Rudy John Valentine, PhD
Assistant Professor
Iowa State University

Rudy Valentine is an Assistant Professor within the department of Kinesiology at Iowa State University. His lab is focused on improving our understanding of bio-behavioral factors linking excess body fat and sedentary lifestyle with risk for cardiometabolic diseases. As both a basic and applied exercise physiologist, his work probes him into mechanistic pathways and addresses public health issues associated with obesity, diabetes, and aging. To tackle these challenges, they use a variety of methods, including cell culture, rodent models, and clinical human studies.

Toward the ultimate goal of improving human health and quality of life, his research agenda is focused on three intersecting themes:

(1) identifying the mechanism(s) through which behavioral (e.g., exercise and diet) and pharmacologic therapies mitigate cardiometabolic disease pathogenesis, with a focus on inflammation;

(2) examining the relationships between physical activity/fitness, diet, and risk factors for physical disability (e.g., muscle strength, muscle quality, and physical function); and

(3) investigating the interactions of fitness, obesity, sleep, inflammation and behavior.

Postdoctoral Fellow (Previously held)
Boston University School of Medicine

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Eo H, Reed CH, Valentine RJ. Imoxin prevents dexamethasone-induced promotion of muscle-specific E3 ubiquitin ligases and stimulates anabolic signaling in C2C12 myotubes. Biomed Pharmacother. 2020 Aug; 128:110238. PMID: 32450522
  2. Summers CM, Valentine RJ. Acute Heat Exposure Alters Autophagy Signaling in C2C12 Myotubes. Front Physiol. 2019; 10:1521. PMID: 31969827
  3. Saande CJ, Steffes MA, Webb JL, Valentine RJ, Rowling MJ, Schalinske KL. Whole Egg Consumption Impairs Insulin Sensitivity in a Rat Model of Obesity and Type 2 Diabetes. Curr Dev Nutr. 2019 Apr; 3(4):nzz015. PMID: 31008440
  4. Valentine RJ, Jefferson MA, Kohut ML, Eo H. Imoxin attenuates LPS-induced inflammation and MuRF1 expression in mouse skeletal muscle. Physiol Rep. 2018 Dec; 6(23):e13941. PMID: 30548229
  5. Mammadova N, Summers CM, Kokemuller RD, He Q, Ding S, Baron T, Yu C, Valentine RJ, Sakaguchi DS, Kanthasamy AG, Greenlee JJ, Heather West Greenlee M. Accelerated accumulation of retinal a-synuclein (pSer129) and tau, neuroinflammation, and autophagic dysregulation in a seeded mouse model of Parkinson's disease. Neurobiol Dis. 2019 01; 121:1-16. PMID: 30218757
  6. Fuller KNZ, Valentine RJ, Miranda ER, Kumar P, Prabhakar BS, Haus JM. A single high-fat meal alters human soluble RAGE profiles and PBMC RAGE expression with no effect of prior aerobic exercise. Physiol Rep. 2018 07; 6(14):e13811. PMID: 30047241
  7. Ganesan S, Summers CM, Pearce SC, Gabler NK, Valentine RJ, Baumgard LH, Rhoads RP, Selsby JT. Short-term heat stress altered metabolism and insulin signaling in skeletal muscle. J Anim Sci. 2018 Feb 15; 96(1):154-167. PMID: 29432553
  8. Allen KM, Coughlan KA, Mahmood FN, Valentine RJ, Ruderman NB, Saha AK. The effects of troglitazone on AMPK in HepG2 cells. Arch Biochem Biophys. 2017 Jun 01; 623-624:49-57.View Related Profiles. PMID: 28526426
  9. Fuller KNZ, Summers CM, Valentine RJ. Effect of a single bout of aerobic exercise on high-fat meal-induced inflammation. Metabolism. 2017 Jun; 71:144-152. PMID: 28521867
  10. Fuller KN, Summers CM, Valentine RJ. Effect of a Single Bout of Aerobic Exercise on NF-?B in Peripheral Blood Mononuclear Cells: 3181 Board #246 June 3, 2: 00 PM - 3: 30 PM. Med Sci Sports Exerc. 2016 May; 48(5 Suppl 1):907. PMID: 27361750; DOI: 10.1249/;
Showing 10 of 43 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 43 publications over 16 distinct years, with a maximum of 6 publications in 2009


Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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