nitric oxide dysfunction and inflammation in aortic smooth muscle cells. J Mol Cell Cardiol. 2014 Jul; 72:56-63.View Related Profiles.

Seta, Francesca
Cohen, Richard
Tong, XiaoYong

PMID: 24631774; PMCID: PMC4037381; DOI: 10.1016/j.yjmcc.2014.02.019;

Mei Y, Thompson MD, Cohen RA, Tong X. Endoplasmic Reticulum Stress and Related Pathological Processes. J Pharmacol Biomed Anal. 2013 Nov 15; 1(2):1000107.View Related Profiles.

Cohen, Richard
Tong, XiaoYong

PMID: 24611136; PMCID: PMC3942890

Qin F, Siwik DA, Lancel S, Zhang J, Kuster GM, Luptak I, Wang L, Tong X, Kang YJ, Cohen RA, Colucci WS. Hydrogen peroxide-mediated SERCA cysteine 674 oxidation contributes to impaired cardiac myocyte relaxation in senescent mouse heart. J Am Heart Assoc. 2013 Aug; 2(4):e000184.View Related Profiles.

Siwik, Deborah
Qin, Fuzhong
Luptak, Ivan
Cohen, Richard
Colucci, Wilson
Tong, XiaoYong

PMID: 23963753; PMCID: PMC3828801; DOI: 10.1161/JAHA.113.000184;

Showing 10 of 25 results. Show More

Evangelista AM, Thompson MD, Bolotina VM, Tong X, Cohen RA. Nox4- and Nox2-dependent oxidant production is required for VEGF-induced SERCA cysteine-674 S-glutathiolation and endothelial cell migration. Free Radic Biol Med. 2012 Dec 15; 53(12):2327-34.View Related Profiles.

Cohen, Richard
Bolotina, Victoria
Tong, XiaoYong

PMID: 23089226; PMCID: PMC3568680; DOI: 10.1016/j.freeradbiomed.2012.10.546;

Evangelista AM, Thompson MD, Weisbrod RM, Pimental DR, Tong X, Bolotina VM, Cohen RA. Redox regulation of SERCA2 is required for vascular endothelial growth factor-induced signaling and endothelial cell migration. Antioxid Redox Signal. 2012 Oct 15; 17(8):1099-108.View Related Profiles.

Cohen, Richard
Bolotina, Victoria
Tong, XiaoYong

PMID: 22472004; PMCID: PMC3423867; DOI: 10.1089/ars.2011.4022;

Tong X, Hou X, Jourd'heuil D, Weisbrod RM, Cohen RA. Upregulation of Nox4 by TGF{beta}1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat. Circ Res. 2010 Oct 15; 107(8):975-83.View Related Profiles.

Cohen, Richard
Tong, XiaoYong

PMID: 20724704; PMCID: PMC2955842; DOI: 10.1161/CIRCRESAHA.110.221242;

Lancel S, Qin F, Lennon SL, Zhang J, Tong X, Mazzini MJ, Kang YJ, Siwik DA, Cohen RA, Colucci WS. Oxidative posttranslational modifications mediate decreased SERCA activity and myocyte dysfunction in Galphaq-overexpressing mice. Circ Res. 2010 Jul 23; 107(2):228-32.View Related Profiles.

Siwik, Deborah
Qin, Fuzhong
Mazzini, Michael
Cohen, Richard
Colucci, Wilson
Tong, XiaoYong

PMID: 20508180; PMCID: PMC2909347; DOI: 10.1161/CIRCRESAHA.110.217570;

Cohen RA, Tong X. Vascular oxidative stress: the common link in hypertensive and diabetic vascular disease. J Cardiovasc Pharmacol. 2010 Apr; 55(4):308-16.View Related Profiles.

Cohen, Richard
Tong, XiaoYong

PMID: 20422735; PMCID: PMC3018745

Tong X, Evangelista A, Cohen RA. Targeting the redox regulation of SERCA in vascular physiology and disease. Curr Opin Pharmacol. 2010 Apr; 10(2):133-8.View Related Profiles.

