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Doherty EL, Aw WY, Warren EC, Hockenberry M, Whitworth CP, Krohn G, Howell S, Diekman BO, Legant WR, Nia HT, Hickey AJ, Polacheck WJ. Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics. Acta Biomater. 2023 Aug; 166:346-359. PMID: 37187299; PMCID: PMC10330735; DOI: 10.1016/j.actbio.2023.05.015;
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Shi L, Herrmann J, Bou Jawde S, Bates JHT, Nia HT, Suki B. Modeling the influence of gravity and the mechanical properties of elastin and collagen fibers on alveolar and lung pressure-volume curves. Sci Rep. 2022 Jul 19; 12(1):12280. PMID: 35853981; PMCID: PMC9294799; DOI: 10.1038/s41598-022-16650-0;
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S. Aoki, K. Inoue, S. Klein, S. Halvorsen, J. Chen, A. Matsui, M. Nikmaneshi, S. Kitahara, T. Hato, X.
Chen, K. Kawakubo, H. T. Nia, I. Chen, D. H Schanne, E. Mamessier, K. Shigeta, H. Kikuchi, R.
Ramjiawan, T. CE Schmidt, M. Iwasaki, T. Yau, T. Hong, A. Quaas, P. S Plum, S. Dima, I. Popescu, N.
Bardeesy, L. L Munn, M. J Borad, S. Sassi, R. K Jain, A. X Zhu, D. G Duda. Placental growth factor
promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma. Gut. 2022; 71(1):185-193.
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Nia HT, Ortiz C, Grodzinsky A. Aggrecan: Approaches to Study Biophysical and Biomechanical Properties. Methods Mol Biol. 2022; 2303:209-226. PMID: 34626381
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Jones D, Wang Z, Chen IX, Zhang S, Banerji R, Lei PJ, Zhou H, Xiao V, Kwong C, van Wijnbergen JWM, Pereira ER, Vakoc BJ, Huang P, Nia HT, Padera TP. Solid stress impairs lymphocyte infiltration into lymph-node metastases. Nat Biomed Eng. 2021 12; 5(12):1426-1436.View Related Profiles. PMID: 34282290; PMCID: PMC8678215; DOI: 10.1038/s41551-021-00766-1;
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Aoki S, Inoue K, Klein S, Halvorsen S, Chen J, Matsui A, Nikmaneshi MR, Kitahara S, Hato T, Chen X, Kawakubo K, Nia HT, Chen I, Schanne DH, Mamessier E, Shigeta K, Kikuchi H, Ramjiawan RR, Schmidt TC, Iwasaki M, Yau T, Hong TS, Quaas A, Plum PS, Dima S, Popescu I, Bardeesy N, Munn LL, Borad MJ, Sassi S, Jain RK, Zhu AX, Duda DG. Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma. Gut. 2022 01; 71(1):185-193. PMID: 33431577; PMCID: PMC8666816; DOI: 10.1136/gutjnl-2020-322493;
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D. Jones, Z. Wang, I. X. Chen, S. Zhang#
, R. Banerji#
, P. Lei, H. Zhou, V. Xiao, C. Kwong, J. W. M. van
Wijnbergen, E. R. Pereira, B. J. Vakoc, P. Huang, H. T. Nia, and T. P. Padera. Solid stress impairs
lymphocyte infiltration into lymph-node metastases. Nature Biomedical Engineering. 2021; 1-11.
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Nia HT, Datta M, Seano G, Zhang S, Ho WW, Roberge S, Huang P, Munn LL, Jain RK. In vivo compression and imaging in mouse brain to measure the effects of solid stress. Nat Protoc. 2020 08; 15(8):2321-2340. PMID: 32681151
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H.T. Nia, L.L. Munn and R.K. Jain. Physical traits of cancer. Science. 2020; 370:eaaz0868.
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H.T. Nia, M. Datta, G. Seano, S. Zhang#
, W.W. Ho, S. Roberge, P. Huang, L.L. Munn and R.K. Jain. In
vivo compression and imaging in mouse brain to measure the effects of solid stress. Nature Protocols. 2020.
