Rudy John Valentine
Postdoctoral Fellow
Boston University School of Medicine

Rudy Valentine is an Assistant Professor within the department of Kinesiology at Iowa State University. His lab is focused on improving our understanding of bio-behavioral factors linking excess body fat and sedentary lifestyle with risk for cardiometabolic diseases. As both a basic and applied exercise physiologist, his work probes him into mechanistic pathways and addresses public health issues associated with obesity, diabetes, and aging. To tackle these challenges, they use a variety of methods, including cell culture, rodent models, and clinical human studies.

Toward the ultimate goal of improving human health and quality of life, his research agenda is focused on three intersecting themes:

(1) identifying the mechanism(s) through which behavioral (e.g., exercise and diet) and pharmacologic therapies mitigate cardiometabolic disease pathogenesis, with a focus on inflammation;

(2) examining the relationships between physical activity/fitness, diet, and risk factors for physical disability (e.g., muscle strength, muscle quality, and physical function); and

(3) investigating the interactions of fitness, obesity, sleep, inflammation and behavior.
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Ganesan S, Summers CM, Pearce SC, Gabler NK, Valentine RJ, Baumgard LH, Rhoads RP, Selsby JT. Short-term heat stress altered metabolism and insulin signaling in skeletal muscle. J Anim Sci. 2018 Feb 15; 96(1):154-167. PMID: 29432553.
  2. Allen KM, Coughlan KA, Mahmood FN, Valentine RJ, Ruderman NB, Saha AK. The effects of troglitazone on AMPK in HepG2 cells. Arch Biochem Biophys. 2017 Jun 01; 623-624:49-57.View Related Profiles. PMID: 28526426.
  3. Fuller KNZ, Summers CM, Valentine RJ. Effect of a single bout of aerobic exercise on high-fat meal-induced inflammation. Metabolism. 2017 Jun; 71:144-152. PMID: 28521867.
  4. Fuller KN, Summers CM, Valentine RJ. Effect of a Single Bout of Aerobic Exercise on NF-?B in Peripheral Blood Mononuclear Cells: 3181 Board #246 June 3, 2: 00 PM - 3: 30 PM. Med Sci Sports Exerc. 2016 May; 48(5 Suppl 1):907. PMID: 27361750; DOI: 10.1249/;.
  5. Coughlan KA, Valentine RJ, Sudit BS, Allen K, Dagon Y, Kahn BB, Ruderman NB, Saha AK. PKD1 Inhibits AMPKa2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells. J Biol Chem. 2016 Mar 11; 291(11):5664-75.View Related Profiles. PMID: 26797128; PMCID: PMC4786706; DOI: 10.1074/jbc.M115.696849;.
  6. Koh GY, Derscheid R, Fuller KN, Valentine RJ, Leow SE, Reed L, Wisecup E, Schalinske KL, Rowling MJ. Circulating adiponectin concentrations are increased by dietary resistant starch and correlate with serum 25-hydroxycholecalciferol concentrations and kidney function in Zucker diabetic fatty rats. Nutr Res. 2016 Apr; 36(4):311-9. PMID: 27001276; DOI: 10.1016/j.nutres.2015.12.006;.
  7. Coughlan KA, Balon TW, Valentine RJ, Petrocelli R, Schultz V, Brandon A, Cooney GJ, Kraegen EW, Ruderman NB, Saha AK. Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats. PLoS One. 2015; 10(5):e0127388.View Related Profiles. PMID: 25996822; PMCID: PMC4440828; DOI: 10.1371/journal.pone.0127388;.
  8. Valentine RJ, Coughlan KA, Ruderman NB, Saha AK. Insulin inhibits AMPK activity and phosphorylates AMPK Ser485/4?¹ through Akt in hepatocytes, myotubes and incubated rat skeletal muscle. Arch Biochem Biophys. 2014 Nov 15; 562:62-9.View Related Profiles. PMID: 25172224; PMCID: PMC4437572; DOI: 10.1016/;.
  9. Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. AMPK activation: a therapeutic target for type 2 diabetes? Diabetes Metab Syndr Obes. 2014; 7:241-53.View Related Profiles. PMID: 25018645; DOI: 10.2147/DMSO.S43731;.
  10. Xu XJ, Valentine RJ, Ruderman NB. AMP-activated Protein Kinase (AMPK): Does This Master Regulator of Cellular Energy State Distinguish Insulin Sensitive from Insulin Resistant Obesity? Curr Obes Rep. 2014 Jun 1; 3(2):248-55.View Related Profiles. PMID: 24891985; PMCID: PMC4039173; DOI: 10.1007/s13679-014-0095-x;.
Showing 10 of 37 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 37 publications over 14 distinct years, with a maximum of 6 publications in 2009

Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Google Map

Valentine's Networks
Click the "See All" links for more information and interactive visualizations
Similar People