Florian Douam, PhD
Assistant Professor
Boston University School of Medicine
Dept of Microbiology

PhD, L'École Normale Supérieure de Lyon




Florian Douam, Ph.D. has a Ph.D. in molecular virology from École normale supérieure de Lyon, France. He previously worked as a postdoctoral research associate in the Ploss Lab, in the department of molecular biology at Princeton University. He currently leads the Douam Lab located at the National Emerging Infectious Disease Laboratories (NEIDL), which investigates how the human immune system as a tissue interacts with specific viral pathogens and ultimately regulates different outcome of infection.

Faculty
Boston University
National Emerging Infectious Disease Lab


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Characterization of a human-specific positive regulator of flavivirus infection
04/12/2021 - 03/31/2023 (PI)
NIH/National Institute of Allergy & Infectious Diseases
1K22AI144050-01

Defining the Impact of Per/Polyfluoroalkyl Substance Exposure on Susceptibility to SARS-CoV-2 Infection and Disease
03/02/2021 - 02/28/2023 (Multi-PI)
PI: Florian Douam, PhD
NIH/National Institute of Environmental Health Sciences
1R21ES032882-01

Therapeutic effects of NAPc2 in SARS-CoV-2 infection of K18-hACE2 transgenic mice
03/15/2021 - 09/15/2021 (Multi-PI)
PI: Florian Douam, PhD
ARCA Biopharma, Inc.




Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Fuchs SY, Connor JH, Douam F, Emili A, Saeed M. SARS-CoV-2 disrupts proximal elements in the JAK-STAT pathway. J Virol. 2021 Jul 14; JVI0086221.View Related Profiles. PMID: 34260266
     
  2. Sanders DW, Jumper CC, Ackerman PJ, Bracha D, Donlic A, Kim H, Kenney D, Castello-Serrano I, Suzuki S, Tamura T, Tavares AH, Saeed M, Holehouse AS, Ploss A, Levental I, Douam F, Padera RF, Levy BD, Brangwynne CP. SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation. Elife. 2021 04 23; 10.View Related Profiles. PMID: 33890572; PMCID: PMC8104966; DOI: 10.7554/eLife.65962;
     
  3. Ren W, Zhu Y, Wang Y, Shi H, Yu Y, Hu G, Feng F, Zhao X, Lan J, Wu J, Kenney DJ, Douam F, Tong Y, Zhong J, Xie Y, Wang X, Yuan Z, Zhou D, Zhang R, Ding Q. Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry. PLoS Pathog. 2021 03; 17(3):e1009392. PMID: 33760889; PMCID: PMC7990223; DOI: 10.1371/journal.ppat.1009392;
     
  4. Loffredo M, Lucero H, Chen DY, O'Connell A, Bergqvist S, Munawar A, Bandara A, De Graef S, Weeks SD, Douam F, Saeed M, Munawar AH. The in-vitro effect of famotidine on sars-cov-2 proteases and virus replication. Sci Rep. 2021 03 08; 11(1):5433.View Related Profiles. PMID: 33686143; PMCID: PMC7940615; DOI: 10.1038/s41598-021-84782-w;
     
  5. Carossino M, Montanaro P, O'Connell A, Kenney D, Gertje H, Grosz KA, Kurnick SA, Bosmann M, Saeed M, Balasuriya UBR, Douam F, Crossland NA. Fatal neuroinvasion of SARS-CoV-2 in K18-hACE2 mice is partially dependent on hACE2 expression. bioRxiv. 2021 Jan 15.View Related Profiles. PMID: 33469581; PMCID: PMC7814818; DOI: 10.1101/2021.01.13.425144;
     
  6. Nimgaonkar I, Archer NF, Becher I, Shahrad M, LeDesma RA, Mateus A, Caballero-Gómez J, Berneshawi AR, Ding Q, Douam F, Gaska JM, Savitski MM, Kim H, Ploss A. Isocotoin suppresses hepatitis E virus replication through inhibition of heat shock protein 90. Antiviral Res. 2021 01; 185:104997. PMID: 33326835
     
  7. Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Kapell S, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Connor JH, Douam F, Emili A, Saeed M. SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway. bioRxiv. 2020 Oct 28.View Related Profiles. PMID: 33140044; PMCID: PMC7605551; DOI: 10.1101/2020.10.27.358259;
     
  8. Ramanathan HN, Zhang S, Douam F, Mar KB, Chang J, Yang PL, Schoggins JW, Ploss A, Lindenbach BD. A Sensitive Yellow Fever Virus Entry Reporter Identifies Valosin-Containing Protein (VCP/p97) as an Essential Host Factor for Flavivirus Uncoating. mBio. 2020 04 14; 11(2). PMID: 32291299; PMCID: PMC7157815; DOI: 10.1128/mBio.00467-20;
     
  9. O'Connell AK, Douam F. Humanized Mice for Live-Attenuated Vaccine Research: From Unmet Potential to New Promises. Vaccines (Basel). 2020 Jan 21; 8(1). PMID: 31973073; PMCID: PMC7157703; DOI: 10.3390/vaccines8010036;
     
  10. Douam F, Ziegler CGK, Hrebikova G, Fant B, Leach R, Parsons L, Wang W, Gaska JM, Winer BY, Heller B, Shalek AK, Ploss A. Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses. Nat Commun. 2018 11 28; 9(1):5031. PMID: 30487575; PMCID: PMC6262001; DOI: 10.1038/s41467-018-07478-2;
     
Showing 10 of 29 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 29 publications over 9 distinct years, with a maximum of 5 publications in 2015 and 2018 and 2021

YearPublications
20121
20132
20144
20155
20161
20172
20185
20204
20215
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