Hadi Nia | Profiles RNS

Hadi T. Nia, PhD Hear my name

Assistant Professor

Boston University College of Engineering

Biomedical Engineering

PhD, Massachusetts Institute of Technology
MS, Massachusetts Institute of Technology
MS, Sharif University of Technology
BS, Sharif University of Technology

Pronouns: he/him/his

Websites

	BU College of Engineering
	LinkedIn
	Google Scholar
	Nia Laboratory
	ResearchGate
	ORCID
	MyNCBI

Dr. Hadi T. Nia (BME, MSE) received his PhD from Massachusetts Institute of Technology in 2013 under the supervision of Drs Alan Grodzinsky and Christine Ortiz. He completed his Postdoctoral training as a NIH NCI Ruth L. Kirschstein Postdoctoral Fellow and at the Department of Radiation Oncology, Harvard Medical School/Massachusetts General Hospital under the supervision of Dr. Rakesh Jain. Currently, the overall research goal in Nia Laboratory is to combine the principles of engineering and physical sciences with molecular biology and oncology to answer key questions in cancer research, discover new vulnerabilities of cancer cells, and propose novel treatment strategies in the fight against cancer. The overall question of our interest is how the abnormal physical microenvironment of tumors affects development, progression and treatment in cancer.

BU Research

Probing immunovascular mechanobiology in pneumonia-associated acute lung injury at the single capillary level
05/01/2023 - 04/30/2028 (Key Person / Mentor)
NIH/National Heart, Lung, and Blood Institute
1F30HL168952-01

Development of Crystal Ribcage for Imaging of Functioning Lung at High Spatiotemporal Resolution
09/01/2022 - 08/31/2026 (PI)
The Arnold and Mabel Beckman Foundation

Probing functioning lung at the cellular resolution in health and disease
09/01/2022 - 08/31/2025 (PI)
NIH/National Heart, Lung, and Blood Institute
1DP2HL168562-01

Classifying malignant pulmonary nodules using biophysics-enhanced artificial intelligence
09/01/2021 - 08/31/2024 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
1R21EB031332-01

Probing the physical and immune microenvironment in lung tumors at high spatiotemporal resolution
01/01/2023 - 12/31/2023 (Multi-PI)
PI: Hadi T. Nia, PhD
Johnson & Johnson Enterprise Innovation, Inc.

Clare Boothe Luce Graduate Fellowship for Gabrielle Grifno
09/01/2021 - 08/31/2023 (PI)
The Henry Luce Foundation, Inc.

Cellular resolution imaging of drug delivery into tumors in functioning ex vivo lung
01/01/2022 - 12/31/2022 (Multi-PI)
PI: Hadi T. Nia, PhD
Johnson & Johnson Enterprise Innovation, Inc.

Biomechanics-enhanced artificial intelligence in lung cancer detection
06/01/2020 - 12/31/2021 (Multi-PI)
PI: Hadi T. Nia, PhD
Johnson & Johnson Enterprise Innovation, Inc.

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Doherty EL, Aw WY, Warren EC, Hockenberry M, Whitworth CP, Krohn G, Howell S, Diekman BO, Legant WR, Nia HT, Hickey AJ, Polacheck WJ. Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics. Acta Biomater. 2023 May 13. PMID: 37187299

Zhang S, Regan K, Najera J, Grinstaff MW, Datta M, Nia HT. The peritumor microenvironment: physics and immunity. Trends Cancer. 2023 May 06.View Related Profiles.

Nia, Hadi
Grinstaff, Mark

PMID: 37156677

Shi L, Herrmann J, Bou Jawde S, Bates JHT, Nia HT, Suki B. Modeling the influence of gravity and the mechanical properties of elastin and collagen fibers on alveolar and lung pressure-volume curves. Sci Rep. 2022 Jul 19; 12(1):12280. PMID: 35853981; PMCID: PMC9294799; DOI: 10.1038/s41598-022-16650-0;

Yuan Z, Herrmann J, Murthy S, Peters K, Gerard SE, Nia HT, Lutchen KR, Suki B. A Personalized Spring Network Representation of Emphysematous Lungs From CT Images. Front Netw Physiol. 2022; 2:828157.View Related Profiles.

