Christopher Chen | Profiles RNS

Christopher Chen, MD, PhD

Professor

Boston University College of Engineering

Biomedical Engineering

MD, Harvard University
PhD, Massachusetts Institute of Technology
MS, Massachusetts Institute of Technology
BA, Harvard University

Websites

	BU College of Engineering
	Google Scholar
	LinkedIn
	Wyss Institute
	The Chen Lab
	ResearchGate

ORCID : 0000-0003-2445-8449

Dr. Chen is the William Fairfield Warren Distinguished Professor at Boston University, director of the Tissue Microfabrication Laboratory, and founding director of the Biological Design Center at Boston University. He has been an instrumental figure in the development of engineered cellular microenvironments to understand and control how cells build tissues. The goal of Dr. Chen’s research is to identify the underlying mechanisms by which cells interact with materials and each other to build tissues, and to apply this knowledge to the biology and engineering of stem cells, tissue vascularization, connective tissues, and cancer. He has received numerous honors, including the Presidential Early Career Award for Scientists and Engineers, the Angiogenesis Foundation Fellowship, the Office of Naval Research Young Investigator Award, the Mary Hulman George Award for Biomedical Research, the Herbert W. Dickerman Award For Outstanding Contribution to Science, and the Robert A. Pritzker Award. He serves a Fellow of the American Institute for Medical and Biological Engineering, and as a member of the Faculty of 1000 Biology, the Board of Trustees for the Society for BioMEMS and Biomedical Nanotechnology, and Defense Sciences Study Group.

He received his A.B. in Biochemistry from Harvard, M.S. in Mechanical Engineering from MIT, and Ph.D. in Medical Engineering and Medical Physics from the Harvard-MIT. Health Sciences and Technology Program. He earned his M.D. from the Harvard Medical School. Dr. Chen previously was Assistant Professor in Biomedical Engineering and in Oncology at Johns Hopkins University, and the Skirkanich Professor of Innovation and founding director of the Center for Engineering Cells and Regeneration at the University of Pennsylvania.

BU Research
NIH RePORTER Research

NRT-URoL: A Convergent Training Program on Biological Control
08/01/2023 - 07/31/2028 (Multi-PI)
PI: Christopher Chen, MD, PhD
National Science Foundation
DGE-2244366

Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision: CELL-MET
10/01/2017 - 09/30/2027 (Multi-PI)
PI: Christopher Chen, MD, PhD
National Science Foundation
EEC-1647837

Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision: CELL-MET
10/01/2017 - 09/30/2027 (Multi-PI)
PI: Christopher Chen, MD, PhD
National Science Foundation
EEC-1647837

Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision: CELL-MET
10/01/2017 - 09/30/2027 (Multi-PI)
PI: Christopher Chen, MD, PhD
National Science Foundation
EEC-1647837

Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision: CELL-MET
10/01/2017 - 09/30/2027 (Multi-PI)
PI: Christopher Chen, MD, PhD
National Science Foundation
EEC-1647837

Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision: CELL-MET
10/01/2017 - 09/30/2027 (Multi-PI)
PI: Christopher Chen, MD, PhD
National Science Foundation
EEC-1647837

Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision: CELL-MET
10/01/2017 - 09/30/2027 (Co-Investigator)
National Science Foundation
EEC-1647837

Synthetic vascularization and regeneration in engineered tissues
09/01/2023 - 08/31/2027 (Multi-PI)
PI: Christopher Chen, MD, PhD
NIH/National Institute of Biomedical Imaging & Bioengineering
5R01EB033821-02

Science and Technology Center for Engineering Mechano-Biology
10/01/2016 - 09/30/2026 (Subcontract PI)
The Trustees of the University of Pennsylvania National Science Fdn
CMMI-1548571

NSF/FDA SiR: Development of a High Throughput Electrical Stimulation Screening Platform for Cardiac Microphysiological Systems
09/01/2024 - 08/31/2026 (PI)
National Science Foundation
CBET-2426759

Showing 10 of 81 results. Show All Results

Title

Yr	Title	Project-Sub Proj
2024	Synthetic vascularization and regeneration in engineered tissues	5R01EB033821-02
2024	Defining Genetic Architecture and Pathways of DCM	5R01HL080494-16
2023	Synthetic vascularization and regeneration in engineered tissues	1R01EB033821-01
2023	Local Regulation of Angiogenesis by Microenvironment	5R01EB000262-23
2023	Synthetic Biology and Biotechnology (SB2) Predoctoral Training Program	5T32GM130546-05
2023	Defining Genetic Architecture and Pathways of DCM	5R01HL080494-15
2022	Local Regulation of Angiogenesis by Microenvironment	5R01EB000262-22
2022	Synthetic Biology and Biotechnology (SB2) Predoctoral Training Program	5T32GM130546-04
2022	Notch signaling and adhesion regulation	5R01HL147585-04
2022	Defining Genetic Architecture and Pathways of DCM	5R01HL080494-14

Showing 10 of 79 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Ching T, van Steen ACI, Gray-Scherr D, Teo JL, Vasan A, Jeon J, Shah J, Patel A, Stoddard AE, Bays JL, Eyckmans J, Chen CS. TapeTech microfluidic connectors: adhesive tape-enabled solution for organ-on-a-chip system integration. Lab Chip. 2025 Mar 11; 25(6):1474-1488.View Related Profiles.

Van Steen, Abraham Christoffel
Chen, Christopher
Eyckmans, Jeroen

PMID: 39907088; PMCID: PMC11795533; DOI: 10.1039/d4lc00970c;

Pandian NKR, Farell A, Davis E, Sundaram S, van Steen ACI, Chang Teo JL, Eyckmans J, Chen CS. Three-dimensional modeling of flow through microvascular beds and surrounding interstitial spaces. bioRxiv. 2025 Feb 15.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen
Sundaram, Subramanian

PMID: 39990367; PMCID: PMC11844386; DOI: 10.1101/2024.02.28.582152;

Tran JC, Kuffner CJ, Marzilli AM, Miller RE, Silfen ZE, McMahan JB, Sloas DC, Chen CS, Ngo JT. Fluorescein-based SynNotch adaptors for regulating gene expression responses to diverse extracellular and matrix-based cues. Nat Commun. 2025 Jan 20; 16(1):852.View Related Profiles.

Chen, Christopher
Ngo, John

PMID: 39833147; PMCID: PMC11756391; DOI: 10.1038/s41467-025-56148-7;

Kim Y, Kim SW, Saul D, Neyazi M, Schmid M, Wakimoto H, Slaven N, Lee JH, Layton O, Wasson LK, Letendre JH, Xiao F, Ewoldt JK, Gkatzis K, Sommer P, Gobert B, Wiest-Daesslé N, McAfee Q, Singhal N, Lun M, Gorham JM, Arany Z, Sharma A, Toepfer CN, Oudit GY, Pu WT, Dickel DE, Pennacchio LA, Visel A, Chen CS, Seidman JG, Seidman CE. Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer. J Clin Invest. 2024 Dec 17; 135(4). PMID: 39688912; PMCID: PMC11827849; DOI: 10.1172/JCI183353;

Sundaram S, Lee JH, Bjørge IM, Michas C, Kim S, Lammers A, Mano JF, Eyckmans J, White AE, Chen CS. Sacrificial capillary pumps to engineer multiscalar biological forms. Nature. 2024 Dec; 636(8042):361-367.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen
Sundaram, Subramanian

PMID: 39663490

DePalma SJ, Jilberto J, Stis AE, Huang DD, Lo J, Davidson CD, Chowdhury A, Kent RN, Jewett ME, Kobeissi H, Chen CS, Lejeune E, Helms AS, Nordsletten DA, Baker BM. Matrix Architecture and Mechanics Regulate Myofibril Organization, Costamere Assembly, and Contractility in Engineered Myocardial Microtissues. Adv Sci (Weinh). 2024 Dec; 11(47):e2309740. PMID: 39558513; PMCID: PMC11653763; DOI: 10.1002/advs.202309740;

Ewoldt JK, DePalma SJ, Jewett ME, Karakan MÇ, Lin YM, Mir Hashemian P, Gao X, Lou L, McLellan MA, Tabares J, Ma M, Salazar Coariti AC, He J, Toussaint KC, Bifano TG, Ramaswamy S, White AE, Agarwal A, Lejeune E, Baker BM, Chen CS. Induced pluripotent stem cell-derived cardiomyocyte in vitro models: benchmarking progress and ongoing challenges. Nat Methods. 2025 Jan; 22(1):24-40.View Related Profiles.

Chen, Christopher
Karakan, Mustafa

PMID: 39516564

Uroz M, Stoddard AE, Sutherland BP, Courbot O, Oria R, Li L, Ravasio CR, Ngo MT, Yang J, Tefft JB, Eyckmans J, Han X, Elosegui-Artola A, Weaver VM, Chen CS. Differential stiffness between brain vasculature and parenchyma promotes metastatic infiltration through vessel co-option. Nat Cell Biol. 2024 Dec; 26(12):2144-2153.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 39448802

Ewoldt JK, Wang MC, McLellan MA, Cloonan PE, Chopra A, Gorham J, Li L, DeLaughter DM, Gao X, Lee JH, Willcox JAL, Layton O, Luu RJ, Toepfer CN, Eyckmans J, Seidman CE, Seidman JG, Chen CS. Hypertrophic cardiomyopathy-associated mutations drive stromal activation via EGFR-mediated paracrine signaling. Sci Adv. 2024 Oct 18; 10(42):eadi6927.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 39413182; PMCID: PMC11482324; DOI: 10.1126/sciadv.adi6927;

Kobeissi H, Gao X, DePalma SJ, Ewoldt JK, Wang MC, Das SL, Jilberto J, Nordsletten D, Baker BM, Chen CS, Lejeune E. MicroBundlePillarTrack: A Python package for automated segmentation, tracking, and analysis of pillar deflection in cardiac microbundles. ArXiv. 2024 Aug 15. PMID: 39184538; PMCID: PMC11343223

Showing 10 of 266 results. Show More

Kobeissi H, Gao X, DePalma SJ, Ewoldt JK, Wang MC, Das SL, Jilberto J, Nordsletten D, Baker BM, Chen CS, Lejeune E. MicroBundlePillarTrack: A Python package for automated segmentation, tracking, and analysis of pillar deflection in cardiac microbundles. MicroPubl Biol. 2024; 2024. PMID: 39114859; PMCID: PMC11304080; DOI: 10.17912/micropub.biology.001231;

Natarajan A, Kim S, Moreno GH, Eyckmans J, Chen CS, Dean D, Vijayan VM. 3D printing assisted surface patterning process on acrylated hydrogels for contact guidance of fibroblasts. Colloids Surf B Biointerfaces. 2024 Oct; 242:114099.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 39024719

Gagnon KA, Huang J, Hix OT, Hui VW, Hinds A, Bullitt E, Eyckmans J, Kotton DN, Chen CS. Multicompartment duct platform to study epithelial-endothelial crosstalk associated with lung adenocarcinoma. APL Bioeng. 2024 Jun; 8(2):026126.View Related Profiles.

Chen, Christopher
Kotton, Darrell
Bullitt, Esther
Eyckmans, Jeroen

PMID: 38911024; PMCID: PMC11191334; DOI: 10.1063/5.0207228;

Lammers A, Hsu HH, Sundaram S, Gagnon KA, Kim S, Lee JH, Tung YC, Eyckmans J, Chen CS. Rapid Tissue Perfusion Using Sacrificial Percolation of Anisotropic Networks. Matter. 2024 Jun 05; 7(6):2184-2204.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen
Sundaram, Subramanian

PMID: 39221109; PMCID: PMC11360881; DOI: 10.1016/j.matt.2024.04.001;

Kobeissi H, Jilberto J, Karakan MÇ, Gao X, DePalma SJ, Das SL, Quach L, Urquia J, Baker BM, Chen CS, Nordsletten D, Lejeune E. MicroBundleCompute: Automated segmentation, tracking, and analysis of subdomain deformation in cardiac microbundles. PLoS One. 2024; 19(3):e0298863.View Related Profiles.