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Han B, Li Q, Wang C, Patel P, Adams SM, Doyran B, Nia HT, Oftadeh R, Zhou S, Li CY, Liu XS, Lu XL, Enomoto-Iwamoto M, Qin L, Mauck RL, Iozzo RV, Birk DE, Han L. Decorin Regulates the Aggrecan Network Integrity and Biomechanical Functions of Cartilage Extracellular Matrix. ACS Nano. 2019 10 22; 13(10):11320-11333. PMID: 31550133; PMCID: PMC6892632; DOI: 10.1021/acsnano.9b04477;
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Zhao Y, Cao J, Melamed A, Worley M, Gockley A, Jones D, Nia HT, Zhang Y, Stylianopoulos T, Kumar AS, Mpekris F, Datta M, Sun Y, Wu L, Gao X, Yeku O, Del Carmen MG, Spriggs DR, Jain RK, Xu L. Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma. Proc Natl Acad Sci U S A. 2019 02 05; 116(6):2210-2219.View Related Profiles. PMID: 30659155; PMCID: PMC6369817; DOI: 10.1073/pnas.1818357116;
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Sellon JB, Azadi M, Oftadeh R, Nia HT, Ghaffari R, Grodzinsky AJ, Freeman DM. Nanoscale Poroelasticity of the Tectorial Membrane Determines Hair Bundle Deflections. Phys Rev Lett. 2019 Jan 18; 122(2):028101. PMID: 30720330; PMCID: PMC6813812; DOI: 10.1103/PhysRevLett.122.028101;
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Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RK. Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. Nat Biomed Eng. 2019 03; 3(3):230-245. PMID: 30948807; PMCID: PMC6452896; DOI: 10.1038/s41551-018-0334-7;
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L. Munn and H. T. Nia. Mechanosensing tensile solid stresses. PNAS. 2019; 116 (44):21960-21962.
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H. T. Nia, L. Munn, and R. K. Jain. Mapping physical tumor microenvironment and drug delivery. Clinical Cancer Research. 2019.
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J. B. Sellon, M. Azadi, R. Oftadeh, H. T. Nia, R. Ghaffari, A. J. Grodzinsky, and D. M. Freeman. Nanoscale Poroelasticity of the Tectorial Membrane Determines Hair Bundle Deflections. Physical
Review Letters. 2019; 122:028101.
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G. Seano*, H. T. Nia*, K. Emblem*, M. Datta, J. Ren, J. Kloepper, S. Krishnan, M. Ghosh, M. Pinho, V.
Askoxylakis, G. Ferraro, L. Riedemann, E.Gerstner, T. Batchelor, P. Wen, N. Lin, A. Grodzinsky, D.
Fukumura, P. Huang, J. Baish, T. Padera, L. Munn, R.K. Jain. Neurological dysfunction induced by brain
tumor-generated solid stress is reversed by lithium treatment. Nature Biomedical Engineering. 2019; 3:230– 245.
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Y. Zhao, J. Cao, A. Melamed, M. Worley, A. Gockley, D. Jones, H. T. Nia, Y. Zhang, T. Stylianopoulos,
A. Kumar, F. Mpekris, M. Datta, Y. Sun, L. Wu, X. Gao, O. Yeku, M. del Carmen, D. Spriggs, R. K. Jain,
L. Xu. Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models
by normalizing the tumor stroma. PNAS. 2019; 116 (6):2210-2219.
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Y. Zhao, J. Cao, A. Melamed, M. Worley, A. Gockley, D. Jones, H. T. Nia, Y. Zhang, T. Stylianopoulos,
A. Kumar, F. Mpekris, M. Datta, Y. Sun, L. Wu, X. Gao, O. Yeku, M. del Carmen, D. Spriggs, R. K. Jain,
L. Xu. Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models
by normalizing the tumor stroma. PNAS. 2019; 116 (6):2210-2219.
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Nia HT, Datta M, Seano G, Huang P, Munn LL, Jain RK. Quantifying solid stress and elastic energy from excised or in situ tumors. Nat Protoc. 2018 05; 13(5):1091-1105. PMID: 29674756; PMCID: PMC6546092; DOI: 10.1038/nprot.2018.020;
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Oftadeh R, Connizzo BK, Nia HT, Ortiz C, Grodzinsky AJ. Biological connective tissues exhibit viscoelastic and poroelastic behavior at different frequency regimes: Application to tendon and skin biophysics. Acta Biomater. 2018 04 01; 70:249-259.View Related Profiles. PMID: 29425716
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H. T. Nia*, M. Datta*, G. Seano, P. Huang, L. Munn, and R.K. Jain. “Quantifying solid stress and elastic
energy from excised or in situ tumors. Nature Protocols. 2018; 13(5):1091.