Nia, Hadi
Lutchen, Kenneth

PMID: 36926064; PMCID: PMC10013051; DOI: 10.3389/fnetp.2022.828157;

S. Aoki, K. Inoue, S. Klein, S. Halvorsen, J. Chen, A. Matsui, M. Nikmaneshi, S. Kitahara, T. Hato, X. Chen, K. Kawakubo, H. T. Nia, I. Chen, D. H Schanne, E. Mamessier, K. Shigeta, H. Kikuchi, R. Ramjiawan, T. CE Schmidt, M. Iwasaki, T. Yau, T. Hong, A. Quaas, P. S Plum, S. Dima, I. Popescu, N. Bardeesy, L. L Munn, M. J Borad, S. Sassi, R. K Jain, A. X Zhu, D. G Duda. Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma. Gut. 2022; 71(1):185-193.

Nia HT, Ortiz C, Grodzinsky A. Aggrecan: Approaches to Study Biophysical and Biomechanical Properties. Methods Mol Biol. 2022; 2303:209-226. PMID: 34626381

Jones D, Wang Z, Chen IX, Zhang S, Banerji R, Lei PJ, Zhou H, Xiao V, Kwong C, van Wijnbergen JWM, Pereira ER, Vakoc BJ, Huang P, Nia HT, Padera TP. Solid stress impairs lymphocyte infiltration into lymph-node metastases. Nat Biomed Eng. 2021 12; 5(12):1426-1436.View Related Profiles.

Jones, Dennis
Nia, Hadi

PMID: 34282290; PMCID: PMC8678215; DOI: 10.1038/s41551-021-00766-1;

Aoki S, Inoue K, Klein S, Halvorsen S, Chen J, Matsui A, Nikmaneshi MR, Kitahara S, Hato T, Chen X, Kawakubo K, Nia HT, Chen I, Schanne DH, Mamessier E, Shigeta K, Kikuchi H, Ramjiawan RR, Schmidt TC, Iwasaki M, Yau T, Hong TS, Quaas A, Plum PS, Dima S, Popescu I, Bardeesy N, Munn LL, Borad MJ, Sassi S, Jain RK, Zhu AX, Duda DG. Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma. Gut. 2022 01; 71(1):185-193. PMID: 33431577; PMCID: PMC8666816; DOI: 10.1136/gutjnl-2020-322493;

D. Jones, Z. Wang, I. X. Chen, S. Zhang# , R. Banerji# , P. Lei, H. Zhou, V. Xiao, C. Kwong, J. W. M. van Wijnbergen, E. R. Pereira, B. J. Vakoc, P. Huang, H. T. Nia, and T. P. Padera. Solid stress impairs lymphocyte infiltration into lymph-node metastases. Nature Biomedical Engineering. 2021; 1-11.

Nia HT, Munn LL, Jain RK. Physical traits of cancer. Science. 2020 10 30; 370(6516). PMID: 33122355; PMCID: PMC8274378; DOI: 10.1126/science.aaz0868;

Showing 10 of 52 results. Show More

Nia HT, Datta M, Seano G, Zhang S, Ho WW, Roberge S, Huang P, Munn LL, Jain RK. In vivo compression and imaging in mouse brain to measure the effects of solid stress. Nat Protoc. 2020 08; 15(8):2321-2340. PMID: 32681151

H.T. Nia, M. Datta, G. Seano, S. Zhang# , W.W. Ho, S. Roberge, P. Huang, L.L. Munn and R.K. Jain. In vivo compression and imaging in mouse brain to measure the effects of solid stress. Nature Protocols. 2020.
H.T. Nia, L.L. Munn and R.K. Jain. Physical traits of cancer. Science. 2020; 370:eaaz0868.

