Rudy John Valentine, PhD
Assistant Professor
Iowa State University

Rudy Valentine is an Assistant Professor within the department of Kinesiology at Iowa State University. His lab is focused on improving our understanding of bio-behavioral factors linking excess body fat and sedentary lifestyle with risk for cardiometabolic diseases. As both a basic and applied exercise physiologist, his work probes him into mechanistic pathways and addresses public health issues associated with obesity, diabetes, and aging. To tackle these challenges, they use a variety of methods, including cell culture, rodent models, and clinical human studies.

Toward the ultimate goal of improving human health and quality of life, his research agenda is focused on three intersecting themes:

(1) identifying the mechanism(s) through which behavioral (e.g., exercise and diet) and pharmacologic therapies mitigate cardiometabolic disease pathogenesis, with a focus on inflammation;

(2) examining the relationships between physical activity/fitness, diet, and risk factors for physical disability (e.g., muscle strength, muscle quality, and physical function); and

(3) investigating the interactions of fitness, obesity, sleep, inflammation and behavior.

Postdoctoral Fellow (Previously held)
Boston University School of Medicine

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Eo H, Valentine RJ. Imoxin inhibits tunicamycin-induced endoplasmic reticulum stress and restores insulin signaling in C2C12 myotubes. Am J Physiol Cell Physiol. 2021 08 01; 321(2):C221-C229. PMID: 34077277
  2. Bries AE, Webb JL, Vogel B, Carrillo C, Day TA, Kimber MJ, Valentine RJ, Rowling MJ, Clark S, Schalinske KL, McNeill EM. RNA Sequencing Reveals Key Metabolic Pathways Are Modified by Short-Term Whole Egg Consumption. Front Nutr. 2021; 8:652192. PMID: 34041258; PMCID: PMC8141817; DOI: 10.3389/fnut.2021.652192;
  3. Buhr TJ, Reed CH, Shoeman A, Bauer EE, Valentine RJ, Clark PJ. The Influence of Moderate Physical Activity on Brain Monoaminergic Responses to Binge-Patterned Alcohol Ingestion in Female Mice. Front Behav Neurosci. 2021; 15:639790. PMID: 33716684; PMCID: PMC7947191; DOI: 10.3389/fnbeh.2021.639790;
  4. Shirazi BR, Valentine RJ, Lang JA. Reproducibility and normalization of reactive hyperemia using laser speckle contrast imaging. PLoS One. 2021; 16(1):e0244795. PMID: 33412561; PMCID: PMC7790538; DOI: 10.1371/journal.pone.0244795;
  5. Webb JL, Bries AE, Vogel B, Carrillo C, Harvison L, Day TA, Kimber MJ, Valentine RJ, Rowling MJ, Clark S, McNeill EM, Schalinske KL. Whole egg consumption increases gene expression within the glutathione pathway in the liver of Zucker Diabetic Fatty rats. PLoS One. 2020; 15(11):e0240885. PMID: 33141822; PMCID: PMC7608885; DOI: 10.1371/journal.pone.0240885;
  6. Eo H, Reed CH, Valentine RJ. Imoxin prevents dexamethasone-induced promotion of muscle-specific E3 ubiquitin ligases and stimulates anabolic signaling in C2C12 myotubes. Biomed Pharmacother. 2020 Aug; 128:110238. PMID: 32450522
  7. Summers CM, Valentine RJ. Acute Heat Exposure Alters Autophagy Signaling in C2C12 Myotubes. Front Physiol. 2019; 10:1521. PMID: 31969827; PMCID: PMC6960406; DOI: 10.3389/fphys.2019.01521;
  8. Saande CJ, Steffes MA, Webb JL, Valentine RJ, Rowling MJ, Schalinske KL. Whole Egg Consumption Impairs Insulin Sensitivity in a Rat Model of Obesity and Type 2 Diabetes. Curr Dev Nutr. 2019 Apr; 3(4):nzz015. PMID: 31008440; PMCID: PMC6462456; DOI: 10.1093/cdn/nzz015;
  9. Valentine RJ, Jefferson MA, Kohut ML, Eo H. Imoxin attenuates LPS-induced inflammation and MuRF1 expression in mouse skeletal muscle. Physiol Rep. 2018 Dec; 6(23):e13941. PMID: 30548229; PMCID: PMC6286898; DOI: 10.14814/phy2.13941;
  10. Mammadova N, Summers CM, Kokemuller RD, He Q, Ding S, Baron T, Yu C, Valentine RJ, Sakaguchi DS, Kanthasamy AG, Greenlee JJ, Heather West Greenlee M. Accelerated accumulation of retinal a-synuclein (pSer129) and tau, neuroinflammation, and autophagic dysregulation in a seeded mouse model of Parkinson's disease. Neurobiol Dis. 2019 01; 121:1-16. PMID: 30218757
Showing 10 of 48 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 48 publications over 17 distinct years, with a maximum of 6 publications in 2009


Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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