James F. Head, PhD
Emeritus Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

PhD, University of Birmingham
BS, University of Manchester



Dr. James Head an Emeritus Professor of Physiology and Biophysics at Chobanian and Avedisian School of Medicine. His research work focuses on characterizing the molecular details of protein-ligand and protein-protein interactions and the mechanisms by which changes in these interactions regulate physiological processes. These studies have concentrated mainly on the role of the calcium ion in mediating changes in protein-ligand interactions which subsequently may alter protein-protein interactions to modulate function. However, other protein-ligand interactions are also under study including enzyme-effector and protein-protein complexes. X-ray crystallography is a major tool used in these studies.

Member
Boston University
Pulmonary Center




Multiple Antibiotic Resistance (MAR) Regulon
05/17/2013 - 04/30/2014 (Subcontract PI)
Trustees of Tufts College, Inc NIH NIAID
R01AI056021-29

Multiple Antibiotic Resistance (MAR) Regulon
01/01/2009 - 12/31/2012 (Subcontract PI)
Trustees of Tufts College, Inc NIH NIAID
5R01AI056021-27

Crystal Structures of Multiple Antibiotic Resistance Proteins
08/08/1999 - 12/31/2006 (PI)
Paratek Pharmaceuticals Inc

Structural Studies on Aequorin
03/01/2000 - 02/29/2004 (PI)
National Science Foundation

Nucleoplasmin & N1: Co-Chaperones in Nucleosome Assembly
01/01/2000 - 12/31/2003 (Co-PI)
NIH/National Institute of General Medical Sciences
5 R01 GM60537 02

Crystal Structures of Multiple Antibiotic Resistance Proteins
08/09/1999 - 08/08/2001 (Co-PI)
PI: Barbara A. Seaton, PhD
Paratek Pharmaceuticals Inc



Title


Yr Title Project-Sub Proj Pubs
2001 MULTIPLE ANTIBIOTIC RESISTANCE REPRESSOR PROTEIN 3P41RR010888-05S1-27 259
2000 MULTIPLE ANTIBIOTIC RESISTANCE REPRESSOR PROTEIN 5P41RR010888-05-27 259
1999 MULTIPLE ANTIBIOTIC RESISTANCE REPRESSOR PROTEIN 5P41RR010888-04-27 259

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Rynkiewicz MJ, Wu H, Cafarella TR, Nikolaidis NM, Head JF, Seaton BA, McCormack FX. Differential Ligand Binding Specificities of the Pulmonary Collectins Are Determined by the Conformational Freedom of a Surface Loop. Biochemistry. 2017 Aug 08; 56(31):4095-4105.View Related Profiles. PMID: 28719181
     
  2. Farelli JD, Gumbart JC, Akey IV, Hempstead A, Amyot W, Head JF, McKnight CJ, Isberg RR, Akey CW. IcmQ in the Type 4b secretion system contains an NAD+ binding domain. Structure. 2013 Aug 6; 21(8):1361-73.View Related Profiles. PMID: 23850453; PMCID: PMC3816012; DOI: 10.1016/j.str.2013.05.017;
     
  3. Duval V, McMurry LM, Foster K, Head JF, Levy SB. Mutational analysis of the multiple-antibiotic resistance regulator MarR reveals a ligand binding pocket at the interface between the dimerization and DNA binding domains. J Bacteriol. 2013 Aug; 195(15):3341-51. PMID: 23687277; PMCID: PMC3719538; DOI: 10.1128/JB.02224-12;
     
  4. van Eijk M, Rynkiewicz MJ, White MR, Hartshorn KL, Zou X, Schulten K, Luo D, Crouch EC, Cafarella TR, Head JF, Haagsman HP, Seaton BA. A unique sugar-binding site mediates the distinct anti-influenza activity of pig surfactant protein D. J Biol Chem. 2012 Aug 3; 287(32):26666-77.View Related Profiles. PMID: 22685299; PMCID: PMC3411006; DOI: 10.1074/jbc.M112.368571;
     
  5. Platonova O, Akey IV, Head JF, Akey CW. Crystal structure and function of human nucleoplasmin (npm2): a histone chaperone in oocytes and embryos. Biochemistry. 2011 Sep 20; 50(37):8078-89.View Related Profiles. PMID: 21863821; PMCID: PMC3172369; DOI: 10.1021/bi2006652;
     
  6. Shang F, Rynkiewicz MJ, McCormack FX, Wu H, Cafarella TM, Head JF, Seaton BA. Crystallographic complexes of surfactant protein A and carbohydrates reveal ligand-induced conformational change. J Biol Chem. 2011 Jan 7; 286(1):757-65.View Related Profiles. PMID: 21047777; PMCID: PMC3013034; DOI: 10.1074/jbc.M110.175265;
     
  7. Hartshorn KL, White MR, Rynkiewicz M, Sorensen G, Holmskov U, Head J, Crouch EC. Monoclonal antibody-assisted structure-function analysis of the carbohydrate recognition domain of surfactant protein D. Am J Physiol Lung Cell Mol Physiol. 2010 Sep; 299(3):L384-92.View Related Profiles. PMID: 20601494; PMCID: PMC2951070; DOI: 10.1152/ajplung.00096.2010;
     
  8. Hartshorn KL, White MR, Smith K, Sorensen G, Kuroki Y, Holmskov U, Head J, Crouch EC. Increasing antiviral activity of surfactant protein d trimers by introducing residues from bovine serum collectins: dissociation of mannan-binding and antiviral activity. Scand J Immunol. 2010 Jul; 72(1):22-30.View Related Profiles. PMID: 20591072; PMCID: PMC3263973; DOI: 10.1111/j.1365-3083.2010.02409.x;
     
  9. Seaton BA, Crouch EC, McCormack FX, Head JF, Hartshorn KL, Mendelsohn R. Review: Structural determinants of pattern recognition by lung collectins. Innate Immun. 2010 Jun; 16(3):143-50.View Related Profiles. PMID: 20423923; DOI: 10.1177/1753425910368716;
     
  10. Crouch E, Hartshorn K, Horlacher T, McDonald B, Smith K, Cafarella T, Seaton B, Seeberger PH, Head J. Recognition of mannosylated ligands and influenza A virus by human surfactant protein D: contributions of an extended site and residue 343. Biochemistry. 2009 Apr 21; 48(15):3335-45.View Related Profiles. PMID: 19249874; PMCID: PMC2720784; DOI: 10.1021/bi8022703;
     
Showing 10 of 60 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 58 publications over 30 distinct years, with a maximum of 4 publications in 2002 and 2006 and 2007 and 2010

YearPublications
19802
19822
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In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Calcium-binding proteins
Lung surfactant proteins
Protein crystallography
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