Munn LL, Nia HT. Mechanosensing tensile solid stresses. Proc Natl Acad Sci U S A. 2019 10 29; 116(44):21960-21962. PMID: 31619566; PMCID: PMC6825278; DOI: 10.1073/pnas.1916115116;

Han B, Li Q, Wang C, Patel P, Adams SM, Doyran B, Nia HT, Oftadeh R, Zhou S, Li CY, Liu XS, Lu XL, Enomoto-Iwamoto M, Qin L, Mauck RL, Iozzo RV, Birk DE, Han L. Decorin Regulates the Aggrecan Network Integrity and Biomechanical Functions of Cartilage Extracellular Matrix. ACS Nano. 2019 10 22; 13(10):11320-11333. PMID: 31550133; PMCID: PMC6892632; DOI: 10.1021/acsnano.9b04477;

Zhao Y, Cao J, Melamed A, Worley M, Gockley A, Jones D, Nia HT, Zhang Y, Stylianopoulos T, Kumar AS, Mpekris F, Datta M, Sun Y, Wu L, Gao X, Yeku O, Del Carmen MG, Spriggs DR, Jain RK, Xu L. Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma. Proc Natl Acad Sci U S A. 2019 02 05; 116(6):2210-2219.View Related Profiles.

Jones, Dennis
Nia, Hadi

PMID: 30659155; PMCID: PMC6369817; DOI: 10.1073/pnas.1818357116;

Sellon JB, Azadi M, Oftadeh R, Nia HT, Ghaffari R, Grodzinsky AJ, Freeman DM. Nanoscale Poroelasticity of the Tectorial Membrane Determines Hair Bundle Deflections. Phys Rev Lett. 2019 Jan 18; 122(2):028101. PMID: 30720330; PMCID: PMC6813812; DOI: 10.1103/PhysRevLett.122.028101;

Nia HT, Munn LL, Jain RK. Mapping Physical Tumor Microenvironment and Drug Delivery. Clin Cancer Res. 2019 04 01; 25(7):2024-2026. PMID: 30630829; PMCID: PMC6445672; DOI: 10.1158/1078-0432.CCR-18-3724;

Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RK. Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. Nat Biomed Eng. 2019 03; 3(3):230-245. PMID: 30948807; PMCID: PMC6452896; DOI: 10.1038/s41551-018-0334-7;

G. Seano*, H. T. Nia*, K. Emblem*, M. Datta, J. Ren, J. Kloepper, S. Krishnan, M. Ghosh, M. Pinho, V. Askoxylakis, G. Ferraro, L. Riedemann, E.Gerstner, T. Batchelor, P. Wen, N. Lin, A. Grodzinsky, D. Fukumura, P. Huang, J. Baish, T. Padera, L. Munn, R.K. Jain. Neurological dysfunction induced by brain tumor-generated solid stress is reversed by lithium treatment. Nature Biomedical Engineering. 2019; 3:230– 245.
J. B. Sellon, M. Azadi, R. Oftadeh, H. T. Nia, R. Ghaffari, A. J. Grodzinsky, and D. M. Freeman. Nanoscale Poroelasticity of the Tectorial Membrane Determines Hair Bundle Deflections. Physical Review Letters. 2019; 122:028101.
Y. Zhao, J. Cao, A. Melamed, M. Worley, A. Gockley, D. Jones, H. T. Nia, Y. Zhang, T. Stylianopoulos, A. Kumar, F. Mpekris, M. Datta, Y. Sun, L. Wu, X. Gao, O. Yeku, M. del Carmen, D. Spriggs, R. K. Jain, L. Xu. Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma. PNAS. 2019; 116 (6):2210-2219.
Y. Zhao, J. Cao, A. Melamed, M. Worley, A. Gockley, D. Jones, H. T. Nia, Y. Zhang, T. Stylianopoulos, A. Kumar, F. Mpekris, M. Datta, Y. Sun, L. Wu, X. Gao, O. Yeku, M. del Carmen, D. Spriggs, R. K. Jain, L. Xu. Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma. PNAS. 2019; 116 (6):2210-2219.
L. Munn and H. T. Nia. Mechanosensing tensile solid stresses. PNAS. 2019; 116 (44):21960-21962.
H. T. Nia, L. Munn, and R. K. Jain. Mapping physical tumor microenvironment and drug delivery. Clinical Cancer Research. 2019.

Nia HT, Datta M, Seano G, Huang P, Munn LL, Jain RK. Quantifying solid stress and elastic energy from excised or in situ tumors. Nat Protoc. 2018 05; 13(5):1091-1105. PMID: 29674756; PMCID: PMC6546092; DOI: 10.1038/nprot.2018.020;

Oftadeh R, Connizzo BK, Nia HT, Ortiz C, Grodzinsky AJ. Biological connective tissues exhibit viscoelastic and poroelastic behavior at different frequency regimes: Application to tendon and skin biophysics. Acta Biomater. 2018 04 01; 70:249-259.View Related Profiles.