Chen, Christopher
Karakan, Mustafa

PMID: 38530829; PMCID: PMC10965069; DOI: 10.1371/journal.pone.0298863;

van Dover G, Javor J, Ewoldt JK, Zhernenkov M, Wasik P, Freychet G, Lee J, Brown D, Chen CS, Bishop DJ. Structural maturation of myofilaments in engineered 3D cardiac microtissues characterized using small angle x-ray scattering. Phys Biol. 2024 Mar 20; 21(3). PMID: 38452380

Karakan MÇ, Ewoldt JK, Segarra AJ, Sundaram S, Wang MC, White AE, Chen CS, Ekinci KL. Geometry and length control of 3D engineered heart tissues using direct laser writing. Lab Chip. 2024 Mar 12; 24(6):1685-1701.View Related Profiles.

Chen, Christopher
Karakan, Mustafa
Sundaram, Subramanian

PMID: 38317604; PMCID: PMC10929702; DOI: 10.1039/d3lc00752a;

Feaster TK, Ewoldt JK, Avila A, Casciola M, Narkar A, Chen CS, Blinova K. Nonclinical evaluation of chronic cardiac contractility modulation on 3D human engineered cardiac tissues. J Cardiovasc Electrophysiol. 2024 May; 35(5):895-905. PMID: 38433304

Yordanov TE, Keyser MS, Enriquez Martinez MA, Esposito T, Tefft JB, Morris EK, Labzin LI, Stehbens SJ, Rowan AE, Hogan BM, Chen CS, Lauko J, Lagendijk AK. Hyaluronic acid turnover controls the severity of cerebral cavernous malformations in bioengineered human micro-vessels. APL Bioeng. 2024 Mar; 8(1):016108. PMID: 38352162; PMCID: PMC10864035; DOI: 10.1063/5.0159330;

Li L, Griebel ME, Uroz M, Bubli SY, Gagnon KA, Trappmann B, Baker BM, Eyckmans J, Chen CS. A Protein-Adsorbent Hydrogel with Tunable Stiffness for Tissue Culture Demonstrates Matrix-Dependent Stiffness Responses. Adv Funct Mater. 2024 Apr 25; 34(17).View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 38693998; PMCID: PMC11060701; DOI: 10.1002/adfm.202309567;

DePalma SJ, Jillberto J, Stis AE, Huang DD, Lo J, Davidson CD, Chowdhury A, Jewett ME, Kobeissi H, Chen CS, Lejeune E, Helms AS, Nordsletten DA, Baker BM. Matrix architecture and mechanics regulate myofibril organization, costamere assembly, and contractility of engineered myocardial microtissues. bioRxiv. 2023 Oct 23. PMID: 37961415; PMCID: PMC10634701; DOI: 10.1101/2023.10.20.563346;

White MJ, Jacobs KA, Singh T, Mayo LN, Lin A, Chen CS, Jun YW, Kutys ML. Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion. J Cell Biol. 2023 Dec 04; 222(12). PMID: 37796194; PMCID: PMC10555887; DOI: 10.1083/jcb.202303013;

Lee E, Chan SL, Lee Y, Polacheck WJ, Kwak S, Wen A, Nguyen DT, Kutys ML, Alimperti S, Kolarzyk AM, Kwak TJ, Eyckmans J, Bielenberg DR, Chen H, Chen CS. A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex. Proc Natl Acad Sci U S A. 2023 Oct 10; 120(41):e2308941120.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 37782785; PMCID: PMC10576061; DOI: 10.1073/pnas.2308941120;

Ristori T, Thuret R, Hooker E, Quicke P, Lanthier K, Ntumba K, Aspalter IM, Uroz M, Herbert SP, Chen CS, Larrivée B, Bentley K. Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe. bioRxiv. 2023 Sep 25. PMID: 37808725; PMCID: PMC10557600; DOI: 10.1101/2023.09.25.557123;

Li H, Sundaram S, Hu R, Lou L, Sanchez F, McDonald W, Agarwal A, Chen CS, Bifano TG. Dynamic Control of Contractile Force in Engineered Heart Tissue. IEEE Trans Biomed Eng. 2023 Jul; 70(7):2237-2245.View Related Profiles.

Chen, Christopher
Sundaram, Subramanian

PMID: 37021994

Ma MS, Sundaram S, Lou L, Agarwal A, Chen CS, Bifano TG. High throughput screening system for engineered cardiac tissues. Front Bioeng Biotechnol. 2023; 11:1177688.View Related Profiles.

Chen, Christopher
Sundaram, Subramanian

PMID: 37251575; PMCID: PMC10210164; DOI: 10.3389/fbioe.2023.1177688;

Paul I, Bolzan D, Youssef A, Gagnon KA, Hook H, Karemore G, Oliphant MUJ, Lin W, Liu Q, Phanse S, White C, Padhorny D, Kotelnikov S, Chen CS, Hu P, Denis GV, Kozakov D, Raught B, Siggers T, Wuchty S, Muthuswamy SK, Emili A. Parallelized multidimensional analytic framework applied to mammary epithelial cells uncovers regulatory principles in EMT. Nat Commun. 2023 Feb 08; 14(1):688.View Related Profiles.

Chen, Christopher
Denis, Gerald
Lin, Weiwei

PMID: 36755019; PMCID: PMC9908882; DOI: 10.1038/s41467-023-36122-x;

Das SL, Sutherland BP, Lejeune E, Eyckmans J, Chen CS. Mechanical response of cardiac microtissues to acute localized injury. Am J Physiol Heart Circ Physiol. 2022 Oct 01; 323(4):H738-H748.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 36053751; PMCID: PMC9662801; DOI: 10.1152/ajpheart.00305.2022;

Chhabra A, Song HG, Grzelak KA, Polacheck WJ, Fleming HE, Chen CS, Bhatia SN. A vascularized model of the human liver mimics regenerative responses. Proc Natl Acad Sci U S A. 2022 Jul 12; 119(28):e2115867119. PMID: 35763565; PMCID: PMC9282349; DOI: 10.1073/pnas.2115867119;

Smith Q, Bays J, Li L, Shareef H, Chen CS, Bhatia SN. Directing Cholangiocyte Morphogenesis in Natural Biomaterial Scaffolds. Adv Sci (Weinh). 2022 May; 9(14):e2201951. PMID: 35570837; PMCID: PMC9109051; DOI: 10.1002/advs.202201951;

Ronaldson-Bouchard K, Teles D, Yeager K, Tavakol DN, Zhao Y, Chramiec A, Tagore S, Summers M, Stylianos S, Tamargo M, Lee BM, Halligan SP, Abaci EH, Guo Z, Jacków J, Pappalardo A, Shih J, Soni RK, Sonar S, German C, Christiano AM, Califano A, Hirschi KK, Chen CS, Przekwas A, Vunjak-Novakovic G. A multi-organ chip with matured tissue niches linked by vascular flow. Nat Biomed Eng. 2022 Apr; 6(4):351-371. PMID: 35478225; PMCID: PMC9250010; DOI: 10.1038/s41551-022-00882-6;

Michas C, Karakan MÇ, Nautiyal P, Seidman JG, Seidman CE, Agarwal A, Ekinci K, Eyckmans J, White AE, Chen CS. Engineering a living cardiac pump on a chip using high-precision fabrication. Sci Adv. 2022 Apr 22; 8(16):eabm3791.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen
Karakan, Mustafa

PMID: 35452278; PMCID: PMC9032966; DOI: 10.1126/sciadv.abm3791;

Selvaraji S, Efthymios M, Foo RSY, Fann DY, Lai MKP, Chen CLH, Lim KL, Arumugam TV. Time-restricted feeding modulates the DNA methylation landscape, attenuates hallmark neuropathology and cognitive impairment in a mouse model of vascular dementia. Theranostics. 2022; 12(7):3007-3023. PMID: 35547760; PMCID: PMC9065201; DOI: 10.7150/thno.71815;

Sundaram S, Chen CS. Next-generation engineered microsystems for cell biology: a systems-level roadmap. Trends Cell Biol. 2022 Jun; 32(6):490-500.View Related Profiles.

Chen, Christopher
Sundaram, Subramanian

PMID: 35105487; PMCID: PMC9106832; DOI: 10.1016/j.tcb.2022.01.003;

Tefft JB, Bays JL, Lammers A, Kim S, Eyckmans J, Chen CS. Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature. Am J Physiol Cell Physiol. 2022 02 01; 322(2):C185-C196.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 34878922; PMCID: PMC8791789; DOI: 10.1152/ajpcell.00320.2021;

Smith Q, Bays J, Li L, Shareef H, Chen CS, Bhatia SN. Directing Cholangiocyte Morphogenesis in Natural Biomaterial Scaffolds. Adv Sci (Weinh). 2022 01; 9(3):e2102698. PMID: 34786888; PMCID: PMC8787431; DOI: 10.1002/advs.202102698;

Zhang K, Cloonan PE, Sundaram S, Liu F, Das SL, Ewoldt JK, Bays JL, Tomp S, Toepfer CN, Marsiglia JDC, Gorham J, Reichart D, Eyckmans J, Seidman JG, Seidman CE, Chen CS. Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization. Sci Adv. 2021 Oct 15; 7(42):eabh3995.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen
Sundaram, Subramanian

PMID: 34652945; PMCID: PMC8519574; DOI: 10.1126/sciadv.abh3995;

Zhao B, Zhang K, Chen CS, Lejeune E. Sarc-Graph: Automated segmentation, tracking, and analysis of sarcomeres in hiPSC-derived cardiomyocytes. PLoS Comput Biol. 2021 10; 17(10):e1009443. PMID: 34613960; PMCID: PMC8523047; DOI: 10.1371/journal.pcbi.1009443;

Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Fuchs SY, Connor JH, Douam F, Emili A, Saeed M. SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway. J Virol. 2021 09 09; 95(19):e0086221.View Related Profiles.

Emili, Andrew
Blum, Benjamin
Chen, Christopher
Kotton, Darrell
Douam, Florian
Connor, John
Saeed, Mohsan
Khan, Nazimuddin
Crossland, Nicholas
Goel, Raghuveera
Chitalia, Vipul

PMID: 34260266; PMCID: PMC8428404; DOI: 10.1128/JVI.00862-21;

Agarwal R, Paulo JA, Toepfer CN, Ewoldt JK, Sundaram S, Chopra A, Zhang Q, Gorham J, DePalma SR, Chen CS, Gygi SP, Seidman CE, Seidman JG. Filamin C Cardiomyopathy Variants Cause Protein and Lysosome Accumulation. Circ Res. 2021 09 17; 129(7):751-766.View Related Profiles.

Chen, Christopher
Sundaram, Subramanian

PMID: 34405687; PMCID: PMC9053646; DOI: 10.1161/CIRCRESAHA.120.317076;

Jayne RK, Karakan MÇ, Zhang K, Pierce N, Michas C, Bishop DJ, Chen CS, Ekinci KL, White AE. Direct laser writing for cardiac tissue engineering: a microfluidic heart on a chip with integrated transducers. Lab Chip. 2021 05 04; 21(9):1724-1737.View Related Profiles.

Chen, Christopher
Karakan, Mustafa

PMID: 33949395

Zhou DW, Fernández-Yagüe MA, Holland EN, García AF, Castro NS, O'Neill EB, Eyckmans J, Chen CS, Fu J, Schlaepfer DD, García AJ. Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair. Nat Commun. 2021 04 21; 12(1):2359.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 33883558; PMCID: PMC8060400; DOI: 10.1038/s41467-021-22602-5;

Song J, Michas C, Chen CS, White AE, Grinstaff MW. Controlled Cell Alignment Using Two-Photon Direct Laser Writing-Patterned Hydrogels in 2D and 3D. Macromol Biosci. 2021 05; 21(5):e2100051.View Related Profiles.

