Florian Douam | Profiles RNS

Florian Douam, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Virology, Immunology & Microbiology

PhD, L'École Normale Supérieure de Lyon
BS, Universite De Tours

Websites

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	National Emerging Infectious Diseases Laboratories Faculty

ORCID : 0000-0002-4791-6767

Florian Douam, Ph.D. is an Assistant Professor of Microbiology at Boston University Chobanian and Avedisian School of Medicine and a core investigator at the National Emerging Infectious Diseases Laboratories (NEIDL). Dr. Douam has a PhD in molecular virology and more than a decade of experience investigating virus biology in cell culture and animal models. Specifically, Dr. Douam is a viral immunologist with deep expertise in generating and using innovative mouse models to investigate viral pathogenesis and immune responses to viruses in BSL-2 and BSL-3 laboratories. At the NEIDL, he leads a research team focused on identifying the molecular and cellular mechanisms shaping immune outcomes in human RNA virus infections, employing a variety of viral pathogens from mosquito-borne viruses to coronaviruses.

Faculty
Boston University
National Emerging Infectious Disease Lab

Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

A self-amplifying RNA-based synthetic nanobody platform for next-generation therapeutics
08/01/2025 - 04/30/2029 (Multi-PI)
PI: Florian Douam, PhD
NIH/National Institute of Biomedical Imaging & Bioengineering
1R01EB038005-01

Human cutaneous responses to arthropod-mediated viral transmission
07/08/2025 - 07/07/2027 (PI)
NIH/National Institute of Allergy & Infectious Diseases
1R21AI193648-01

Characterizing A Novel Humanized Mouse Platform To Model Arbovirus Transmission
11/01/2024 - 10/31/2026 (Subcontract PI)
Health Resources in Action, Inc. Richard/Susan Smith

Reverse genetic tools and novel models of henipavirus infection
10/28/2022 - 09/30/2026 (Co-Investigator)
PI: Elke Muhlberger, PhD
Bill and Melinda Gates Foundation

Low-dose RNA vaccine platform for tickborne flaviviruses
03/01/2024 - 09/30/2024 (Subcontract PI)
Tiba Biotech LLC NIH NIAID
1R43AI165194-01A1

Evaluation of mRNA-based vaccine approaches against endemic coronaviruses
12/07/2021 - 09/30/2024 (PI)
Moderna Therapeutics

CFAR Developmental Award: A humanized mouse model to investigate the impact of HIV persistence and antiretroviral treatment on vaccine-induced immune responses
07/01/2023 - 06/30/2024 (Subcontract PI)
The Miriam Hospital NIH NIAID
2P30AI042853-25

Evaluation of mRNA-based vaccine approaches against DENV
03/14/2023 - 05/30/2024 (Multi-PI)
PI: Florian Douam, PhD
Moderna Therapeutics

Characterization of a human-specific positive regulator of flavivirus infection
04/12/2021 - 03/31/2024 (PI)
NIH/National Institute of Allergy & Infectious Diseases
3K22AI144050-02S1

Defining the Impact of Per/Polyfluoroalkyl Substance Exposure on Susceptibility to SARS-CoV-2 Infection and Disease
03/02/2021 - 02/29/2024 (Multi-PI)
PI: Florian Douam, PhD
NIH/National Institute of Environmental Health Sciences
5R21ES032882-02

Showing 10 of 11 results. Show All Results

Title

Immunogenicity and efficacy studies of mRNA-LNP against COVID-19 in hamsters
07/01/2025 - 06/30/2027 (Multi-PI)
PI: Florian Douam, PhD
MGH/Moderna SRA

Yr	Title	Project-Sub Proj
2025	A self-amplifying RNA-based synthetic nanobody platform for next-generation therapeutics	1R01EB038005-01
2025	Human cutaneous responses to arthropod-mediated viral transmission	1R21AI193648-01
2023	Characterization of a human-specific positive regulator of flavivirus infection	3K22AI144050-02S1
2022	Characterization of a human-specific positive regulator of flavivirus infection	5K22AI144050-02
2022	Defining the Impact of Per/Polyfluoroalkyl Substance Exposure on Susceptibility to SARS-CoV-2 Infection and Disease	5R21ES032882-02
2021	Characterization of a human-specific positive regulator of flavivirus infection	1K22AI144050-01
2021	Defining the Impact of Per/Polyfluoroalkyl Substance Exposure on Susceptibility to SARS-CoV-2 Infection and Disease	1R21ES032882-01

