Libin Liu, PhD
Research Assistant Professor
Boston University School of Medicine
Dept of Pharmacology & Experimental Therapeutics

PhD, Gunma University

White adipose tissue (WAT) is a highly dynamic organ and can respond rapidly to alterations in nutrient excess and deprivation, thereby fulfilling its major role in whole body energy homeostasis. Dysfunctional WAT leads to the etiology of a large number of metabolic disorders including the metabolic syndrome and type II diabetes. As the major cell type in WAT, a healthy, highly metabolic responsible adipocyte itself is essential in maintaining adipose tissue functions. However, it has been known that the functions of adipocyte start to fail under many physiological (such as aging) and pathological (obesity, metabolic stress and lipodystrophy) conditions. We are trying to ask the questions about: what are the key factors and mechanisms that control adipocyte functional set limit beyond which WAT fails to function properly? One of our recent studies has shown the capacity of adipocyte ribosome biogenesis which is controlled by ribosomal transcription determines the maximal limit of functional homeostasis. Further studies for the components and mechanism details of this regulatory machinery will help us not only to understand the importance of the ribosome biogenesis for adipocyte physiology, but also to develop the potential biomarkers and drug targets for diagnosis, prognosis, and therapy in human obesity.

Boston Nutrition Obesity Research Center
10/01/2017 - 03/31/2018 (PI)
Boston Nutrition Obesity Research Center NIH NIDDK

The Role of Cavin/PTRF in Caveolae
12/01/2007 - 03/31/2009 (PI)
Boston Medical Center NIH NIDDK

Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Wang H, Pilch PF, Liu L. Cavin-1/PTRF mediates insulin-dependent focal adhesion remodeling and ameliorates high-fat diet-induced inflammatory responses in mice. J Biol Chem. 2019 Jul 05; 294(27):10544-10552.View Related Profiles. PMID: 31126986.
  2. Williams JJL, Alotaiq N, Mullen W, Burchmore R, Liu L, Baillie GS, Schaper F, Pilch PF, Palmer TM. Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability. Nat Commun. 2018 01 12; 9(1):168.View Related Profiles. PMID: 29330478.
  3. Ding SY, Liu L, Pilch PF. Muscular dystrophy in PTFR/cavin-1 null mice. JCI Insight. 2017 03 09; 2(5):e91023.View Related Profiles. PMID: 28289716; DOI: 10.1172/jci.insight.91023;.
  4. Wang H, Liu L, Lin JZ, Aprahamian TR, Farmer SR. Browning of White Adipose Tissue with Roscovitine Induces a Distinct Population of UCP1+ Adipocytes. Cell Metab. 2016 Dec 13; 24(6):835-847.View Related Profiles. PMID: 27974179; DOI: 10.1016/j.cmet.2016.10.005;.
  5. Liu L, Pilch PF. PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges. Elife. 2016 Aug 16; 5.View Related Profiles. PMID: 27528195; PMCID: PMC4987143; DOI: 10.7554/eLife.17508;.
  6. Jedrychowski MP, Liu L, Laflamme CJ, Karastergiou K, Meshulam T, Ding SY, Wu Y, Lee MJ, Gygi SP, Fried SK, Pilch PF. Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes. Mol Metab. 2015 Nov; 4(11):758-70.View Related Profiles. PMID: 26629401; DOI: 10.1016/j.molmet.2015.09.002;.
  7. Liu L, Hansen CG, Honeyman BJ, Nichols BJ, Pilch PF. Cavin-3 knockout mice show that cavin-3 is not essential for caveolae formation, for maintenance of body composition, or for glucose tolerance. PLoS One. 2014; 9(7):e102935.View Related Profiles. PMID: 25036884; PMCID: PMC4103889; DOI: 10.1371/journal.pone.0102935;.
  8. Ding SY, Lee MJ, Summer R, Liu L, Fried SK, Pilch PF. Pleiotropic effects of cavin-1 deficiency on lipid metabolism. J Biol Chem. 2014 Mar 21; 289(12):8473-83.View Related Profiles. PMID: 24509860; PMCID: PMC3961672; DOI: 10.1074/jbc.M113.546242;.
  9. Govender P, Romero F, Shah D, Paez J, Ding SY, Liu L, Gower A, Baez E, Aly SS, Pilch P, Summer R. Cavin1; a regulator of lung function and macrophage phenotype. PLoS One. 2013; 8(4):e62045.View Related Profiles. PMID: 23634221; PMCID: PMC3636273; DOI: 10.1371/journal.pone.0062045;.
  10. Hill MM, Daud NH, Aung CS, Loo D, Martin S, Murphy S, Black DM, Barry R, Simpson F, Liu L, Pilch PF, Hancock JF, Parat MO, Parton RG. Co-regulation of cell polarization and migration by caveolar proteins PTRF/Cavin-1 and caveolin-1. PLoS One. 2012; 7(8):e43041.View Related Profiles. PMID: 22912783; PMCID: PMC3418245; DOI: 10.1371/journal.pone.0043041;.
Showing 10 of 20 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 20 publications over 14 distinct years, with a maximum of 3 publications in 2007 and 2011

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Metabolism, diabetes, obesity, Insulin resistance, adipocyte, ribosome biogenesis, ribosomal transcription.
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72 E. Concord St Silvio Conte (K)
Boston MA 02118
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