John Snyder | Profiles RNS

John Snyder, PhD

Emeritus Professor

Boston University College of Arts and Sciences

Chemistry

PhD, University of Chicago
BS, Denison University

Websites

	Chemistry Faculty
	Snyder Group Homepage
	Center for Molecular Discovery (BU-CMD)
	Google Scholar
	ResearchGate

The Snyder Group focuses on both organic synthesis and the discovery of new synthetic methodology that allow for the synthesis of natural product type chemotypes that occupy new chemical space. These efforts explore novel applications of inverse electron demand Diels-Alder reactions, homo Diels-Alder reactions, and other chemistries in organic synthesis. They are also exploring the use of abundant natural products as scaffolds in the synthesis of small molecule libraries. The goal of this work is the discovery of completely novel compounds that have significant biological activities against disease targets. Our library synthesis work coordinates with the Boston University Center for Molecular Discovery (BU-CMD).

Techniques & Resources:

NMR Spectroscopy – The Chemistry Department as well as the BU-CMD have excellent spectroscopy facilities to aid synthetic organic chemists. Included are a 500 MHz, two 400 MHz and numerous 300 MHz NMR spectrometers.

Multimode Microwave Reactors Multimode - Microwave reactors have proven invaluable in both reaction condition optimization and in library synthesis.

LC-MS/UPLC – Reaction monitoring is rapidly achieved with LC-MS and UPLC spectrometers.

ISCO CombiFlash (CMD) – For rapid, automated purification.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Associate Chair
Boston University College of Arts and Sciences
Chemistry

BU Research

REU Site: Research Addressing Problems in Biological Chemistry
09/01/2019 - 08/31/2023 (Multi-PI)
PI: John Snyder, PhD
National Science Foundation
CHE-1852275

Chemistry Research Addressing Biological Problems
05/01/2016 - 04/30/2019 (PI)
National Science Foundation
CHE-1560152

REU Site: Fundamental Research in Chemistry Addressing Biological Problems
08/01/2012 - 07/31/2015 (PI)
National Science Foundation
CHE-1156666

COMPLEX CHEMOTYPES: DISCOVERY, METHODOLOGY, AND LIBRARY EXPANSION - LSC
09/01/2010 - 08/31/2014 (Key Person)
PI: John A. Porco, PhD
NIH/National Institute of General Medical Sciences
5P50GM067041-10

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

An X, Majumder A, McNeely J, Yang J, Puri T, He Z, Liang T, Snyder JK, Straub JE, Reinhard BM. Interfacial hydration determines orientational and functional dimorphism of sterol-derived Raman tags in lipid-coated nanoparticles. Proc Natl Acad Sci U S A. 2021 08 17; 118(33).View Related Profiles.

Snyder, John
Straub, John

PMID: 34389679; PMCID: PMC8379971; DOI: 10.1073/pnas.2105913118;

Liang L, Rasmussen MH, Piening B, Shen X, Chen S, Röst H, Snyder JK, Tibshirani R, Skotte L, Lee NC, Contrepois K, Feenstra B, Zackriah H, Snyder M, Melbye M. Metabolic Dynamics and Prediction of Gestational Age and Time to Delivery in Pregnant Women. Cell. 2020 06 25; 181(7):1680-1692.e15. PMID: 32589958; PMCID: PMC7327522; DOI: 10.1016/j.cell.2020.05.002;

Kearney SE, Zahoránszky-Kohalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. ACS Cent Sci. 2018 Dec 26; 4(12):1727-1741.View Related Profiles.

Porco, John
Snyder, John
Brown, Lauren

PMID: 30648156; PMCID: PMC6311695; DOI: 10.1021/acscentsci.8b00747;

Manier S, Huynh D, Shen YJ, Zhou J, Yusufzai T, Salem KZ, Ebright RY, Shi J, Park J, Glavey SV, Devine WG, Liu CJ, Leleu X, Quesnel B, Roche-Lestienne C, Snyder JK, Brown LE, Gray N, Bradner J, Whitesell L, Porco JA, Ghobrial IM. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Sci Transl Med. 2017 May 10; 9(389).View Related Profiles.

Porco, John
Snyder, John
Brown, Lauren

PMID: 28490664; PMCID: PMC5718051; DOI: 10.1126/scitranslmed.aal2668;

Strom KR, Impastato AC, Moy KJ, Landreth AJ, Snyder JK. Gallium(III)-Promoted Halocyclizations of 1,6-Diynes. Org Lett. 2015 May 1; 17(9):2126-9. PMID: 25885017; DOI: 10.1021/acs.orglett.5b00716;

Grenning AJ, Snyder JK, Porco JA. Remodeling of fumagillol: discovery of an oxygen-directed oxidative Mannich reaction. Org Lett. 2014 Feb 7; 16(3):792-5.View Related Profiles.

