Rudy John Valentine, PhD
Assistant Professor
Iowa State University

Rudy Valentine is an Assistant Professor within the department of Kinesiology at Iowa State University. His lab is focused on improving our understanding of bio-behavioral factors linking excess body fat and sedentary lifestyle with risk for cardiometabolic diseases. As both a basic and applied exercise physiologist, his work probes him into mechanistic pathways and addresses public health issues associated with obesity, diabetes, and aging. To tackle these challenges, they use a variety of methods, including cell culture, rodent models, and clinical human studies.

Toward the ultimate goal of improving human health and quality of life, his research agenda is focused on three intersecting themes:

(1) identifying the mechanism(s) through which behavioral (e.g., exercise and diet) and pharmacologic therapies mitigate cardiometabolic disease pathogenesis, with a focus on inflammation;

(2) examining the relationships between physical activity/fitness, diet, and risk factors for physical disability (e.g., muscle strength, muscle quality, and physical function); and

(3) investigating the interactions of fitness, obesity, sleep, inflammation and behavior.

Postdoctoral Fellow (Previously held)
Boston University Chobanian & Avedisian School of Medicine

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Buhr TJ, Reed CH, Wee OM, Lee JH, Yuan LL, Fleshner M, Valentine RJ, Clark PJ. The persistence of stress-induced physical inactivity in rats: an investigation of central monoamine neurotransmitters and skeletal muscle oxidative stress. Front Behav Neurosci. 2023; 17:1169151. PMID: 37273279; PMCID: PMC10237271; DOI: 10.3389/fnbeh.2023.1169151;
  2. Krishna S, Spaulding HR, Koltes JE, Quindry JC, Valentine RJ, Selsby JT. Indicators of increased ER stress and UPR in aged D2-mdx and human dystrophic skeletal muscles. Front Physiol. 2023; 14:1152576. PMID: 37179835; PMCID: PMC10166835; DOI: 10.3389/fphys.2023.1152576;
  3. Lefferts WK, Davis MM, Valentine RJ. Exercise as an Aging Mimetic: A New Perspective on the Mechanisms Behind Exercise as Preventive Medicine Against Age-Related Chronic Disease. Front Physiol. 2022; 13:866792. PMID: 36045751; PMCID: PMC9420936; DOI: 10.3389/fphys.2022.866792;
  4. Reed CH, Buhr TJ, Tystahl AC, Bauer EE, Clark PJ, Valentine RJ. The effects of voluntary binge-patterned ethanol ingestion and daily wheel running on signaling of muscle protein synthesis and degradation in female mice. Alcohol. 2022 Nov; 104:45-52. PMID: 35926812
  5. Eo H, Valentine RJ. Saturated Fatty Acid-Induced Endoplasmic Reticulum Stress and Insulin Resistance Are Prevented by Imoxin in C2C12 Myotubes. Front Physiol. 2022; 13:842819. PMID: 35936891; PMCID: PMC9355746; DOI: 10.3389/fphys.2022.842819;
  6. Alley JR, Valentine RJ, Kohut ML. Mitochondrial Mass of Naïve T Cells Is Associated with Aerobic Fitness and Energy Expenditure of Active and Inactive Adults. Med Sci Sports Exerc. 2022 Aug 01; 54(8):1288-1299. PMID: 35389948
  7. Summers CM, Valentine RJ. Two hours of heat stress induces MAP-kinase signaling and autophagasome accumulation in C2C12 myotubes. Cell Biochem Biophys. 2022 Jun; 80(2):367-373. PMID: 35122618
  8. Buhr TJ, Reed CH, Shoeman A, Bauer EE, Valentine RJ, Clark PJ. Corrigendum: The Influence of Moderate Physical Activity on Brain Monoaminergic Responses to Binge-Patterned Alcohol Ingestion in Female Mice. Front Behav Neurosci. 2021; 15:780189. PMID: 34759803; PMCID: PMC8574212; DOI: 10.3389/fnbeh.2021.780189;
  9. Eo H, Valentine RJ. Imoxin inhibits tunicamycin-induced endoplasmic reticulum stress and restores insulin signaling in C2C12 myotubes. Am J Physiol Cell Physiol. 2021 08 01; 321(2):C221-C229. PMID: 34077277
  10. Bries AE, Webb JL, Vogel B, Carrillo C, Day TA, Kimber MJ, Valentine RJ, Rowling MJ, Clark S, Schalinske KL, McNeill EM. RNA Sequencing Reveals Key Metabolic Pathways Are Modified by Short-Term Whole Egg Consumption. Front Nutr. 2021; 8:652192. PMID: 34041258; PMCID: PMC8141817; DOI: 10.3389/fnut.2021.652192;
Showing 10 of 56 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 56 publications over 19 distinct years, with a maximum of 6 publications in 2009


Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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