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Website Copy PMIDs To Clipboard

Unali G, Douam F. Orthoflavivirus Vaccine Platforms: Current Strategies and Challenges. Vaccines (Basel). 2025 Sep 29; 13(10). PMID: 41150403; PMCID: PMC12568211; DOI: 10.3390/vaccines13101015;

Kenney D, O'Connell AK, Tseng AE, Turcinovic J, Sheehan ML, Nitido AD, Montanaro P, Gertje HP, Ericsson M, Connor JH, Vrbanac V, Crossland NA, Harly C, Balazs AB, Douam F. Immune signatures of SARS-CoV-2 infection resolution in human lung tissues. PLoS Pathog. 2025 Sep; 21(9):e1013469.View Related Profiles.

Kenney, Devin James
Douam, Florian
Connor, John
Crossland, Nicholas

PMID: 40920821; PMCID: PMC12425302; DOI: 10.1371/journal.ppat.1013469;

Kenney D, Matsuo M, Unali G, Wacquiez A, Saeed M, Douam F. Comprehensive Analysis of the Impact of Weight Loss Thresholds on Mouse Models of Fatal Viral Infection. Viruses. 2025 Sep 07; 17(9).View Related Profiles.

Douam, Florian
Saeed, Mohsan

PMID: 41012653; PMCID: PMC12474137; DOI: 10.3390/v17091225;

Zhang J, Chavez EC, Winkler M, Liu J, Carver S, Lin AE, Biswas A, Tamura T, Tseng A, Wang D, Benhamou A, O' Connell AK, Matsuo M, Norton JE, Kenney D, Adamson B, Kleiner RE, Burwitz B, Crossland NA, Douam F, Ploss A. Amino acid changes in two viral proteins drive attenuation of the yellow fever 17D vaccine. Nat Microbiol. 2025 Aug; 10(8):1902-1917.View Related Profiles.

Douam, Florian
Crossland, Nicholas

PMID: 40629111; PMCID: PMC12313524; DOI: 10.1038/s41564-025-02047-y;

Caobi A, Su CM, Beusch CM, Kenney D, Darling TL, Feng S, Semaan M, Wacquiez A, Sanders NL, Tully ES, Chen DY, Evdokimova M, Ding Z, Jones D, Alysandratos KD, Mizgerd JP, Kirchdoerfer RN, Kotton DN, Douam F, Crossland NA, Boon ACM, Gordon DE, Baker SC, Saeed M. SARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses. Proc Natl Acad Sci U S A. 2025 Jun 17; 122(24):e2426528122.View Related Profiles.

Wacquiez, Alan Cyril Jacques
Caobi, Allen
Kotton, Darrell
Kenney, Devin James
Douam, Florian
Mizgerd, Joseph
Alysandratos, Kostas
Saeed, Mohsan
Crossland, Nicholas

PMID: 40504150; PMCID: PMC12184426; DOI: 10.1073/pnas.2426528122;

Shastry A, Hiller BE, Sanders NL, Tseng AE, Kothari J, O'Connell AK, Gertje HP, Ha CT, Murzin E, Traber KE, Lederer JA, Jones MR, Douam F, Beach TG, Remick DG, Crossland NA, Monti S, Campbell JD, Mizgerd JP. Sub-phenotypes of pneumonia defined by pulmonary histopathological features. bioRxiv. 2025 May 20.View Related Profiles.

Hiller, Bradley
Douam, Florian
Mizgerd, Joseph
Traber, Katrina
Crossland, Nicholas
Monti, Stefano

PMID: 40475544; PMCID: PMC12139937; DOI: 10.1101/2025.05.18.654716;

Mcconney CS, Kenney D, Ennis CS, Smith-Mahoney EL, Ayuso MJ, Zhong J, Douam F, Sagar M, Snyder-Cappione JE. Individuals Infected with SARS-CoV-2 Prior to COVID-19 Vaccination Maintain Vaccine-Induced RBD-Specific Antibody Levels and Viral Neutralization Activity for One Year. Viruses. 2025 Apr 29; 17(5).View Related Profiles.

