Christopher Chen, MD, PhD
Professor
Boston University College of Engineering
Dept of Biomedical Engineering

MD, Harvard University
PhD, Massachusetts Institute of Technology
MS, Massachusetts Institute of Technology




Dr. Chen is the William Fairfield Warren Distinguished Professor at Boston University, director of the Tissue Microfabrication Laboratory, and founding director of the Biological Design Center at Boston University. He has been an instrumental figure in the development of engineered cellular microenvironments to understand and control how cells build tissues. The goal of Dr. Chen’s research is to identify the underlying mechanisms by which cells interact with materials and each other to build tissues, and to apply this knowledge to the biology and engineering of stem cells, tissue vascularization, connective tissues, and cancer. He has received numerous honors, including the Presidential Early Career Award for Scientists and Engineers, the Angiogenesis Foundation Fellowship, the Office of Naval Research Young Investigator Award, the Mary Hulman George Award for Biomedical Research, the Herbert W. Dickerman Award For Outstanding Contribution to Science, and the Robert A. Pritzker Award. He serves a Fellow of the American Institute for Medical and Biological Engineering, and as a member of the Faculty of 1000 Biology, the Board of Trustees for the Society for BioMEMS and Biomedical Nanotechnology, and Defense Sciences Study Group.

He received his A.B. in Biochemistry from Harvard, M.S. in Mechanical Engineering from MIT, and Ph.D. in Medical Engineering and Medical Physics from the Harvard-MIT. Health Sciences and Technology Program. He earned his M.D. from the Harvard Medical School. Dr. Chen previously was Assistant Professor in Biomedical Engineering and in Oncology at Johns Hopkins University, and the Skirkanich Professor of Innovation and founding director of the Center for Engineering Cells and Regeneration at the University of Pennsylvania.


Science and Technology Center for Engineering Mechano-Biology
10/01/2016 - 09/30/2026 (Subcontract PI)
The Trustees of the University of Pennsylvania National Science Fdn
CMMI-1548571

Defining Genetic Architecture and Pathways of DCM
02/17/2021 - 01/31/2025 (Subcontract PI)
Hansjorg Wyss Institute for Biologically Inspired Engineering at Harvard NIH NHLBI
5R01HL080494-14

Novel strategies to understand, predict, and prevent vascular toxicity of targeted CML therapies
01/01/2021 - 12/31/2024 (Subcontract PI)
Tufts - New England Medical Center NIH NHLBI
1R01HL155078-01

Engineering Branching Networks Through Synthetic Turing Morphogen Circuits
12/10/2021 - 12/09/2024 (Multi-PI)
PI: Christopher Chen, MD, PhD
Allen Institute d/b/a The Paul G. Allen Frontiers Group


Elucidating Mechanisms for Rapid Vascularization by Modeling Vascular Islands in Early Embryogenesis
09/01/2021 - 08/31/2024 (Key Person / Mentor)
NIH/National Heart, Lung, and Blood Institute
1F31HL156517-01A1

Synthetic Biology and Biotechnology (SB2) Predoctoral Training Program
07/01/2019 - 06/30/2024 (Multi-PI)
PI: Christopher Chen, MD, PhD
NIH/National Institute of General Medical Sciences
5T32GM130546-03

Hypertrophic cardiomyopathy-induced paracrine signaling and stromal activation
06/01/2021 - 05/31/2024 (Key Person / Mentor)
NIH/National Heart, Lung, and Blood Institute
5F31HL158195-02

Engineering high density functional vascular, lymphatic, and ductal trees
04/01/2021 - 03/31/2024 (Subcontract PI)
Hansjorg Wyss Institute for Biologically Inspired Engineering at Harvard Wellcome Leap


Engineering high density functional vascular, lymphatic, and ductal trees
04/01/2021 - 03/31/2024 (Subcontract PI)
Hansjorg Wyss Institute for Biologically Inspired Engineering at Harvard Wellcome Leap


Local Regulation of Angiogenesis by Microenvironment
05/01/2020 - 01/31/2024 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
5R01EB000262-22

Showing 10 of 66 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2022 Local Regulation of Angiogenesis by Microenvironment 5R01EB000262-22
2022 Synthetic Biology and Biotechnology (SB2) Predoctoral Training Program 5T32GM130546-04
2022 Notch signaling and adhesion regulation 5R01HL147585-04
2022 Defining Genetic Architecture and Pathways of DCM 5R01HL080494-14
2021 Local Regulation of Angiogenesis by Microenvironment 5R01EB000262-21 96
2021 Synthetic Biology and Biotechnology (SB2) Predoctoral Training Program 5T32GM130546-03
2021 Notch signaling and adhesion regulation 5R01HL147585-03
2021 Defining Genetic Architecture and Pathways of DCM 2R01HL080494-13 61
2020 Local Regulation of Angiogenesis by Microenvironment 2R01EB000262-20 96
2020 Synthetic Biology and Biotechnology (SB2) Predoctoral Training Program 5T32GM130546-02
Showing 10 of 73 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Chhabra A, Song HG, Grzelak KA, Polacheck WJ, Fleming HE, Chen CS, Bhatia SN. A vascularized model of the human liver mimics regenerative responses. Proc Natl Acad Sci U S A. 2022 Jul 12; 119(28):e2115867119. PMID: 35763565; PMCID: PMC9282349; DOI: 10.1073/pnas.2115867119;
     
