Dr. Kim Vanuytsel is a stem cell biologist with expertise in developmental hematopoiesis, red blood cell development and hematopoietic stem cell biology. As part of the research community at Boston University and Boston Medical Center, she has focused on developing tools and resources that help us understand important concepts in hematopoietic development with the goal of translating this knowledge into the realization of the immense potential that induced pluripotent stem cells (iPSCs) and hematopoietic stem cells hold for disease modeling and regenerative medicine.
With her work, Dr. Vanuytsel aims to find better solutions for patients suffering from blood disorders. To achieve this, her lab 1) studies hematopoietic development and the biology of blood stem cells to improve hematopoietic stem cell transplantation outcomes and 2) generates red blood cells from sickle cell disease patient-specific iPSCs to assess novel therapeutic options across the diverse patient population served at Boston Medical Center.
Diversity, Equity, Inclusion and Accessibility
I am very much inspired by and proud of our hospital’s mission “Exceptional care without exception” and I hope to reflect a similar inclusivity in my research as I strive to factor in our patient population’s diverse genetic backgrounds to ensure that we develop treatments that work for all patients. This is especially relevant given my research focus on sickle cell disease, a condition that directly impacts our patient population here at BMC, which has historically been undervalued and understudied. I have a unique skill set (gene editing, iPSCs, in vitro hematopoietic differentiation, single cell multi-omics) to bring to the problems and questions that we as a field need to address and I am eager to pass these skills on to the next generation of scientists. Mentoring budding researchers is one of the things that makes me most excited about working in academia. Moving forward as an independent investigator I hope to expand my role as a mentor and guide a diverse set of trainees on their journey of scientific exploration. I intend to do this in a nurturing environment while imprinting on them the values of scientific rigor and open source biology and reminding them of the responsibility that we have as researchers to improve the world around us in an equitable way.
To actively work towards a more equitable and diverse research environment, I have participated in an outreach program designed to introduce STEM concepts such as cell biology and coding to 4th and 5th graders at the Mother Caroline Academy in Dorchester as part of their after-school enrichment programming. This program was aimed at actively empowering future STEM students from diverse socioeconomic and racial backgrounds through regular interactions with a diverse team of researchers engaging in fun scientific challenges, thereby redefining (and challenging stereotypes of) what scientists look like. Realizing that talent is everywhere but resources are not, I have also functioned as an Instrumental Access Reviewer for Seeding Labs (Nonprofit Organization) for several years, screening applications from universities and research institutes around the world requesting the tools and equipment they need to fully participate in the global science community. Lastly to bring attention to the importance of diverse perspectives in academia, I have chaired the session on “Careers in stem cells, cell therapy and lung bioengineering” and moderated a panel discussion on “Women and Diversity in STEM” during the 2019 Vermont Lung Stem Cell and Bioengineering Conference in Burlington.
Member
Boston University
Center for Regenerative Medicine
This tab shows grant data from BMC Sponsored Research. It includes:
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- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data from BU Sponsored Research. It includes:
- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data that did not automatically get imported into Profiles
from BU or BMC sources.
- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data from the Boston VA. We are only showing grant title, and only for people in the role of PI.
