Tara L. Moore, PhD
Associate Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, Boston University School of Medicine




Dr. Moore’s primary research interests involve the investigation of the recovery of fine motor function and re-organization of the motor cortex following cortical injury. Using a non-human primate (NHP) model of cortical injury developed with Dr. Rosene, she is establishing the rate and pattern of recovery of fine motor function of the hand and the histopathological response of the brain to injury in this model with young and aged NHPs. Additional studies with this model include assessing the efficacy of various therapeutics to enhance the recovery of function following ischemia. A current study includes investigating the role of exosomes as a restorative treatment to facilitate recovery of function following cortical injury. This work is being conducted in collaboration with researchers at the Henry Ford Hospital in Detroit, MI.

Finally, as part of my role as director of the MS in Forensic Anthropology I also participate in studies of the rate and process of decomposition in a cold climate using a porcine model.

Associate Professor
Boston University School of Medicine
Neurology


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Extracellular Vesicle treatment and age-related neuropathology in non-human primates
09/15/2020 - 04/30/2025 (PI)
NIH/National Institute on Aging
1R01AG068168-01

Neural Substrates of Diffusion Imaging in Cognitively Aging Rhesus Monkeys
08/15/2019 - 04/30/2024 (Subcontract Co-PI)
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG042512-07

Neural substrates of exosome-mediated enhancement of recovery after cortical injury in non-human primates.
04/15/2020 - 03/31/2021 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1R56NS112207-01A1

Recovery of Motor Function Impaired by Cortical Injury: An Exploratory Comparison of the influences of Four Different Post-injury Treatments on Processes Affecting Neuroplasticity
04/01/2019 - 03/31/2021 (Multi-PI)
PI: Tara L. Moore, PhD
NIH/National Institute of Neurological Disorders & Stroke
1R21NS111174-01

The efficacy of curcumin to facilitate recovery of function in a rhesus monkey model of cortical injury
09/30/2018 - 08/31/2020 (Multi-PI)
PI: Tara L. Moore, PhD
NIH/National Institute on Aging
1R56AG059693-01

Exosomes from bone marrow-derived mesenchymal stem cells as a restorative treatment in a non-human primate model of cerebral injury
07/15/2017 - 06/30/2020 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R21NS102991-02

The effects of a D1 partial agonist on cognition and brain functionality in the rhesus monkey
01/15/2014 - 01/31/2017 (PI)
Pfizer, Inc.


Facilitating the Recovery of Function Following Stroke: The Efficacy of Inosine
09/01/2012 - 08/31/2015 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R21NS081261-02



Title

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Tsintou M, Dalamagkas K, Moore TL, Rathi Y, Kubicki M, Rosene DL, Makris N. The use of hydrogel-delivered extracellular vesicles in recovery of motor function in stroke: a testable experimental hypothesis for clinical translation including behavioral and neuroimaging assessment approaches. Neural Regen Res. 2021 Apr; 16(4):605-613.View Related Profiles. PMID: 33063708
     
  2. Calderazzo SM, Busch SE, Moore TL, Rosene DL, Medalla M. Distribution and overlap of entorhinal, premotor, and amygdalar connections in the monkey anterior cingulate cortex. J Comp Neurol. 2020 Jul 17.View Related Profiles. PMID: 32677044
     
  3. Medalla M, Chang W, Calderazzo SM, Go V, Tsolias A, Goodliffe JW, Pathak D, De Alba D, Pessina M, Rosene DL, Buller B, Moore TL. Treatment with Mesenchymal-Derived Extracellular Vesicles Reduces Injury-Related Pathology in Pyramidal Neurons of Monkey Perilesional Ventral Premotor Cortex. J Neurosci. 2020 04 22; 40(17):3385-3407.View Related Profiles. PMID: 32241837
     
  4. Go V, Bowley BGE, Pessina MA, Zhang ZG, Chopp M, Finklestein SP, Rosene DL, Medalla M, Buller B, Moore TL. Extracellular vesicles from mesenchymal stem cells reduce microglial-mediated neuroinflammation after cortical injury in aged Rhesus monkeys. Geroscience. 2020 02; 42(1):1-17.View Related Profiles. PMID: 31691891
     
  5. Moreira JD, Chaudhary P, Frame AA, Puleo F, Nist KM, Abkin EA, Moore TL, George JC, Wainford RD. Inhibition of microglial activation in rats attenuates paraventricular nucleus inflammation in Gai2 protein-dependent, salt-sensitive hypertension. Exp Physiol. 2019 12; 104(12):1892-1910.View Related Profiles. PMID: 31631436
     
  6. Orczykowski ME, Calderazzo SM, Shobin E, Pessina MA, Oblak AL, Finklestein SP, Kramer BC, Mortazavi F, Rosene DL, Moore TL. Cell based therapy reduces secondary damage and increases extent of microglial activation following cortical injury. Brain Res. 2019 08 15; 1717:147-159.View Related Profiles. PMID: 30998931
     
  7. Pessina MA, Bowley BGE, Rosene DL, Moore TL. A method for assessing recovery of fine motor function of the hand in a rhesus monkey model of cortical injury: an adaptation of the Fugl-Meyer Scale and Eshkol-Wachman Movement Notation. Somatosens Mot Res. 2019 03; 36(1):69-77.View Related Profiles. PMID: 31072219
     
  8. Moore TL, Bowley BGE, Pessina MA, Calderazzo SM, Medalla M, Go V, Zhang ZG, Chopp M, Finklestein S, Harbaugh AG, Rosene DL, Buller B. Mesenchymal derived exosomes enhance recovery of motor function in a monkey model of cortical injury. Restor Neurol Neurosci. 2019; 37(4):347-362.View Related Profiles. PMID: 31282441
     
  9. Koo BB, Calderazzo S, Bowley BGE, Kolli A, Moss MB, Rosene DL, Moore TL. Long-term effects of curcumin in the non-human primate brain. Brain Res Bull. 2018 09; 142:88-95.View Related Profiles. PMID: 29981358
     
  10. Mella M, Schweitzer B, Mallet CR, Moore T, Botch-Jones S. Detection of Cocaine and Metabolites in Bone Following Decomposition Using 2D LC-MS-MS. J Anal Toxicol. 2018 May 01; 42(4):265-275.View Related Profiles. PMID: 29300918
     
Showing 10 of 36 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 35 publications over 16 distinct years, with a maximum of 5 publications in 2018 and 2019

YearPublications
20021
20032
20041
20054
20062
20091
20102
20111
20121
20131
20151
20163
20173
20185
20195
20202

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

aging
cortical injury
non-human primates
pharmaceutical collaborations
recovery
stroke

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Research / Scholarly Mentor
Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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