Florian Douam | Profiles RNS

Florian Douam, PhD

Assistant Professor

Boston University School of Medicine

Dept of Microbiology

Websites

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	ResearchGate
	National Emerging Infectious Diseases Laboratories Faculty

Florian Douam, Ph.D. has a Ph.D. in molecular virology from École normale supérieure de Lyon, France. He previously worked as a postdoctoral research associate in the Ploss Lab, in the department of molecular biology at Princeton University. He currently leads the Douam Lab located at the National Emerging Infectious Disease Laboratories (NEIDL), which investigates how the human immune system as a tissue interacts with specific viral pathogens and ultimately regulates different outcome of infection.

Faculty
Boston University
National Emerging Infectious Disease Lab

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Ren W, Zhu Y, Wang Y, Shi H, Yu Y, Hu G, Feng F, Zhao X, Lan J, Wu J, Kenney DJ, Douam F, Tong Y, Zhong J, Xie Y, Wang X, Yuan Z, Zhou D, Zhang R, Ding Q. Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry. PLoS Pathog. 2021 03; 17(3):e1009392. PMID: 33760889

Loffredo M, Lucero H, Chen DY, O'Connell A, Bergqvist S, Munawar A, Bandara A, De Graef S, Weeks SD, Douam F, Saeed M, Munawar AH. The in-vitro effect of famotidine on sars-cov-2 proteases and virus replication. Sci Rep. 2021 03 08; 11(1):5433.View Related Profiles.

Douam, Florian
Saeed, Mohsan

PMID: 33686143

Carossino M, Montanaro P, O'Connell A, Kenney D, Gertje H, Grosz KA, Kurnick SA, Bosmann M, Saeed M, Balasuriya UBR, Douam F, Crossland NA. Fatal neuroinvasion of SARS-CoV-2 in K18-hACE2 mice is partially dependent on hACE2 expression. bioRxiv. 2021 Jan 15.View Related Profiles.

Douam, Florian
Bosmann, Markus
Saeed, Mohsan
Crossland, Nicholas

PMID: 33469581

Nimgaonkar I, Archer NF, Becher I, Shahrad M, LeDesma RA, Mateus A, Caballero-Gómez J, Berneshawi AR, Ding Q, Douam F, Gaska JM, Savitski MM, Kim H, Ploss A. Isocotoin suppresses hepatitis E virus replication through inhibition of heat shock protein 90. Antiviral Res. 2021 01; 185:104997. PMID: 33326835

Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Kapell S, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Connor JH, Douam F, Emili A, Saeed M. SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway. bioRxiv. 2020 Oct 28.View Related Profiles.

Emili, Andrew
Blum, Benjamin
Kotton, Darrell
Douam, Florian
Connor, John
Saeed, Mohsan
Crossland, Nicholas
Goel, Raghuveera
Kapell, Sebastian
Chitalia, Vipul

PMID: 33140044

Ramanathan HN, Zhang S, Douam F, Mar KB, Chang J, Yang PL, Schoggins JW, Ploss A, Lindenbach BD. A Sensitive Yellow Fever Virus Entry Reporter Identifies Valosin-Containing Protein (VCP/p97) as an Essential Host Factor for Flavivirus Uncoating. mBio. 2020 04 14; 11(2). PMID: 32291299

O'Connell AK, Douam F. Humanized Mice for Live-Attenuated Vaccine Research: From Unmet Potential to New Promises. Vaccines (Basel). 2020 Jan 21; 8(1). PMID: 31973073

Douam F, Ziegler CGK, Hrebikova G, Fant B, Leach R, Parsons L, Wang W, Gaska JM, Winer BY, Heller B, Shalek AK, Ploss A. Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses. Nat Commun. 2018 11 28; 9(1):5031. PMID: 30487575

Douam F, Ploss A. Yellow Fever Virus: Knowledge Gaps Impeding the Fight Against an Old Foe. Trends Microbiol. 2018 11; 26(11):913-928. PMID: 29933925

Ding Q, Gaska JM, Douam F, Wei L, Kim D, Balev M, Heller B, Ploss A. Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease. Proc Natl Acad Sci U S A. 2018 07 03; 115(27):E6310-E6318. PMID: 29915078

Showing 10 of 27 results. Show More

Douam F, Ploss A. The use of humanized mice for studies of viral pathogenesis and immunity. Curr Opin Virol. 2018 04; 29:62-71. PMID: 29604551

Douam F, Fusil F, Enguehard M, Dib L, Nadalin F, Schwaller L, Hrebikova G, Mancip J, Mailly L, Montserret R, Ding Q, Maisse C, Carlot E, Xu K, Verhoeyen E, Baumert TF, Ploss A, Carbone A, Cosset FL, Lavillette D. A protein coevolution method uncovers critical features of the Hepatitis C Virus fusion mechanism. PLoS Pathog. 2018 03; 14(3):e1006908. PMID: 29505618

Douam F, Soto Albrecht YE, Hrebikova G, Sadimin E, Davidson C, Kotenko SV, Ploss A. Type III Interferon-Mediated Signaling Is Critical for Controlling Live Attenuated Yellow Fever Virus Infection In Vivo. MBio. 2017 08 15; 8(4). PMID: 28811340

