Florian Douam, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Virology, Immunology & Microbiology

PhD, L'École Normale Supérieure de Lyon
BS, Universite De Tours



Florian Douam, Ph.D. has a Ph.D. in molecular virology from École normale supérieure de Lyon, France. He previously worked as a postdoctoral research associate in the Ploss Lab, in the department of molecular biology at Princeton University. He currently leads the Douam Lab located at the National Emerging Infectious Disease Laboratories (NEIDL), which investigates how the human immune system as a tissue interacts with specific viral pathogens and ultimately regulates different outcome of infection.

Faculty
Boston University
National Emerging Infectious Disease Lab


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Reverse genetic tools and novel models of henipavirus infection
10/28/2022 - 09/30/2025 (Co-Investigator)
PI: Elke Muhlberger, PhD
Bill and Melinda Gates Foundation


Evaluation of mRNA-based vaccine approaches against endemic coronaviruses
12/07/2021 - 09/30/2024 (PI)
Moderna Therapeutics


CFAR Developmental Award: A humanized mouse model to investigate the impact of HIV persistence and antiretroviral treatment on vaccine-induced immune responses
07/01/2023 - 06/30/2024 (Subcontract PI)
The Miriam Hospital NIH NIAID
2P30AI042853-25

Low-dose RNA vaccine platform for tickborne flaviviruses
03/01/2024 - 05/31/2024 (Subcontract PI)
Tiba Biotech LLC NIH NIAID
1R43AI165194-01A1

Evaluation of mRNA-based vaccine approaches against DENV
03/14/2023 - 05/30/2024 (Multi-PI)
PI: Florian Douam, PhD
Moderna Therapeutics


Characterization of a human-specific positive regulator of flavivirus infection
04/12/2021 - 03/31/2024 (PI)
NIH/National Institute of Allergy & Infectious Diseases
3K22AI144050-02S1

Defining the Impact of Per/Polyfluoroalkyl Substance Exposure on Susceptibility to SARS-CoV-2 Infection and Disease
03/02/2021 - 02/29/2024 (Multi-PI)
PI: Florian Douam, PhD
NIH/National Institute of Environmental Health Sciences
5R21ES032882-02

Therapeutic effects of NAPc2 in SARS-CoV-2 infection of K18-hACE2 transgenic mice
03/15/2021 - 03/31/2022 (Multi-PI)
PI: Florian Douam, PhD
ARCA Biopharma, Inc.




Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Kenney D, O'Connell AK, Tseng AE, Turcinovic J, Sheehan ML, Nitido AD, Montanaro P, Gertje HP, Ericsson M, Connor JH, Vrbanac V, Crossland NA, Harly C, Balazs AB, Douam F. Resolution of SARS-CoV-2 infection in human lung tissues is driven by extravascular CD163+ monocytes. bioRxiv. 2024 Mar 08.View Related Profiles. PMID: 38496468; PMCID: PMC10942442; DOI: 10.1101/2024.03.08.583965;
     
  2. Mesev EV, Lin AE, Guare EG, Heller BL, Douam F, Adamson B, Toettcher JE, Ploss A. Membrane-proximal motifs encode differences in signaling strength between type I and III interferon receptors. Sci Signal. 2023 Oct 10; 16(806):eadf5494. PMID: 37816090; PMCID: PMC10939449; DOI: 10.1126/scisignal.adf5494;
     
  3. McGee JE, Kirsch JR, Kenney D, Chavez E, Shih TY, Douam F, Wong WW, Grinstaff MW. Complete substitution with modified nucleotides suppresses the early interferon response and increases the potency of self-amplifying RNA. bioRxiv. 2023 Sep 17.View Related Profiles. PMID: 37745375; PMCID: PMC10516017; DOI: 10.1101/2023.09.15.557994;
     