Connizzo, Brianne
Nia, Hadi

PMID: 29425716

H. T. Nia*, M. Datta*, G. Seano, P. Huang, L. Munn, and R.K. Jain. “Quantifying solid stress and elastic energy from excised or in situ tumors. Nature Protocols. 2018; 13(5):1091.
R Oftadeh, B. Connizzo, H. T. Nia, C. Ortiz, A. Grodzinsky. “Biological connective tissues exhibit viscoelastic and poroelastic behavior at different frequency regimes: application to tendon and skin biophysics. Acta Biomaterialia. 2018; 70:249-259.

Han B, Nia HT, Wang C, Chandrasekaran P, Li Q, Chery DR, Li H, Grodzinsky AJ, Han L. AFM-Nanomechanical Test: An Interdisciplinary Tool That Links the Understanding of Cartilage and Meniscus Biomechanics, Osteoarthritis Degeneration, and Tissue Engineering. ACS Biomater Sci Eng. 2017 Sep 11; 3(9):2033-2049. PMID: 31423463; PMCID: PMC6697429; DOI: 10.1021/acsbiomaterials.7b00307;

B. Han, H. T. Nia, C. Wang, O. Chandrasekaran, Q. Li, D. Chery, H. Li A. J. Grodzinsky, and L. Han. AFM-nanomechanical test: an interdisciplinary tool that links the understanding of cartilage and meniscus biomechanics, osteoarthritis degeneration, and tissue engineering. ACS Biomater. Sci. Eng. 2017; 3 (9):2033-2049.

Hajjarian Z, Nia HT, Ahn S, Grodzinsky AJ, Jain RK, Nadkarni SK. Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds. Sci Rep. 2016 12 01; 6:37949. PMID: 27905494

Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, Grodzinsky AJ, Baish JW, Munn LL, Jain RK. Solid stress and elastic energy as measures of tumour mechanopathology. Nat Biomed Eng. 2016; 1.View Related Profiles.

Jones, Dennis
Nia, Hadi

PMID: 28966873; PMCID: PMC5621647; DOI: 10.1038/s41551-016-0004;

Rahbari NN, Kedrin D, Incio J, Liu H, Ho WW, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin JD, Huang Y, Maimon N, Reissfelder C, Weitz J, Boucher Y, Clark JW, Grodzinsky AJ, Duda DG, Jain RK, Fukumura D. Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases. Sci Transl Med. 2016 Oct 12; 8(360):360ra135. PMID: 27733559

Incio J, Liu H, Suboj P, Chin SM, Chen IX, Pinter M, Ng MR, Nia HT, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari NN, Han X, Chauhan VP, Martin JD, Kahn J, Huang P, Desphande V, Michaelson J, Michelakos TP, Ferrone CR, Soares R, Boucher Y, Fukumura D, Jain RK. Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy. Cancer Discov. 2016 08; 6(8):852-69. PMID: 27246539

Azadi M, Nia HT, Gauci SJ, Ortiz C, Fosang AJ, Grodzinsky AJ. Wide bandwidth nanomechanical assessment of murine cartilage reveals protection of aggrecan knock-in mice from joint-overuse. J Biomech. 2016 06 14; 49(9):1634-1640. PMID: 27086115

Z. Hajjarian, H. T. Nia, S. Ahn, A. J. Grodzinsky, R. K. Jain, and S. K. Nadkarni. Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds. Scientific Report. 2016; 6.
M. Azadi*, H. T. Nia*, S. Gauci, A. Fosang, C. Ortiz and A. Grodzinsky. Wide bandwidth nanomechanical assessment of murine cartilage reveals protection of aggrecan knock-in mice from jointoveruse. Journal of Biomechanics. 2016; 49 (9):1634–1640.
N. Rahbari, D. Kedrin, J. Incio, T. Reiberger, H. Liu, H. T. Nia, C. Edrich, J. Dubroix, I. Chen, T. Heishi, J. Martin, Y. Huang, A. J. Grodzinsky, D. G. Duda, R. K. Jain & D. Fukumura,. Extracellular matrix remodeling after anti-VEGF therapy contributes to therapeutic resistance in colorectal cancer liver metastases. Science Translational Medicine. 2016; 8 (360).
H. T. Nia, H. Liu, G. Seano, M. Datta, D. Jones, N. Rahbari, J. Incio, V. P. Chauhan, K. Jung, J. D. Martin, V. Askoxylakis, T. P. Padera, D. Fukumura, Y. Boucher, F. J. Hornicek, A. J. Grodzinsky, J. W. Baish, L. Munn, and R.K. Jain. Solid stress and elastic energy as measures of tumour mechanopathology. Nature Biomedical Engineering. 2016; 1:0004.

