Junghee Lee, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Neurology

PhD, Kangwon National University
MS, Kangwon National University
BS, Kangwon National University



Dr. Junghee Lee is Assistant Professor of Neurology at Boston University (BU) Chobanian & Avedisian School of Medicine and Principal Investigator at BU Alzheimer’s Disease Research Center (ADRC). As a postdoctoral fellow in the Department of Neurology at Harvard Medical School and Beth Israel Deaconess Medical Center, Dr. Lee carried out intensive research projects related to oxidative stress and neuronal gene regulation using cell lines, primary cortical neurons, and astrocytes from rodent animal models of various neurodegenerative disorders. As a junior faculty at Boston University, she established translational studies that focus on in vivo mechanisms and therapeutic applications in animal models of neurodegenerative diseases such as Alzheimer’s Disease (AD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS). Dr. Lee joined VA Bedford as a research scientist in 2003 and moved to VA Boston Healthcare System in 2008 where she has been managing an active research laboratory as the PI of NIH R01 grant. Dr. Lee’s research lab, Laboratory for Neuronal Injury and Inflammation has established various advanced skills and resources for studying cellular and molecular neurodegenerative mechanisms including neuronal gene regulation and epigenetic modifications in pre-existing cell lines and animal models of neurodegeneration as well as in human postmortem brains and spinal cords.

Research Interests:
Epigenetic mechanisms of neurodegeneration in HD, ALS, and AD: Epigenetic mechanisms are associated with the pathogenesis of neurodegenerative disorders. The identification of new epigenetic mechanisms and markers will lead to the development of novel therapeutics for the treatment of neurodegenerative disorders. Epigenetics is one of Dr. Lee’s major research interests. Her lab has investigated the association of epigenetic mechanisms with HD, ALS, and AD. Her previous and recent findings provide fundamental components that can be translated into epigenetic therapy to treat neurodegenerative disorders. In addition, she found that deregulation of SIRT3, a mitochondrial histone deacetylase, is linked to mitochondrial dysfunction in AD via mitochondrial p53 and mitochondrial transcription-dependent manner.


Personnel Agreement for Research Services of Junghee Lee
10/20/2024 - 10/19/2026 (PI)
VA Boston Healthcare System


Modulation of neuronal atrophy in Huntington's disease
09/01/2018 - 08/31/2025 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS109537-05

Personnel Agreement for Research Services of Junghee Lee
02/01/2011 - 09/14/2014 (Key Person)
PI: Neil W. Kowall, MD
VA Boston Healthcare System


Mechanisms of Arginine-Mediated Neuroprotection
01/01/2008 - 12/31/2009 (PI)
Les Turner ALS Foundation



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Giong HK, Hyeon SJ, Lee JG, Cho HJ, Park U, Stein TD, Lee J, Yu K, Ryu H, Lee JS. Tau accumulation is cleared by the induced expression of VCP via autophagy. Acta Neuropathol. 2024 Sep 24; 148(1):46.View Related Profiles. PMID: 39316141; PMCID: PMC11422276; DOI: 10.1007/s00401-024-02804-z;
     
  2. Kim S, Chun H, Kim Y, Kim Y, Park U, Chu J, Bhalla M, Choi SH, Yousefian-Jazi A, Kim S, Hyeon SJ, Kim S, Kim Y, Ju YH, Lee SE, Lee H, Lee K, Oh SJ, Hwang EM, Lee J, Lee CJ, Ryu H. Astrocytic autophagy plasticity modulates Aß clearance and cognitive function in Alzheimer's disease. Mol Neurodegener. 2024 Jul 23; 19(1):55.View Related Profiles. PMID: 39044253; PMCID: PMC11267931; DOI: 10.1186/s13024-024-00740-w;
     
  3. Yousefian-Jazi A, Kim S, Choi SH, Chu J, Nguyen PT, Park U, Lim K, Hwang H, Lee K, Kim Y, Hyeon SJ, Rhim H, Ryu HL, Lim G, Stein TD, Ryu H, Lee J. Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice. bioRxiv. 2024 Jul 17.View Related Profiles. PMID: 39071309; PMCID: PMC11275751; DOI: 10.1101/2024.07.15.603186;
     
