Kim Vanuytsel, PhD
Research Assistant Professor
Boston University School of Medicine
Dept of Medicine
Hematology & Medical Oncology

PhD, Katholieke Univ Leuven
MS, Katholieke Univ Leuven

I aim to find better solutions for sickle cell disease patients by using patient-specific induced pluripotent stem cells (iPSCs) as a versatile platform to study the disease, screen for compounds that can ameliorate the condition and explore potential curative gene editing approaches. Inherently linked to my efforts in modeling blood-borne diseases, I have a strong interest in understanding the molecular underpinnings of hematopoietic development and differentiation. My research therefore focuses on the development of tools and resources that can help us understand important concepts in hematopoietic development with the goal of translating this knowledge into the realization of the immense potential that iPSCs hold for disease modeling and regenerative medicine.

Boston University
Center for Regenerative Medicine

2020-2022 BUSM: National Blood Foundation (NBF) Early-Career Scientific Research Grant
2020 BUSM: CTSI Integrated Pilot Award
2019 BUSM: CReM Award 2019
2017 BUSM: American Society of Hematology (ASH) Abstract Achievement Award
2017 BUSM: CReM Single Cell RNA Sequencing Grant Award
2016 BUSM: Cooley’s Anemia Foundation Research Fellowship
2015 BUSM: International Society for Stem Cell Research (ISSCR) Travel Award
2010-2014 Katholieke Universiteit Leuven: IWT Strategic Basic Research Fund Fellowship Award

Validation of a potential curative gene editing approach across the diverse sickle cell disease…
07/01/2020 - 06/30/2022 (PI)
National Blood Fdtn

Induced pluripotent stem cell (iPSC)-based modeling of beta thalassemia
07/01/2016 - 06/30/2017 (PI)
Cooleys Anemia Foundation


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Wagner DE, Ikonomou L, Gilpin SE, Magin CM, Cruz F, Greaney A, Magnusson M, Chen YW, Davis B, Vanuytsel K, Rolandsson Enes S, Krasnodembskaya A, Lehmann M, Westergren-Thorsson G, Stegmayr J, Alsafadi HN, Hoffman ET, Weiss DJ, Ryan AL. Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019. ERJ Open Res. 2020 Oct; 6(4). PMID: 33123557; PMCID: PMC7569162; DOI: 10.1183/23120541.00123-2020;
  2. Giadone RM, Mithal A, Miller GJ, Matte TM, Yeung AK, Dowrey TW, Werder RB, Miller NS, Andry CD, Vanuytsel K, Murphy GJ. qRT-PCR Platforms for Diagnosing and Reporting SARS-CoV-2 Infection in Human Samples. STAR Protoc. 2020 Sep 18; 1(2):100102.View Related Profiles. PMID: 32954369; PMCID: PMC7490627; DOI: 10.1016/j.xpro.2020.100102;
  3. Vanuytsel K, Mithal A, Giadone RM, Yeung AK, Matte TM, Dowrey TW, Werder RB, Miller GJ, Miller NS, Andry CD, Murphy GJ. Rapid Implementation of a SARS-CoV-2 Diagnostic Quantitative Real-Time PCR Test with Emergency Use Authorization at a Large Academic Safety Net Hospital. Med (N Y). 2020 Dec 18; 1(1):152-157.e3.View Related Profiles. PMID: 32838351; PMCID: PMC7235561; DOI: 10.1016/j.medj.2020.05.001;
  4. Vanuytsel K, Cai Q, Khurana S, Shetty S, Vermeesch JR, Ordovas L, Verfaillie CM. Corrigendum to "FANCA knockout in human embryonic stem cells causes a severe growth disadvantage" [Stem Cell Res.13/2 (2014) 240-50]. Stem Cell Res. 2020 04; 44:101763. PMID: 32199280
  5. Steinberg MH, Kumar S, Murphy GJ, Vanuytsel K. Sickle cell disease in the era of precision medicine: looking to the future. Expert Rev Precis Med Drug Dev. 2019; 4(6):357-367.View Related Profiles. PMID: 33015364; PMCID: PMC7531762; DOI: 10.1080/23808993.2019.1688658;
  6. Vanuytsel K, Steinberg MH, Murphy GJ. In: Haruhisa Inoue, Yukio Nakamura (Eds.), Medical Applications of iPS Cells. Recapitulating Hematopoietic Development in a Dish. 2019; 45-71.
  7. Vanuytsel K, Matte T, Leung A, Naing ZH, Morrison T, Chui DHK, Steinberg MH, Murphy GJ. Induced pluripotent stem cell-based mapping of ß-globin expression throughout human erythropoietic development. Blood Adv. 2018 08 14; 2(15):1998-2011.View Related Profiles. PMID: 30108108; PMCID: PMC6093724; DOI: 10.1182/bloodadvances.2018020560;
  8. Leung A, Zulick E, Skvir N, Vanuytsel K, Morrison TA, Naing ZH, Wang Z, Dai Y, Chui DHK, Steinberg MH, Sherr DH, Murphy GJ. Notch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells. Stem Cells. 2018 07; 36(7):1004-1019.View Related Profiles. PMID: 29569827; PMCID: PMC6099224; DOI: 10.1002/stem.2822;
  9. Ordovás L, Boon R, Pistoni M, Chen Y, Wolfs E, Guo W, Sambathkumar R, Bobis-Wozowicz S, Helsen N, Vanhove J, Berckmans P, Cai Q, Vanuytsel K, Eggermont K, Vanslembrouck V, Schmidt BZ, Raitano S, Van Den Bosch L, Nahmias Y, Cathomen T, Struys T, Verfaillie CM. Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition. Stem Cell Reports. 2018 02 13; 10(2):673. PMID: 29444475; PMCID: PMC5830959; DOI: 10.1016/j.stemcr.2018.01.034;
  10. Park S, Gianotti-Sommer A, Molina-Estevez FJ, Vanuytsel K, Skvir N, Leung A, Rozelle SS, Shaikho EM, Weir I, Jiang Z, Luo HY, Chui DHK, Figueiredo MS, Alsultan A, Al-Ali A, Sebastiani P, Steinberg MH, Mostoslavsky G, Murphy GJ. A Comprehensive, Ethnically Diverse Library of Sickle Cell Disease-Specific Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 Apr 11; 8(4):1076-1085.View Related Profiles. PMID: 28111279; PMCID: PMC5390092; DOI: 10.1016/j.stemcr.2016.12.017;
Showing 10 of 17 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 17 publications over 9 distinct years, with a maximum of 4 publications in 2020

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