Douam F, Hrebikova G, Albrecht YE, Sellau J, Sharon Y, Ding Q, Ploss A. Single-cell tracking of flavivirus RNA uncovers species-specific interactions with the immune system dictating disease outcome. Nat Commun. 2017 03 14; 8:14781. PMID: 28290449

Douam F, Ding Q, Ploss A. Recent advances in understanding hepatitis C. F1000Res. 2016; 5. PMID: 26918166; PMCID: PMC4755394

Douam F, Bobay LM, Maurin G, Fresquet J, Calland N, Maisse C, Durand T, Cosset FL, Féray C, Lavillette D. Specialization of Hepatitis C Virus Envelope Glycoproteins for B Lymphocytes in Chronically Infected Patients. J Virol. 2016 01 15; 90(2):992-1008. PMID: 26537674

Douam F, Gaska JM, Winer BY, Ding Q, von Schaewen M, Ploss A. Genetic Dissection of the Host Tropism of Human-Tropic Pathogens. Annu Rev Genet. 2015; 49:21-45. PMID: 26407032

Fusil F, Calattini S, Amirache F, Mancip J, Costa C, Robbins JB, Douam F, Lavillette D, Law M, Defrance T, Verhoeyen E, Cosset FL. A Lentiviral Vector Allowing Physiologically Regulated Membrane-anchored and Secreted Antibody Expression Depending on B-cell Maturation Status. Mol Ther. 2015 Nov; 23(11):1734-1747. PMID: 26281898; PMCID: PMC4817946

Fénéant L, Potel J, François C, Sané F, Douam F, Belouzard S, Calland N, Vausselin T, Rouillé Y, Descamps V, Baumert TF, Duverlie G, Lavillette D, Hober D, Dubuisson J, Wychowski C, Cocquerel L. New Insights into the Understanding of Hepatitis C Virus Entry and Cell-to-Cell Transmission by Using the Ionophore Monensin A. J Virol. 2015 Aug; 89(16):8346-64. PMID: 26041282; PMCID: PMC4524216

Douam F, Ploss A. Proteomic approaches to analyzing hepatitis C virus biology. Proteomics. 2015 Jun; 15(12):2051-65. PMID: 25809442; PMCID: PMC4559851

Douam F, Lavillette D, Cosset FL. The mechanism of HCV entry into host cells. Prog Mol Biol Transl Sci. 2015; 129:63-107. PMID: 25595801

Cartier F, Marcq I, Douam F, Ossart C, Regnier A, Debuysscher V, Lavillette D, Bouhlal H. The expression of the hepatocyte SLAMF3 (CD229) receptor enhances the hepatitis C virus infection. PLoS One. 2014; 9(6):e99601. PMID: 24927415; PMCID: PMC4057114

Bocchetta S, Maillard P, Yamamoto M, Gondeau C, Douam F, Lebreton S, Lagaye S, Pol S, Helle F, Plengpanich W, Guérin M, Bourgine M, Michel ML, Lavillette D, Roingeard P, le Goff W, Budkowska A. Up-regulation of the ATP-binding cassette transporter A1 inhibits hepatitis C virus infection. PLoS One. 2014; 9(3):e92140. PMID: 24646941; PMCID: PMC3960176

Douam F, Dao Thi VL, Maurin G, Fresquet J, Mompelat D, Zeisel MB, Baumert TF, Cosset FL, Lavillette D. Critical interaction between E1 and E2 glycoproteins determines binding and fusion properties of hepatitis C virus during cell entry. Hepatology. 2014 Mar; 59(3):776-88. PMID: 24038151

de Bossoreille de Ribou S, Douam F, Hamant O, Frohlich MW, Negrutiu I. Plant science and agricultural productivity: why are we hitting the yield ceiling? Plant Sci. 2013 Sep; 210:159-76. PMID: 23849123

Vausselin T, Calland N, Belouzard S, Descamps V, Douam F, Helle F, François C, Lavillette D, Duverlie G, Wahid A, Fénéant L, Cocquerel L, Guérardel Y, Wychowski C, Biot C, Dubuisson J. The antimalarial ferroquine is an inhibitor of hepatitis C virus. Hepatology. 2013 Jul; 58(1):86-97. PMID: 23348596

Boo I, teWierik K, Douam F, Lavillette D, Poumbourios P, Drummer HE. Distinct roles in folding, CD81 receptor binding and viral entry for conserved histidine residues of hepatitis C virus glycoprotein E1 and E2. Biochem J. 2012 Apr 01; 443(1):85-94. PMID: 22240035

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 27 publications over 9 distinct years, with a maximum of 5 publications in 2015 and 2018

Bar chart showing 27 publications over 9 distinct years, with a maximum of 5 publications in 2015 and 2018

Year	Publications
2012	1
2013	2
2014	4
2015	5
2016	1
2017	2
2018	5
2020	4
2021	3

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In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Virology
Immunology
Human immune response to viral infection
Human/virus interactions
Viral pathogenesis
Viral immunogenicity
Humanized mouse models
Live-attenuated vaccines

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617.358.9174

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