Scarcelli G, Polacheck WJ, Nia HT, Patel K, Grodzinsky AJ, Kamm RD, Yun SH. Noncontact three-dimensional mapping of intracellular hydromechanical properties by Brillouin microscopy. Nat Methods. 2015 Dec; 12(12):1132-4. PMID: 26436482

Nia HT, Han L, Bozchalooi IS, Roughley P, Youcef-Toumi K, Grodzinsky AJ, Ortiz C. Aggrecan nanoscale solid-fluid interactions are a primary determinant of cartilage dynamic mechanical properties. ACS Nano. 2015 Mar 24; 9(3):2614-25. PMID: 25758717

Nia HT, Jain AD, Liu Y, Alam MR, Barnas R, Makris NC. The evolution of air resonance power efficiency in the violin and its ancestors. Proc Math Phys Eng Sci. 2015 Mar 08; 471(2175):20140905. PMID: 25792964

Nia HT, Ortiz C, Grodzinsky A. Aggrecan: approaches to study biophysical and biomechanical properties. Methods Mol Biol. 2015; 1229:221-37. PMID: 25325957

H. T. Nia, L. Han, I. Soltani, P. Roughley, K. Youcef-Toumi, A. Grodzinsky and C. Ortiz. Aggrecan nanoscale solid-fluid interactions are a primary determinant of cartilage dynamic mechanical properties. ACS Nano. 2015; 9 (3):2614-2625.
G. Scarcelli, W. Polacheck, H. T. Nia, K. Patel, A. J. Grodzinsky, R. Kamm and SH Yun. Noncontact mapping of intracellular hydromechanical properties by Brillouin confocal microscopy. Nature Methods. 2015; 12 (12): 1132-1134.

Nia HT, Gauci SJ, Azadi M, Hung HH, Frank E, Fosang AJ, Ortiz C, Grodzinsky AJ. High-bandwidth AFM-based rheology is a sensitive indicator of early cartilage aggrecan degradation relevant to mouse models of osteoarthritis. J Biomech. 2015 Jan 02; 48(1):162-5. PMID: 25435386

Batista MA, Nia HT, Önnerfjord P, Cox KA, Ortiz C, Grodzinsky AJ, Heinegård D, Han L. Nanomechanical phenotype of chondroadherin-null murine articular cartilage. Matrix Biol. 2014 Sep; 38:84-90. PMID: 24892719

Rubin DJ, Nia HT, Desire T, Nguyen PQ, Gevelber M, Ortiz C, Joshi NS. Mechanical reinforcement of polymeric fibers through peptide nanotube incorporation. Biomacromolecules. 2013 Oct 14; 14(10):3370-5. PMID: 24070499

Nia HT, Bozchalooi IS, Li Y, Han L, Hung HH, Frank E, Youcef-Toumi K, Ortiz C, Grodzinsky A. High-bandwidth AFM-based rheology reveals that cartilage is most sensitive to high loading rates at early stages of impairment. Biophys J. 2013 Apr 02; 104(7):1529-37. PMID: 23561529

H. T. Nia, I. Soltani, Y. Li, L. Han, H. Hung, E. Frank, K. Youcef-Toumi, C. Ortiz and A. Grodzinsky. High bandwidth AFM-based rheology reveals that cartilage is most sensitive to high loading rates at early stages of impairment. Biophysical Journal. 2013; 104(7):1529-1537.

Nia HT, Han L, Li Y, Ortiz C, Grodzinsky A. Poroelasticity of cartilage at the nanoscale. Biophys J. 2011 Nov 02; 101(9):2304-13. PMID: 22067171

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 52 publications over 12 distinct years, with a maximum of 12 publications in 2019