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R Oftadeh, B. Connizzo, H. T. Nia, C. Ortiz, A. Grodzinsky. “Biological connective tissues exhibit
viscoelastic and poroelastic behavior at different frequency regimes: application to tendon and skin
biophysics. Acta Biomaterialia. 2018; 70:249-259.
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Han B, Nia HT, Wang C, Chandrasekaran P, Li Q, Chery DR, Li H, Grodzinsky AJ, Han L. AFM-Nanomechanical Test: An Interdisciplinary Tool That Links the Understanding of Cartilage and Meniscus Biomechanics, Osteoarthritis Degeneration, and Tissue Engineering. ACS Biomater Sci Eng. 2017 Sep 11; 3(9):2033-2049. PMID: 31423463; PMCID: PMC6697429; DOI: 10.1021/acsbiomaterials.7b00307;
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B. Han, H. T. Nia, C. Wang, O. Chandrasekaran, Q. Li, D. Chery, H. Li A. J. Grodzinsky, and L. Han. AFM-nanomechanical test: an interdisciplinary tool that links the understanding of cartilage and
meniscus biomechanics, osteoarthritis degeneration, and tissue engineering. ACS Biomater. Sci. Eng. 2017; 3 (9):2033-2049.
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Hajjarian Z, Nia HT, Ahn S, Grodzinsky AJ, Jain RK, Nadkarni SK. Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds. Sci Rep. 2016 12 01; 6:37949. PMID: 27905494
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Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, Grodzinsky AJ, Baish JW, Munn LL, Jain RK. Solid stress and elastic energy as measures of tumour mechanopathology. Nat Biomed Eng. 2016; 1.View Related Profiles. PMID: 28966873; PMCID: PMC5621647; DOI: 10.1038/s41551-016-0004;
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Rahbari NN, Kedrin D, Incio J, Liu H, Ho WW, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin JD, Huang Y, Maimon N, Reissfelder C, Weitz J, Boucher Y, Clark JW, Grodzinsky AJ, Duda DG, Jain RK, Fukumura D. Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases. Sci Transl Med. 2016 Oct 12; 8(360):360ra135. PMID: 27733559
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Incio J, Liu H, Suboj P, Chin SM, Chen IX, Pinter M, Ng MR, Nia HT, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari NN, Han X, Chauhan VP, Martin JD, Kahn J, Huang P, Desphande V, Michaelson J, Michelakos TP, Ferrone CR, Soares R, Boucher Y, Fukumura D, Jain RK. Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy. Cancer Discov. 2016 08; 6(8):852-69. PMID: 27246539
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Azadi M, Nia HT, Gauci SJ, Ortiz C, Fosang AJ, Grodzinsky AJ. Wide bandwidth nanomechanical assessment of murine cartilage reveals protection of aggrecan knock-in mice from joint-overuse. J Biomech. 2016 06 14; 49(9):1634-1640. PMID: 27086115
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Z. Hajjarian, H. T. Nia, S. Ahn, A. J. Grodzinsky, R. K. Jain, and S. K. Nadkarni. Laser Speckle Rheology
for evaluating the viscoelastic properties of hydrogel scaffolds. Scientific Report. 2016; 6.
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N. Rahbari, D. Kedrin, J. Incio, T. Reiberger, H. Liu, H. T. Nia, C. Edrich, J. Dubroix, I. Chen, T. Heishi,
J. Martin, Y. Huang, A. J. Grodzinsky, D. G. Duda, R. K. Jain & D. Fukumura,. Extracellular matrix
remodeling after anti-VEGF therapy contributes to therapeutic resistance in colorectal cancer liver
metastases. Science Translational Medicine. 2016; 8 (360).
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M. Azadi*, H. T. Nia*, S. Gauci, A. Fosang, C. Ortiz and A. Grodzinsky. Wide bandwidth
nanomechanical assessment of murine cartilage reveals protection of aggrecan knock-in mice from jointoveruse. Journal of Biomechanics. 2016; 49 (9):1634–1640.