  4. Hogan G, Winer BY, Ahodantin J, Sellau J, Huang T, Douam F, Funaki M, Chiriboga L, Su L, Ploss A. Persistent hepatitis B virus and HIV coinfections in dually humanized mice engrafted with human liver and immune system. J Med Virol. 2023 Jul; 95(7):e28930. PMID: 37403703
     
  5. Chen DY, Turcinovic J, Feng S, Kenney DJ, Chin CV, Choudhary MC, Conway HL, Semaan M, Close BJ, Tavares AH, Seitz S, Khan N, Kapell S, Crossland NA, Li JZ, Douam F, Baker SC, Connor JH, Saeed M. Cell culture systems for isolation of SARS-CoV-2 clinical isolates and generation of recombinant virus. iScience. 2023 May 19; 26(5):106634.View Related Profiles. PMID: 37095858; PMCID: PMC10083141; DOI: 10.1016/j.isci.2023.106634;
     
  6. Chen DY, Chin CV, Kenney D, Tavares AH, Khan N, Conway HL, Liu G, Choudhary MC, Gertje HP, O'Connell AK, Adams S, Kotton DN, Herrmann A, Ensser A, Connor JH, Bosmann M, Li JZ, Gack MU, Baker SC, Kirchdoerfer RN, Kataria Y, Crossland NA, Douam F, Saeed M. Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation. Nature. 2023 Mar; 615(7950):143-150.View Related Profiles. PMID: 36630998
     
  7. Chen DY, Kenney D, Chin CV, Tavares AH, Khan N, Conway HL, Liu G, Choudhary MC, Gertje HP, O'Connell AK, Kotton DN, Herrmann A, Ensser A, Connor JH, Bosmann M, Li JZ, Gack MU, Baker SC, Kirchdoerfer RN, Kataria Y, Crossland NA, Douam F, Saeed M. Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron. bioRxiv. 2023 Jan 10.View Related Profiles. PMID: 36263066; PMCID: PMC9580375; DOI: 10.1101/2022.10.13.512134;
     
  8. Douam F, Ploss A. A humanized "new-trophil" mouse to study early inflammatory processes. Proc Natl Acad Sci U S A. 2022 Dec 06; 119(49):e2216699119. PMID: 36442110; PMCID: PMC9894160; DOI: 10.1073/pnas.2216699119;
     
  9. Kenney DJ, O'Connell AK, Turcinovic J, Montanaro P, Hekman RM, Tamura T, Berneshawi AR, Cafiero TR, Al Abdullatif S, Blum B, Goldstein SI, Heller BL, Gertje HP, Bullitt E, Trachtenberg AJ, Chavez E, Nono ET, Morrison C, Tseng AE, Sheikh A, Kurnick S, Grosz K, Bosmann M, Ericsson M, Huber BR, Saeed M, Balazs AB, Francis KP, Klose A, Paragas N, Campbell JD, Connor JH, Emili A, Crossland NA, Ploss A, Douam F. Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection. Cell Rep. 2022 Apr 19; 39(3):110714.View Related Profiles. PMID: 35421379; PMCID: PMC8977517; DOI: 10.1016/j.celrep.2022.110714;
     
  10. Ren W, Ju X, Gong M, Lan J, Yu Y, Long Q, Kenney DJ, O'Connell AK, Zhang Y, Zhong J, Zhong G, Douam F, Wang X, Huang A, Zhang R, Ding Q. Characterization of SARS-CoV-2 Variants B.1.617.1 (Kappa), B.1.617.2 (Delta), and B.1.618 by Cell Entry and Immune Evasion. mBio. 2022 Apr 26; 13(2):e0009922. PMID: 35266815; PMCID: PMC9040861; DOI: 10.1128/mbio.00099-22;
     
Showing 10 of 41 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 41 publications over 12 distinct years, with a maximum of 6 publications in 2021 and 2023

YearPublications
20121
20132
20144
20155
20161
20172
20185
20204
20216
20224
20236
20241
Contact for Mentoring:
Douam's Networks
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