Validation of a potential curative gene editing approach across the diverse sickle cell disease (SCD) patient population using induced pluripotent stem cells (iPSC)07/01/2020 - 06/30/2024 (PI)
National Blood Foundation
Induced pluripotent stem cell (iPSC)-based modeling of beta thalassemia07/01/2016 - 06/30/2017 (PI)
Cooleys Anemia Foundation
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Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
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Yeung AK, Villacorta-Martin C, Lindstrom-Vautrin J, Belkina AC, Vanuytsel K, Dowrey TW, Ysasi AB, Bawa P, Wang F, Vrbanac V, Mostoslavsky G, Balazs AB, Murphy GJ. De novo hematopoiesis from the fetal lung. Blood Adv. 2023 Nov 28; 7(22):6898-6912.View Related Profiles. PMID: 37729429; PMCID: PMC10685174; DOI: 10.1182/bloodadvances.2022008347;
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Sae-Lee W, McCafferty CL, Verbeke EJ, Havugimana PC, Papoulas O, McWhite CD, Houser JR, Vanuytsel K, Murphy GJ, Drew K, Emili A, Taylor DW, Marcotte EM. The protein organization of a red blood cell. Cell Rep. 2022 Jul 19; 40(3):111103.View Related Profiles. PMID: 35858567; PMCID: PMC9764456; DOI: 10.1016/j.celrep.2022.111103;
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Teo WW, Cao X, Wu CS, Tan HK, Zhou Q, Gao C, Vanuytsel K, Kumar SS, Murphy GJ, Yang H, Chai L, Tenen DG. Non-coding RNA LEVER sequestration of PRC2 can mediate long range gene regulation. Commun Biol. 2022 Apr 11; 5(1):343.View Related Profiles. PMID: 35411071; PMCID: PMC9001699; DOI: 10.1038/s42003-022-03250-x;
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Vanuytsel K, Yeung AK, Dowrey TW, Murphy GJ, Belkina AC. CPHEN-013: Comprehensive phenotyping of hematopoietic stem and progenitor cells in the human fetal liver. Cytometry A. 2022 Nov; 101(11):903-908.View Related Profiles. PMID: 35253987
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Vanuytsel K, Villacorta-Martin C, Lindstrom-Vautrin J, Wang Z, Garcia-Beltran WF, Vrbanac V, Parsons D, Lam EC, Matte TM, Dowrey TW, Kumar SS, Li M, Wang F, Yeung AK, Mostoslavsky G, Dries R, Campbell JD, Belkina AC, Balazs AB, Murphy GJ. Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment. Nat Commun. 2022 03 01; 13(1):1103.View Related Profiles. PMID: 35232959; PMCID: PMC8888592; DOI: 10.1038/s41467-022-28616-x;
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Wagner DE, Ikonomou L, Gilpin SE, Magin CM, Cruz F, Greaney A, Magnusson M, Chen YW, Davis B, Vanuytsel K, Rolandsson Enes S, Krasnodembskaya A, Lehmann M, Westergren-Thorsson G, Stegmayr J, Alsafadi HN, Hoffman ET, Weiss DJ, Ryan AL. Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019. ERJ Open Res. 2020 Oct; 6(4). PMID: 33123557; PMCID: PMC7569162; DOI: 10.1183/23120541.00123-2020;
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Giadone RM, Mithal A, Miller GJ, Matte TM, Yeung AK, Dowrey TW, Werder RB, Miller NS, Andry CD, Vanuytsel K, Murphy GJ. qRT-PCR Platforms for Diagnosing and Reporting SARS-CoV-2 Infection in Human Samples. STAR Protoc. 2020 Sep 18; 1(2):100102.View Related Profiles. PMID: 32954369; PMCID: PMC7490627; DOI: 10.1016/j.xpro.2020.100102;
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Vanuytsel K, Mithal A, Giadone RM, Yeung AK, Matte TM, Dowrey TW, Werder RB, Miller GJ, Miller NS, Andry CD, Murphy GJ. Rapid Implementation of a SARS-CoV-2 Diagnostic Quantitative Real-Time PCR Test with Emergency Use Authorization at a Large Academic Safety Net Hospital. Med (N Y). 2020 Dec 18; 1(1):152-157.e3.View Related Profiles. PMID: 32838351; PMCID: PMC7235561; DOI: 10.1016/j.medj.2020.05.001;
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Vanuytsel K, Cai Q, Khurana S, Shetty S, Vermeesch JR, Ordovas L, Verfaillie CM. Corrigendum to "FANCA knockout in human embryonic stem cells causes a severe growth disadvantage" [Stem Cell Res.13/2 (2014) 240-50]. Stem Cell Res. 2020 04; 44:101763. PMID: 32199280
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Showing 10 of 22 results.
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Vanuytsel K, Steinberg MH, Murphy GJ. In: Haruhisa Inoue, Yukio Nakamura (Eds.), Medical Applications of iPS Cells. Recapitulating Hematopoietic Development in a Dish. 2019; 45-71.
