Barbara A. Seaton, PhD
Emeritus Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, Massachusetts Institute of Technology



The long-term research interests of our lab concern interactions between mammalian proteins and biomembranes or other large assemblies such as viruses. Our current focus is on the lung surfactant proteins A and D (SP-A and SP-D) and their role in innate defense against inhaled pathogens such as seasonal and pandemic strains of influenza A virus (IAV). These proteins are C-type lectins that can recognize sugars and other signature components on microbial surfaces, and can initiate events leading to pathogen neutralization. In our lab, we use x-ray crystallography, molecular modeling, and various biochemical and biophysical methods to understand the nature of these interactions at the highest resolution possible.


Enhancing Collectin-Mediated Defense Against Influenza
08/11/2011 - 06/30/2015 (PI)
Boston Medical Center Corporation NIH NHLBI
5R01HL069031-13

X-Ray Analysis of Pulmonary Surfactant Protein A
12/01/2001 - 11/30/2006 (PI)
University of Cincinnati NIH NHLBI

Annexin Crystal Structures and Membrane Interactions
07/01/1998 - 11/30/2003 (PI)
NIH/National Institute of General Medical Sciences
5 R01 GM44554 13

X-ray Studies of Prothrombin
06/01/1998 - 06/30/2003 (PI)
Beth Israel Deaconess Medical Center NIH NHLBI

Crystal Structures of Multiple Antibiotic Resistance Proteins
08/09/1999 - 08/08/2001 (PI)
Paratek Pharmaceuticals Inc




Yr Title Project-Sub Proj Pubs
2010 Collectins and Innate Defense against Inhaled Pathogens 5P01AI083222-02 18
2009 Collectins and Innate Defense against Inhaled Pathogens 3P01AI083222-01A2S1 18
2009 Collectins and Innate Defense against Inhaled Pathogens 1P01AI083222-01A2 18
2003 ANNEXIN CRYSTAL STRUCTURES AND MEMBRANE INTERACTIONS 5R01GM044554-13
2002 ANNEXIN CRYSTAL STRUCTURES AND MEMBRANE INTERACTIONS 5R01GM044554-12
2001 ANNEXIN CRYSTAL STRUCTURES AND MEMBRANE INTERACTIONS 5R01GM044554-11
2000 ANNEXIN CRYSTAL STRUCTURES AND MEMBRANE INTERACTIONS 2R01GM044554-10
1999 ANNEXIN CRYSTAL STRUCTURES AND MEMBRANE INTERACTIONS 3R01GM044554-09S1
1998 ANNEXIN CRYSTAL STRUCTURES AND MEMBRANE INTERACTIONS 5R01GM044554-09
1997 ANNEXIN CRYSTAL STRUCTURES AND MEMBRANE INTERACTIONS 5R01GM044554-08
Showing 10 of 17 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. van Eijk M, Rynkiewicz MJ, Khatri K, Leymarie N, Zaia J, White MR, Hartshorn KL, Cafarella TR, van Die I, Hessing M, Seaton BA, Haagsman HP. Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus. J Biol Chem. 2018 Jul 06; 293(27):10646-10662.View Related Profiles. PMID: 29769321.
     
  2. Rynkiewicz MJ, Wu H, Cafarella TR, Nikolaidis NM, Head JF, Seaton BA, McCormack FX. Differential Ligand Binding Specificities of the Pulmonary Collectins Are Determined by the Conformational Freedom of a Surface Loop. Biochemistry. 2017 Aug 08; 56(31):4095-4105.View Related Profiles. PMID: 28719181.
     
  3. Goh BC, Wu H, Rynkiewicz MJ, Schulten K, Seaton BA, McCormack FX. Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations. Biochemistry. 2016 Jul 05; 55(26):3692-701.View Related Profiles. PMID: 27324153; DOI: 10.1021/acs.biochem.6b00048;.
     
  4. Tripathi S, Wang G, White M, Rynkiewicz M, Seaton B, Hartshorn K. Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis. PLoS One. 2015; 10(8):e0133454.View Related Profiles. PMID: 26308522; PMCID: PMC4550355; DOI: 10.1371/journal.pone.0133454;.
     
  5. Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Roche MI, Seaton BA, Sharon J. Functional and structural characterization of Francisella tularensis O-antigen antibodies at the low end of antigen reactivity. Monoclon Antib Immunodiagn Immunother. 2014 Aug; 33(4):235-45.View Related Profiles. PMID: 25171003; PMCID: PMC4151076; DOI: 10.1089/mab.2014.0022;.
     
  6. Lu Z, Rynkiewicz MJ, Madico G, Li S, Yang CY, Perkins HM, Sompuram SR, Kodela V, Liu T, Morris T, Wang D, Roche MI, Seaton BA, Sharon J. B-cell epitopes in GroEL of Francisella tularensis. PLoS One. 2014; 9(6):e99847.View Related Profiles. PMID: 24968190; PMCID: PMC4072690; DOI: 10.1371/journal.pone.0099847;.
     
  7. Nikolaidis NM, White MR, Allen K, Tripathi S, Qi L, McDonald B, Taubenberger J, Seaton BA, McCormack FX, Crouch EC, Hartshorn KL. Mutations flanking the carbohydrate binding site of surfactant protein D confer antiviral activity for pandemic influenza A viruses. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1; 306(11):L1036-44.View Related Profiles. PMID: 24705721; PMCID: PMC4042192; DOI: 10.1152/ajplung.00035.2014;.
     
  8. Goh BC, Rynkiewicz MJ, Cafarella TR, White MR, Hartshorn KL, Allen K, Crouch EC, Calin O, Seeberger PH, Schulten K, Seaton BA. Molecular mechanisms of inhibition of influenza by surfactant protein D revealed by large-scale molecular dynamics simulation. Biochemistry. 2013 Nov 26; 52(47):8527-38.View Related Profiles. PMID: 24224757; PMCID: PMC3927399; DOI: 10.1021/bi4010683;.
     
  9. Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Wang Q, Costello CE, Zaia J, Seaton BA, Sharon J. The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide. Immunology. 2013 Nov; 140(3):374-89.View Related Profiles. PMID: 23844703; PMCID: PMC3800442; DOI: 10.1111/imm.12150;.
     
  10. Rynkiewicz MJ, Lu Z, Hui JH, Sharon J, Seaton BA. Structural analysis of a protective epitope of the Francisella tularensis O-polysaccharide. Biochemistry. 2012 Jul 17; 51(28):5684-94.View Related Profiles. PMID: 22747335; PMCID: PMC3566871.
     
Showing 10 of 62 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 62 publications over 30 distinct years, with a maximum of 4 publications in 1994 and 1999 and 2001 and 2007

YearPublications
19832
19841
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19944
19951
19961
19971
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20074
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20092
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In addition to these self-described keywords below, a list of MeSH based concepts is available here.

influenza
molecular modeling
surfactant proteins
x-ray crystallography
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700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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