Chen, Christopher
Grinstaff, Mark

PMID: 33738917

Kostecki GM, Shi Y, Chen CS, Reich DH, Entcheva E, Tung L. Optogenetic current in myofibroblasts acutely alters electrophysiology and conduction of co-cultured cardiomyocytes. Sci Rep. 2021 02 24; 11(1):4430. PMID: 33627695; PMCID: PMC7904933; DOI: 10.1038/s41598-021-83398-4;

Ward T, Tai W, Morton S, Impens F, Van Damme P, Van Haver D, Timmerman E, Venturini G, Zhang K, Jang MY, Willcox JAL, Haghighi A, Gelb BD, Chung WK, Goldmuntz E, Porter GA, Lifton RP, Brueckner M, Yost HJ, Bruneau BG, Gorham J, Kim Y, Pereira A, Homsy J, Benson CC, DePalma SR, Varland S, Chen CS, Arnesen T, Gevaert K, Seidman C, Seidman JG. Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency. Circ Res. 2021 04 16; 128(8):1156-1169. PMID: 33557580; PMCID: PMC8048381; DOI: 10.1161/CIRCRESAHA.120.316966;

Tsang JM, Gritton HJ, Das SL, Weber TD, Chen CS, Han X, Mertz J. Fast, multiplane line-scan confocal microscopy using axially distributed slits. Biomed Opt Express. 2021 Mar 01; 12(3):1339-1350.View Related Profiles.

Chen, Christopher
Mertz, Jerome
Han, Xue

PMID: 33796357; PMCID: PMC7984773; DOI: 10.1364/BOE.417286;

Du Y, Khandekar G, Llewellyn J, Polacheck WJ, Chen CS, Wells RG. REPLY. Hepatology. 2021 02; 73(2):872-873. PMID: 33128466

Javor J, Ewoldt JK, Cloonan PE, Chopra A, Luu RJ, Freychet G, Zhernenkov M, Ludwig K, Seidman JG, Seidman CE, Chen CS, Bishop DJ. Probing the subcellular nanostructure of engineered human cardiomyocytes in 3D tissue. Microsyst Nanoeng. 2021; 7:10. PMID: 34567727; PMCID: PMC8433147; DOI: 10.1038/s41378-020-00234-x;

Tefft JB, Chen CS, Eyckmans J. Reconstituting the dynamics of endothelial cells and fibroblasts in wound closure. APL Bioeng. 2021 Mar; 5(1):016102.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 33511324; PMCID: PMC7817247; DOI: 10.1063/5.0028651;

Kim S, Uroz M, Bays JL, Chen CS. Harnessing Mechanobiology for Tissue Engineering. Dev Cell. 2021 01 25; 56(2):180-191. PMID: 33453155; PMCID: PMC7855912; DOI: 10.1016/j.devcel.2020.12.017;

Chua XY, Ho LTY, Xiang P, Chew WS, Lam BWS, Chen CP, Ong WY, Lai MKP, Herr DR. Preclinical and Clinical Evidence for the Involvement of Sphingosine 1-Phosphate Signaling in the Pathophysiology of Vascular Cognitive Impairment. Neuromolecular Med. 2021 03; 23(1):47-67. PMID: 33180310

Chen D, Smith LR, Khandekar G, Patel P, Yu CK, Zhang K, Chen CS, Han L, Wells RG. Distinct effects of different matrix proteoglycans on collagen fibrillogenesis and cell-mediated collagen reorganization. Sci Rep. 2020 11 04; 10(1):19065. PMID: 33149218; PMCID: PMC7642422; DOI: 10.1038/s41598-020-76107-0;

Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Kapell S, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Connor JH, Douam F, Emili A, Saeed M. SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway. bioRxiv. 2020 Oct 28.View Related Profiles.

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Pua CJ, Tham N, Chin CWL, Walsh R, Khor CC, Toepfer CN, Repetti GG, Garfinkel AC, Ewoldt JF, Cloonan P, Chen CS, Lim SQ, Cai J, Loo LY, Kong SC, Chiang CWK, Whiffin N, de Marvao A, Lio PM, Hii AA, Yang CX, Le TT, Bylstra Y, Lim WK, Teo JX, Padilha K, Silva GV, Pan B, Govind R, Buchan RJ, Barton PJR, Tan P, Foo R, Yip JWL, Wong RCC, Chan WX, Pereira AC, Tang HC, Jamuar SS, Ware JS, Seidman JG, Seidman CE, Cook SA. Genetic Studies of Hypertrophic Cardiomyopathy in Singaporeans Identify Variants in TNNI3 and TNNT2 That Are Common in Chinese Patients. Circ Genom Precis Med. 2020 10; 13(5):424-434. PMID: 32815737; PMCID: PMC7676617; DOI: 10.1161/CIRCGEN.119.002823;

Song D, Dong L, Gupta M, Li L, Klaas O, Loghin A, Beall M, Chen CS, Oberai AA. Recovery of Tractions Exerted by Single Cells in Three-Dimensional Nonlinear Matrices. J Biomech Eng. 2020 08 01; 142(8). PMID: 32320015; PMCID: PMC7477711; DOI: 10.1115/1.4046974;

Kutys ML, Polacheck WJ, Welch MK, Gagnon KA, Koorman T, Kim S, Li L, McClatchey AI, Chen CS. Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform. Nat Commun. 2020 07 06; 11(1):3377. PMID: 32632100; PMCID: PMC7338408; DOI: 10.1038/s41467-020-17102-x;

Song HG, Lammers A, Sundaram S, Rubio L, Chen AX, Li L, Eyckmans J, Bhatia SN, Chen CS. Transient Support from Fibroblasts is Sufficient to Drive Functional Vascularization in Engineered Tissues. Adv Funct Mater. 2020 Nov 25; 30(48).View Related Profiles.

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PMID: 33613149; PMCID: PMC7891457; DOI: 10.1002/adfm.202003777;

Chen AX, Chhabra A, Song HG, Fleming HE, Chen CS, Bhatia SN. Controlled Apoptosis of Stromal Cells to Engineer Human Microlivers. Adv Funct Mater. 2020 Nov 25; 30(48). PMID: 33776613; PMCID: PMC7996305; DOI: 10.1002/adfm.201910442;

Tian L, Oikonomopoulos A, Liu C, Kitani T, Shrestha R, Chen CL, Ong SG, Smeets M, Karakikes I, Sayed N, Wu JC. Molecular Signatures of Beneficial Class Effects of Statins on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circulation. 2020 04 07; 141(14):1208-1210. PMID: 32250699; PMCID: PMC7170011; DOI: 10.1161/CIRCULATIONAHA.118.035906;

Shroff SN, Das SL, Tseng HA, Noueihed J, Fernandez F, White JA, Chen CS, Han X. Voltage Imaging of Cardiac Cells and Tissue Using the Genetically Encoded Voltage Sensor Archon1. iScience. 2020 Apr 24; 23(4):100974.View Related Profiles.

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PMID: 32299055; PMCID: PMC7160579; DOI: 10.1016/j.isci.2020.100974;

Park JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G. Mechanical regulation of glycolysis via cytoskeleton architecture. Nature. 2020 02; 578(7796):621-626. PMID: 32051585; PMCID: PMC7210009; DOI: 10.1038/s41586-020-1998-1;

Toepfer CN, Garfinkel AC, Venturini G, Wakimoto H, Repetti G, Alamo L, Sharma A, Agarwal R, Ewoldt JF, Cloonan P, Letendre J, Lun M, Olivotto I, Colan S, Ashley E, Jacoby D, Michels M, Redwood CS, Watkins HC, Day SM, Staples JF, Padrón R, Chopra A, Ho CY, Chen CS, Pereira AC, Seidman JG, Seidman CE. Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy. Circulation. 2020 03 10; 141(10):828-842. PMID: 31983222; PMCID: PMC7077965; DOI: 10.1161/CIRCULATIONAHA.119.042339;

Song J, Michas C, Chen CS, White AE, Grinstaff MW. From Simple to Architecturally Complex Hydrogel Scaffolds for Cell and Tissue Engineering Applications: Opportunities Presented by Two-Photon Polymerization. Adv Healthc Mater. 2020 01; 9(1):e1901217.View Related Profiles.

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Du Y, Khandekar G, Llewellyn J, Polacheck W, Chen CS, Wells RG. A Bile Duct-on-a-Chip With Organ-Level Functions. Hepatology. 2020 04; 71(4):1350-1363. PMID: 31465556; PMCID: PMC7048662; DOI: 10.1002/hep.30918;

Nguyen DT, Lee E, Alimperti S, Norgard RJ, Wong A, Lee JJ, Eyckmans J, Stanger BZ, Chen CS. A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling. Sci Adv. 2019 08; 5(8):eaav6789.View Related Profiles.

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PMID: 31489365; PMCID: PMC6713506; DOI: 10.1126/sciadv.aav6789;

Cardenas-Diaz FL, Osorio-Quintero C, Diaz-Miranda MA, Kishore S, Leavens K, Jobaliya C, Stanescu D, Ortiz-Gonzalez X, Yoon C, Chen CS, Haliyur R, Brissova M, Powers AC, French DL, Gadue P. Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A. Cell Stem Cell. 2019 08 01; 25(2):273-289.e5. PMID: 31374199; PMCID: PMC6785828; DOI: 10.1016/j.stem.2019.07.007;

Li S, Chopra A, Keung W, Chan CWY, Costa KD, Kong CW, Hajjar RJ, Chen CS, Li RA. Sarco/endoplasmic reticulum Ca2+-ATPase is a more effective calcium remover than sodium-calcium exchanger in human embryonic stem cell-derived cardiomyocytes. Am J Physiol Heart Circ Physiol. 2019 11 01; 317(5):H1105-H1115. PMID: 31347915; DOI: 10.1152/ajpheart.00540.2018;

Yoon C, Choi C, Stapleton S, Mirabella T, Howes C, Dong L, King J, Yang J, Oberai A, Eyckmans J, Chen CS. Myosin IIA-mediated forces regulate multicellular integrity during vascular sprouting. Mol Biol Cell. 2019 07 22; 30(16):1974-1984.View Related Profiles.

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PMID: 31318321; PMCID: PMC6727772; DOI: 10.1091/mbc.E19-02-0076;

Chow MZ, Sadrian SN, Keung W, Geng L, Ren L, Kong CW, Wong AO, Hulot JS, Chen CS, Costa KD, Hajjar RJ, Li RA. Modulation of chromatin remodeling proteins SMYD1 and SMARCD1 promotes contractile function of human pluripotent stem cell-derived ventricular cardiomyocyte in 3D-engineered cardiac tissues. Sci Rep. 2019 05 16; 9(1):7502. PMID: 31097748; PMCID: PMC6522495; DOI: 10.1038/s41598-019-42953-w;

Toepfer CN, Sharma A, Cicconet M, Garfinkel AC, Mücke M, Neyazi M, Willcox JAL, Agarwal R, Schmid M, Rao J, Ewoldt J, Pourquié O, Chopra A, Chen CS, Seidman JG, Seidman CE. SarcTrack. Circ Res. 2019 04 12; 124(8):1172-1183. PMID: 30700234; PMCID: PMC6485312; DOI: 10.1161/CIRCRESAHA.118.314505;

Polacheck WJ, Kutys ML, Tefft JB, Chen CS. Microfabricated blood vessels for modeling the vascular transport barrier. Nat Protoc. 2019 05; 14(5):1425-1454. PMID: 30953042; PMCID: PMC7046311; DOI: 10.1038/s41596-019-0144-8;

Cheng D, Jayne RK, Tamborini A, Eyckmans J, White AE, Chen CS. Studies of 3D directed cell migration enabled by direct laser writing of curved wave topography. Biofabrication. 2019 02 25; 11(2):021001.View Related Profiles.

