Susan P. Perrine-Faller, MD
Professor
Boston University School of Medicine
Dept of Pediatrics
Pediatric Subspecialties (Pediatric Hematology)

MD, Tufts University School of Medicine
MMS, Rutgers University–Camden
SM, Harvard School of Public Health



Professor
Boston University School of Medicine
Medicine
Hematology & Medical Oncology

Professor
Boston University School of Medicine
Pharmacology & Experimental Therapeutics


Research Faculty Member
Boston University School of Medicine
Cancer Research Center




STTR PHASE I: NOVEL HDAC INHIBITORS FOR TREATMENT OF HEMOGLOBINOPATHIES
09/01/2017 - 08/31/2018 (PI)
Cetya Therapeutics NIH NHLBI
1R41HL136068-01

LAUNCHING A NOVEL THERAPEUTIC OF GLOBAL HEMOGLOBIN DISEASES
01/01/2016 - 12/31/2017 (PI)
Harrington Discovery Institute

NOVEL GLOBIN GENE MODULATORS
12/01/2015 - 11/30/2017 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
4R01DK052962-13

NOVEL GLOBIN GENE MODULATORS
12/07/2012 - 11/30/2015 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK052962-12

TOPICAL THERAPEUTIC TO PROMOTE HEALING OF CHRONIC WOUNDS
08/01/2013 - 07/31/2015 (PI)
Phoenicia Biosciences, Inc. NIH NIGMS
1R41GM101869-01A1

NEXT GENERATION THERAPEUTICS FOR HEMOGLOBINOPATHIES
07/01/2012 - 06/30/2014 (PI)
Phoenicia Biosciences, Inc. NIH NHLBI
1R41HL108516-01

SELECTIVE HDAC INHIBITORS FOR TREATMENT OF HEMOGLOBINOPATHIES
08/01/2013 - 04/30/2014 (PI)
Acetylon Pharmaceuticals, Inc. NIH NHLBI
1R41HL118917-01

Novel Globin Modulators/ Comparative Activity of Compounds
09/12/2008 - 09/11/2009 (PI)
Hemaquest Pharmaceuticals, Inc.

Novel Globin Gene Modulators
06/01/1998 - 05/31/2009 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5 R01 DK52962 09

Erythropoiesis & Pulse Arginine Butyrate in Sickle Cell Disease
09/30/2002 - 09/29/2008 (PI)
HHS/Food and Drug Administration

Showing 10 of 18 results. Show All Results

Sickle Cell - Butyrate Study
04/01/2003 - 03/31/2008 (PI)
NIH-NHLBI
5 U54 HL070819-05



Yr Title Project-Sub Proj Pubs
2017 Novel HDAC Inhibitors for Treatment of Hemoglobinopathies 1R41HL136068-01
2016 Virus-targeted therapeutic for EBV-Associated Malignancies 2R44CA153474-02A1
2016 Novel Globin Gene Modulators 4R01DK052962-13 20
2015 Development of a clinical hemoglobin modulator 5R42HL110727-03 1
2015 Novel Globin Gene Modulators 5R01DK052962-12 20
2014 Development of a clinical hemoglobin modulator 2R42HL110727-02 1
2014 Novel Globin Gene Modulators 5R01DK052962-11 20
2013 Topical Therapeutic to Promote Healing of Chronic Wounds 1R41GM101869-01A1
2013 Novel Globin Gene Modulators 2R01DK052962-10A1 20
2012 Next Generation Therapeutics for Hemoglobinopathies 1R41HL108516-01A1 5
Showing 10 of 57 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Faller DV, Castaneda SA, Zhou D, Vedamony M, Newburger PE, White GL, Kosanke S, Plett PA, Orschell CM, Boosalis MS, Perrine SP. An oral HemokineTM, a-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo. Blood Cells Mol Dis. 2017 Mar; 63:1-8.View Related Profiles. PMID: 27888688; DOI: 10.1016/j.bcmd.2016.10.021;.
     
