Tara L. Moore, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Anatomy & Neurobiology

PhD, Boston University School of Medicine
BA, Univ Calgary



Dr. Moore’s primary research interests involve the investigation of the recovery of fine motor function and re-organization of the motor cortex following cortical injury. Using a non-human primate (NHP) model of cortical injury developed with Dr. Rosene, she is establishing the rate and pattern of recovery of fine motor function of the hand and the histopathological response of the brain to injury in this model with young and aged NHPs. Additional studies with this model include assessing the efficacy of various therapeutics to enhance the recovery of function following ischemia. A current study includes investigating the role of exosomes as a restorative treatment to facilitate recovery of function following cortical injury. This work is being conducted in collaboration with researchers at the Henry Ford Hospital in Detroit, MI.

Finally, as part of my role as director of the MS in Forensic Anthropology I also participate in studies of the rate and process of decomposition in a cold climate using a porcine model.

Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Neurology


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Mechanisms underlying extracellular vesicle mediated changes in inflammation, neural circuitry and plasticity following cortical injury in aged monkeys
07/15/2022 - 06/30/2027 (Multi-PI)
PI: Tara L. Moore, PhD
NIH/National Institute on Aging
1R01AG078460-01

Extracellular Vesicle treatment and age-related neuropathology in non-human primates
09/15/2020 - 04/30/2025 (PI)
NIH/National Institute on Aging
5R01AG068168-04

Neural Substrates of Diffusion Imaging in Cognitively Aging Rhesus Monkeys
08/15/2019 - 04/30/2024 (Co-Investigator)
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG042512-09

Neural substrates of exosome-mediated enhancement of recovery after cortical injury in non-human primates.
04/15/2020 - 03/31/2022 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1R56NS112207-01A1

Recovery of Motor Function Impaired by Cortical Injury: An Exploratory Comparison of the influences of Four Different Post-injury Treatments on Processes Affecting Neuroplasticity
04/01/2019 - 03/31/2022 (Multi-PI)
PI: Tara L. Moore, PhD
NIH/National Institute of Neurological Disorders & Stroke
1R21NS111174-01

The efficacy of curcumin to facilitate recovery of function in a rhesus monkey model of cortical injury
09/30/2018 - 08/31/2021 (Multi-PI)
PI: Tara L. Moore, PhD
NIH/National Institute on Aging
1R56AG059693-01

Exosomes from bone marrow-derived mesenchymal stem cells as a restorative treatment in a non-human primate model of cerebral injury
07/15/2017 - 06/30/2020 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R21NS102991-02

The effects of a D1 partial agonist on cognition and brain functionality in the rhesus monkey
01/15/2014 - 01/31/2017 (PI)
Pfizer, Inc.


Facilitating the Recovery of Function Following Stroke: The Efficacy of Inosine
09/01/2012 - 08/31/2015 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R21NS081261-02



Title


Yr Title Project-Sub Proj Pubs
2023 Extracellular Vesicle treatment and age-related neuropathology in non-human primates 5R01AG068168-04
2022 Mechanisms underlying extracellular vesicle mediated changes in inflammation, neural circuitry and plasticity following cortical injury in aged monkeys 1R01AG078460-01
2021 Extracellular Vesicle treatment and age-related neuropathology in non-human primates 5R01AG068168-02
2020 Extracellular Vesicle treatment and age-related neuropathology in non-human primates 1R01AG068168-01
2020 Neural substrates of exosome-mediated enhancement of recovery after cortical injury in non-human primates. 1R56NS112207-01A1
2019 Recovery of Motor Function Impaired by Cortical Injury: An Exploratory Comparison of the Influences of Four Different Post-injury Treatments on Processes Affecting Neuroplasticity 1R21NS111174-01 1
2018 The efficacy of curcumin to facilitate recovery of function in a rhesus monkey model of cortical injury. 1R56AG059693-01
2018 Exosomes from bone marrow-derived mesenchymal stem cells as a restorative treatment in a non-human primate model of cerebral injury 5R21NS102991-02 4
2017 Exosomes from bone marrow-derived mesenchymal stem cells as a restorative treatment in a non-human primate model of cerebral injury 1R21NS102991-01 4
2013 Facilitating the Recovery of Function Following Stroke: The Efficacy of Inosine 5R21NS081261-02 3
Showing 10 of 13 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Moore TL, Medalla M, Ibañez S, Wimmer K, Mojica CA, Killiany RJ, Moss MB, Luebke JI, Rosene DL. Neuronal properties of pyramidal cells in lateral prefrontal cortex of the aging rhesus monkey brain are associated with performance deficits on spatial working memory but not executive function. Geroscience. 2023 Apr 28.View Related Profiles. PMID: 37106282
     