Cohen, Richard
Tong, XiaoYong

PMID: 20045379; PMCID: PMC2843760; DOI: 10.1016/j.coph.2009.11.008;

Tong X, Schröder K. NADPH oxidases are responsible for the failure of nitric oxide to inhibit migration of smooth muscle cells exposed to high glucose. Free Radic Biol Med. 2009 Dec 1; 47(11):1578-83. PMID: 19733235; PMCID: PMC2784138; DOI: 10.1016/j.freeradbiomed.2009.08.026;

Lancel S, Zhang J, Evangelista A, Trucillo MP, Tong X, Siwik DA, Cohen RA, Colucci WS. Nitroxyl activates SERCA in cardiac myocytes via glutathiolation of cysteine 674. Circ Res. 2009 Mar 27; 104(6):720-3.View Related Profiles.

Siwik, Deborah
Cohen, Richard
Colucci, Wilson
Tong, XiaoYong

PMID: 19265039; PMCID: PMC3046805; DOI: 10.1161/CIRCRESAHA.108.188441;

Tong X, Ying J, Pimentel DR, Trucillo M, Adachi T, Cohen RA. High glucose oxidizes SERCA cysteine-674 and prevents inhibition by nitric oxide of smooth muscle cell migration. J Mol Cell Cardiol. 2008 Feb; 44(2):361-9.View Related Profiles.

Pimentel, David
Cohen, Richard
Tong, XiaoYong

PMID: 18164028; PMCID: PMC2394666; DOI: 10.1016/j.yjmcc.2007.10.022;

Malester B, Tong X, Ghiu I, Kontogeorgis A, Gutstein DE, Xu J, Hendricks-Munoz KD, Coetzee WA. Transgenic expression of a dominant negative K(ATP) channel subunit in the mouse endothelium: effects on coronary flow and endothelin-1 secretion. FASEB J. 2007 Jul; 21(9):2162-72. PMID: 17341678

Ying J, Tong X, Pimentel DR, Weisbrod RM, Trucillo MP, Adachi T, Cohen RA. Cysteine-674 of the sarco/endoplasmic reticulum calcium ATPase is required for the inhibition of cell migration by nitric oxide. Arterioscler Thromb Vasc Biol. 2007 Apr; 27(4):783-90.View Related Profiles.

Pimentel, David
Cohen, Richard
Tong, XiaoYong

PMID: 17234728

Tong X, Porter LM, Liu G, Dhar-Chowdhury P, Srivastava S, Pountney DJ, Yoshida H, Artman M, Fishman GI, Yu C, Iyer R, Morley GE, Gutstein DE, Coetzee WA. Consequences of cardiac myocyte-specific ablation of KATP channels in transgenic mice expressing dominant negative Kir6 subunits. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H543-51. PMID: 16501027; PMCID: PMC2950019; DOI: 10.1152/ajpheart.00051.2006;

Morrissey A, Parachuru L, Leung M, Lopez G, Nakamura TY, Tong X, Yoshida H, Srivastiva S, Chowdhury PD, Artman M, Coetzee WA. Expression of ATP-sensitive K+ channel subunits during perinatal maturation in the mouse heart. Pediatr Res. 2005 Aug; 58(2):185-92. PMID: 16085792; DOI: 10.1203/01.PDR.0000169967.83576.CB;

Morrissey A, Rosner E, Lanning J, Parachuru L, Dhar Chowdhury P, Han S, Lopez G, Tong X, Yoshida H, Nakamura TY, Artman M, Giblin JP, Tinker A, Coetzee WA. Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. BMC Physiol. 2005; 5(1):1. PMID: 15647111; PMCID: PMC546210; DOI: 10.1186/1472-6793-5-1;

Pan Y, Xu X, Tong X, Wang X. Messenger RNA and protein expression analysis of voltage-gated potassium channels in the brain of Abeta(25-35)-treated rats. J Neurosci Res. 2004 Jul 1; 77(1):94-9. PMID: 15197742; DOI: 10.1002/jnr.20134;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

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