Kenney, Devin James
Douam, Florian
Snyder-Cappione , Jennifer
Sagar, Manish

PMID: 40431652; PMCID: PMC12115583; DOI: 10.3390/v17050640;

Subramaniam S, Jose A, Kenney D, O'Connell AK, Bosmann M, Douam F, Crossland N. Challenging the notion of endothelial infection by SARS-CoV-2: insights from the current scientific evidence. Front Immunol. 2025; 16:1443932.View Related Profiles.

Jose, Asha
Kenney, Devin James
Douam, Florian
Bosmann, Markus
Crossland, Nicholas

PMID: 39967675; PMCID: PMC11832389; DOI: 10.3389/fimmu.2025.1443932;

Subramaniam S, Napoleon MA, Lotfollahzadeh S, Kamal MH, Kurniawan H, Elsadawi M, Kenney D, Douam F, Bosmann M, Whelan S, Cabral H, Burks EJ, Zhao G, Kolachalama V, Ravid K, Chitalia V. Tryptophan metabolism reprogramming contributes to the prothrombotic milieu in mice and humans infected with SARS-CoV-2. bioRxiv. 2025 Jan 30.View Related Profiles.

Kenney, Devin James
Burks, Eric
Douam, Florian
Cabral, Howard
Ravid, Katya
Bosmann, Markus
Lotfollahzadeh, Saran
Kolachalama, Vijaya
Chitalia, Vipul

PMID: 39896681; PMCID: PMC11785031; DOI: 10.1101/2025.01.17.633602;

Joseph J, Baby HM, Quintero JR, Kenney D, Mebratu YA, Bhatia E, Shah P, Swain K, Lee D, Kaur S, Li XL, Mwangi J, Snapper O, Nair R, Agus E, Ranganathan S, Kage J, Gao J, Luo JN, Yu A, Park D, Douam F, Tesfaigzi Y, Karp JM, Joshi N. Toward a Radically Simple Multi-Modal Nasal Spray for Preventing Respiratory Infections. Adv Mater. 2024 Nov; 36(46):e2406348.View Related Profiles.

Kenney, Devin James
Douam, Florian

PMID: 39318086

Showing 10 of 54 results. Show More

McGee JE, Kirsch JR, Kenney D, Cerbo F, Chavez EC, Shih TY, Douam F, Wong WW, Grinstaff MW. Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency. Nat Biotechnol. 2025 May; 43(5):720-726.View Related Profiles.

Kenney, Devin James
Douam, Florian
Grinstaff, Mark
Wong, Wilson

PMID: 38977924; PMCID: PMC11707045; DOI: 10.1038/s41587-024-02306-z;

Subramaniam S, Kenney D, Jayaraman A, O'Connell AK, Walachowski S, Montanaro P, Reinhardt C, Colucci G, Crossland NA, Douam F, Bosmann M. Aging is associated with an insufficient early inflammatory response of lung endothelial cells in SARS-CoV-2 infection. Front Immunol. 2024; 15:1397990.View Related Profiles.

Jayaraman, Archana
Kenney, Devin James
Douam, Florian
Bosmann, Markus
Crossland, Nicholas
Walachowski, Sarah

PMID: 38911865; PMCID: PMC11190167; DOI: 10.3389/fimmu.2024.1397990;

Hartmann JA, Cardoso MR, Talarico MCR, Kenney DJ, Leone MR, Reese DC, Turcinovic J, O'Connell AK, Gertje HP, Marino C, Ojeda PE, De Paula EV, Orsi FA, Velloso LA, Cafiero TR, Connor JH, Ploss A, Hoelzemer A, Carrington M, Barczak AK, Crossland NA, Douam F, Boucau J, Garcia-Beltran WF. Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses. Cell. 2024 May 09; 187(10):2393-2410.e14.View Related Profiles.

Douam, Florian
Connor, John
Crossland, Nicholas

PMID: 38653235; PMCID: PMC11088510; DOI: 10.1016/j.cell.2024.03.026;

Kenney D, O'Connell AK, Tseng AE, Turcinovic J, Sheehan ML, Nitido AD, Montanaro P, Gertje HP, Ericsson M, Connor JH, Vrbanac V, Crossland NA, Harly C, Balazs AB, Douam F. Resolution of SARS-CoV-2 infection in human lung tissues is driven by extravascular CD163+ monocytes. bioRxiv. 2024 Mar 08.View Related Profiles.