Porco, John
Snyder, John

PMID: 24410175; PMCID: PMC3927640; DOI: 10.1021/ol4035269;

Filone CM, Hodges EN, Honeyman B, Bushkin GG, Boyd K, Platt A, Ni F, Strom K, Hensley L, Snyder JK, Connor JH. Identification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach. Chem Biol. 2013 Mar 21; 20(3):424-33.View Related Profiles.

Filone, Claire Marie
Bushkin, Gary
Connor, John
Snyder, John

PMID: 23521799; PMCID: PMC3712830; DOI: 10.1016/j.chembiol.2013.02.011;

Ma Z, Ni F, Woo GH, Lo SM, Roveto PM, Schaus SE, Snyder JK. An intramolecular inverse electron demand Diels-Alder approach to annulated a-carbolines. Beilstein J Org Chem. 2012; 8:829-40.View Related Profiles.

Snyder, John
Schaus, Scott

PMID: 23015831; PMCID: PMC3388871; DOI: 10.3762/bjoc.8.93;

Kota S, Takahashi V, Ni F, Snyder JK, Strosberg AD. Direct binding of a hepatitis C virus inhibitor to the viral capsid protein. PLoS One. 2012; 7(2):e32207. PMID: 22389688; PMCID: PMC3289641; DOI: 10.1371/journal.pone.0032207;

Balthaser BR, Maloney MC, Beeler AB, Porco JA, Snyder JK. Remodelling of the natural product fumagillol employing a reaction discovery approach. Nat Chem. 2011 Dec; 3(12):969-73.View Related Profiles.

Beeler, Aaron
Porco, John
Snyder, John

PMID: 22213919; PMCID: PMC3254213; DOI: 10.1038/nchem.1178;

Showing 10 of 35 results. Show More

Gibeau AL, Snyder JK. Indium(III)-catalyzed hydrative cyclization of 1,7-diynyl ethers. Org Lett. 2011 Aug 19; 13(16):4280-3. PMID: 21761825; DOI: 10.1021/ol201624b;

Brown LE, Chih-Chien Cheng K, Wei WG, Yuan P, Dai P, Trilles R, Ni F, Yuan J, MacArthur R, Guha R, Johnson RL, Su XZ, Dominguez MM, Snyder JK, Beeler AB, Schaus SE, Inglese J, Porco JA. Discovery of new antimalarial chemotypes through chemical methodology and library development. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):6775-80.View Related Profiles.

Beeler, Aaron
Porco, John
Snyder, John
Brown, Lauren
Schaus, Scott

PMID: 21498685; PMCID: PMC3084078; DOI: 10.1073/pnas.1017666108;

Ni F, Kota S, Takahashi V, Strosberg AD, Snyder JK. Potent inhibitors of hepatitis C core dimerization as new leads for anti-hepatitis C agents. Bioorg Med Chem Lett. 2011 Apr 15; 21(8):2198-202. PMID: 21440437; PMCID: PMC3086078; DOI: 10.1016/j.bmcl.2011.03.014;

Strosberg AD, Kota S, Takahashi V, Snyder JK, Mousseau G. Core as a novel viral target for hepatitis C drugs. Viruses. 2010 Aug; 2(8):1734-51. PMID: 21994704; PMCID: PMC3185734; DOI: 10.3390/v2081734;

Jones AL, Snyder JK. Synthesis of unique scaffolds via Diels-Alder cycloadditions of tetrasubstituted cyclohexadienes. Org Lett. 2010 Apr 2; 12(7):1592-5. PMID: 20210307; PMCID: PMC2851182; DOI: 10.1021/ol100318f;

Jones AL, Liu X, Snyder JK. Enantioselective syntheses of candenatenins B and C using a chiral anthracene auxiliary. Tetrahedron Lett. 2010 Feb 17; 51(7):1091-1094. PMID: 20305722; PMCID: PMC2839163; DOI: 10.1016/j.tetlet.2009.12.108;

Kota S, Scampavia L, Spicer T, Beeler AB, Takahashi V, Snyder JK, Porco JA, Hodder P, Strosberg AD. A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization. Assay Drug Dev Technol. 2010 Feb; 8(1):96-105.View Related Profiles.

Beeler, Aaron
Porco, John
Snyder, John

PMID: 20035614; PMCID: PMC2971647; DOI: 10.1089/adt.2009.0217;

Wei W, Cai C, Kota S, Takahashi V, Ni F, Strosberg AD, Snyder JK. New small molecule inhibitors of hepatitis C virus. Bioorg Med Chem Lett. 2009 Dec 15; 19(24):6926-30. PMID: 19896376; PMCID: PMC2783740; DOI: 10.1016/j.bmcl.2009.10.070;

Jones AL, Snyder JK. Intramolecular rhodium-catalyzed [2+2+2] cyclizations of diynes with enones. J Org Chem. 2009 Apr 3; 74(7):2907-10. PMID: 19281162; PMCID: PMC2739116; DOI: 10.1021/jo9001678;

Zhou Y, Beeler AB, Cho S, Wang Y, Franzblau SG, Snyder JK. Library synthesis using 5,6,7,8-tetrahydro-1,6-naphthyridines as scaffolds. J Comb Chem. 2008 Jul-Aug; 10(4):534-40.View Related Profiles.