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PMID: 30721899; PMCID: PMC8117727; DOI: 10.1088/1758-5090/ab047f;

Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV. Vascular dysfunction-The disregarded partner of Alzheimer's disease. Alzheimers Dement. 2019 01; 15(1):158-167.View Related Profiles.

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PMID: 30642436; PMCID: PMC6338083; DOI: 10.1016/j.jalz.2018.07.222;

Wang WY, Pearson AT, Kutys ML, Choi CK, Wozniak MA, Baker BM, Chen CS. Extracellular matrix alignment dictates the organization of focal adhesions and directs uniaxial cell migration. APL Bioeng. 2018 Dec; 2(4):046107. PMID: 31069329; PMCID: PMC6481732; DOI: 10.1063/1.5052239;

Bose P, Eyckmans J, Nguyen TD, Chen CS, Reich DH. Effects of Geometry on the Mechanics and Alignment of Three-Dimensional Engineered Microtissues. ACS Biomater Sci Eng. 2019 Aug 12; 5(8):3843-3855.View Related Profiles.

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PMID: 33438424; DOI: 10.1021/acsbiomaterials.8b01183;

Anastasiadou E, Stroopinsky D, Alimperti S, Jiao AL, Pyzer AR, Cippitelli C, Pepe G, Severa M, Rosenblatt J, Etna MP, Rieger S, Kempkes B, Coccia EM, Sui SJH, Chen CS, Uccini S, Avigan D, Faggioni A, Trivedi P, Slack FJ. Epstein-Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas. Leukemia. 2019 01; 33(1):132-147. PMID: 29946193; PMCID: PMC6327052; DOI: 10.1038/s41375-018-0178-x;

Hassell BA, Goyal G, Lee E, Sontheimer-Phelps A, Levy O, Chen CS, Ingber DE. Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro. Cell Rep. 2018 Jun 19; 23(12):3698. PMID: 29925009; DOI: 10.1016/j.celrep.2018.06.028;

Bendell AC, Anderson N, Blumenthal D, Williamson EK, Chen CS, Burkhardt JK, Hammer DA. Motile Dendritic Cells Sense and Respond to Substrate Geometry. Ann Biomed Eng. 2018 Sep; 46(9):1348-1361. PMID: 29789970; PMCID: PMC6095716; DOI: 10.1007/s10439-018-2041-7;

Benhamouche-Trouillet S, O'Loughlin E, Liu CH, Polacheck W, Fitamant J, McKee M, El-Bardeesy N, Chen CS, McClatchey AI. Proliferation-independent role of NF2 (merlin) in limiting biliary morphogenesis. Development. 2018 04 30; 145(9). PMID: 29712669; DOI: 10.1242/dev.162123;

Greco Song HH, Rumma RT, Ozaki CK, Edelman ER, Chen CS. Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise. Cell Stem Cell. 2018 04 05; 22(4):608. PMID: 29625073; PMCID: PMC5909377; DOI: 10.1016/j.stem.2018.03.014;

Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Treviño-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, Reynolds J, Mejia P, Tao M, Sharma G, Wang R, Corpataux JM, Haefliger JA, Ahn KH, Lee CH, Manning BD, Sinclair DA, Chen CS, Ozaki CK, Mitchell JR. Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production. Cell. 2018 03 22; 173(1):117-129.e14. PMID: 29570992; PMCID: PMC5901681; DOI: 10.1016/j.cell.2018.03.001;

Song HG, Rumma RT, Ozaki CK, Edelman ER, Chen CS. Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise. Cell Stem Cell. 2018 03 01; 22(3):340-354. PMID: 29499152; PMCID: PMC5849079; DOI: 10.1016/j.stem.2018.02.009;

von Erlach TC, Bertazzo S, Wozniak MA, Horejs CM, Maynard SA, Attwood S, Robinson BK, Autefage H, Kallepitis C, Del Río Hernández A, Chen CS, Goldoni S, Stevens MM. Cell-geometry-dependent changes in plasma membrane order direct stem cell signalling and fate. Nat Mater. 2018 03; 17(3):237-242. PMID: 29434303; PMCID: PMC5901718; DOI: 10.1038/s41563-017-0014-0;

Chopra A, Kutys ML, Zhang K, Polacheck WJ, Sheng CC, Luu RJ, Eyckmans J, Hinson JT, Seidman JG, Seidman CE, Chen CS. Force Generation via ß-Cardiac Myosin, Titin, and a-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions. Dev Cell. 2018 01 08; 44(1):87-96.e5.View Related Profiles.

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Eyckmans, Jeroen

PMID: 29316444; PMCID: PMC6421364; DOI: 10.1016/j.devcel.2017.12.012;

Bose P, Huang CY, Eyckmans J, Chen CS, Reich DH. Fabrication and Mechanical Properties Measurements of 3D Microtissues for the Study of Cell-Matrix Interactions. Methods Mol Biol. 2018; 1722:303-328.View Related Profiles.

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PMID: 29264812; DOI: 10.1007/978-1-4939-7553-2_18;

Li L, Eyckmans J, Chen CS. Designer biomaterials for mechanobiology. Nat Mater. 2017 11 24; 16(12):1164-1168.View Related Profiles.

Chen, Christopher
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PMID: 29170549; PMCID: PMC7001850; DOI: 10.1038/nmat5049;

Polacheck WJ, Kutys ML, Yang J, Eyckmans J, Wu Y, Vasavada H, Hirschi KK, Chen CS. A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature. 2017 12 14; 552(7684):258-262.View Related Profiles.

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PMID: 29160307; PMCID: PMC5730479; DOI: 10.1038/nature24998;

Chen CS. Forces as regulators of cell adhesions. Nat Rev Mol Cell Biol. 2017 12; 18(12):715. PMID: 29093558; PMCID: PMC7001849; DOI: 10.1038/nrm.2017.112;

Eyckmans J, Chen CS. Making bone via nanoscale kicks. Nat Biomed Eng. 2017 Sep; 1(9):689-690.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 31015669; DOI: 10.1038/s41551-017-0133-6;

Trappmann B, Baker BM, Polacheck WJ, Choi CK, Burdick JA, Chen CS. Matrix degradability controls multicellularity of 3D cell migration. Nat Commun. 2017 08 29; 8(1):371. PMID: 28851858; PMCID: PMC5575316; DOI: 10.1038/s41467-017-00418-6;

Bendell AC, Williamson EK, Chen CS, Burkhardt JK, Hammer DA. The Arp2/3 complex binding protein HS1 is required for efficient dendritic cell random migration and force generation. Integr Biol (Camb). 2017 08 14; 9(8):695-708. PMID: 28678266; PMCID: PMC5830129; DOI: 10.1039/c7ib00070g;

Alimperti S, Mirabella T, Bajaj V, Polacheck W, Pirone DM, Duffield J, Eyckmans J, Assoian RK, Chen CS. Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and N-cadherin balance in mural cell-endothelial cell-regulated barrier function. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8758-8763.View Related Profiles.

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PMID: 28765370; PMCID: PMC5565405; DOI: 10.1073/pnas.1618333114;

Stevens KR, Scull MA, Ramanan V, Fortin CL, Chaturvedi RR, Knouse KA, Xiao JW, Fung C, Mirabella T, Chen AX, McCue MG, Yang MT, Fleming HE, Chung K, de Jong YP, Chen CS, Rice CM, Bhatia SN. In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease. Sci Transl Med. 2017 07 19; 9(399). PMID: 28724577; PMCID: PMC5896001; DOI: 10.1126/scitranslmed.aah5505;

Nguyen DT, Gao L, Wong A, Chen CS. Cdc42 regulates branching in angiogenic sprouting in vitro. Microcirculation. 2017 07; 24(5). PMID: 28376260; PMCID: PMC5505782; DOI: 10.1111/micc.12372;

Hinson JT, Chopra A, Lowe A, Sheng CC, Gupta RM, Kuppusamy R, O'Sullivan J, Rowe G, Wakimoto H, Gorham J, Burke MA, Zhang K, Musunuru K, Gerszten RE, Wu SM, Chen CS, Seidman JG, Seidman CE. Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis. Cell Rep. 2017 06 13; 19(11):2410. PMID: 28614725

Cao X, Ban E, Baker BM, Lin Y, Burdick JA, Chen CS, Shenoy VB. Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices. Proc Natl Acad Sci U S A. 2017 06 06; 114(23):E4549-E4555. PMID: 28468803; PMCID: PMC5468675; DOI: 10.1073/pnas.1620486114;

Shaya O, Binshtok U, Hersch M, Rivkin D, Weinreb S, Amir-Zilberstein L, Khamaisi B, Oppenheim O, Desai RA, Goodyear RJ, Richardson GP, Chen CS, Sprinzak D. Cell-Cell Contact Area Affects Notch Signaling and Notch-Dependent Patterning. Dev Cell. 2017 03 13; 40(5):505-511.e6. PMID: 28292428; PMCID: PMC5435110; DOI: 10.1016/j.devcel.2017.02.009;

Choi D, Park E, Jung E, Seong YJ, Yoo J, Lee E, Hong M, Lee S, Ishida H, Burford J, Peti-Peterdi J, Adams RH, Srikanth S, Gwack Y, Chen CS, Vogel HJ, Koh CJ, Wong AK, Hong YK. Laminar flow downregulates Notch activity to promote lymphatic sprouting. J Clin Invest. 2017 Apr 03; 127(4):1225-1240. PMID: 28263185; PMCID: PMC5373895; DOI: 10.1172/JCI87442;

McCurley A, Alimperti S, Campos-Bilderback SB, Sandoval RM, Calvino JE, Reynolds TL, Quigley C, Mugford JW, Polacheck WJ, Gomez IG, Dovey J, Marsh G, Huang A, Qian F, Weinreb PH, Dolinski BM, Moore S, Duffield JS, Chen CS, Molitoris BA, Violette SM, Crackower MA. Inhibition of avß5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury. J Am Soc Nephrol. 2017 Jun; 28(6):1741-1752. PMID: 28062569; PMCID: PMC5461783; DOI: 10.1681/ASN.2016020200;

Eyckmans J, Chen CS. 3D culture models of tissues under tension. J Cell Sci. 2017 01 01; 130(1):63-70.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 27909243; PMCID: PMC5394782; DOI: 10.1242/jcs.198630;

Heo SJ, Driscoll TP, Thorpe SD, Nerurkar NL, Baker BM, Yang MT, Chen CS, Lee DA, Mauck RL. Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity. Elife. 2016 11 30; 5. PMID: 27901466; PMCID: PMC5148611; DOI: 10.7554/eLife.18207;

Schadler KL, Thomas NJ, Galie PA, Bhang DH, Roby KC, Addai P, Till JE, Sturgeon K, Zaslavsky A, Chen CS, Ryeom S. Tumor vessel normalization after aerobic exercise enhances chemotherapeutic efficacy. Oncotarget. 2016 10 04; 7(40):65429-65440. PMID: 27589843; PMCID: PMC5323166; DOI: 10.18632/oncotarget.11748;

Keung W, Ren L, Sen Li, Wong AO, Chopra A, Kong CW, Tomaselli GF, Chen CS, Li RA. Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial KATP channels. Sci Rep. 2016 Sep 28; 6:34154. PMID: 27677332

Liu AS, Wang H, Copeland CR, Chen CS, Shenoy VB, Reich DH. Matrix viscoplasticity and its shielding by active mechanics in microtissue models: experiments and mathematical modeling. Sci Rep. 2016 Sep 27; 6:33919. PMID: 27671239; PMCID: PMC5037370; DOI: 10.1038/srep33919;

