Yang You | Profiles RNS

Yang You, PhD

Postdoctoral Associate (previously held)

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

Websites

	ResearchGate
	Google Scholar

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Ikezu T, Bodart-Santos V, Ravula AR, You Y, Abdullah M, Ruan Z, Ellison J, Radhakishun S, Ray NB, Melvin B, Kurti A, Liang Z, Sakai Y, O'Brien D, Nguyen S, Shaffer S, Fiddes L, Butovsky O, Springer W, Ikezu S. P2RX7 regulates tauopathy progression via tau and mitochondria loading in extracellular vesicles. Res Sq. 2025 Jun 23.View Related Profiles.

Ikezu, Tsuneya
You, Yang

PMID: 40678243; PMCID: PMC12270207; DOI: 10.21203/rs.3.rs-6771517/v1;

You Y, Zhang Z, Cortes S, Nguyen SN, Vadakattu P, Melvin BC, Jr Mann SD, Ray NB, Bregendahl M, McLean PJ, Gonzalez-Perez MP, Ikezu S, Ikezu T. Rapid and high-yield recovery of plasma-derived extracellular vesicles using modified chromatography with soluble protein depletion for biomarker discovery. Cell Commun Signal. 2025 May 30; 23(1):253.View Related Profiles.

Ikezu, Tsuneya
You, Yang

PMID: 40448170; PMCID: PMC12124018; DOI: 10.1186/s12964-025-02263-3;

Ikezu T, Zhang Z, Yu K, Bao H, Ikezu T, Ravula AR, Melvin B, Scholes C, You Y, Ellison J, Kanekiyo T, Wszolek Z, DeTure M, Dickson D, Han X, Peng J, Ikezu S. Unique lipid cargoes in APOE4 human brain-derived extracellular vesicles recruit cell adhesion molecules and promote tauopathy in Alzheimer's disease. Res Sq. 2025 May 26.View Related Profiles.

Ikezu, Tsuneya
You, Yang

PMID: 40502793; PMCID: PMC12154133; DOI: 10.21203/rs.3.rs-6508552/v1;

Wang J, Li J, Wang F, You Y. Exercise Intervention Influences on Sleep and Anxiety in Children with Autism Spectrum Disorder: A Meta-Analyses of Randomized Controlled Trials. Neuropediatrics. 2025 Oct; 56(5):302-309. PMID: 40107307

Yeh H, De Cruz MA, You Y, Ikezu S, Ikezu T. Development and characterization of in vitro inducible immortalization of a murine microglia cell line for high throughput studies. Sci Rep. 2025 Jan 25; 15(1):3207.View Related Profiles.

Ikezu, Tsuneya
You, Yang

PMID: 39863723; PMCID: PMC11762310; DOI: 10.1038/s41598-025-87543-1;

Jin Y, Li F, Li Z, Ikezu TC, O'Leary J, Selvaraj M, Zhu Y, Martens YA, Koga S, Santhakumar H, Li Y, Lu W, You Y, Lolo K, DeTure M, Beasley AI, Davis MD, McLean PJ, Ross OA, Kanekiyo T, Ikezu T, Caulfield T, Carr J, Wszolek ZK, Bu G, Dickson DW, Zhao N. Modeling Lewy body disease with SNCA triplication iPSC-derived cortical organoids and identifying therapeutic drugs. Sci Adv. 2024 Sep 13; 10(37):eadk3700.View Related Profiles.

Ikezu, Tsuneya
You, Yang

PMID: 39259788; PMCID: PMC11389790; DOI: 10.1126/sciadv.adk3700;

Nogueras-Ortiz CJ, Eren E, Yao P, Calzada E, Dunn C, Volpert O, Delgado-Peraza F, Mustapic M, Lyashkov A, Rubio FJ, Vreones M, Cheng L, You Y, Hill AF, Ikezu T, Eitan E, Goetzl EJ, Kapogiannis D. Single-extracellular vesicle (EV) analyses validate the use of L1 Cell Adhesion Molecule (L1CAM) as a reliable biomarker of neuron-derived EVs. J Extracell Vesicles. 2024 Jun; 13(6):e12459.View Related Profiles.

Ikezu, Tsuneya
You, Yang

PMID: 38868956; PMCID: PMC11170079; DOI: 10.1002/jev2.12459;

Zhao HL, You Y, Tian Y, Wang L, An Y, Zhang G, Shu C, Yu M, Zhu Y, Li Q, Zhang Y, Sun N, Hu S, Liu G. Impact of LDLR polymorphisms on lipid levels and atorvastatin's efficacy in a northern Chinese adult Han cohort with dyslipidemia. Lipids Health Dis. 2024 Apr 14; 23(1):106. PMID: 38616260; PMCID: PMC11016223; DOI: 10.1186/s12944-024-02101-4;

You Y, Jiang W, Yi L, Zhang G, Peng Z, Chang S, Hou F. Seeding alpine grasses in low altitude region increases global warming potential during early seedling growth. J Environ Manage. 2024 Apr; 356:120679. PMID: 38531141

You Y, Zhang Z, Sultana N, Ericsson M, Martens YA, Sun M, Kanekiyo T, Ikezu S, Shaffer SA, Ikezu T. ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids. Sci Adv. 2023 Sep 15; 9(37):eadi3647.View Related Profiles.

