I aim to find better solutions for sickle cell disease patients by using patient-specific induced pluripotent stem cells (iPSCs) as a versatile platform to study the disease, screen for compounds that can ameliorate the condition and explore potential curative gene editing approaches. Inherently linked to my efforts in modeling blood-borne diseases, I have a strong interest in understanding the molecular underpinnings of hematopoietic development and differentiation. My research therefore focuses on the development of tools and resources that can help us understand important concepts in hematopoietic development with the goal of translating this knowledge into the realization of the immense potential that iPSCs hold for disease modeling and regenerative medicine.
Diversity, Equity, Inclusion and Accessibility
I am very much inspired by and proud of our hospital’s mission “Exceptional care without exception” and I hope to reflect a similar inclusivity in my research as I strive to factor in our patient population’s diverse genetic backgrounds to ensure that we develop treatments that work for all patients. This is especially relevant given my research focus on sickle cell disease, a condition that directly impacts our patient population here at BMC, which has historically been undervalued and understudied. I have a unique skill set (gene editing, iPSCs, in vitro hematopoietic differentiation, single cell multi-omics) to bring to the problems and questions that we as a field need to address and I am eager to pass these skills on to the next generation of scientists. Mentoring budding researchers is one of the things that makes me most excited about working in academia. Moving forward as an independent investigator I hope to expand my role as a mentor and guide a diverse set of trainees on their journey of scientific exploration. I intend to do this in a nurturing environment while imprinting on them the values of scientific rigor and open source biology and reminding them of the responsibility that we have as researchers to improve the world around us in an equitable way.
To actively work towards a more equitable and diverse research environment, I have participated in an outreach program designed to introduce STEM concepts such as cell biology and coding to 4th and 5th graders at the Mother Caroline Academy in Dorchester as part of their after-school enrichment programming. This program was aimed at actively empowering future STEM students from diverse socioeconomic and racial backgrounds through regular interactions with a diverse team of researchers engaging in fun scientific challenges, thereby redefining (and challenging stereotypes of) what scientists look like. Realizing that talent is everywhere but resources are not, I have also functioned as an Instrumental Access Reviewer for Seeding Labs (Nonprofit Organization) for several years, screening applications from universities and research institutes around the world requesting the tools and equipment they need to fully participate in the global science community. Lastly to bring attention to the importance of diverse perspectives in academia, I have chaired the session on “Careers in stem cells, cell therapy and lung bioengineering” and moderated a panel discussion on “Women and Diversity in STEM” during the 2019 Vermont Lung Stem Cell and Bioengineering Conference in Burlington.
Center for Regenerative Medicine
Validation of a potential curative gene editing approach across the diverse sickle cell disease…
07/01/2020 - 06/30/2022 (PI)
National Blood Fdtn
Induced pluripotent stem cell (iPSC)-based modeling of beta thalassemia
07/01/2016 - 06/30/2017 (PI)
Cooleys Anemia Foundation
Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
to make corrections and additions.
Showing 10 of 21 results.
Sae-Lee W, McCafferty CL, Verbeke EJ, Havugimana PC, Papoulas O, McWhite CD, Houser JR, Vanuytsel K, Murphy GJ, Drew K, Emili A, Taylor DW, Marcotte EM. The protein organization of a red blood cell. Cell Rep. 2022 Jul 19; 40(3):111103.View Related Profiles. PMID: 35858567
Teo WW, Cao X, Wu CS, Tan HK, Zhou Q, Gao C, Vanuytsel K, Kumar SS, Murphy GJ, Yang H, Chai L, Tenen DG. Non-coding RNA LEVER sequestration of PRC2 can mediate long range gene regulation. Commun Biol. 2022 Apr 11; 5(1):343.View Related Profiles. PMID: 35411071; PMCID: PMC9001699; DOI: 10.1038/s42003-022-03250-x;
Vanuytsel K, Yeung AK, Dowrey TW, Murphy GJ, Belkina AC. Comprehensive phenotyping of hematopoietic stem and progenitor cells in the human fetal liver. Cytometry A. 2022 Mar 07.View Related Profiles. PMID: 35253987
Vanuytsel K, Villacorta-Martin C, Lindstrom-Vautrin J, Wang Z, Garcia-Beltran WF, Vrbanac V, Parsons D, Lam EC, Matte TM, Dowrey TW, Kumar SS, Li M, Wang F, Yeung AK, Mostoslavsky G, Dries R, Campbell JD, Belkina AC, Balazs AB, Murphy GJ. Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment. Nat Commun. 2022 03 01; 13(1):1103.View Related Profiles. PMID: 35232959; PMCID: PMC8888592; DOI: 10.1038/s41467-022-28616-x;
Wagner DE, Ikonomou L, Gilpin SE, Magin CM, Cruz F, Greaney A, Magnusson M, Chen YW, Davis B, Vanuytsel K, Rolandsson Enes S, Krasnodembskaya A, Lehmann M, Westergren-Thorsson G, Stegmayr J, Alsafadi HN, Hoffman ET, Weiss DJ, Ryan AL. Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019. ERJ Open Res. 2020 Oct; 6(4). PMID: 33123557; PMCID: PMC7569162; DOI: 10.1183/23120541.00123-2020;
Giadone RM, Mithal A, Miller GJ, Matte TM, Yeung AK, Dowrey TW, Werder RB, Miller NS, Andry CD, Vanuytsel K, Murphy GJ. qRT-PCR Platforms for Diagnosing and Reporting SARS-CoV-2 Infection in Human Samples. STAR Protoc. 2020 Sep 18; 1(2):100102.View Related Profiles. PMID: 32954369; PMCID: PMC7490627; DOI: 10.1016/j.xpro.2020.100102;
Vanuytsel K, Mithal A, Giadone RM, Yeung AK, Matte TM, Dowrey TW, Werder RB, Miller GJ, Miller NS, Andry CD, Murphy GJ. Rapid Implementation of a SARS-CoV-2 Diagnostic Quantitative Real-Time PCR Test with Emergency Use Authorization at a Large Academic Safety Net Hospital. Med (N Y). 2020 Dec 18; 1(1):152-157.e3.View Related Profiles. PMID: 32838351; PMCID: PMC7235561; DOI: 10.1016/j.medj.2020.05.001;
Vanuytsel K, Cai Q, Khurana S, Shetty S, Vermeesch JR, Ordovas L, Verfaillie CM. Corrigendum to "FANCA knockout in human embryonic stem cells causes a severe growth disadvantage" [Stem Cell Res.13/2 (2014) 240-50]. Stem Cell Res. 2020 04; 44:101763. PMID: 32199280
Vanuytsel K, Steinberg MH, Murphy GJ. In: Haruhisa Inoue, Yukio Nakamura (Eds.), Medical Applications of iPS Cells. Recapitulating Hematopoietic Development in a Dish. 2019; 45-71.
This graph shows the total number of publications by year, by first, middle/unknown,
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National Blood Foundation (NBF) Early-Career Scientific Research Grant
CTSI Integrated Pilot Award
CReM Award 2019
American Society of Hematology (ASH) Abstract Achievement Award
CReM Single Cell RNA Sequencing Grant Award
Cooley’s Anemia Foundation Research Fellowship
International Society for Stem Cell Research (ISSCR) Travel Award
2010-2014 Katholieke Universiteit Leuven:
IWT Strategic Basic Research Fund Fellowship Award