  2. Whitesell PL, Owoyemi O, Oneal P, Nouraie M, Klings ES, Rock A, Mellman TA, Berihun T, Lavella J, Taylor RE, Perrine SP. Sleep-disordered breathing and nocturnal hypoxemia in young adults with sickle cell disease. Sleep Med. 2016 Jun; 22:47-49.View Related Profiles. PMID: 27544835; PMCID: PMC4994534; DOI: 10.1016/j.sleep.2016.05.006;.
     
  3. Boosalis MS, Sangerman JI, White GL, Wolf RF, Shen L, Dai Y, White E, Makala LH, Li B, Pace BS, Nouraie M, Faller DV, Perrine SP. Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice. PLoS One. 2015; 10(12):e0144660.View Related Profiles. PMID: 26713848; PMCID: PMC4694699; DOI: 10.1371/journal.pone.0144660;.
     
  4. Dai Y, Sangerman J, Luo HY, Fucharoen S, Chui DH, Faller DV, Perrine SP. Therapeutic fetal-globin inducers reduce transcriptional repression in hemoglobinopathy erythroid progenitors through distinct mechanisms. Blood Cells Mol Dis. 2016 Jan; 56(1):62-9.View Related Profiles. PMID: 26603726; PMCID: PMC4667977; DOI: 10.1016/j.bcmd.2015.10.004;.
     
  5. Perrine SP, Pace BS, Faller DV. Targeted fetal hemoglobin induction for treatment of beta hemoglobinopathies. Hematol Oncol Clin North Am. 2014 Apr; 28(2):233-48.View Related Profiles. PMID: 24589264; DOI: 10.1016/j.hoc.2013.11.009;.
     
  6. Patthamalai P, Fuchareon S, Chaneiam N, Ghalie RG, Chui DH, Boosalis MS, Perrine SP. A phase 2 trial of HQK-1001 in HbE-ß thalassemia demonstrates HbF induction and reduced anemia. Blood. 2014 Mar 20; 123(12):1956-7. PMID: 24652964; PMCID: PMC3962168; DOI: 10.1182/blood-2013-11-538470;.
     
  7. Inati A, Kahale M, Perrine SP, Chui DH, Taher AT, Koussa S, Abi Nasr T, Abbas HA, Ghalie RG. A phase 2 study of HQK-1001, an oral fetal haemoglobin inducer, in ß-thalassaemia intermedia. Br J Haematol. 2014 Feb; 164(3):456-8. PMID: 24224649; PMCID: PMC3904791; DOI: 10.1111/bjh.12635;.
     
  8. Kutlar A, Reid ME, Inati A, Taher AT, Abboud MR, El-Beshlawy A, Buchanan GR, Smith H, Ataga KI, Perrine SP, Ghalie RG. A dose-escalation phase IIa study of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease. Am J Hematol. 2013 Nov; 88(11):E255-60.View Related Profiles. PMID: 23828223; DOI: 10.1002/ajh.23533;.
     
  9. Fucharoen S, Inati A, Siritanaratku N, Thein SL, Wargin WC, Koussa S, Taher A, Chaneim N, Boosalis M, Berenson R, Perrine SP. A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in ß-thalassaemia intermedia and HbE/ß-thalassaemia. Br J Haematol. 2013 May; 161(4):587-93. PMID: 23530969; DOI: 10.1111/bjh.12304;.
     
  10. Kutlar A, Ataga K, Reid M, Vichinsky EP, Neumayr L, Blair-Britt L, Labotka R, Glass J, Keefer JR, Wargin WA, Berenson R, Perrine SP. A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease. Am J Hematol. 2012 Nov; 87(11):1017-21. PMID: 22887019; DOI: 10.1002/ajh.23306;.
     
Showing 10 of 75 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 75 publications over 31 distinct years, with a maximum of 6 publications in 1989 and 2006 and 2011

YearPublications
19801
19831
19852
19862
19872
19882
19896
19903
19922
19932
19942
19952
19961
19971
19984
19991
20014
20021
20033
20053
20066
20071
20081
20092
20102
20116
20123
20133
20142
20152
20162
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72 E. Concord St Instructional (L)
Boston MA 02118
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