Ikezu, Tsuneya
You, Yang

PMID: 37713494; PMCID: PMC10881047; DOI: 10.1126/sciadv.adi3647;

Showing 10 of 29 results. Show More

Zhang Z, Yu K, You Y, Jiang P, Wu Z, DeTure MA, Dickson DW, Ikezu S, Peng J, Ikezu T. Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications. J Extracell Vesicles. 2023 Aug; 12(8):e12358.View Related Profiles.

Ikezu, Tsuneya
You, Yang

PMID: 37563857; PMCID: PMC10415636; DOI: 10.1002/jev2.12358;

You Y, Hersh SW, Aslebagh R, Shaffer SA, Ikezu S, Mez J, Lunetta KL, Logue MW, Farrer LA, Ikezu T. Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells. Aging Cell. 2022 Jun; 21(6):e13617.View Related Profiles.

Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Logue, Mark
Ikezu, Tsuneya
You, Yang

PMID: 35567427; PMCID: PMC9197405; DOI: 10.1111/acel.13617;

Li J, Sun X, You Y, Li Q, Wei C, Zhao L, Sun M, Meng H, Zhang T, Yue W, Wang L, Zhang D. Auts2 deletion involves in DG hypoplasia and social recognition deficit: The developmental and neural circuit mechanisms. Sci Adv. 2022 03 04; 8(9):eabk1238. PMID: 35235353; PMCID: PMC8890717; DOI: 10.1126/sciadv.abk1238;

You Y, Muraoka S, Jedrychowski MP, Hu J, McQuade AK, Young-Pearse T, Aslebagh R, Shaffer SA, Gygi SP, Blurton-Jones M, Poon WW, Ikezu T. Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain. J Extracell Vesicles. 2022 01; 11(1):e12183.View Related Profiles.

Ikezu, Tsuneya
You, Yang

PMID: 35029059; PMCID: PMC8758831; DOI: 10.1002/jev2.12183;

Xia M, Gao C, Wang H, Shang J, Liu R, You Y, Zang W, Zhang J. Novel PSEN1 (P284S) Mutation Causes Alzheimer's Disease with Cerebellar Amyloid ß-Protein Deposition. Curr Alzheimer Res. 2022; 19(7):523-529. PMID: 35850649; PMCID: PMC9933047; DOI: 10.2174/1567205019666220718151357;

Hersh SW, You Y, Aslebagh R, Shaffer SA, Ikezu S, Mez J, Lunetta KL, Logue MW, Farrer LA, Ikezu T. Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells. Alzheimers Dement. 2021 Dec; 17 Suppl 2:e058592.View Related Profiles.

Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Logue, Mark
Ikezu, Tsuneya
You, Yang

PMID: 34971140; DOI: 10.1002/alz.058592;

Muraoka S, DeLeo AM, Sethi MK, Yukawa-Takamatsu K, Yang Z, Ko J, Hogan JD, Ruan Z, You Y, Wang Y, Medalla M, Ikezu S, Chen M, Xia W, Gorantla S, Gendelman HE, Issadore D, Zaia J, Ikezu T. Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues. Alzheimers Dement. 2020 06; 16(6):896-907.View Related Profiles.

Zaia, Joseph
Sethi, Manveen
Medalla, Maria
Ikezu, Seiko
Ikezu, Tsuneya
Xia, Weiming
You, Yang
Ruan, Zhi

PMID: 32301581; PMCID: PMC7293582; DOI: 10.1002/alz.12089;

Ikezu S, Yeh H, Delpech JC, Woodbury ME, Van Enoo AA, Ruan Z, Sivakumaran S, You Y, Holland C, Guillamon-Vivancos T, Yoshii-Kitahara A, Botros MB, Madore C, Chao PH, Desani A, Manimaran S, Kalavai SV, Johnson WE, Butovsky O, Medalla M, Luebke JI, Ikezu T. Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities. Mol Psychiatry. 2021 06; 26(6):1808-1831.View Related Profiles.