Chen CS. 3D Biomimetic Cultures: The Next Platform for Cell Biology. Trends Cell Biol. 2016 11; 26(11):798-800. PMID: 27637342

Foolen J, Shiu JY, Mitsi M, Zhang Y, Chen CS, Vogel V. Full-Length Fibronectin Drives Fibroblast Accumulation at the Surface of Collagen Microtissues during Cell-Induced Tissue Morphogenesis. PLoS One. 2016; 11(8):e0160369. PMID: 27564551

Kutys ML, Chen CS. Forces and mechanotransduction in 3D vascular biology. Curr Opin Cell Biol. 2016 10; 42:73-79. PMID: 27209346

Polacheck WJ, Chen CS. Measuring cell-generated forces: a guide to the available tools. Nat Methods. 2016 04 28; 13(5):415-23. PMID: 27123817; PMCID: PMC5474291; DOI: 10.1038/nmeth.3834;

Sakar MS, Eyckmans J, Pieters R, Eberli D, Nelson BJ, Chen CS. Cellular forces and matrix assembly coordinate fibrous tissue repair. Nat Commun. 2016 Mar 16; 7:11036.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 26980715; PMCID: PMC4799373; DOI: 10.1038/ncomms11036;

Mui KL, Chen CS, Assoian RK. The mechanical regulation of integrin-cadherin crosstalk organizes cells, signaling and forces. J Cell Sci. 2016 Mar 15; 129(6):1093-100. PMID: 26919980

Yang YH, Meguro K, Kim SY, Shim YS, Yu X, Chen CL, Wang H, Lam L, Senanarong V, Dominguez J, Lu PY, Lin YT, Hu CJ, Chiu PY, Fuh JL, Wang WF, Yu BC, Li T, Wang MW, Situmeang RF, Jang JW, Zhang J, Chan WC, Zhou YY, Lou HL, Zhang L, Ye M, Chen X. Impact of Alzheimer's Disease in Nine Asian Countries. Gerontology. 2016; 62(4):425-33. PMID: 26829322

Lee E, Song HG, Chen CS. Biomimetic on-a-chip platforms for studying cancer metastasis. Curr Opin Chem Eng. 2016 Feb; 11:20-27. PMID: 27570735

Baker BM, Trappmann B, Wang WY, Sakar MS, Kim IL, Shenoy VB, Burdick JA, Chen CS. Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments. Nat Mater. 2015 Dec; 14(12):1262-8. PMID: 26461445

Hinson JT, Chopra A, Nafissi N, Polacheck WJ, Benson CC, Swist S, Gorham J, Yang L, Schafer S, Sheng CC, Haghighi A, Homsy J, Hubner N, Church G, Cook SA, Linke WA, Chen CS, Seidman JG, Seidman CE. HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy. Science. 2015 Aug 28; 349(6251):982-6. PMID: 26315439; PMCID: PMC4618316; DOI: 10.1126/science.aaa5458;

Henry SJ, Chen CS, Crocker JC, Hammer DA. Protrusive and Contractile Forces of Spreading Human Neutrophils. Biophys J. 2015 Aug 18; 109(4):699-709. PMID: 26287622; PMCID: PMC4547143; DOI: 10.1016/j.bpj.2015.05.041;

Bagley AF, Scherz-Shouval R, Galie PA, Zhang AQ, Wyckoff J, Whitesell L, Chen CS, Lindquist S, Bhatia SN. Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors. Cancer Res. 2015 Aug 15; 75(16):3255-67. PMID: 26122846; PMCID: PMC4833008; DOI: 10.1158/0008-5472.CAN-15-0325;

Cohen DM, Won KJ, Nguyen N, Lazar MA, Chen CS, Steger DJ. ATF4 licenses C/EBPß activity in human mesenchymal stem cells primed for adipogenesis. Elife. 2015 Jun 25; 4:e06821. PMID: 26111340; PMCID: PMC4501333; DOI: 10.7554/eLife.06821;

Stevens KR, Miller JS, Blakely BL, Chen CS, Bhatia SN. Degradable hydrogels derived from PEG-diacrylamide for hepatic tissue engineering. J Biomed Mater Res A. 2015 Oct; 103(10):3331-8. PMID: 25851120; PMCID: PMC4890565; DOI: 10.1002/jbm.a.35478;

Mui KL, Bae YH, Gao L, Liu SL, Xu T, Radice GL, Chen CS, Assoian RK. N-Cadherin Induction by ECM Stiffness and FAK Overrides the Spreading Requirement for Proliferation of Vascular Smooth Muscle Cells. Cell Rep. 2015 Mar 10; 10(9):1477-1486. PMID: 25753414; PMCID: PMC4560684; DOI: 10.1016/j.celrep.2015.02.023;

Chaturvedi RR, Stevens KR, Solorzano RD, Schwartz RE, Eyckmans J, Baranski JD, Stapleton SC, Bhatia SN, Chen CS. Patterning vascular networks in vivo for tissue engineering applications. Tissue Eng Part C Methods. 2015 May; 21(5):509-17.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 25390971; PMCID: PMC4410304; DOI: 10.1089/ten.TEC.2014.0258;

Elliott H, Fischer RS, Myers KA, Desai RA, Gao L, Chen CS, Adelstein RS, Waterman CM, Danuser G. Myosin II controls cellular branching morphogenesis and migration in three dimensions by minimizing cell-surface curvature. Nat Cell Biol. 2015 Feb; 17(2):137-47. PMID: 25621949

Byron A, Askari JA, Humphries JD, Jacquemet G, Koper EJ, Warwood S, Choi CK, Stroud MJ, Chen CS, Knight D, Humphries MJ. A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting. Nat Commun. 2015 Jan 22; 6:6135. PMID: 25609142; PMCID: PMC4317495; DOI: 10.1038/ncomms7135;

Rana MK, Srivastava J, Yang M, Chen CS, Barber DL. Hypoxia increases the abundance but not the assembly of extracellular fibronectin during epithelial cell transdifferentiation. J Cell Sci. 2015 Mar 15; 128(6):1083-9. PMID: 25616899

Chen G, Li S, Karakikes I, Ren L, Chow MZ, Chopra A, Keung W, Yan B, Chan CW, Costa KD, Kong CW, Hajjar RJ, Chen CS, Li RA. Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs. Circ Arrhythm Electrophysiol. 2015 Feb; 8(1):193-202. PMID: 25504561

Wang H, Abhilash AS, Chen CS, Wells RG, Shenoy VB. Long-range force transmission in fibrous matrices enabled by tension-driven alignment of fibers. Biophys J. 2014 Dec 02; 107(11):2592-603. PMID: 25468338; PMCID: PMC4255175; DOI: 10.1016/j.bpj.2014.09.044;

Ronan W, McMeeking RM, Chen CS, McGarry JP, Deshpande VS. Cooperative contractility: the role of stress fibres in the regulation of cell-cell junctions. J Biomech. 2015 Feb 05; 48(3):520-8. PMID: 25553672; DOI: 10.1016/j.jbiomech.2014.11.025;

Abhilash AS, Baker BM, Trappmann B, Chen CS, Shenoy VB. Remodeling of fibrous extracellular matrices by contractile cells: predictions from discrete fiber network simulations. Biophys J. 2014 Oct 21; 107(8):1829-1840. PMID: 25418164; PMCID: PMC4213674; DOI: 10.1016/j.bpj.2014.08.029;

Blakely BL, Dumelin CE, Trappmann B, McGregor LM, Choi CK, Anthony PC, Duesterberg VK, Baker BM, Block SM, Liu DR, Chen CS. A DNA-based molecular probe for optically reporting cellular traction forces. Nat Methods. 2014 Dec; 11(12):1229-32. PMID: 25306545; PMCID: PMC4247985; DOI: 10.1038/nmeth.3145;

Bellas E, Chen CS. Forms, forces, and stem cell fate. Curr Opin Cell Biol. 2014 Dec; 31:92-7. PMID: 25269668

Galie PA, Byfield FJ, Chen CS, Kresh JY, Janmey PA. Mechanically stimulated contraction of engineered cardiac constructs using a microcantilever. IEEE Trans Biomed Eng. 2015 Feb; 62(2):438-42. PMID: 25248171; PMCID: PMC5478378; DOI: 10.1109/TBME.2014.2357778;

Moreno V, Gonzalo P, Gómez-Escudero J, Pollán Á, Acín-Pérez R, Breckenridge M, Yáñez-Mó M, Barreiro O, Orsenigo F, Kadomatsu K, Chen CS, Enríquez JA, Dejana E, Sánchez-Madrid F, Arroyo AG. An EMMPRIN-?-catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions. J Cell Sci. 2014 Sep 01; 127(Pt 17):3768-81. PMID: 24994937

Atluri P, Miller JS, Emery RJ, Hung G, Trubelja A, Cohen JE, Lloyd K, Han J, Gaffey AC, MacArthur JW, Chen CS, Woo YJ. Tissue-engineered, hydrogel-based endothelial progenitor cell therapy robustly revascularizes ischemic myocardium and preserves ventricular function. J Thorac Cardiovasc Surg. 2014 Sep; 148(3):1090-7; discussion 1097-8. PMID: 25129603

Eyckmans J, Chen CS. Stem cell differentiation: sticky mechanical memory. Nat Mater. 2014 Jun; 13(6):542-3.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 24845990; DOI: 10.1038/nmat3989;

Galie PA, Nguyen DH, Choi CK, Cohen DM, Janmey PA, Chen CS. Fluid shear stress threshold regulates angiogenic sprouting. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):7968-73. PMID: 24843171; PMCID: PMC4050561; DOI: 10.1073/pnas.1310842111;

Stapleton SC, Chopra A, Chen CS. Force measurement tools to explore cadherin mechanotransduction. Cell Commun Adhes. 2014 Jun; 21(3):193-205. PMID: 24754475; PMCID: PMC7079283; DOI: 10.3109/15419061.2014.905929;

Zhao R, Boudou T, Wang WG, Chen CS, Reich DH. Magnetic approaches to study collective three-dimensional cell mechanics in long-term cultures (invited). J Appl Phys. 2014 May 07; 115(17):172616. PMID: 24803684; PMCID: PMC4000393; DOI: 10.1063/1.4870918;

Choi CK, Chen CS. Jostling for position in angiogenic sprouts: continuous rearrangement of cells explained by differential adhesion dynamics. EMBO J. 2014 May 16; 33(10):1089-90. PMID: 24711516

Zhao R, Chen CS, Reich DH. Force-driven evolution of mesoscale structure in engineered 3D microtissues and the modulation of tissue stiffening. Biomaterials. 2014 Jun; 35(19):5056-64. PMID: 24630092; PMCID: PMC4046864; DOI: 10.1016/j.biomaterials.2014.02.020;

Rodriguez NM, Desai RA, Trappmann B, Baker BM, Chen CS. Micropatterned multicolor dynamically adhesive substrates to control cell adhesion and multicellular organization. Langmuir. 2014 Feb 11; 30(5):1327-35. PMID: 24401172; PMCID: PMC3983373; DOI: 10.1021/la404037s;

Obbink-Huizer C, Foolen J, Oomens CW, Borochin M, Chen CS, Bouten CV, Baaijens FP. Computational and experimental investigation of local stress fiber orientation in uniaxially and biaxially constrained microtissues. Biomech Model Mechanobiol. 2014 Oct; 13(5):1053-63. PMID: 24458588

Thompson SA, Blazeski A, Copeland CR, Cohen DM, Chen CS, Reich DM, Tung L. Acute slowing of cardiac conduction in response to myofibroblast coupling to cardiomyocytes through N-cadherin. J Mol Cell Cardiol. 2014 Mar; 68:29-37. PMID: 24412534; PMCID: PMC3993970; DOI: 10.1016/j.yjmcc.2013.12.025;