Beeler, Aaron
Snyder, John

PMID: 18517255; DOI: 10.1021/cc800038r;

Liu X, Snyder JK. Anthracene cycloadducts as highly selective chiral auxiliaries. J Org Chem. 2008 Apr 4; 73(7):2935-8. PMID: 18321128; DOI: 10.1021/jo702724t;

Woo GH, Beeler AB, Snyder JK. 1,2,3,4-Tetrahydro-1,5-naphthyridines and related heterocyclic scaffolds: Exploration of suitable chemistry for library development. Tetrahedron. 2007 Jun 18; 63(25):5649-5655.View Related Profiles.

Beeler, Aaron
Snyder, John

PMID: 19112520; PMCID: PMC2608727; DOI: 10.1016/j.tet.2007.04.003;

Zhou Y, Porco JA, Snyder JK. Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridines and related heterocycles by cobalt-catalyzed [2 + 2 + 2] cyclizations. Org Lett. 2007 Feb 1; 9(3):393-6.View Related Profiles.

Porco, John
Snyder, John

PMID: 17249770

Burgess KL, Corbett MS, Eugenio P, Lajkiewicz NJ, Liu X, Sanyal A, Yan W, Yuan Q, Snyder JK. Chiral anthracene and anthrone templates as stereocontrolling elements in Diels-Alder/retro Diels-Alder sequences. Bioorg Med Chem. 2005 Sep 1; 13(17):5299-309. PMID: 16046136

Su S, Acquilano DE, Arumugasamy J, Beeler AB, Eastwood EL, Giguere JR, Lan P, Lei X, Min GK, Yeager AR, Zhou Y, Panek JS, Snyder JK, Schaus SE, Porco JA. Convergent synthesis of a complex oxime library using chemical domain shuffling. Org Lett. 2005 Jun 23; 7(13):2751-4.View Related Profiles.

Beeler, Aaron
Panek, James
Porco, John
Snyder, John
Schaus, Scott

PMID: 15957938

Burgess KL, Lajkiewicz NJ, Sanyal A, Yan W, Snyder JK. A new chiral anthracene for the asymmetric Diels-Alder/retro-Diels-Alder sequence. Org Lett. 2005 Jan 6; 7(1):31-4. PMID: 15624970

Lahue BR, Lo SM, Wan ZK, Woo GH, Snyder JK. Intramolecular inverse-electron-demand Diels-Alder reactions of imidazoles with 1,2,4-triazines: a new route to 1,2,3,4-tetrahydro-1,5-naphthyridines and related heterocycles. J Org Chem. 2004 Oct 15; 69(21):7171-82. PMID: 15471466

Lahue BR, Wan ZK, Snyder JK. Dienophilicity of imidazole in inverse electron demand Diels-Alder reactions. 4. Intermolecular reactions with 1,2,4-triazines. J Org Chem. 2003 May 30; 68(11):4345-54. PMID: 12762735

Ma B, Snyder JK. A homo Diels-Alder approach to bicyclo[4.2.1]nonanes. Org Lett. 2002 Aug 8; 4(16):2731-4. PMID: 12153221

Deng Y, Snyder JK. Preparation of a 24-nor-1,4-dien-3-one triterpene derivative from betulin: a new route to 24-nortriterpene analogues. J Org Chem. 2002 May 3; 67(9):2864-73. PMID: 11975539

Chen Y, Snyder JK. Opening the [4 + 2 + 2] cycloadducts of bicyclo[2.2.1]hepta-2,5-dienes (norbornadienes) to cis-fused bicyclo[5.3.0]decanes. J Org Chem. 2001 Oct 19; 66(21):6943-57. PMID: 11597213

Chen Y, Kiattansakul R, Ma B, Snyder JK. Transition metal-catalyzed [4 + 2 + 2] cycloadditions of bicyclo[2.2.1]hepta-2,5-dienes (norbornadienes) and bicyclo[2.2.2]octa-2,5-dienes. J Org Chem. 2001 Oct 19; 66(21):6932-42. PMID: 11597212

Sanyal A, Snyder JK. Stereoselective diels-alder reactions of chiral anthracenes Org Lett. 2000 Aug 10; 2(16):2527-30. PMID: 10956538

Deng Y, Lee JP, Tianasoa-Ramamonjy M, Snyder JK, Des Etages SA, Kanada D, Snyder MP, Turner CJ. New antimicrobial flavanones from Physena madagascariensis. J Nat Prod. 2000 Aug; 63(8):1082-9. PMID: 10978202

Deng Y, Jiang TY, Sheng S, Tianasoa-Ramamonjy M, Snyder JK. Remangilones A-C, new cytotoxic triterpenes from Physena madagascariensis. J Nat Prod. 1999 Mar; 62(3):471-6. PMID: 10096861

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 35 publications over 20 distinct years, with a maximum of 4 publications in 2010 and 2011