  2. Smith Q, Bays J, Li L, Shareef H, Chen CS, Bhatia SN. Directing Cholangiocyte Morphogenesis in Natural Biomaterial Scaffolds. Adv Sci (Weinh). 2022 May; 9(14):e2201951. PMID: 35570837; PMCID: PMC9109051; DOI: 10.1002/advs.202201951;
     
  3. Ronaldson-Bouchard K, Teles D, Yeager K, Tavakol DN, Zhao Y, Chramiec A, Tagore S, Summers M, Stylianos S, Tamargo M, Lee BM, Halligan SP, Abaci EH, Guo Z, Jacków J, Pappalardo A, Shih J, Soni RK, Sonar S, German C, Christiano AM, Califano A, Hirschi KK, Chen CS, Przekwas A, Vunjak-Novakovic G. A multi-organ chip with matured tissue niches linked by vascular flow. Nat Biomed Eng. 2022 Apr; 6(4):351-371. PMID: 35478225; PMCID: PMC9250010; DOI: 10.1038/s41551-022-00882-6;
     
  4. Michas C, Karakan MÇ, Nautiyal P, Seidman JG, Seidman CE, Agarwal A, Ekinci K, Eyckmans J, White AE, Chen CS. Engineering a living cardiac pump on a chip using high-precision fabrication. Sci Adv. 2022 Apr 22; 8(16):eabm3791.View Related Profiles. PMID: 35452278; PMCID: PMC9032966; DOI: 10.1126/sciadv.abm3791;
     
  5. Selvaraji S, Efthymios M, Foo RSY, Fann DY, Lai MKP, Chen CLH, Lim KL, Arumugam TV. Time-restricted feeding modulates the DNA methylation landscape, attenuates hallmark neuropathology and cognitive impairment in a mouse model of vascular dementia. Theranostics. 2022; 12(7):3007-3023. PMID: 35547760; PMCID: PMC9065201; DOI: 10.7150/thno.71815;
     
  6. Sundaram S, Chen CS. Next-generation engineered microsystems for cell biology: a systems-level roadmap. Trends Cell Biol. 2022 Jun; 32(6):490-500. PMID: 35105487; PMCID: PMC9106832; DOI: 10.1016/j.tcb.2022.01.003;
     
  7. Tefft JB, Bays JL, Lammers A, Kim S, Eyckmans J, Chen CS. Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature. Am J Physiol Cell Physiol. 2022 02 01; 322(2):C185-C196.View Related Profiles. PMID: 34878922; PMCID: PMC8791789; DOI: 10.1152/ajpcell.00320.2021;
     
  8. Smith Q, Bays J, Li L, Shareef H, Chen CS, Bhatia SN. Directing Cholangiocyte Morphogenesis in Natural Biomaterial Scaffolds. Adv Sci (Weinh). 2022 01; 9(3):e2102698. PMID: 34786888; PMCID: PMC8787431; DOI: 10.1002/advs.202102698;
     
  9. Zhang K, Cloonan PE, Sundaram S, Liu F, Das SL, Ewoldt JK, Bays JL, Tomp S, Toepfer CN, Marsiglia JDC, Gorham J, Reichart D, Eyckmans J, Seidman JG, Seidman CE, Chen CS. Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization. Sci Adv. 2021 Oct 15; 7(42):eabh3995.View Related Profiles. PMID: 34652945; PMCID: PMC8519574; DOI: 10.1126/sciadv.abh3995;
     
  10. Zhao B, Zhang K, Chen CS, Lejeune E. Sarc-Graph: Automated segmentation, tracking, and analysis of sarcomeres in hiPSC-derived cardiomyocytes. PLoS Comput Biol. 2021 10; 17(10):e1009443. PMID: 34613960; PMCID: PMC8523047; DOI: 10.1371/journal.pcbi.1009443;
     
Showing 10 of 238 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 238 publications over 21 distinct years, with a maximum of 22 publications in 2013

YearPublications
20024
20034
20049
20058
20064
200712
20088
20099
201011
201113
201216
201322
201421
201512
201613
201715
201812
201911
202012
202116
20226

2019 The Charles DeLisi Lecture Award
2019 The Charles DeLisi Lecture Award
2019 The Biomedical Engineering Society Robert A. Pritzker Distinguished Lecture Award
2010 The George H. Heilmeier Faculty Award for Excellence in Researc
2006 MicroTAS: Scientific Advisory Board
2005 Biomedical Engineering Society: Scientific Advisory Board
2004 The Herbert W. Dickerman Award for Outstanding Contribution to Science
2003-2005 Defense Sciences Research Council: fellow
2002 The Mary Hulman George Award for Biomedical Research
2001-2002 SmallTalk: Scientific Committee Member
2000 Presidential Early Career Award for Scientists and Engineers
2000 Presidential Early Career Award for Scientists and Engineers
2000 Presidential Early Career Award for Scientists and Engineers
1999 ONR Young Investigator Award
1997 Angiogenesis Foundation Fellowship
1994-1995 Health Sciences and Technology Research Fund Award
1993-1997 Medical Engineering and Medical Physics Fellow
1991-1993 National Science Foundation Graduate Research Fellow
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