Kenney, Devin James
Douam, Florian
Connor, John
Crossland, Nicholas

PMID: 38496468; PMCID: PMC10942442; DOI: 10.1101/2024.03.08.583965;

Mesev EV, Lin AE, Guare EG, Heller BL, Douam F, Adamson B, Toettcher JE, Ploss A. Membrane-proximal motifs encode differences in signaling strength between type I and III interferon receptors. Sci Signal. 2023 Oct 10; 16(806):eadf5494. PMID: 37816090; PMCID: PMC10939449; DOI: 10.1126/scisignal.adf5494;

McGee JE, Kirsch JR, Kenney D, Chavez E, Shih TY, Douam F, Wong WW, Grinstaff MW. Complete substitution with modified nucleotides suppresses the early interferon response and increases the potency of self-amplifying RNA. bioRxiv. 2023 Sep 17.View Related Profiles.

Kenney, Devin James
Douam, Florian
Grinstaff, Mark

PMID: 37745375; PMCID: PMC10516017; DOI: 10.1101/2023.09.15.557994;

Hogan G, Winer BY, Ahodantin J, Sellau J, Huang T, Douam F, Funaki M, Chiriboga L, Su L, Ploss A. Persistent hepatitis B virus and HIV coinfections in dually humanized mice engrafted with human liver and immune system. J Med Virol. 2023 Jul; 95(7):e28930. PMID: 37403703; PMCID: PMC11298785; DOI: 10.1002/jmv.28930;

Chen DY, Turcinovic J, Feng S, Kenney DJ, Chin CV, Choudhary MC, Conway HL, Semaan M, Close BJ, Tavares AH, Seitz S, Khan N, Kapell S, Crossland NA, Li JZ, Douam F, Baker SC, Connor JH, Saeed M. Cell culture systems for isolation of SARS-CoV-2 clinical isolates and generation of recombinant virus. iScience. 2023 May 19; 26(5):106634.View Related Profiles.

Chin, Chue Vin
Kenney, Devin James
Douam, Florian
Connor, John
Saeed, Mohsan
Khan, Nazimuddin
Crossland, Nicholas
Seitz, Scott
Kapell, Sebastian

PMID: 37095858; PMCID: PMC10083141; DOI: 10.1016/j.isci.2023.106634;

Chen DY, Chin CV, Kenney D, Tavares AH, Khan N, Conway HL, Liu G, Choudhary MC, Gertje HP, O'Connell AK, Adams S, Kotton DN, Herrmann A, Ensser A, Connor JH, Bosmann M, Li JZ, Gack MU, Baker SC, Kirchdoerfer RN, Kataria Y, Crossland NA, Douam F, Saeed M. Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation. Nature. 2023 Mar; 615(7950):143-150.View Related Profiles.

Chin, Chue Vin
Kotton, Darrell
Kenney, Devin James
Douam, Florian
Connor, John
Bosmann, Markus
Saeed, Mohsan
Khan, Nazimuddin
Crossland, Nicholas
Kataria, Yachana

PMID: 36630998

Chen DY, Kenney D, Chin CV, Tavares AH, Khan N, Conway HL, Liu G, Choudhary MC, Gertje HP, O'Connell AK, Kotton DN, Herrmann A, Ensser A, Connor JH, Bosmann M, Li JZ, Gack MU, Baker SC, Kirchdoerfer RN, Kataria Y, Crossland NA, Douam F, Saeed M. Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron. bioRxiv. 2023 Jan 10.View Related Profiles.