Ramade A, Legant WR, Picart C, Chen CS, Boudou T. Microfabrication of a platform to measure and manipulate the mechanics of engineered microtissues. Methods Cell Biol. 2014; 121:191-211. PMID: 24560511

Desai RA, Rodriguez NM, Chen CS. "Stamp-off" to micropattern sparse, multicomponent features. Methods Cell Biol. 2014; 119:3-16. PMID: 24439276; DOI: 10.1016/B978-0-12-416742-1.00001-9;

Li F, Xu T, Nguyen DH, Huang X, Chen CS, Zhou C. Label-free evaluation of angiogenic sprouting in microengineered devices using ultrahigh-resolution optical coherence microscopy. J Biomed Opt. 2014 Jan; 19(1):16006. PMID: 24395588; PMCID: PMC3881608; DOI: 10.1117/1.JBO.19.1.016006;

Wang H, Svoronos AA, Boudou T, Sakar MS, Schell JY, Morgan JR, Chen CS, Shenoy VB. Necking and failure of constrained 3D microtissues induced by cellular tension. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):20923-8. PMID: 24324149

Thavandiran N, Dubois N, Mikryukov A, Massé S, Beca B, Simmons CA, Deshpande VS, McGarry JP, Chen CS, Nanthakumar K, Keller GM, Radisic M, Zandstra PW. Design and formulation of functional pluripotent stem cell-derived cardiac microtissues. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):E4698-707. PMID: 24255110; PMCID: PMC3856835; DOI: 10.1073/pnas.1311120110;

Chopra A, Murray ME, Byfield FJ, Mendez MG, Halleluyan R, Restle DJ, Raz-Ben Aroush D, Galie PA, Pogoda K, Bucki R, Marcinkiewicz C, Prestwich GD, Zarembinski TI, Chen CS, Puré E, Kresh JY, Janmey PA. Augmentation of integrin-mediated mechanotransduction by hyaluronic acid. Biomaterials. 2014 Jan; 35(1):71-82. PMID: 24120037; PMCID: PMC3930571; DOI: 10.1016/j.biomaterials.2013.09.066;

Breckenridge MT, Desai RA, Yang MT, Fu J, Chen CS. Substrates with engineered step changes in rigidity induce traction force polarity and durotaxis. Cell Mol Bioeng. 2014 Mar; 7(1):26-34. PMID: 27721906; PMCID: PMC5055071; DOI: 10.1007/s12195-013-0307-6;

Desai RA, Gopal SB, Chen S, Chen CS. Contact inhibition of locomotion probabilities drive solitary versus collective cell migration. J R Soc Interface. 2013 Nov 06; 10(88):20130717. PMID: 24047876; PMCID: PMC3785843; DOI: 10.1098/rsif.2013.0717;

Wozniak MA, Baker BM, Chen CS, Wilson KL. The emerin-binding transcription factor Lmo7 is regulated by association with p130Cas at focal adhesions. PeerJ. 2013; 1:e134. PMID: 24010014; PMCID: PMC3757464; DOI: 10.7717/peerj.134;

Jacquemet G, Morgan MR, Byron A, Humphries JD, Choi CK, Chen CS, Caswell PT, Humphries MJ. Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway. J Cell Sci. 2013 Sep 15; 126(Pt 18):4121-35. PMID: 23843620

Wang C, Baker BM, Chen CS, Schwartz MA. Endothelial cell sensing of flow direction. Arterioscler Thromb Vasc Biol. 2013 Sep; 33(9):2130-6. PMID: 23814115; PMCID: PMC3812824; DOI: 10.1161/ATVBAHA.113.301826;

Baker BM, Trappmann B, Stapleton SC, Toro E, Chen CS. Microfluidics embedded within extracellular matrix to define vascular architectures and pattern diffusive gradients. Lab Chip. 2013 Aug 21; 13(16):3246-52. PMID: 23787488

Dumbauld DW, Lee TT, Singh A, Scrimgeour J, Gersbach CA, Zamir EA, Fu J, Chen CS, Curtis JE, Craig SW, García AJ. How vinculin regulates force transmission. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9788-93. PMID: 23716647; PMCID: PMC3683711; DOI: 10.1073/pnas.1216209110;

Conway DE, Breckenridge MT, Hinde E, Gratton E, Chen CS, Schwartz MA. Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1. Curr Biol. 2013 Jun 03; 23(11):1024-30. PMID: 23684974

Wang YK, Chen CS. Cell adhesion and mechanical stimulation in the regulation of mesenchymal stem cell differentiation. J Cell Mol Med. 2013 Jul; 17(7):823-32. PMID: 23672518

Kim IL, Khetan S, Baker BM, Chen CS, Burdick JA. Fibrous hyaluronic acid hydrogels that direct MSC chondrogenesis through mechanical and adhesive cues. Biomaterials. 2013 Jul; 34(22):5571-80. PMID: 23623322; PMCID: PMC3652578; DOI: 10.1016/j.biomaterials.2013.04.004;

Baranski JD, Chaturvedi RR, Stevens KR, Eyckmans J, Carvalho B, Solorzano RD, Yang MT, Miller JS, Bhatia SN, Chen CS. Geometric control of vascular networks to enhance engineered tissue integration and function. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):7586-91.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 23610423; PMCID: PMC3651499; DOI: 10.1073/pnas.1217796110;

Trappmann B, Chen CS. How cells sense extracellular matrix stiffness: a material's perspective. Curr Opin Biotechnol. 2013 Oct; 24(5):948-53. PMID: 23611564; PMCID: PMC4037408; DOI: 10.1016/j.copbio.2013.03.020;

Nguyen DH, Stapleton SC, Yang MT, Cha SS, Choi CK, Galie PA, Chen CS. Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6712-7. PMID: 23569284; PMCID: PMC3637738; DOI: 10.1073/pnas.1221526110;

Eyckmans J, Roberts SJ, Bolander J, Schrooten J, Chen CS, Luyten FP. Mapping calcium phosphate activated gene networks as a strategy for targeted osteoinduction of human progenitors. Biomaterials. 2013 Jun; 34(19):4612-21.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 23537666; PMCID: PMC4037407; DOI: 10.1016/j.biomaterials.2013.03.011;

Khetan S, Guvendiren M, Legant WR, Cohen DM, Chen CS, Burdick JA. Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels. Nat Mater. 2013 May; 12(5):458-65. PMID: 23524375; PMCID: PMC3633615; DOI: 10.1038/nmat3586;

Lin GL, Cohen DM, Desai RA, Breckenridge MT, Gao L, Humphries MJ, Chen CS. Activation of beta 1 but not beta 3 integrin increases cell traction forces. FEBS Lett. 2013 Mar 18; 587(6):763-9. PMID: 23395612; PMCID: PMC3966909; DOI: 10.1016/j.febslet.2013.01.068;

Zhao R, Boudou T, Wang WG, Chen CS, Reich DH. Decoupling cell and matrix mechanics in engineered microtissues using magnetically actuated microcantilevers. Adv Mater. 2013 Mar 25; 25(12):1699-705. PMID: 23355085; PMCID: PMC4037409; DOI: 10.1002/adma.201203585;

Schwartz MA, Chen CS. Cell biology. Deconstructing dimensionality. Science. 2013 Jan 25; 339(6118):402-4. PMID: 23349278; DOI: 10.1126/science.1233814;

Cohen DM, Yang MT, Chen CS. Measuring cell-cell tugging forces using bowtie-patterned mPADs (microarray post detectors). Methods Mol Biol. 2013; 1066:157-68. PMID: 23955742; DOI: 10.1007/978-1-62703-604-7_14;

Legant WR, Choi CK, Miller JS, Shao L, Gao L, Betzig E, Chen CS. Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions. Proc Natl Acad Sci U S A. 2013 Jan 15; 110(3):881-6. PMID: 23277584

Sakar MS, Neal D, Boudou T, Borochin MA, Li Y, Weiss R, Kamm RD, Chen CS, Asada HH. Formation and optogenetic control of engineered 3D skeletal muscle bioactuators. Lab Chip. 2012 Dec 07; 12(23):4976-85. PMID: 22976544; PMCID: PMC3586563; DOI: 10.1039/c2lc40338b;

West AR, Zaman N, Cole DJ, Walker MJ, Legant WR, Boudou T, Chen CS, Favreau JT, Gaudette GR, Cowley EA, Maksym GN. Development and characterization of a 3D multicell microtissue culture model of airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2013 Jan 01; 304(1):L4-16. PMID: 23125251

Wozniak MA, Cheng CQ, Shen CJ, Gao L, Olarerin-George AO, Won KJ, Hogenesch JB, Chen CS. Adhesion regulates MAP kinase/ternary complex factor exchange to control a proliferative transcriptional switch. Curr Biol. 2012 Nov 06; 22(21):2017-26. PMID: 23063436; PMCID: PMC3586562; DOI: 10.1016/j.cub.2012.08.050;

Legant WR, Chen CS, Vogel V. Force-induced fibronectin assembly and matrix remodeling in a 3D microtissue model of tissue morphogenesis. Integr Biol (Camb). 2012 Oct; 4(10):1164-74. PMID: 22961409

Leight JL, Liu WF, Chaturvedi RR, Chen S, Yang MT, Raghavan S, Chen CS. Manipulation of 3D Cluster Size and Geometry by Release from 2D Micropatterns. Cell Mol Bioeng. 2012 Sep 01; 5(3):299-306. PMID: 23730348; PMCID: PMC3665517; DOI: 10.1007/s12195-012-0236-9;

Eyckmans J, Lin GL, Chen CS. Adhesive and mechanical regulation of mesenchymal stem cell differentiation in human bone marrow and periosteum-derived progenitor cells. Biol Open. 2012 Nov 15; 1(11):1058-68.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 23213385; PMCID: PMC3507189; DOI: 10.1242/bio.20122162;

Miller JS, Stevens KR, Yang MT, Baker BM, Nguyen DH, Cohen DM, Toro E, Chen AA, Galie PA, Yu X, Chaturvedi R, Bhatia SN, Chen CS. Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues. Nat Mater. 2012 Sep; 11(9):768-74. PMID: 22751181; PMCID: PMC3586565; DOI: 10.1038/nmat3357;

Baker BM, Chen CS. Deconstructing the third dimension: how 3D culture microenvironments alter cellular cues. J Cell Sci. 2012 Jul 01; 125(Pt 13):3015-24. PMID: 22797912

Felton EJ, Copeland CR, Chen CS, Reich DH. Heterotypic cell pair co-culturing on patterned microarrays. Lab Chip. 2012 Sep 07; 12(17):3117-26. PMID: 22739471; PMCID: PMC3444241; DOI: 10.1039/c2lc40349h;

Yu X, Cohen DM, Chen CS. miR-125b Is an adhesion-regulated microRNA that protects mesenchymal stem cells from anoikis. Stem Cells. 2012 May; 30(5):956-64. PMID: 22331826

Sun Y, Chen CS, Fu J. Forcing stem cells to behave: a biophysical perspective of the cellular microenvironment. Annu Rev Biophys. 2012; 41:519-42. PMID: 22404680; PMCID: PMC4123632; DOI: 10.1146/annurev-biophys-042910-155306;

Lin YC, Kramer CM, Chen CS, Reich DH. Probing cellular traction forces with magnetic nanowires and microfabricated force sensor arrays. Nanotechnology. 2012 Feb 24; 23(7):075101. PMID: 22260885; PMCID: PMC3376533; DOI: 10.1088/0957-4484/23/7/075101;

Leight JL, Wozniak MA, Chen S, Lynch ML, Chen CS. Matrix rigidity regulates a switch between TGF-ß1-induced apoptosis and epithelial-mesenchymal transition. Mol Biol Cell. 2012 Mar; 23(5):781-91. PMID: 22238361; PMCID: PMC3290638; DOI: 10.1091/mbc.E11-06-0537;

