Jason Rock, PhD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

PhD, University of Florida College of Medicine

Jason Rock, PhD, is an Associate Professor of Medicine at the Boston University School of Medicine. The Rock Lab int he Center for Regenerative Medicine studies how the many different cell types of our lungs are generated during development and how they respond to normal wear and tear, acute injury and disease. The underlying hypothesis is that aberrant (stem) cell behaviors explain many features of lung diseases such as chronic obstructive pulmonary disease, cystic fibrosis, asthma, and pulmonary fibrosis. We use in vivo and in vitro models to identify and test the progenitor capacity of putative stem cell populations and the molecular mechanisms and environmental influences (i.e., niches) that regulate their proliferation and differentiation. Our ultimate goal is to identify genetic, molecular and cellular therapies for the treatment of lung disease.

Boston University School of Medicine
Center for Regenerative Medicine

2012 Disease Models and Mechanisms: Most Cited Paper
2008-2012 Developmental Biology: Most Cited Paper
2003-2008 University of Florida: Graduate Alumni Fellowship
2002 Florida State University: Magna Cum Laude
2002 Florida State University: Completed Honors Program

Mechanisms of adult lung alveologenesis
08/01/2017 - 04/30/2020 (PI)
NIH/National Heart, Lung, and Blood Institute

Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage
09/21/2016 - 05/31/2019 (PI of Sub-Project / SP)
PI: Darrell Nelson Kotton, MD
The Regents of the University of California, San Francisco NIH NHLBI

Nutrient signaling and stem cell maintenance in aging epithelia
06/01/2017 - 12/31/2017 (PI)
Buck Institute for Research on Aging NIH NIA

Yr Title Project-Sub Proj Pubs
2019 Mechanisms of adult lung alveologenesis 5R01HL127002-06 2
2018 Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage 5U01HL134766-03 8
2018 Mechanisms of adult lung alveologenesis 5R01HL127002-05 2
2017 Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage 5U01HL134766-02 8
2017 Mechanisms of adult lung alveologenesis 5R01HL127002-03 2
2017 Mechanisms of adult lung alveologenesis 7R01HL127002-04 2
2016 Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage 1U01HL134766-01 8
2016 Mechanisms of adult lung alveologenesis 5R01HL127002-02 2
2015 Mechanisms of adult lung alveologenesis 1R01HL127002-01 2
2011 Cell Biology of Airway Epithelial Basal Cell Progenitors 5F32HL102920-02 2
Showing 10 of 11 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Henriques T, Agostinelli E, Hernandez-Clavijo A, Maurya DK, Rock JR, Harfe BD, Menini A, Pifferi S. TMEM16A calcium-activated chloride currents in supporting cells of the mouse olfactory epithelium. J Gen Physiol. 2019 May 02. PMID: 31048412.
  2. Hwang SJ, Pardo DM, Zheng H, Bayguinov Y, Blair PJ, Fortune-Grant R, Cook RS, Hennig GW, Shonnard MC, Grainger N, Peri LE, Verma SD, Rock J, Sanders KM, Ward SM. Differential sensitivity of gastric and small intestinal muscles to inducible knockdown of anoctamin 1 and the effects on gastrointestinal motility. J Physiol. 2019 May; 597(9):2337-2360. PMID: 30843201.
  3. Zawieja SD, Castorena JA, Gui P, Li M, Bulley SA, Jaggar JH, Rock JR, Davis MJ. Ano1 mediates pressure-sensitive contraction frequency changes in mouse lymphatic collecting vessels. J Gen Physiol. 2019 Apr 01; 151(4):532-554. PMID: 30862712.
  4. Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z, Kessenbrock K. Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity. Nat Commun. 2018 05 23; 9(1):2028. PMID: 29795293.
  5. Sung TS, Hwang SJ, Koh SD, Bayguinov Y, Peri LE, Blair PJ, Webb TI, Pardo DM, Rock JR, Sanders KM, Ward SM. The cells and conductance mediating cholinergic neurotransmission in the murine proximal stomach. J Physiol. 2018 05 01; 596(9):1549-1574. PMID: 29430647.
  6. Haller S, Kapuria S, Riley RR, O'Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H. mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance. Cell Stem Cell. 2017 Dec 07; 21(6):806-818.e5. PMID: 29220665.
  7. Benedetto R, Ousingsawat J, Wanitchakool P, Zhang Y, Holtzman MJ, Amaral M, Rock JR, Schreiber R, Kunzelmann K. Epithelial Chloride Transport by CFTR Requires TMEM16A. Sci Rep. 2017 09 29; 7(1):12397. PMID: 28963502; DOI: 10.1038/s41598-017-10910-0;.
  8. Lechner AJ, Driver IH, Lee J, Conroy CM, Nagle A, Locksley RM, Rock JR. Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy. Cell Stem Cell. 2017 Jul 06; 21(1):120-134.e7. PMID: 28506464; DOI: 10.1016/j.stem.2017.03.024;.
  9. Hawkins F, Kramer P, Jacob A, Driver I, Thomas DC, McCauley KB, Skvir N, Crane AM, Kurmann AA, Hollenberg AN, Nguyen S, Wong BG, Khalil AS, Huang SX, Guttentag S, Rock JR, Shannon JM, Davis BR, Kotton DN. Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells. J Clin Invest. 2017 Jun 01; 127(6):2277-2294.View Related Profiles. PMID: 28463226.
  10. Cobine CA, Hannah EE, Zhu MH, Lyle HE, Rock JR, Sanders KM, Ward SM, Keef KD. ANO1 in intramuscular interstitial cells of Cajal plays a key role in the generation of slow waves and tone in the internal anal sphincter. J Physiol. 2017 Mar 15; 595(6):2021-2041. PMID: 28054347; DOI: 10.1113/JP273618;.
Showing 10 of 53 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 53 publications over 13 distinct years, with a maximum of 7 publications in 2014

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Boston MA 02118
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