Chin, Alice
Chin, Chue Vin
Kotton, Darrell
Douam, Florian
Connor, John
Bosmann, Markus
Saeed, Mohsan
Khan, Nazimuddin
Crossland, Nicholas
Kataria, Yachana

PMID: 36263066; PMCID: PMC9580375; DOI: 10.1101/2022.10.13.512134;

Douam F, Ploss A. A humanized "new-trophil" mouse to study early inflammatory processes. Proc Natl Acad Sci U S A. 2022 Dec 06; 119(49):e2216699119. PMID: 36442110; PMCID: PMC9894160; DOI: 10.1073/pnas.2216699119;

Kenney DJ, O'Connell AK, Turcinovic J, Montanaro P, Hekman RM, Tamura T, Berneshawi AR, Cafiero TR, Al Abdullatif S, Blum B, Goldstein SI, Heller BL, Gertje HP, Bullitt E, Trachtenberg AJ, Chavez E, Nono ET, Morrison C, Tseng AE, Sheikh A, Kurnick S, Grosz K, Bosmann M, Ericsson M, Huber BR, Saeed M, Balazs AB, Francis KP, Klose A, Paragas N, Campbell JD, Connor JH, Emili A, Crossland NA, Ploss A, Douam F. Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection. Cell Rep. 2022 Apr 19; 39(3):110714.View Related Profiles.

Emili, Andrew
Blum, Benjamin
Huber, Bertrand
Kenney, Devin James
Bullitt, Esther
Douam, Florian
Connor, John
Campbell, Joshua
Bosmann, Markus
Saeed, Mohsan
Crossland, Nicholas

PMID: 35421379; PMCID: PMC8977517; DOI: 10.1016/j.celrep.2022.110714;

Ren W, Ju X, Gong M, Lan J, Yu Y, Long Q, Kenney DJ, O'Connell AK, Zhang Y, Zhong J, Zhong G, Douam F, Wang X, Huang A, Zhang R, Ding Q. Characterization of SARS-CoV-2 Variants B.1.617.1 (Kappa), B.1.617.2 (Delta), and B.1.618 by Cell Entry and Immune Evasion. mBio. 2022 Apr 26; 13(2):e0009922.View Related Profiles.

Kenney, Devin James
Douam, Florian

PMID: 35266815; PMCID: PMC9040861; DOI: 10.1128/mbio.00099-22;

Carossino M, Kenney D, O'Connell AK, Montanaro P, Tseng AE, Gertje HP, Grosz KA, Ericsson M, Huber BR, Kurnick SA, Subramaniam S, Kirkland TA, Walker JR, Francis KP, Klose AD, Paragas N, Bosmann M, Saeed M, Balasuriya UBR, Douam F, Crossland NA. Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression. Viruses. 2022 03 05; 14(3).View Related Profiles.

Huber, Bertrand
Kenney, Devin James
Douam, Florian
Bosmann, Markus
Saeed, Mohsan
Crossland, Nicholas
Subramaniam, Saravanan

PMID: 35336942; PMCID: PMC8955233; DOI: 10.3390/v14030535;

Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Fuchs SY, Connor JH, Douam F, Emili A, Saeed M. SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway. J Virol. 2021 09 09; 95(19):e0086221.View Related Profiles.

Emili, Andrew
Blum, Benjamin
Chen, Christopher
Kotton, Darrell
Kenney, Devin James
Douam, Florian
Connor, John
Saeed, Mohsan
Khan, Nazimuddin
Crossland, Nicholas
Goel, Raghuveera
Chitalia, Vipul

PMID: 34260266; PMCID: PMC8428404; DOI: 10.1128/JVI.00862-21;

Yen HL, Valkenburg S, Sia SF, Choy KT, Peiris JSM, Wong KHM, Crossland N, Douam F, Nicholls JM. Cellular tropism of SARS-CoV-2 in the respiratory tract of Syrian hamsters and B6.Cg-Tg(K18-ACE2)2Prlmn/J transgenic mice. Vet Pathol. 2022 Jul; 59(4):639-647.View Related Profiles.

Douam, Florian
Crossland, Nicholas

PMID: 34467820; PMCID: PMC8721337; DOI: 10.1177/03009858211043084;

Sanders DW, Jumper CC, Ackerman PJ, Bracha D, Donlic A, Kim H, Kenney D, Castello-Serrano I, Suzuki S, Tamura T, Tavares AH, Saeed M, Holehouse AS, Ploss A, Levental I, Douam F, Padera RF, Levy BD, Brangwynne CP. SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation. Elife. 2021 04 23; 10.View Related Profiles.