Boudou T, Legant WR, Mu A, Borochin MA, Thavandiran N, Radisic M, Zandstra PW, Epstein JA, Margulies KB, Chen CS. A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues. Tissue Eng Part A. 2012 May; 18(9-10):910-9. PMID: 22092279; PMCID: PMC3338105; DOI: 10.1089/ten.tea.2011.0341;

Underhill GH, Galie P, Chen CS, Bhatia SN. Bioengineering methods for analysis of cells in vitro. Annu Rev Cell Dev Biol. 2012; 28:385-410. PMID: 23057744; DOI: 10.1146/annurev-cellbio-101011-155709;

Ricart BG, Yang MT, Hunter CA, Chen CS, Hammer DA. Measuring traction forces of motile dendritic cells on micropost arrays. Biophys J. 2011 Dec 07; 101(11):2620-8. PMID: 22261049

Singh N, Karambelkar A, Gu L, Lin K, Miller JS, Chen CS, Sailor MJ, Bhatia SN. Bioresponsive mesoporous silica nanoparticles for triggered drug release. J Am Chem Soc. 2011 Dec 14; 133(49):19582-5. PMID: 21981330; PMCID: PMC3295203; DOI: 10.1021/ja206998x;

Wang YK, Yu X, Cohen DM, Wozniak MA, Yang MT, Gao L, Eyckmans J, Chen CS. Bone morphogenetic protein-2-induced signaling and osteogenesis is regulated by cell shape, RhoA/ROCK, and cytoskeletal tension. Stem Cells Dev. 2012 May 01; 21(7):1176-86.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 21967638; PMCID: PMC3328763; DOI: 10.1089/scd.2011.0293;

Low HQ, Chen CP, Kasiman K, Thalamuthu A, Ng SS, Foo JN, Chang HM, Wong MC, Tai ES, Liu J. A comprehensive association analysis of homocysteine metabolic pathway genes in Singaporean Chinese with ischemic stroke. PLoS One. 2011; 6(9):e24757. PMID: 21935458

Cristancho AG, Schupp M, Lefterova MI, Cao S, Cohen DM, Chen CS, Steger DJ, Lazar MA. Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells. Proc Natl Acad Sci U S A. 2011 Sep 27; 108(39):16271-6. PMID: 21914845; PMCID: PMC3182685; DOI: 10.1073/pnas.1109409108;

Eyckmans J, Boudou T, Yu X, Chen CS. A hitchhiker's guide to mechanobiology. Dev Cell. 2011 Jul 19; 21(1):35-47.View Related Profiles.

Chen, Christopher
Eyckmans, Jeroen

PMID: 21763607; PMCID: PMC3155761; DOI: 10.1016/j.devcel.2011.06.015;

Shen CJ, Raghavan S, Xu Z, Baranski JD, Yu X, Wozniak MA, Miller JS, Gupta M, Buckbinder L, Chen CS. Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner. Exp Cell Res. 2011 Aug 01; 317(13):1860-71. PMID: 21640103; PMCID: PMC3123418; DOI: 10.1016/j.yexcr.2011.05.006;

Yang MT, Reich DH, Chen CS. Measurement and analysis of traction force dynamics in response to vasoactive agonists. Integr Biol (Camb). 2011 Jun; 3(6):663-74. PMID: 21445393

Mohamed NE, Zhao Y, Lee JH, Tan MG, Esiri MM, Wilcock GK, Smith AD, Wong PT, Chen CP, Lai MK. Upregulation of AMPA receptor GluR2 (GluA2) subunits in subcortical ischemic vascular dementia is repressed in the presence of Alzheimer's disease. Neurochem Int. 2011 Jun; 58(7):820-5. PMID: 21419184

Tee SY, Fu J, Chen CS, Janmey PA. Cell shape and substrate rigidity both regulate cell stiffness. Biophys J. 2011 Mar 02; 100(5):L25-7. PMID: 21354386; PMCID: PMC3043219; DOI: 10.1016/j.bpj.2010.12.3744;

Gao L, Gorski JL, Chen CS. The Cdc42 guanine nucleotide exchange factor FGD1 regulates osteogenesis in human mesenchymal stem cells. Am J Pathol. 2011 Mar; 178(3):969-74. PMID: 21356349

Desai RA, Khan MK, Gopal SB, Chen CS. Subcellular spatial segregation of integrin subtypes by patterned multicomponent surfaces. Integr Biol (Camb). 2011 May; 3(5):560-7. PMID: 21298148; PMCID: PMC3586560; DOI: 10.1039/c0ib00129e;

Yang MT, Fu J, Wang YK, Desai RA, Chen CS. Assaying stem cell mechanobiology on microfabricated elastomeric substrates with geometrically modulated rigidity. Nat Protoc. 2011 Feb; 6(2):187-213. PMID: 21293460; PMCID: PMC7183577; DOI: 10.1038/nprot.2010.189;

Legant WR, Miller JS, Blakely BL, Cohen DM, Genin GM, Chen CS. Measurement of mechanical tractions exerted by cells in three-dimensional matrices. Nat Methods. 2010 Dec; 7(12):969-71. PMID: 21076420

Choi CK, Breckenridge MT, Chen CS. Engineered materials and the cellular microenvironment: a strengthening interface between cell biology and bioengineering. Trends Cell Biol. 2010 Dec; 20(12):705-14. PMID: 20965727

Raghavan S, Desai RA, Kwon Y, Mrksich M, Chen CS. Micropatterned dynamically adhesive substrates for cell migration. Langmuir. 2010 Nov 16; 26(22):17733-8. PMID: 20886900; DOI: 10.1021/la102955m;

Raghavan S, Shen CJ, Desai RA, Sniadecki NJ, Nelson CM, Chen CS. Decoupling diffusional from dimensional control of signaling in 3D culture reveals a role for myosin in tubulogenesis. J Cell Sci. 2010 Sep 01; 123(Pt 17):2877-83. PMID: 20682635

Fu J, Wang YK, Yang MT, Desai RA, Yu X, Liu Z, Chen CS. Mechanical regulation of cell function with geometrically modulated elastomeric substrates. Nat Methods. 2010 Sep; 7(9):733-6. PMID: 20676108; PMCID: PMC3069358; DOI: 10.1038/nmeth.1487;

Grashoff C, Hoffman BD, Brenner MD, Zhou R, Parsons M, Yang MT, McLean MA, Sligar SG, Chen CS, Ha T, Schwartz MA. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature. 2010 Jul 08; 466(7303):263-6. PMID: 20613844; PMCID: PMC2901888; DOI: 10.1038/nature09198;

Raghavan S, Nelson CM, Baranski JD, Lim E, Chen CS. Geometrically controlled endothelial tubulogenesis in micropatterned gels. Tissue Eng Part A. 2010 Jul; 16(7):2255-63. PMID: 20180698; PMCID: PMC2947948; DOI: 10.1089/ten.TEA.2009.0584;

Liu Z, Tan JL, Cohen DM, Yang MT, Sniadecki NJ, Ruiz SA, Nelson CM, Chen CS. Mechanical tugging force regulates the size of cell-cell junctions. Proc Natl Acad Sci U S A. 2010 Jun 01; 107(22):9944-9. PMID: 20463286; PMCID: PMC2890446; DOI: 10.1073/pnas.0914547107;

Gao L, McBeath R, Chen CS. Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherin. Stem Cells. 2010 Mar 31; 28(3):564-72. PMID: 20082286

Liu Z, Sniadecki NJ, Chen CS. Mechanical Forces in Endothelial Cells during Firm Adhesion and Early Transmigration of Human Monocytes. Cell Mol Bioeng. 2010 Mar 01; 3(1):50-59. PMID: 20862208; PMCID: PMC2942779; DOI: 10.1007/s12195-010-0105-3;

Miller JS, Shen CJ, Legant WR, Baranski JD, Blakely BL, Chen CS. Bioactive hydrogels made from step-growth derived PEG-peptide macromers. Biomaterials. 2010 May; 31(13):3736-43. PMID: 20138664; PMCID: PMC2837100; DOI: 10.1016/j.biomaterials.2010.01.058;

Treiser MD, Yang EH, Gordonov S, Cohen DM, Androulakis IP, Kohn J, Chen CS, Moghe PV. Cytoskeleton-based forecasting of stem cell lineage fates. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):610-5. PMID: 20080726; PMCID: PMC2818905; DOI: 10.1073/pnas.0909597107;

De Silva DA, Woon FP, Lee MP, Chen CL, Chang HM, Wong MC. Metabolic syndrome is associated with intracranial large artery disease among ethnic Chinese patients with stroke. J Stroke Cerebrovasc Dis. 2009 Nov-Dec; 18(6):424-7. PMID: 19900643

Guilak F, Cohen DM, Estes BT, Gimble JM, Liedtke W, Chen CS. Control of stem cell fate by physical interactions with the extracellular matrix. Cell Stem Cell. 2009 Jul 02; 5(1):17-26. PMID: 19570510

Legant WR, Pathak A, Yang MT, Deshpande VS, McMeeking RM, Chen CS. Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues. Proc Natl Acad Sci U S A. 2009 Jun 23; 106(25):10097-102. PMID: 19541627

Kasiman K, Eikelboom JW, Hankey GJ, Lee SP, Lim JP, Lee JH, Chang HM, Wong MC, Chen CP. Ethnicity does not affect the homocysteine-lowering effect of B-vitamin therapy in Singaporean stroke patients. Stroke. 2009 Jun; 40(6):2209-11. PMID: 19372453

Desai RA, Gao L, Raghavan S, Liu WF, Chen CS. Cell polarity triggered by cell-cell adhesion via E-cadherin. J Cell Sci. 2009 Apr 01; 122(Pt 7):905-11. PMID: 19258396

Ostuni E, Whitesides GM, Ingber DE, Chen CS. Using self-assembled monolayers to pattern ECM proteins and cells on substrates. Methods Mol Biol. 2009; 522:183-94. PMID: 19247618

Lemmon CA, Chen CS, Romer LH. Cell traction forces direct fibronectin matrix assembly. Biophys J. 2009 Jan; 96(2):729-38. PMID: 19167317; PMCID: PMC2716473; DOI: 10.1016/j.bpj.2008.10.009;

Wozniak MA, Chen CS. Mechanotransduction in development: a growing role for contractility. Nat Rev Mol Cell Biol. 2009 Jan; 10(1):34-43. PMID: 19197330; PMCID: PMC2952188; DOI: 10.1038/nrm2592;

Chen CS. Mechanotransduction - a field pulling together? J Cell Sci. 2008 Oct 15; 121(Pt 20):3285-92. PMID: 18843115

Wang AY, Leong S, Liang YC, Huang RC, Chen CS, Yu SM. Immobilization of growth factors on collagen scaffolds mediated by polyanionic collagen mimetic peptides and its effect on endothelial cell morphogenesis. Biomacromolecules. 2008 Oct; 9(10):2929-36. PMID: 18816098; DOI: 10.1021/bm800727z;

Ruiz SA, Chen CS. Emergence of patterned stem cell differentiation within multicellular structures. Stem Cells. 2008 Nov; 26(11):2921-7. PMID: 18703661

Pirone DM, Qi L, Colecraft H, Chen CS. Spatial patterning of gene expression using surface-immobilized recombinant adenovirus. Biomed Microdevices. 2008 Aug; 10(4):561-6. PMID: 18246428; DOI: 10.1007/s10544-008-9166-7;

Parker KK, Tan J, Chen CS, Tung L. Myofibrillar architecture in engineered cardiac myocytes. Circ Res. 2008 Aug 15; 103(4):340-2. PMID: 18635822; PMCID: PMC3910252; DOI: 10.1161/CIRCRESAHA.108.182469;

