Nicholas A. Bosch, MD, MSc
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, New York Medical College
MS, Boston University School of Public Health
BS, University of California, Davis
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ORCID ORCID Icon : 0000-0001-7161-5254



Dr. Bosch is a health services researcher, epidemiologist, and critical care physician specializing in leveraging health services, quasi-experimental and causal-inference methods to inform and optimize the care of patients with critical illness. His research interests include learning health systems, sepsis, cardiovascular and endocrine disease during critical illness, substance use disorders in the ICU, and acute respiratory distress syndrome.


A Learning Health System Approach to Improve the Effectiveness of Blood Transfusions during Septic Shock
08/15/2024 - 07/31/2029 (PI)
NIH/National Heart, Lung, and Blood Institute
5K23HL173709-02

Improving the Effective Use of Blood Transfusions During Critical Illness for Patients with Cardiovascular Disease
04/01/2024 - 03/31/2027 (PI)
American Heart Association


The Relationship Between Type of Opioid Used During Critical Illness and Transition to Chronic Pain
09/01/2021 - 08/31/2024 (Subcontract PI)
Sunnybrook Research Institute Dept of Defense


Normalizing vasopressor dose to standardize vasopressors practice in septic shock
02/15/2020 - 06/27/2021 (PI)
NIH/National Institute of General Medical Sciences
5F32GM133061-02



Title

A Learning Health System Approach to Identify the Optimal Use of Secondary Vasopressors during Septic
04/01/2022 - 03/01/2024 (PI)
NIH/National Center for Advancing Translational Sciences
KL2TR001411


Yr Title Project-Sub Proj Pubs
2025 A Learning Health System Approach to Improve the Effectiveness of Blood Transfusions during Septic Shock 5K23HL173709-02
2024 A Learning Health System Approach to Improve the Effectiveness of Blood Transfusions during Septic Shock 1K23HL173709-01
2021 Normalizing vasopressor dose to standardize vasopressors practice in septic shock 5F32GM133061-02
2019 Normalizing vasopressor dose to standardize vasopressors practice in septic shock 1F32GM133061-01

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Steel TL, Shaw PA, Bradley KA, Johnson NJ, Hallgren KA, Matson TE, Bobb JF, Bosch NA, Afshar M, Burnham EL, Hough CL, Tolles J. Opening the DOOR to More Informative Hospital Trials by Ranking Treatment Experiences. Ann Am Thorac Soc. 2025 Nov; 22(11):1641-1644. PMID: 40705497
     
  2. Hill AD, Teja B, Burry L, Pinto R, Bosch NA, Walkey A, Stelfox HT, Chapman M, Scales DC, Wunsch H. Variation in Maximal Doses of Vasopressors Used for Treatment of Shock in Intensive Care Units in Alberta Canada: A Retrospective Cohort Study. Anesth Analg. 2025 Oct 29. PMID: 41165255; DOI: 10.1213/ANE.0000000000007821;
     
  3. Shen BH, Shankar DA, Bosch NA, Walkey AJ, Piazza G, Klings ES, Law AC. Contemporary reperfusion therapies in patients with intermediate- and high-risk pulmonary embolism. Thromb Res. 2025 Dec; 256:109523.View Related Profiles. PMID: 41175547; PMCID: PMC12667197; DOI: 10.1016/j.thromres.2025.109523;
     
  4. Austad K, Fantasia KL, Mohanty A, Jones KC, Bosch NA, Drainoni ML. Failing to Succeed: Advancing Mechanistic Understanding of Implementation Strategies Through Retrospective and Prospective Use of Causal Pathway Diagrams. Res Sq. 2025 Sep 23.View Related Profiles. PMID: 41041569; PMCID: PMC12486080; DOI: 10.21203/rs.3.rs-7482638/v1;
     
  5. Li B, Gershengorn HB, Vail EA, Wunsch H, Walkey AJ, Law AC, Ko D, Ayalon N, Kearney CM, Bosch NA. Inotrope Selection in Mixed Cardiogenic Shock with Sepsis: A Comparative Analysis between Milrinone and Dobutamine. Ann Am Thorac Soc. 2025 Sep 17.View Related Profiles. PMID: 40960311; DOI: 10.1513/AnnalsATS.202503-339OC;
     
  6. Erfle BA, Steel TL, Law AC, Kaufman DA, Hills-Dunlap K, Afshar M, Walkey AJ, Austad KE, Drainoni ML, Bosch NA. Pharmacological Interventions for Alcohol Withdrawal Syndrome Among Hospitalized Adults: A Multicenter Cohort Study. J Gen Intern Med. 2025 Aug 28.View Related Profiles. PMID: 40877712; DOI: 10.1007/s11606-025-09817-8;
     