Kenney, Devin James
Douam, Florian
Saeed, Mohsan

PMID: 33890572; PMCID: PMC8104966; DOI: 10.7554/eLife.65962;

Ren W, Zhu Y, Wang Y, Shi H, Yu Y, Hu G, Feng F, Zhao X, Lan J, Wu J, Kenney DJ, Douam F, Tong Y, Zhong J, Xie Y, Wang X, Yuan Z, Zhou D, Zhang R, Ding Q. Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry. PLoS Pathog. 2021 03; 17(3):e1009392.View Related Profiles.

Kenney, Devin James
Douam, Florian

PMID: 33760889; PMCID: PMC7990223; DOI: 10.1371/journal.ppat.1009392;

Loffredo M, Lucero H, Chen DY, O'Connell A, Bergqvist S, Munawar A, Bandara A, De Graef S, Weeks SD, Douam F, Saeed M, Munawar AH. The in-vitro effect of famotidine on sars-cov-2 proteases and virus replication. Sci Rep. 2021 03 08; 11(1):5433.View Related Profiles.

Douam, Florian
Saeed, Mohsan

PMID: 33686143; PMCID: PMC7940615; DOI: 10.1038/s41598-021-84782-w;

Carossino M, Montanaro P, O'Connell A, Kenney D, Gertje H, Grosz KA, Kurnick SA, Bosmann M, Saeed M, Balasuriya UBR, Douam F, Crossland NA. Fatal neuroinvasion of SARS-CoV-2 in K18-hACE2 mice is partially dependent on hACE2 expression. bioRxiv. 2021 Jan 15.View Related Profiles.

Huber, Bertrand
Kenney, Devin James
Douam, Florian
Bosmann, Markus
Saeed, Mohsan
Crossland, Nicholas
Subramaniam, Saravanan

PMID: 33469581; PMCID: PMC7814818; DOI: 10.1101/2021.01.13.425144;

Nimgaonkar I, Archer NF, Becher I, Shahrad M, LeDesma RA, Mateus A, Caballero-Gómez J, Berneshawi AR, Ding Q, Douam F, Gaska JM, Savitski MM, Kim H, Ploss A. Isocotoin suppresses hepatitis E virus replication through inhibition of heat shock protein 90. Antiviral Res. 2021 01; 185:104997. PMID: 33326835; PMCID: PMC8649941; DOI: 10.1016/j.antiviral.2020.104997;

Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Kapell S, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Connor JH, Douam F, Emili A, Saeed M. SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway. bioRxiv. 2020 Oct 28.View Related Profiles.

Emili, Andrew
Blum, Benjamin
Chen, Christopher
Kotton, Darrell
Douam, Florian
Connor, John
Saeed, Mohsan
Khan, Nazimuddin
Crossland, Nicholas
Goel, Raghuveera
Kapell, Sebastian
Chitalia, Vipul

PMID: 33140044; PMCID: PMC7605551; DOI: 10.1101/2020.10.27.358259;

Ramanathan HN, Zhang S, Douam F, Mar KB, Chang J, Yang PL, Schoggins JW, Ploss A, Lindenbach BD. A Sensitive Yellow Fever Virus Entry Reporter Identifies Valosin-Containing Protein (VCP/p97) as an Essential Host Factor for Flavivirus Uncoating. mBio. 2020 04 14; 11(2). PMID: 32291299; PMCID: PMC7157815; DOI: 10.1128/mBio.00467-20;

O'Connell AK, Douam F. Humanized Mice for Live-Attenuated Vaccine Research: From Unmet Potential to New Promises. Vaccines (Basel). 2020 Jan 21; 8(1). PMID: 31973073; PMCID: PMC7157703; DOI: 10.3390/vaccines8010036;

Douam F, Ziegler CGK, Hrebikova G, Fant B, Leach R, Parsons L, Wang W, Gaska JM, Winer BY, Heller B, Shalek AK, Ploss A. Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses. Nat Commun. 2018 11 28; 9(1):5031. PMID: 30487575; PMCID: PMC6262001; DOI: 10.1038/s41467-018-07478-2;

Douam F, Ploss A. Yellow Fever Virus: Knowledge Gaps Impeding the Fight Against an Old Foe. Trends Microbiol. 2018 11; 26(11):913-928. PMID: 29933925; PMCID: PMC6340642; DOI: 10.1016/j.tim.2018.05.012;