Gray DS, Liu WF, Shen CJ, Bhadriraju K, Nelson CM, Chen CS. Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton. Exp Cell Res. 2008 Sep 10; 314(15):2846-54. PMID: 18652824; PMCID: PMC2601564; DOI: 10.1016/j.yexcr.2008.06.023;

Sniadecki NJ, Lamb CM, Liu Y, Chen CS, Reich DH. Magnetic microposts for mechanical stimulation of biological cells: fabrication, characterization, and analysis. Rev Sci Instrum. 2008 Apr; 79(4):044302. PMID: 18447536; PMCID: PMC2809695; DOI: 10.1063/1.2906228;

Fournier AK, Campbell LE, Castagnino P, Liu WF, Chung BM, Weaver VM, Chen CS, Assoian RK. Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion. J Cell Sci. 2008 Jan 15; 121(Pt 2):226-33. PMID: 18187454

Chen CS. Biotechnology: remote control of living cells. Nat Nanotechnol. 2008 Jan; 3(1):13-4. PMID: 18654443; DOI: 10.1038/nnano.2007.431;

Gómez-Sjöberg R, Leyrat AA, Pirone DM, Chen CS, Quake SR. Versatile, fully automated, microfluidic cell culture system. Anal Chem. 2007 Nov 15; 79(22):8557-63. PMID: 17953452; DOI: 10.1021/ac071311w;

Sniadecki NJ, Anguelouch A, Yang MT, Lamb CM, Liu Z, Kirschner SB, Liu Y, Reich DH, Chen CS. Magnetic microposts as an approach to apply forces to living cells. Proc Natl Acad Sci U S A. 2007 Sep 11; 104(37):14553-8. PMID: 17804810

Liu WF, Nelson CM, Tan JL, Chen CS. Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells. Circ Res. 2007 Aug 31; 101(5):e44-52. PMID: 17712140; DOI: 10.1161/CIRCRESAHA.107.158329;

Liu WF, Chen CS. Cellular and multicellular form and function. Adv Drug Deliv Rev. 2007 Nov 10; 59(13):1319-28. PMID: 17884241; PMCID: PMC2134975; DOI: 10.1016/j.addr.2007.08.011;

Bhadriraju K, Yang M, Alom Ruiz S, Pirone D, Tan J, Chen CS. Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension. Exp Cell Res. 2007 Oct 01; 313(16):3616-23. PMID: 17673200

Chen CS. Bait and switch: synthetic GEFs divert an input signal to diverse cellular responses. Dev Cell. 2007 Jul; 13(1):9-10. PMID: 17609105; DOI: 10.1016/j.devcel.2007.06.007;

Du Y, Chen CP, Tseng CY, Eisenberg Y, Firestein BL. Astroglia-mediated effects of uric acid to protect spinal cord neurons from glutamate toxicity. Glia. 2007 Apr 01; 55(5):463-72. PMID: 17203476

Chen CS. Separate but not equal: differential mechanical roles for Myosin isoforms. Biophys J. 2007 May 01; 92(9):2984-5. PMID: 17325018; PMCID: PMC1852349; DOI: 10.1529/biophysj.106.100065;

Alom Ruiz S, Chen CS. Microcontact printing: A tool to pattern. Soft Matter. 2007 Jan 23; 3(2):168-177. PMID: 32680260; DOI: 10.1039/b613349e;

Sniadecki NJ, Chen CS. Microfabricated silicone elastomeric post arrays for measuring traction forces of adherent cells. Methods Cell Biol. 2007; 83:313-28. PMID: 17613314

Nelson CM, Liu WF, Chen CS. Manipulation of cell-cell adhesion using bowtie-shaped microwells. Methods Mol Biol. 2007; 370:1-10. PMID: 17416983; DOI: 10.1007/978-1-59745-353-0_1;

Pirone DM, Liu WF, Ruiz SA, Gao L, Raghavan S, Lemmon CA, Romer LH, Chen CS. An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling. J Cell Biol. 2006 Jul 17; 174(2):277-88. PMID: 16847103; PMCID: PMC2064187; DOI: 10.1083/jcb.200510062;

Vandenberghe LH, Wang L, Somanathan S, Zhi Y, Figueredo J, Calcedo R, Sanmiguel J, Desai RA, Chen CS, Johnston J, Grant RL, Gao G, Wilson JM. Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid. Nat Med. 2006 Aug; 12(8):967-71. PMID: 16845388; DOI: 10.1038/nm1445;

Liu WF, Nelson CM, Pirone DM, Chen CS. E-cadherin engagement stimulates proliferation via Rac1. J Cell Biol. 2006 May 08; 173(3):431-41. PMID: 16682529; PMCID: PMC2063843; DOI: 10.1083/jcb.200510087;

Sniadecki NJ, Desai RA, Ruiz SA, Chen CS. Nanotechnology for cell-substrate interactions. Ann Biomed Eng. 2006 Jan; 34(1):59-74. PMID: 16525764; DOI: 10.1007/s10439-005-9006-3;

Yim EK, Reano RM, Pang SW, Yee AF, Chen CS, Leong KW. Nanopattern-induced changes in morphology and motility of smooth muscle cells. Biomaterials. 2005 Sep; 26(26):5405-13. PMID: 15814139

Jean RP, Chen CS, Spector AA. Finite-element analysis of the adhesion-cytoskeleton-nucleus mechanotransduction pathway during endothelial cell rounding: axisymmetric model. J Biomech Eng. 2005 Aug; 127(4):594-600. PMID: 16121529; DOI: 10.1115/1.1933997;

Nelson CM, Jean RP, Tan JL, Liu WF, Sniadecki NJ, Spector AA, Chen CS. Emergent patterns of growth controlled by multicellular form and mechanics. Proc Natl Acad Sci U S A. 2005 Aug 16; 102(33):11594-9. PMID: 16049098

Herndon TM, Pirone DM, Tsokos GC, Chen CS. T cell-to-T cell clustering enhances NF-kappaB activity by a PI3K signal mediated by Cbl-b and Rho. Biochem Biophys Res Commun. 2005 Jul 15; 332(4):1133-9. PMID: 15922296; DOI: 10.1016/j.bbrc.2005.05.064;

Tanase M, Felton EJ, Gray DS, Hultgren A, Chen CS, Reich DH. Assembly of multicellular constructs and microarrays of cells using magnetic nanowires. Lab Chip. 2005 Jun; 5(6):598-605. PMID: 15915251; DOI: 10.1039/b500243e;

Wang AY, Mo X, Chen CS, Yu SM. Facile modification of collagen directed by collagen mimetic peptides. J Am Chem Soc. 2005 Mar 30; 127(12):4130-1. PMID: 15783169

Hultgren A, Tanase M, Felton EJ, Bhadriraju K, Salem AK, Chen CS, Reich DH. Optimization of yield in magnetic cell separations using nickel nanowires of different lengths. Biotechnol Prog. 2005 Mar-Apr; 21(2):509-15. PMID: 15801791

Lemmon CA, Sniadecki NJ, Ruiz SA, Tan JL, Romer LH, Chen CS. Shear force at the cell-matrix interface: enhanced analysis for microfabricated post array detectors. Mech Chem Biosyst. 2005; 2(1):1-16. PMID: 16708468; PMCID: PMC1480360

Pirone DM, Chen CS. Strategies for engineering the adhesive microenvironment. J Mammary Gland Biol Neoplasia. 2004 Oct; 9(4):405-17. PMID: 15838609; DOI: 10.1007/s10911-004-1410-z;

Jean RP, Gray DS, Spector AA, Chen CS. Characterization of the nuclear deformation caused by changes in endothelial cell shape. J Biomech Eng. 2004 Oct; 126(5):552-8. PMID: 15648807; DOI: 10.1115/1.1800559;

Gray DS, Tan JL, Voldman J, Chen CS. Dielectrophoretic registration of living cells to a microelectrode array. Biosens Bioelectron. 2004 Jul 15; 19(12):1765-74. PMID: 15198083

De Silva DA, Woon FP, Lee MP, Fook-Chong S, Chang HM, Chen CL, Wong MC. Ischemic cerebrovascular disease: differences between ethnic South Asian and ethnic Chinese patients. Cerebrovasc Dis. 2005; 20(5):407-9. PMID: 16205060

Tan JL, Liu W, Nelson CM, Raghavan S, Chen CS. Simple approach to micropattern cells on common culture substrates by tuning substrate wettability. Tissue Eng. 2004 May-Jun; 10(5-6):865-72. PMID: 15265304; DOI: 10.1089/1076327041348365;

Nelson CM, Pirone DM, Tan JL, Chen CS. Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA. Mol Biol Cell. 2004 Jun; 15(6):2943-53. PMID: 15075376; PMCID: PMC420116; DOI: 10.1091/mbc.e03-10-0745;

McBeath R, Pirone DM, Nelson CM, Bhadriraju K, Chen CS. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell. 2004 Apr; 6(4):483-95. PMID: 15068789; DOI: 10.1016/s1534-5807(04)00075-9;

Gray DS, Tan JL, Voldman J, Chen CS. Dielectrophoretic registration of living cells to a microelectrode array. Biosens Bioelectron. 2004 Feb 15; 19(7):771-80. PMID: 14709396; DOI: 10.1016/j.bios.2003.08.013;

Chen CS, Tan J, Tien J. Mechanotransduction at cell-matrix and cell-cell contacts. Annu Rev Biomed Eng. 2004; 6:275-302.View Related Profiles.

Chen, Christopher
Tien, Joe

PMID: 15255771; DOI: 10.1146/annurev.bioeng.6.040803.140040;

Gray DS, Tien J, Chen CS. Repositioning of cells by mechanotaxis on surfaces with micropatterned Young's modulus. J Biomed Mater Res A. 2003 Sep 01; 66(3):605-14.View Related Profiles.

Chen, Christopher
Tien, Joe

PMID: 12918044; DOI: 10.1002/jbm.a.10585;

Chen CS, Alonso JL, Ostuni E, Whitesides GM, Ingber DE. Cell shape provides global control of focal adhesion assembly. Biochem Biophys Res Commun. 2003 Jul 25; 307(2):355-61. PMID: 12859964

Nelson CM, Chen CS. VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension. J Cell Sci. 2003 Sep 01; 116(Pt 17):3571-81. PMID: 12876221

Tan JL, Tien J, Pirone DM, Gray DS, Bhadriraju K, Chen CS. Cells lying on a bed of microneedles: an approach to isolate mechanical force. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1484-9.View Related Profiles.

Chen, Christopher
Tien, Joe

PMID: 12552122; PMCID: PMC149857; DOI: 10.1073/pnas.0235407100;

Bhadriraju K, Chen CS. Engineering cellular microenvironments to improve cell-based drug testing. Drug Discov Today. 2002 Jun 01; 7(11):612-20. PMID: 12047872; DOI: 10.1016/s1359-6446(02)02273-0;

Nelson CM, Chen CS. Cell-cell signaling by direct contact increases cell proliferation via a PI3K-dependent signal. FEBS Lett. 2002 Mar 13; 514(2-3):238-42. PMID: 11943158; DOI: 10.1016/s0014-5793(02)02370-0;

Tien J, Nelson CM, Chen CS. Fabrication of aligned microstructures with a single elastomeric stamp. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):1758-62.View Related Profiles.

Chen, Christopher
Tien, Joe

PMID: 11842197; PMCID: PMC122266; DOI: 10.1073/pnas.042493399;

Tien J, Chen CS. Patterning the cellular microenvironment. IEEE Eng Med Biol Mag. 2002 Jan-Feb; 21(1):95-8.View Related Profiles.

Chen, Christopher
Tien, Joe

PMID: 11935995; DOI: 10.1109/memb.2002.993201;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 266 publications over 24 distinct years, with a maximum of 22 publications in 2013