MD, Wannan Medical College
PhD, Peking Union Medical College
MS, Henan Medical University

Retinoic ace receptor, lipid metabolism, and fatty liver disease
01/01/2015 - 12/31/2016 (PI)

RO1 DK 100603-02, Retinoic Acid Receptor, Lipid, Metabolism, and Fatty Liver Disease
01/01/2015 - 12/31/2016 (PI)
Univ of Texas Health Science CTR - San Antonio NIH-NHLBI

mTORC1 activation and alcoholic liver injury
09/15/2013 - 03/31/2016 (PI)

Retinoic Acid Receptor Functions as a Novel Regulator of Hepatic Lipid Metabolism
01/01/2015 - 02/29/2016 (PI)
Amer Diabetes Asso

Sir2 Regulates AMPK and Lipid Metabolism in Diabetes
07/15/2008 - 05/31/2015 (PI)
5R01 DK076942-05

Sir2 Regulates AMPK and Lipid Metabolism in Diabetes
12/28/2009 - 02/28/2010 (PI)
3 R01 DK076942-02S1


Yr Title Project-Sub Proj Pubs
2024 Deciphering RNA Splicing Control of Lipid Metabolism and Alcoholic Liver Injury 1R01AA031407-01
2023 South Texas Medical Scientist Training Program (STX-MSTP) 1T32GM145432-01
2020 Hepatokine Control of Metabolic Crosstalk and Insulin Resistance 5R01DK121527-02
2020 Alcohol-induced dysregulation of thiol homeostasis and endothelial function 5R21AA026922-02 2
2019 Hepatokine Control of Metabolic Crosstalk and Insulin Resistance 1R01DK121527-01
2019 Alcohol-induced dysregulation of thiol homeostasis and endothelial function 1R21AA026922-01A1 2
2018 Retinoic Acid Receptor, Lipid Metabolism, and Fatty Liver Disease 5R01DK100603-04 10
2017 Retinoic Acid Receptor, Lipid Metabolism, and Fatty Liver Disease 7R01DK100603-03 10
2016 Retinoic acid receptor, lipid metabolism, and fatty liver disease 5R01DK100603-02 10
2015 Retinoic acid receptor, lipid metabolism, and fatty liver disease 1R01DK100603-01A1 10
Showing 10 of 19 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Luo T, Nocon A, Fry J, Sherban A, Rui X, Jiang B, Xu XJ, Han J, Yan Y, Yang Q, Li Q, Zang M. AMPK Activation by Metformin Suppresses Abnormal Extracellular Matrix Remodeling in Adipose Tissue and Ameliorates Insulin Resistance in Obesity. Diabetes. 2016 Aug; 65(8):2295-310.View Related Profiles. PMID: 27207538; PMCID: PMC4955985; DOI: 10.2337/db15-1122;
  2. Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, Gao J, Chen X, Han Y, Liang Q, Ye D, Shi L, Chin YE, Wang Y, Xiao H, Guo F, Liu Y, Zang M, Xu A, Li Y. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. Hepatology. 2016 Aug; 64(2):425-38. PMID: 26926384; DOI: 10.1002/hep.28523;
  3. Li X, Kover KL, Heruth DP, Watkins DJ, Moore WV, Jackson K, Zang M, Clements MA, Yan Y. New Insight Into Metformin Action: Regulation of ChREBP and FOXO1 Activities in Endothelial Cells. Mol Endocrinol. 2015 Aug; 29(8):1184-94. PMID: 26147751; DOI: 10.1210/ME.2015-1090;
  4. Li Y, Wong K, Giles A, Jiang J, Lee JW, Adams AC, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M. Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. Gastroenterology. 2014 Feb; 146(2):539-49.e7.View Related Profiles. PMID: 24184811; PMCID: PMC4228483; DOI: 10.1053/j.gastro.2013.10.059;
  5. Li Y, Xu S, Jiang B, Cohen RA, Zang M. Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs. PLoS One. 2013; 8(6):e67532.View Related Profiles. PMID: 23825667; PMCID: PMC3692453; DOI: 10.1371/journal.pone.0067532;
  6. Li Y, Wong K, Walsh K, Gao B, Zang M. Retinoic acid receptor ß stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice. J Biol Chem. 2013 Apr 12; 288(15):10490-504.View Related Profiles. PMID: 23430257; PMCID: PMC3624431; DOI: 10.1074/jbc.M112.429852;
  7. Xu S, Jiang B, Hou X, Shi C, Bachschmid MM, Zang M, Verbeuren TJ, Cohen RA. High-fat diet increases and the polyphenol, S17834, decreases acetylation of the sirtuin-1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice. J Cardiovasc Pharmacol. 2011 Sep; 58(3):263-71.View Related Profiles. PMID: 21654327; PMCID: PMC3168693; DOI: 10.1097/FJC.0b013e3182239eb7;
  8. Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 2011 Apr 6; 13(4):376-88.View Related Profiles. PMID: 21459323; PMCID: PMC3086578; DOI: 10.1016/j.cmet.2011.03.009;
  9. Li Y, Xu S, Giles A, Nakamura K, Lee JW, Hou X, Donmez G, Li J, Luo Z, Walsh K, Guarente L, Zang M. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB J. 2011 May; 25(5):1664-79.View Related Profiles. PMID: 21321189; PMCID: PMC3079300; DOI: 10.1096/fj.10-173492;
  10. Ponugoti B, Kim DH, Xiao Z, Smith Z, Miao J, Zang M, Wu SY, Chiang CM, Veenstra TD, Kemper JK. SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism. J Biol Chem. 2010 Oct 29; 285(44):33959-70. PMID: 20817729; PMCID: PMC2962496; DOI: 10.1074/jbc.M110.122978;
Showing 10 of 23 results. Show More

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