Ding Q, Gaska JM, Douam F, Wei L, Kim D, Balev M, Heller B, Ploss A. Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease. Proc Natl Acad Sci U S A. 2018 07 03; 115(27):E6310-E6318. PMID: 29915078; PMCID: PMC6142274; DOI: 10.1073/pnas.1803406115;

Douam F, Ploss A. The use of humanized mice for studies of viral pathogenesis and immunity. Curr Opin Virol. 2018 04; 29:62-71. PMID: 29604551; PMCID: PMC5940492; DOI: 10.1016/j.coviro.2018.03.003;

Douam F, Fusil F, Enguehard M, Dib L, Nadalin F, Schwaller L, Hrebikova G, Mancip J, Mailly L, Montserret R, Ding Q, Maisse C, Carlot E, Xu K, Verhoeyen E, Baumert TF, Ploss A, Carbone A, Cosset FL, Lavillette D. A protein coevolution method uncovers critical features of the Hepatitis C Virus fusion mechanism. PLoS Pathog. 2018 03; 14(3):e1006908. PMID: 29505618; PMCID: PMC5854445; DOI: 10.1371/journal.ppat.1006908;

Douam F, Soto Albrecht YE, Hrebikova G, Sadimin E, Davidson C, Kotenko SV, Ploss A. Type III Interferon-Mediated Signaling Is Critical for Controlling Live Attenuated Yellow Fever Virus Infection In Vivo. MBio. 2017 08 15; 8(4). PMID: 28811340; PMCID: PMC5559630; DOI: 10.1128/mBio.00819-17;

Douam F, Hrebikova G, Albrecht YE, Sellau J, Sharon Y, Ding Q, Ploss A. Single-cell tracking of flavivirus RNA uncovers species-specific interactions with the immune system dictating disease outcome. Nat Commun. 2017 03 14; 8:14781. PMID: 28290449; PMCID: PMC5424064; DOI: 10.1038/ncomms14781;

Douam F, Ding Q, Ploss A. Recent advances in understanding hepatitis C. F1000Res. 2016; 5. PMID: 26918166; PMCID: PMC4755394; DOI: 10.12688/f1000research.7354.1;

Douam F, Bobay LM, Maurin G, Fresquet J, Calland N, Maisse C, Durand T, Cosset FL, Féray C, Lavillette D. Specialization of Hepatitis C Virus Envelope Glycoproteins for B Lymphocytes in Chronically Infected Patients. J Virol. 2016 01 15; 90(2):992-1008. PMID: 26537674; PMCID: PMC4702674; DOI: 10.1128/JVI.02516-15;

Douam F, Gaska JM, Winer BY, Ding Q, von Schaewen M, Ploss A. Genetic Dissection of the Host Tropism of Human-Tropic Pathogens. Annu Rev Genet. 2015; 49:21-45. PMID: 26407032; PMCID: PMC5075990; DOI: 10.1146/annurev-genet-112414-054823;

Fusil F, Calattini S, Amirache F, Mancip J, Costa C, Robbins JB, Douam F, Lavillette D, Law M, Defrance T, Verhoeyen E, Cosset FL. A Lentiviral Vector Allowing Physiologically Regulated Membrane-anchored and Secreted Antibody Expression Depending on B-cell Maturation Status. Mol Ther. 2015 Nov; 23(11):1734-1747. PMID: 26281898; PMCID: PMC4817946; DOI: 10.1038/mt.2015.148;

Fénéant L, Potel J, François C, Sané F, Douam F, Belouzard S, Calland N, Vausselin T, Rouillé Y, Descamps V, Baumert TF, Duverlie G, Lavillette D, Hober D, Dubuisson J, Wychowski C, Cocquerel L. New Insights into the Understanding of Hepatitis C Virus Entry and Cell-to-Cell Transmission by Using the Ionophore Monensin A. J Virol. 2015 Aug; 89(16):8346-64. PMID: 26041282; PMCID: PMC4524216; DOI: 10.1128/JVI.00192-15;

Douam F, Ploss A. Proteomic approaches to analyzing hepatitis C virus biology. Proteomics. 2015 Jun; 15(12):2051-65. PMID: 25809442; PMCID: PMC4559851; DOI: 10.1002/pmic.201500009;