  7. Bosch NA, Law AC, Roubinian NH, Reza Jafarzadeh S, Walkey AJ. Variation in effectiveness of blood transfusion by hospital day: A multicenter retrospective study. J Hosp Med. 2025 Jul 14.View Related Profiles. PMID: 40659365; PMCID: PMC12635911; DOI: 10.1002/jhm.70133;
     
  8. Connelly D, Delahanty J, Patel S, Ackerbauer KA, Bosch NA, Klings ES, Lui JK. Inhaled epoprostenol for management of acute respiratory failure and pulmonary vascular disease. Pulm Pharmacol Ther. 2025 Sep; 90:102374.View Related Profiles. PMID: 40513981; PMCID: PMC12261948; DOI: 10.1016/j.pupt.2025.102374;
     
  9. Ganti RS, Lee G, Bosch NA. Temporal Trends in Acetazolamide Use in Decompensated Heart Failure After Publication of the ADVOR Trial. Can J Cardiol. 2025 Aug; 41(8):1649-1651. PMID: 40482853
     
  10. Bosch NA, Wilson KC, Law AC. Are Procalcitonin Measures a Reliable Predictor of Stopping Antibiotics Among Patients With Sepsis? JAMA. 2025 May 20; 333(19):1728.View Related Profiles. PMID: 40227721
     
Showing 10 of 105 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 105 publications over 10 distinct years, with a maximum of 23 publications in 2024

YearPublications
20141
20151
20181
20193
20206
202112
202216
202322
202423
202520


Lactated Ringer Solution Better Than Normal Saline for Sickle Cell Pain Crises

Health Day 9/17/2024

Better outcomes with lactated Ringer’s in vaso-occlusive crises

Sickle Cell Anemia News 9/12/2024

Study Supports Lactated Ringer Solution for Fluid Resuscitation in SCD

Medpage Today 9/9/2024

Hydrocortisone Plus Fludrocortisone Superior for Septic Shock

Health Day 4/13/2023

Combo of two steroids may reduce death risk for people with sepsis

UPI 3/30/2023

Combo Steroid Treatment May Work Best When Sepsis Strikes

HealthDay 3/29/2023

Combo Steroid Treatment May Work Best When Sepsis Strikes

US News and World Report 3/29/2023

Are Covid vaccine mandates ethical? Here’s what medical experts think

CNBC 11/24/2021

Vaccine panel recommends J&J boosters after data says vaccine's effectiveness has 'headroom to improve': Live COVID-19 updates

USA Today 11/16/2021

Have vaccine lotteries worked? Studies so far show mixed results

Politifact 8/22/2021

Trending Clinical Topic: Prone Positioning in COVID-19

Medscape 10/9/2020

Experts Divided on Awake Prone Position for Severe COVID-19

Medscape 9/18/2020

Could Flipping COVID-19 Patients Over Ease Breathing?

Futurity 4/27/2020

For COVID-19 Patients, Could Breathing Easier Be as Simple as Flipping Over?

Mirage News 4/18/2020

2025 American Society for Clinical Investigation (ASCI): Young Physician-Scientist Awards
2025 CHEST Critical Care Journal: Top Downloaded Article of the Year 2024: Interpreting Clinical Trial Results
2025 Boston University Medical Center Internal Medicine Residency : Research Mentor Award
2025 Boston University Medical Center Internal Medicine Residency : Top Faculty Excellence in Teaching
2024 CHEST: Best of CHEST: How We Escalate Vasopressor and Corticosteroid Therapy in Patients with Septic Shock
2024 American Thoracic Society: Clinical Year in Review, Sepsis: PMC10043800
2024 American Thoracic Society: Critical Care Assembly Early Career Professional of the Month
2022 Boston University School of Medicine Department of Medicine : Robert Dawson Evans Quality Improvement Award
2022 Boston University Medical Center Internal Medicine Residency : Top Faculty Excellence in Teaching
2022-2024 Boston University CTSI - NCATS: KL2 Career Development Award (1KL2TR001411)
2022-2024 Boston University Chobanian & Avedisian School of Medicine : Department of Medicine Career Investment Award
2011 New York Medical College: Gold Humanism Honor Society
2011 New York Medical College: Alpha Omega Alpha Honor Society
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Sepsis
Alcohol Withdrawal Syndrome
Health Services Research
Quasi-Experimental Studies
Acute Respiratory Distress Syndrome
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