Luebke, Jennifer
Medalla, Maria
Woodbury, Maya
Ikezu, Seiko
Ikezu, Tsuneya
Johnson, William
You, Yang
Ruan, Zhi

PMID: 32071385; PMCID: PMC7431382; DOI: 10.1038/s41380-020-0671-2;

You Y, Borgmann K, Edara VV, Stacy S, Ghorpade A, Ikezu T. Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing. J Extracell Vesicles. 2020; 9(1):1706801.View Related Profiles.

Ikezu, Tsuneya
You, Yang

PMID: 32002171; PMCID: PMC6968484; DOI: 10.1080/20013078.2019.1706801;

You Y, Botros MB, Enoo AAV, Bockmiller A, Herron S, Delpech JC, Ikezu T. Cre-inducible Adeno Associated Virus-mediated Expression of P301L Mutant Tau Causes Motor Deficits and Neuronal Degeneration in the Substantia Nigra. Neuroscience. 2019 12 01; 422:65-74.View Related Profiles.

Ikezu, Tsuneya
You, Yang

PMID: 31689387; PMCID: PMC6898791; DOI: 10.1016/j.neuroscience.2019.10.001;

Zhang Z, Ye M, Li Q, You Y, Yu H, Ma Y, Mei L, Sun X, Wang L, Yue W, Li R, Li J, Zhang D. The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling. Cell Rep. 2019 Oct 01; 29(1):49-61.e7. PMID: 31577955; DOI: 10.1016/j.celrep.2019.08.091;

You Y, Ikezu T. Emerging roles of extracellular vesicles in neurodegenerative disorders. Neurobiol Dis. 2019 10; 130:104512.View Related Profiles.

Ikezu, Tsuneya
You, Yang

PMID: 31229685; PMCID: PMC6689424; DOI: 10.1016/j.nbd.2019.104512;

Wu Z, Qin J, You Y, Ma Y, Jia M, Wang L, Lu T, Yue W, Ruan Y, Zhang D, Li J, Wang L. Genetic variants in the transcription regulatory region of MEGF10 are associated with autism in Chinese Han population. Sci Rep. 2017 05 23; 7(1):2292. PMID: 28536440; PMCID: PMC5442155; DOI: 10.1038/s41598-017-02348-1;

Zhang Z, Zheng F, You Y, Ma Y, Lu T, Yue W, Zhang D. Growth arrest specific gene 7 is associated with schizophrenia and regulates neuronal migration and morphogenesis. Mol Brain. 2016 05 18; 9(1):54. PMID: 27189492; PMCID: PMC4870797; DOI: 10.1186/s13041-016-0238-y;

Li J, You Y, Yue W, Jia M, Yu H, Lu T, Wu Z, Ruan Y, Wang L, Zhang D. Genetic Evidence for Possible Involvement of the Calcium Channel Gene CACNA1A in Autism Pathogenesis in Chinese Han Population. PLoS One. 2015; 10(11):e0142887. PMID: 26566276; PMCID: PMC4643966; DOI: 10.1371/journal.pone.0142887;

Li J, You Y, Yue W, Yu H, Lu T, Wu Z, Jia M, Ruan Y, Liu J, Zhang D, Wang L. Chromatin remodeling gene EZH2 involved in the genetic etiology of autism in Chinese Han population. Neurosci Lett. 2016 Jan 01; 610:182-6. PMID: 26552012; DOI: 10.1016/j.neulet.2015.10.074;

Li J, Zhao L, You Y, Lu T, Jia M, Yu H, Ruan Y, Yue W, Liu J, Lu L, Zhang D, Wang L. Schizophrenia Related Variants in CACNA1C also Confer Risk of Autism. PLoS One. 2015; 10(7):e0133247. PMID: 26204268; PMCID: PMC4512676; DOI: 10.1371/journal.pone.0133247;

Long R, Mao K, Gong M, Zhou S, Hu J, Zhi M, You Y, Bai S, Jiang J, Zhang Q, Wu X, Xiong Y. Tunable oxygen activation for catalytic organic oxidation: Schottky junction versus plasmonic effects. Angew Chem Int Ed Engl. 2014 Mar 17; 53(12):3205-9. PMID: 24520003

You Y, Duan Y, Liu SW, Zhang XL, Zhang XL, Feng JT, Yan CH, Han YL. Anti-atherosclerotic function of Astragali Radix extract: downregulation of adhesion molecules in vitro and in vivo. BMC Complement Altern Med. 2012 Apr 26; 12:54. PMID: 22536886; PMCID: PMC3478196; DOI: 10.1186/1472-6882-12-54;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 29 publications over 12 distinct years, with a maximum of 5 publications in 2025

Bar chart showing 29 publications over 12 distinct years, with a maximum of 5 publications in 2025

Year	Publications
2012	1
2014	1
2015	3
2016	1
2017	1
2019	4
2020	2
2021	1
2022	4
2023	2
2024	4
2025	5

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