Jason Rock, PhD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

PhD, University of Florida College of Medicine




Jason Rock, PhD, is an Associate Professor of Medicine at the Boston University School of Medicine. The Rock Lab int he Center for Regenerative Medicine studies how the many different cell types of our lungs are generated during development and how they respond to normal wear and tear, acute injury and disease. The underlying hypothesis is that aberrant (stem) cell behaviors explain many features of lung diseases such as chronic obstructive pulmonary disease, cystic fibrosis, asthma, and pulmonary fibrosis. We use in vivo and in vitro models to identify and test the progenitor capacity of putative stem cell populations and the molecular mechanisms and environmental influences (i.e., niches) that regulate their proliferation and differentiation. Our ultimate goal is to identify genetic, molecular and cellular therapies for the treatment of lung disease.

Faculty
Boston University
National Emerging Infectious Disease Lab


Member
Boston University
Pulmonary Center


Member
Boston University
Center for Regenerative Medicine


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences



2012 Disease Models and Mechanisms: Most Cited Paper
2008-2012 Developmental Biology: Most Cited Paper
2003-2008 University of Florida: Graduate Alumni Fellowship
2002 Florida State University: Magna Cum Laude
2002 Florida State University: Completed Honors Program


Generation of functional lung stem cells from human iPSCs
07/01/2019 - 06/30/2021 (Multi-PI)
PI: Jason Rock, PhD
NIH/National Heart, Lung, and Blood Institute
5U01HL148692-02

PCTC Administrative Coordinating Center
12/01/2019 - 05/31/2021 (Subcontract Co-PI)
University of Maryland d.b.a. University of Maryland Baltimore Campus NIH NHLBI
5U24HL134763-04

Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage
09/21/2016 - 05/31/2021 (Subcontract Co-PI)
The Regents of the University of California, San Francisco NIH NHLBI
5U01HL134766-05

Mechanisms of adult lung alveologenesis
08/01/2017 - 04/30/2021 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL127002-06

Myeloid lineages and type 2 cytokines in lung homeostasis and repair
07/01/2020 - 07/02/2020 (PI)
NIH/National Heart, Lung, and Blood Institute
1R01HL153369-01

PCTC Admin coordinating center: scRNA-Seq to define the heterogeneity of iPSC-derived lung progenitors
12/01/2019 - 05/31/2020 (Subcontract Co-PI)
University of Maryland NIH NHLBI
55U24HL134763-04-04

Nutrient signaling and stem cell maintenance in aging epithelia
06/01/2017 - 12/31/2017 (Subcontract PI)
Buck Institute for Research on Aging NIH NIA
5R01AG047497-03



Title


Yr Title Project-Sub Proj Pubs
2020 Myeloid lineages and type 2 cytokines in lung homeostasis and repair 1R01HL153369-01
2020 Generation of functional lung stem cells from human iPSCs 5U01HL148692-02 1
2020 Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage 5U01HL134766-05 10
2019 Generation of functional lung stem cells from human iPSCs 1U01HL148692-01 1
2019 Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage 5U01HL134766-04 10
2019 Mechanisms of adult lung alveologenesis 5R01HL127002-06 3
2018 Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage 5U01HL134766-03 10
2018 Mechanisms of adult lung alveologenesis 5R01HL127002-05 3
2017 Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage 5U01HL134766-02 10
2017 Mechanisms of adult lung alveologenesis 5R01HL127002-03 3
Showing 10 of 16 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Basil MC, Katzen J, Engler AE, Guo M, Herriges MJ, Kathiriya JJ, Windmueller R, Ysasi AB, Zacharias WJ, Chapman HA, Kotton DN, Rock JR, Snoeck HW, Vunjak-Novakovic G, Whitsett JA, Morrisey EE. The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future. Cell Stem Cell. 2020 04 02; 26(4):482-502.View Related Profiles. PMID: 32243808
     
  2. Engler AE, Mostoslavsky G, Miller L, Rock JR. Isolation, Maintenance and Differentiation of Primary Tracheal Basal Cells from Adult Rhesus Macaque. Methods Protoc. 2019 Oct 01; 2(4).View Related Profiles. PMID: 31581513
     
  3. Henriques T, Agostinelli E, Hernandez-Clavijo A, Maurya DK, Rock JR, Harfe BD, Menini A, Pifferi S. TMEM16A calcium-activated chloride currents in supporting cells of the mouse olfactory epithelium. J Gen Physiol. 2019 07 01; 151(7):954-966. PMID: 31048412
     
  4. Hwang SJ, Pardo DM, Zheng H, Bayguinov Y, Blair PJ, Fortune-Grant R, Cook RS, Hennig GW, Shonnard MC, Grainger N, Peri LE, Verma SD, Rock J, Sanders KM, Ward SM. Differential sensitivity of gastric and small intestinal muscles to inducible knockdown of anoctamin 1 and the effects on gastrointestinal motility. J Physiol. 2019 05; 597(9):2337-2360. PMID: 30843201
     
  5. Zawieja SD, Castorena JA, Gui P, Li M, Bulley SA, Jaggar JH, Rock JR, Davis MJ. Ano1 mediates pressure-sensitive contraction frequency changes in mouse lymphatic collecting vessels. J Gen Physiol. 2019 04 01; 151(4):532-554. PMID: 30862712
     
  6. Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z, Kessenbrock K. Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity. Nat Commun. 2018 05 23; 9(1):2028. PMID: 29795293
     
  7. Sung TS, Hwang SJ, Koh SD, Bayguinov Y, Peri LE, Blair PJ, Webb TI, Pardo DM, Rock JR, Sanders KM, Ward SM. The cells and conductance mediating cholinergic neurotransmission in the murine proximal stomach. J Physiol. 2018 05 01; 596(9):1549-1574. PMID: 29430647
     
  8. Haller S, Kapuria S, Riley RR, O'Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H. mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance. Cell Stem Cell. 2017 Dec 07; 21(6):806-818.e5. PMID: 29220665
     
  9. Benedetto R, Ousingsawat J, Wanitchakool P, Zhang Y, Holtzman MJ, Amaral M, Rock JR, Schreiber R, Kunzelmann K. Epithelial Chloride Transport by CFTR Requires TMEM16A. Sci Rep. 2017 09 29; 7(1):12397. PMID: 28963502; DOI: 10.1038/s41598-017-10910-0;
     
  10. Lechner AJ, Driver IH, Lee J, Conroy CM, Nagle A, Locksley RM, Rock JR. Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy. Cell Stem Cell. 2017 Jul 06; 21(1):120-134.e7. PMID: 28506464; DOI: 10.1016/j.stem.2017.03.024;
     
Showing 10 of 55 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 55 publications over 14 distinct years, with a maximum of 7 publications in 2014

YearPublications
20071
20083
20096
20104
20116
20126
20132
20147
20155
20163
20175
20182
20194
20201

Contact for Mentoring:

670 Albany Street
Boston MA 02118
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