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H. T. Nia, H. Liu, G. Seano, M. Datta, D. Jones, N. Rahbari, J. Incio, V. P. Chauhan, K. Jung, J. D. Martin,
V. Askoxylakis, T. P. Padera, D. Fukumura, Y. Boucher, F. J. Hornicek, A. J. Grodzinsky, J. W. Baish,
L. Munn, and R.K. Jain. Solid stress and elastic energy as measures of tumour mechanopathology. Nature Biomedical Engineering. 2016; 1:0004.
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Scarcelli G, Polacheck WJ, Nia HT, Patel K, Grodzinsky AJ, Kamm RD, Yun SH. Noncontact three-dimensional mapping of intracellular hydromechanical properties by Brillouin microscopy. Nat Methods. 2015 Dec; 12(12):1132-4. PMID: 26436482
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Nia HT, Han L, Bozchalooi IS, Roughley P, Youcef-Toumi K, Grodzinsky AJ, Ortiz C. Aggrecan nanoscale solid-fluid interactions are a primary determinant of cartilage dynamic mechanical properties. ACS Nano. 2015 Mar 24; 9(3):2614-25. PMID: 25758717
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Nia HT, Jain AD, Liu Y, Alam MR, Barnas R, Makris NC. The evolution of air resonance power efficiency in the violin and its ancestors. Proc Math Phys Eng Sci. 2015 Mar 08; 471(2175):20140905. PMID: 25792964
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Nia HT, Ortiz C, Grodzinsky A. Aggrecan: approaches to study biophysical and biomechanical properties. Methods Mol Biol. 2015; 1229:221-37. PMID: 25325957
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H. T. Nia, L. Han, I. Soltani, P. Roughley, K. Youcef-Toumi, A. Grodzinsky and C. Ortiz. Aggrecan
nanoscale solid-fluid interactions are a primary determinant of cartilage dynamic mechanical properties. ACS Nano. 2015; 9 (3):2614-2625.
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G. Scarcelli, W. Polacheck, H. T. Nia, K. Patel, A. J. Grodzinsky, R. Kamm and SH Yun. Noncontact
mapping of intracellular hydromechanical properties by Brillouin confocal microscopy. Nature
Methods. 2015; 12 (12): 1132-1134.
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Nia HT, Gauci SJ, Azadi M, Hung HH, Frank E, Fosang AJ, Ortiz C, Grodzinsky AJ. High-bandwidth AFM-based rheology is a sensitive indicator of early cartilage aggrecan degradation relevant to mouse models of osteoarthritis. J Biomech. 2015 Jan 02; 48(1):162-5. PMID: 25435386
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Batista MA, Nia HT, Önnerfjord P, Cox KA, Ortiz C, Grodzinsky AJ, Heinegård D, Han L. Nanomechanical phenotype of chondroadherin-null murine articular cartilage. Matrix Biol. 2014 Sep; 38:84-90. PMID: 24892719
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Rubin DJ, Nia HT, Desire T, Nguyen PQ, Gevelber M, Ortiz C, Joshi NS. Mechanical reinforcement of polymeric fibers through peptide nanotube incorporation. Biomacromolecules. 2013 Oct 14; 14(10):3370-5. PMID: 24070499
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Nia HT, Bozchalooi IS, Li Y, Han L, Hung HH, Frank E, Youcef-Toumi K, Ortiz C, Grodzinsky A. High-bandwidth AFM-based rheology reveals that cartilage is most sensitive to high loading rates at early stages of impairment. Biophys J. 2013 Apr 02; 104(7):1529-37. PMID: 23561529
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H. T. Nia, I. Soltani, Y. Li, L. Han, H. Hung, E. Frank, K. Youcef-Toumi, C. Ortiz and A. Grodzinsky. High bandwidth AFM-based rheology reveals that cartilage is most sensitive to high loading rates at
early stages of impairment. Biophysical Journal. 2013; 104(7):1529-1537.
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Nia HT, Han L, Li Y, Ortiz C, Grodzinsky A. Poroelasticity of cartilage at the nanoscale. Biophys J. 2011 Nov 02; 101(9):2304-13. PMID: 22067171