  2. Welke LA, Moore TL, Rosene DL, Killiany RJ, Moss MB. Prefrontal and medial temporal interactions in memory functions in the rhesus monkey. Behav Neurosci. 2023 Jun; 137(3):211-222.View Related Profiles. PMID: 37023305
     
  3. Campbell NB, Patel Y, Moore TL, Medalla M, Zeldich E. Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome. Int J Mol Sci. 2023 Feb 09; 24(4).View Related Profiles. PMID: 36834891; PMCID: PMC9960302; DOI: 10.3390/ijms24043477;
     
  4. Moore TL, Medalla M, Iba Ez S, Wimmer K, Mojica CA, Killiany RJ, Moss MB, Luebke JI, Rosene DL. Neuronal properties of pyramidal cells in lateral prefrontal cortex of the aging rhesus monkey brain are associated with performance deficits on spatial working memory but not executive function. bioRxiv. 2023 Feb 08.View Related Profiles. PMID: 36798388; PMCID: PMC9934587; DOI: 10.1101/2023.02.07.527321;
     
  5. Calderazzo S, Covert M, Alba D, Bowley BE, Pessina MA, Rosene DL, Buller B, Medalla M, Moore TL. Neural recovery after cortical injury: Effects of MSC derived extracellular vesicles on motor circuit remodeling in rhesus monkeys. IBRO Neurosci Rep. 2022 Dec; 13:243-254.View Related Profiles. PMID: 36590089; PMCID: PMC9795302; DOI: 10.1016/j.ibneur.2022.08.001;
     
  6. Dimovasili C, Fair AE, Garza IR, Batterman KV, Mortazavi F, Moore TL, Rosene DL. Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain. Geroscience. 2023 Feb; 45(1):249-264.View Related Profiles. PMID: 35930094; PMCID: PMC9886778; DOI: 10.1007/s11357-022-00621-4;
     
  7. Medalla M, Chang W, Ibañez S, Guillamon-Vivancos T, Nittmann M, Kapitonava A, Busch SE, Moore TL, Rosene DL, Luebke JI. Layer-specific pyramidal neuron properties underlie diverse anterior cingulate cortical motor and limbic networks. Cereb Cortex. 2022 05 14; 32(10):2170-2196.View Related Profiles. PMID: 34613380; PMCID: PMC9113240; DOI: 10.1093/cercor/bhab347;
     
  8. Moore TL, Young DA, Killiany RJ, Fonseca KR, Volfson D, Gray DL, Balice-Gordon R, Kozak R. The Effects of a Novel Non-catechol Dopamine Partial Agonist on Working Memory in the Aged Rhesus Monkey. Front Aging Neurosci. 2021; 13:757850.View Related Profiles. PMID: 34899271; PMCID: PMC8662559; DOI: 10.3389/fnagi.2021.757850;
     
  9. Uprety A, Moss MB, Rosene DL, Killiany RJ, Moore TL. Curcumin improves reversal learning in middle-aged rhesus monkeys. Behav Neurosci. 2022 Apr; 136(2):126-138.View Related Profiles. PMID: 34780208
     
  10. Zhang J, Buller BA, Zhang ZG, Zhang Y, Lu M, Rosene DL, Medalla M, Moore TL, Chopp M. Exosomes derived from bone marrow mesenchymal stromal cells promote remyelination and reduce neuroinflammation in the demyelinating central nervous system. Exp Neurol. 2022 01; 347:113895.View Related Profiles. PMID: 34653510
     
Showing 10 of 51 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 51 publications over 19 distinct years, with a maximum of 8 publications in 2021

YearPublications
20021
20032
20041
20054
20062
20091
20102
20111
20121
20131
20151
20163
20173
20185
20195
20203
20218
20223
20234

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

aging
cortical injury
non-human primates
pharmaceutical collaborations
recovery
stroke

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Research / Scholarly Mentor
Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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617.638.4054
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