  4. Heo JY, Park AH, Lee MJ, Ryu MJ, Kim YK, Jang YS, Kim SJ, Shin SY, Son HJ, Stein TD, Huh YH, Chung SK, Choi SY, Kim JM, Hwang O, Shong M, Hyeon SJ, Lee J, Ryu H, Kim D, Kweon GR. Correction: Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism. Mol Psychiatry. 2023 Oct; 28(10):4485.View Related Profiles. PMID: 37783789
     
  5. Jung JW, Kim H, Park J, Woo J, Jeon E, Lee G, Park M, Kim S, Seo H, Cheon S, Dan K, Lee J, Ryu H, Han D. In-depth proteome analysis of brain tissue from Ewsr1 knockout mouse by multiplexed isobaric tandem mass tag labeling. Sci Rep. 2023 Sep 14; 13(1):15261.View Related Profiles. PMID: 37709831; PMCID: PMC10502055; DOI: 10.1038/s41598-023-42161-7;
     
  6. Heo JY, Park AH, Lee MJ, Ryu MJ, Kim YK, Jang YS, Kim SJ, Shin SY, Son HJ, Stein TD, Huh YH, Chung SK, Choi SY, Kim JM, Hwang O, Shong M, Hyeon SJ, Lee J, Ryu H, Kim D, Kweon GR. Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism. Mol Psychiatry. 2023 Oct; 28(10):4474-4484.View Related Profiles. PMID: 37648779
     
  7. Lim S, Shin S, Sung Y, Lee HE, Kim KH, Song JY, Lee GH, Aziz H, Lukianenko N, Kang DM, Boesen N, Jeong H, Abdildinova A, Lee J, Yu BY, Lim SM, Lee JS, Ryu H, Pae AN, Kim YK. Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in TauP301L-BiFC mice. Exp Mol Med. 2023 Mar; 55(3):612-627.View Related Profiles. PMID: 36914856; PMCID: PMC10073126; DOI: 10.1038/s12276-023-00959-5;
     
  8. Choi SH, Yousefian-Jazi A, Hyeon SJ, Nguyen PTT, Chu J, Kim S, Kim S, Ryu HL, Kowall NW, Ryu H, Lee J. Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropathology in a mouse model of ALS. J Biomed Sci. 2022 Dec 20; 29(1):106.View Related Profiles. PMID: 36536341; PMCID: PMC9764677; DOI: 10.1186/s12929-022-00890-3;
     
  9. Lee HN, Hyeon SJ, Kim H, Sim KM, Kim Y, Ju J, Lee J, Wang Y, Ryu H, Seong J. Decreased FAK activity and focal adhesion dynamics impair proper neurite formation of medium spiny neurons in Huntington's disease. Acta Neuropathol. 2022 Sep; 144(3):521-536.View Related Profiles. PMID: 35857122
     
  10. Lee J, Kim S, Kim YH, Park U, Lee J, McKee AC, Kim KH, Ryu H, Lee J. Non-Targeted Metabolomics Approach Revealed Significant Changes in Metabolic Pathways in Patients with Chronic Traumatic Encephalopathy. Biomedicines. 2022 Jul 15; 10(7).View Related Profiles. PMID: 35885023; PMCID: PMC9313062; DOI: 10.3390/biomedicines10071718;
     
Showing 10 of 74 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 74 publications over 26 distinct years, with a maximum of 6 publications in 2013

YearPublications
19972
20002
20011
20022
20034
20043
20053
20062
20071
20082
20094
20102
20112
20123
20136
20142
20152
20163
20174
20182
20192
20205
20214
20224
20234
20243


Breakthrough Alzheimer’s Discovery: Scientists Discover New Treatment Path

SciTechDaily 10/9/2024

New insights into astrocytes offer hope for Alzheimer's treatment

MSN 9/30/2024

2018 RO1 Grant Award from NINDS
2011 Boston University: BU-CMD Ignition Award
2008 Les Turner Amyotrophic Lateral Sclerosis (ALS) Foundation: Research Grant Award
2004 Alzheimer’s Disease Core Center (ADC): Young Investigator Pilot Award
2000 Korea Science and Engineering Foundation: Postdoc Fellowship Award
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Epigenetics
Neurodegeneration
Inflammation
Alzheimer's Disease
Amyotrophic Lateral Sclerosis
Huntington's Disease
Neuron
Astrocyte

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