Douam F, Lavillette D, Cosset FL. The mechanism of HCV entry into host cells. Prog Mol Biol Transl Sci. 2015; 129:63-107. PMID: 25595801

Cartier F, Marcq I, Douam F, Ossart C, Regnier A, Debuysscher V, Lavillette D, Bouhlal H. The expression of the hepatocyte SLAMF3 (CD229) receptor enhances the hepatitis C virus infection. PLoS One. 2014; 9(6):e99601. PMID: 24927415; PMCID: PMC4057114; DOI: 10.1371/journal.pone.0099601;

Bocchetta S, Maillard P, Yamamoto M, Gondeau C, Douam F, Lebreton S, Lagaye S, Pol S, Helle F, Plengpanich W, Guérin M, Bourgine M, Michel ML, Lavillette D, Roingeard P, le Goff W, Budkowska A. Up-regulation of the ATP-binding cassette transporter A1 inhibits hepatitis C virus infection. PLoS One. 2014; 9(3):e92140. PMID: 24646941; PMCID: PMC3960176; DOI: 10.1371/journal.pone.0092140;

Douam F, Dao Thi VL, Maurin G, Fresquet J, Mompelat D, Zeisel MB, Baumert TF, Cosset FL, Lavillette D. Critical interaction between E1 and E2 glycoproteins determines binding and fusion properties of hepatitis C virus during cell entry. Hepatology. 2014 Mar; 59(3):776-88. PMID: 24038151

de Bossoreille de Ribou S, Douam F, Hamant O, Frohlich MW, Negrutiu I. Plant science and agricultural productivity: why are we hitting the yield ceiling? Plant Sci. 2013 Sep; 210:159-76. PMID: 23849123

Vausselin T, Calland N, Belouzard S, Descamps V, Douam F, Helle F, François C, Lavillette D, Duverlie G, Wahid A, Fénéant L, Cocquerel L, Guérardel Y, Wychowski C, Biot C, Dubuisson J. The antimalarial ferroquine is an inhibitor of hepatitis C virus. Hepatology. 2013 Jul; 58(1):86-97. PMID: 23348596; PMCID: PMC7165689; DOI: 10.1002/hep.26273;

Boo I, teWierik K, Douam F, Lavillette D, Poumbourios P, Drummer HE. Distinct roles in folding, CD81 receptor binding and viral entry for conserved histidine residues of hepatitis C virus glycoprotein E1 and E2. Biochem J. 2012 Apr 01; 443(1):85-94. PMID: 22240035

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 54 publications over 13 distinct years, with a maximum of 9 publications in 2025

Bar chart showing 54 publications over 13 distinct years, with a maximum of 9 publications in 2025

Year	Publications
2012	1
2013	2
2014	4
2015	5
2016	1
2017	2
2018	5
2020	4
2021	6
2022	4
2023	6
2024	5
2025	9

Media Mentions
Tweets

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2024 Kilachand Fund Awards Boost Projects Building Antivirus Platform, Improving Brain Imaging, and Fighting Antibiotic Resistance

The Brink 11/13/2024

A New Type of RNA Could Revolutionize Vaccines and Cancer Treatments

The Brink 9/9/2024

Modified Self-Amplifying RNA Provides Opportunities For New Vaccines And Treatments

Forbes 7/23/2024

NEIDL Researchers Discover New SARS-CoV-2 Weak Spot—Which Could Inspire Improved Vaccines

BU Today 1/15/2023

Best of The Brink 2022: BU’s Most-Read Science and Research Stories

BU Today 12/13/2022

From Lovesick Frogs to Music-Making to Mouse Memories, Photo Contest Shows Stunning Breadth of BU Research

BU Today 9/27/2022

Pausing J&J Vaccine Rollout Is a Move to Keep Public Trust

The Brink 4/14/2021

WHAT YOU SHOULD KNOW ABOUT THE JOHNSON & JOHNSON VACCINE PAUSE

Futurity 4/14/2021

Experts: 2 COVID-19 Vaccines Bring Us Into ‘New Territory’

Futurity 11/20/2020

Junior Faculty Recognized with Career Development Awards

BU Today 9/18/2019

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Virology
Immunology
Human immune response to viral infection
Human/virus interactions
Viral pathogenesis
Viral immunogenicity
Humanized mouse models
Live-attenuated vaccines

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