John Snyder, PhD
Emeritus Professor
Boston University College of Arts and Sciences

PhD, University of Chicago
BS, Denison University

The Snyder Group focuses on both organic synthesis and the discovery of new synthetic methodology that allow for the synthesis of natural product type chemotypes that occupy new chemical space. These efforts explore novel applications of inverse electron demand Diels-Alder reactions, homo Diels-Alder reactions, and other chemistries in organic synthesis. They are also exploring the use of abundant natural products as scaffolds in the synthesis of small molecule libraries. The goal of this work is the discovery of completely novel compounds that have significant biological activities against disease targets. Our library synthesis work coordinates with the Boston University Center for Molecular Discovery (BU-CMD).

Techniques & Resources:

NMR Spectroscopy – The Chemistry Department as well as the BU-CMD have excellent spectroscopy facilities to aid synthetic organic chemists. Included are a 500 MHz, two 400 MHz and numerous 300 MHz NMR spectrometers.

Multimode Microwave Reactors Multimode - Microwave reactors have proven invaluable in both reaction condition optimization and in library synthesis.

LC-MS/UPLC – Reaction monitoring is rapidly achieved with LC-MS and UPLC spectrometers.

ISCO CombiFlash (CMD) – For rapid, automated purification.

Boston University
Evans Center for Interdisciplinary Biomedical Research

Associate Chair
Boston University College of Arts and Sciences

REU Site: Research Addressing Problems in Biological Chemistry
09/01/2019 - 08/31/2023 (Multi-PI)
PI: John Snyder, PhD
National Science Foundation

Chemistry Research Addressing Biological Problems
05/01/2016 - 04/30/2019 (PI)
National Science Foundation

REU Site: Fundamental Research in Chemistry Addressing Biological Problems
08/01/2012 - 07/31/2015 (PI)
National Science Foundation

09/01/2010 - 08/31/2014 (Key Person)
PI: John A. Porco, PhD
NIH/National Institute of General Medical Sciences


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. An X, Majumder A, McNeely J, Yang J, Puri T, He Z, Liang T, Snyder JK, Straub JE, Reinhard BM. Interfacial hydration determines orientational and functional dimorphism of sterol-derived Raman tags in lipid-coated nanoparticles. Proc Natl Acad Sci U S A. 2021 08 17; 118(33).View Related Profiles. PMID: 34389679; PMCID: PMC8379971; DOI: 10.1073/pnas.2105913118;
  2. Liang L, Rasmussen MH, Piening B, Shen X, Chen S, Röst H, Snyder JK, Tibshirani R, Skotte L, Lee NC, Contrepois K, Feenstra B, Zackriah H, Snyder M, Melbye M. Metabolic Dynamics and Prediction of Gestational Age and Time to Delivery in Pregnant Women. Cell. 2020 06 25; 181(7):1680-1692.e15. PMID: 32589958; PMCID: PMC7327522; DOI: 10.1016/j.cell.2020.05.002;
  3. Kearney SE, Zahoránszky-Kohalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. ACS Cent Sci. 2018 Dec 26; 4(12):1727-1741.View Related Profiles. PMID: 30648156; PMCID: PMC6311695; DOI: 10.1021/acscentsci.8b00747;
  4. Manier S, Huynh D, Shen YJ, Zhou J, Yusufzai T, Salem KZ, Ebright RY, Shi J, Park J, Glavey SV, Devine WG, Liu CJ, Leleu X, Quesnel B, Roche-Lestienne C, Snyder JK, Brown LE, Gray N, Bradner J, Whitesell L, Porco JA, Ghobrial IM. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Sci Transl Med. 2017 May 10; 9(389).View Related Profiles. PMID: 28490664; PMCID: PMC5718051; DOI: 10.1126/scitranslmed.aal2668;
  5. Strom KR, Impastato AC, Moy KJ, Landreth AJ, Snyder JK. Gallium(III)-Promoted Halocyclizations of 1,6-Diynes. Org Lett. 2015 May 1; 17(9):2126-9. PMID: 25885017; DOI: 10.1021/acs.orglett.5b00716;
  6. Grenning AJ, Snyder JK, Porco JA. Remodeling of fumagillol: discovery of an oxygen-directed oxidative Mannich reaction. Org Lett. 2014 Feb 7; 16(3):792-5.View Related Profiles. PMID: 24410175; PMCID: PMC3927640; DOI: 10.1021/ol4035269;
  7. Filone CM, Hodges EN, Honeyman B, Bushkin GG, Boyd K, Platt A, Ni F, Strom K, Hensley L, Snyder JK, Connor JH. Identification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach. Chem Biol. 2013 Mar 21; 20(3):424-33.View Related Profiles. PMID: 23521799; PMCID: PMC3712830; DOI: 10.1016/j.chembiol.2013.02.011;
  8. Ma Z, Ni F, Woo GH, Lo SM, Roveto PM, Schaus SE, Snyder JK. An intramolecular inverse electron demand Diels-Alder approach to annulated a-carbolines. Beilstein J Org Chem. 2012; 8:829-40.View Related Profiles. PMID: 23015831; PMCID: PMC3388871; DOI: 10.3762/bjoc.8.93;
  9. Kota S, Takahashi V, Ni F, Snyder JK, Strosberg AD. Direct binding of a hepatitis C virus inhibitor to the viral capsid protein. PLoS One. 2012; 7(2):e32207. PMID: 22389688; PMCID: PMC3289641; DOI: 10.1371/journal.pone.0032207;
  10. Balthaser BR, Maloney MC, Beeler AB, Porco JA, Snyder JK. Remodelling of the natural product fumagillol employing a reaction discovery approach. Nat Chem. 2011 Dec; 3(12):969-73.View Related Profiles. PMID: 22213919; PMCID: PMC3254213; DOI: 10.1038/nchem.1178;
Showing 10 of 35 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 35 publications over 20 distinct years, with a maximum of 4 publications in 2010 and 2011


1989 Boston University: Metcalf Award for Excellence in Teaching
1983 Henry and Camille Dreyfus Foundation: Newly Appointed Young Faculty in Chemistry
1983 National Academy of Sciences, Committee for Scholarly Communication with the People’s Republic of Ch: Research Fellowship
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590 Commonwealth Ave
Boston MA 02215
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(617) 353-6466 (fax)

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