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Leung A, Zulick E, Skvir N, Vanuytsel K, Morrison TA, Naing ZH, Wang Z, Dai Y, Chui DHK, Steinberg MH, Sherr DH, Murphy GJ. Notch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells. Stem Cells. 2018 07; 36(7):1004-1019.View Related Profiles. PMID: 29569827; PMCID: PMC6099224; DOI: 10.1002/stem.2822;
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Ordovás L, Boon R, Pistoni M, Chen Y, Wolfs E, Guo W, Sambathkumar R, Bobis-Wozowicz S, Helsen N, Vanhove J, Berckmans P, Cai Q, Vanuytsel K, Eggermont K, Vanslembrouck V, Schmidt BZ, Raitano S, Van Den Bosch L, Nahmias Y, Cathomen T, Struys T, Verfaillie CM. Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition. Stem Cell Reports. 2018 02 13; 10(2):673. PMID: 29444475; PMCID: PMC5830959; DOI: 10.1016/j.stemcr.2018.01.034;
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Park S, Gianotti-Sommer A, Molina-Estevez FJ, Vanuytsel K, Skvir N, Leung A, Rozelle SS, Shaikho EM, Weir I, Jiang Z, Luo HY, Chui DHK, Figueiredo MS, Alsultan A, Al-Ali A, Sebastiani P, Steinberg MH, Mostoslavsky G, Murphy GJ. A Comprehensive, Ethnically Diverse Library of Sickle Cell Disease-Specific Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 Apr 11; 8(4):1076-1085.View Related Profiles. PMID: 28111279; PMCID: PMC5390092; DOI: 10.1016/j.stemcr.2016.12.017;
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Ordovás L, Boon R, Pistoni M, Chen Y, Sambathkumar R, Helsen N, Vanhove J, Berckmans P, Cai Q, Vanuytsel K, Raitano S, Verfaillie CM. Rapid and Efficient Generation of Recombinant Human Pluripotent Stem Cells by Recombinase-mediated Cassette Exchange in the AAVS1 Locus. J Vis Exp. 2016 11 20; (117). PMID: 27911376; PMCID: PMC5226264; DOI: 10.3791/54718;
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Ordovás L, Boon R, Pistoni M, Chen Y, Wolfs E, Guo W, Sambathkumar R, Bobis-Wozowicz S, Helsen N, Vanhove J, Berckmans P, Cai Q, Vanuytsel K, Eggermont K, Vanslembrouck V, Schmidt BZ, Raitano S, Van Den Bosch L, Nahmias Y, Cathomen T, Struys T, Verfaillie CM. Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition. Stem Cell Reports. 2015 Nov 10; 5(5):918-931. PMID: 26455413; PMCID: PMC4649136; DOI: 10.1016/j.stemcr.2015.09.004;
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Raitano S, Ordovàs L, De Muynck L, Guo W, Espuny-Camacho I, Geraerts M, Khurana S, Vanuytsel K, Tóth BI, Voets T, Vandenberghe R, Cathomen T, Van Den Bosch L, Vanderhaeghen P, Van Damme P, Verfaillie CM. Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia. Stem Cell Reports. 2015 Jan 13; 4(1):16-24. PMID: 25556567; PMCID: PMC4297877; DOI: 10.1016/j.stemcr.2014.12.001;
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Vanuytsel K, Cai Q, Nair N, Khurana S, Shetty S, Vermeesch JR, Ordovas L, Verfaillie CM. FANCA knockout in human embryonic stem cells causes a severe growth disadvantage. Stem Cell Res. 2014 Sep; 13(2):240-50. PMID: 25108529; DOI: 10.1016/j.scr.2014.07.005;
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Cai Q, Bonfanti P, Sambathkumar R, Vanuytsel K, Vanhove J, Gysemans C, Debiec-Rychter M, Raitano S, Heimberg H, Ordovas L, Verfaillie CM. Prospectively isolated NGN3-expressing progenitors from human embryonic stem cells give rise to pancreatic endocrine cells. Stem Cells Transl Med. 2014 Apr; 3(4):489-99. PMID: 24493854; PMCID: PMC3973709; DOI: 10.5966/sctm.2013-0078;
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Roobrouck VD, Vanuytsel K, Verfaillie CM. Concise review: culture mediated changes in fate and/or potency of stem cells. Stem Cells. 2011 Apr; 29(4):583-9. PMID: 21305670; DOI: 10.1002/stem.603;
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Roelandt P, Pauwelyn KA, Sancho-Bru P, Subramanian K, Bose B, Ordovas L, Vanuytsel K, Geraerts M, Firpo M, De Vos R, Fevery J, Nevens F, Hu WS, Verfaillie CM. Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS One. 2010 Aug 11; 5(8):e12101. PMID: 20711405; PMCID: PMC2920330; DOI: 10.1371/journal.pone.0012101;
This graph shows the total number of publications by year, by first, middle/unknown,
or last author.
| Year | Publications |
|---|
| 2010 | 1 |
| 2011 | 1 |
| 2014 | 3 |
| 2015 | 1 |
| 2016 | 1 |
| 2017 | 1 |
| 2018 | 3 |
| 2019 | 2 |
| 2020 | 4 |
| 2022 | 4 |
| 2023 | 1 |
2020-2022 BUSM:
National Blood Foundation (NBF) Early-Career Scientific Research Grant
2020 BUSM:
CTSI Integrated Pilot Award
2019 BUSM:
CReM Award 2019
2017 BUSM:
American Society of Hematology (ASH) Abstract Achievement Award
2017 BUSM:
CReM Single Cell RNA Sequencing Grant Award
2016 BUSM:
Cooley’s Anemia Foundation Research Fellowship
2015 BUSM:
International Society for Stem Cell Research (ISSCR) Travel Award
2010-2014 Katholieke Universiteit Leuven:
IWT Strategic Basic Research Fund Fellowship Award