Roger Theberge, PhD
Visiting Scientist
Pfizer




Ph.D in analytical chemistry with over 20 years experience in biological mass spectrometry in academic and industry settings. Detailed characterization of sequence liabilities in therapeutic mAbs using LCMSMS.

Characterization of biotherapeutics. LCMSMS analysis of therapeutic mAbs to identify and characterize post-translation modifications induced by degradation studies. Awarded 2018 Team Impact Citation for outstanding contribution to the Structural and Computational Biology Team (SCBT) at Pfizer. Implemented installation of mass spectrometry capabilities and expertise in the Bioanalytical Development Group of the Protein Therapeutics Division at Genzyme to support program goals. Conducted complete characterization of recombinant biotherapeutics using mass spectrometry in a team oriented environment. Led the development and validation of an HPLC-based peptide map used for the approval of the Fabrazyme® IND application and an LC-MS method for labeled oligosaccharides released from biotherapeutics to replace less advanced methods of oligosaccharide profiling. Designed and implemented cross-training and education of group members . Represented the Bioanalytical Development Group at designated program/project levels with the responsibility of producing and distributing meeting summaries to articulate program goals for the group. Acquired expertise in a broad range of mass spectrometry techniques (LCMSMS, MALDI, ESI and Top-Down) at the Center for Biomedical Mass Spectrometry at the Boston University School of Mecicne. Established mass spectrometry methods for the analysis and identification of amyloidogenic proteins in the clinical patient diagnosis workflow of the Amyloidosis Center for Familial Amyloidotic Polyneuropathy (FAP) patients. Used expertise in Top-Down to develop an assay to detect and characterize hemoglobinopathies. Sustained commitment to teaching mass spectrometry and training new users on a variety of platforms.

Postdoctoral Fellow (Previously held)
Boston University Chobanian & Avedisian School of Medicine


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Premasiri WR, Lee JC, Sauer-Budge A, Théberge R, Costello CE, Ziegler LD. The biochemical origins of the surface-enhanced Raman spectra of bacteria: a metabolomics profiling by SERS. Anal Bioanal Chem. 2016 Jul; 408(17):4631-47.View Related Profiles. PMID: 27100230; PMCID: PMC4911336; DOI: 10.1007/s00216-016-9540-x;
     
  2. Jiang Z, Luo HY, Huang S, Farrell JJ, Davis L, Théberge R, Benson KA, Riolueang S, Viprakasit V, Al-Allawi NA, Ünal S, Gümrük F, Akar N, Basak AN, Osorio L, Badens C, Pissard S, Joly P, Campbell AD, Gallagher PG, Steinberg MH, Forget BG, Chui DH. The genetic basis of asymptomatic codon 8 frame-shift (HBB:c25_26delAA) ß(0) -thalassaemia homozygotes. Br J Haematol. 2016 Mar; 172(6):958-65.View Related Profiles. PMID: 26771086; DOI: 10.1111/bjh.13909;
     
  3. Baker ES, Burnum-Johnson KE, Ibrahim YM, Orton DJ, Monroe ME, Kelly RT, Moore RJ, Zhang X, Théberge R, Costello CE, Smith RD. Enhancing bottom-up and top-down proteomic measurements with ion mobility separations. Proteomics. 2015 Aug; 15(16):2766-76.View Related Profiles. PMID: 26046661; PMCID: PMC4534090; DOI: 10.1002/pmic.201500048;
     
  4. Théberge R, Dikler S, Heckendorf C, Chui DH, Costello CE, McComb ME. MALDI-ISD Mass Spectrometry Analysis of Hemoglobin Variants: a Top-Down Approach to the Characterization of Hemoglobinopathies. J Am Soc Mass Spectrom. 2015 Aug; 26(8):1299-310.View Related Profiles. PMID: 26002792; PMCID: PMC4496427; DOI: 10.1007/s13361-015-1164-4;
     
  5. Smith BW, Rozelle SS, Leung A, Ubellacker J, Parks A, Nah SK, French D, Gadue P, Monti S, Chui DH, Steinberg MH, Frelinger AL, Michelson AD, Theberge R, McComb ME, Costello CE, Kotton DN, Mostoslavsky G, Sherr DH, Murphy GJ. The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. Blood. 2013 Jul 18; 122(3):376-85.View Related Profiles. PMID: 23723449; PMCID: PMC3716202; DOI: 10.1182/blood-2012-11-466722;
     
  6. Théberge R, Infusini G, Tong W, McComb ME, Costello CE. Top-Down Analysis of Small Plasma Proteins Using an LTQ-Orbitrap. Potential for Mass Spectrometry-Based Clinical Assays for Transthyretin and Hemoglobin. Int J Mass Spectrom. 2011 Mar 01; 300(2-3):130-142.View Related Profiles. PMID: 21607198; PMCID: PMC3098445; DOI: 10.1016/j.ijms.2010.08.012;
     
  7. Ying W, Perlman DH, Li L, Théberge R, Costello CE, McComb ME. Highly efficient and selective enrichment of peptide subsets combining fluorous chemistry with reversed-phase chromatography. Rapid Commun Mass Spectrom. 2009 Dec; 23(24):4019-30.View Related Profiles. PMID: 19924777; PMCID: PMC3584324; DOI: 10.1002/rcm.4343;
     
  8. Connors LH, Prokaeva T, Lim A, Théberge R, Falk RH, Doros G, Berg A, Costello CE, O'Hara C, Seldin DC, Skinner M. Cardiac amyloidosis in African Americans: comparison of clinical and laboratory features of transthyretin V122I amyloidosis and immunoglobulin light chain amyloidosis. Am Heart J. 2009 Oct; 158(4):607-14.View Related Profiles. PMID: 19781421; DOI: 10.1016/j.ahj.2009.08.006;
     
  9. Lavatelli F, Perlman DH, Spencer B, Prokaeva T, McComb ME, Théberge R, Connors LH, Bellotti V, Seldin DC, Merlini G, Skinner M, Costello CE. Amyloidogenic and associated proteins in systemic amyloidosis proteome of adipose tissue. Mol Cell Proteomics. 2008 Aug; 7(8):1570-83.View Related Profiles. PMID: 18474516; PMCID: PMC2494907; DOI: 10.1074/mcp.M700545-MCP200;
     
  10. Kingsbury JS, Laue TM, Klimtchuk ES, Théberge R, Costello CE, Connors LH. The modulation of transthyretin tetramer stability by cysteine 10 adducts and the drug diflunisal. Direct analysis by fluorescence-detected analytical ultracentrifugation. J Biol Chem. 2008 May 2; 283(18):11887-96.View Related Profiles. PMID: 18326041; PMCID: PMC2335343; DOI: 10.1074/jbc.M709638200;
     
Showing 10 of 23 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 23 publications over 12 distinct years, with a maximum of 4 publications in 2007

YearPublications
19961
19993
20002
20021
20032
20074
20082
20092
20111
20131
20152
20162

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