Junghee Lee, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine

PhD, Kangwon National University
MS, Kangwon National University
BS, Kangwon National University

Dr. Junghee Lee received her PhD in Neuroimmunology from Kangwon National University. She had a predoctoral fellowship at Dana-Farber Cancer Institute and completed a postdoctoral research fellowship at the Department of Neurology at Beth Israel Deaconess Medical Center and Harvard Medical School in 2004. She joined Chobanian and Avedisian School of Medicine’s Department of Neurology in 2005 as an Assistant Research Professor. Now she is an investigator at the Boston University Alzheimer’s Disease Center and VA Boston Healthcare System. She works on the mechanisms of neuroinflammation in brain disorders. She has published over 55 original research papers.

Modulation of neuronal atrophy in Huntington's disease
09/01/2018 - 08/31/2024 (PI)
NIH/National Institute of Neurological Disorders & Stroke

Personnel Agreement for Research Services of Junghee Lee
02/01/2011 - 09/14/2014 (Key Person)
PI: Neil W. Kowall, MD
VA Boston Healthcare System

Mechanisms of Arginine-Mediated Neuroprotection
01/01/2008 - 12/31/2009 (PI)
Les Turner ALS Foundation


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Kim YH, Shim HS, Kim KH, Lee J, Chung BC, Kowall NW, Ryu H, Lee J. Metabolomic Analysis Identifies Alterations of Amino Acid Metabolome Signatures in the Postmortem Brain of Alzheimer's Disease. Exp Neurobiol. 2019 Jun; 28(3):376-389.View Related Profiles. PMID: 31308797; PMCID: PMC6614073; DOI: 10.5607/en.2019.28.3.376;
  2. Yoon Y, Park H, Kim S, Nguyen PT, Hyeon SJ, Chung S, Im H, Lee J, Lee SB, Ryu H. Genetic Ablation of EWS RNA Binding Protein 1 (EWSR1) Leads to Neuroanatomical Changes and Motor Dysfunction in Mice. Exp Neurobiol. 2018 Apr; 27(2):103-111.View Related Profiles. PMID: 29731676; PMCID: PMC5934541; DOI: 10.5607/en.2018.27.2.103;
  3. Lee J, Kim Y, Liu T, Hwang YJ, Hyeon SJ, Im H, Lee K, Alvarez VE, McKee AC, Um SJ, Hur M, Mook-Jung I, Kowall NW, Ryu H. SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease. Aging Cell. 2018 02; 17(1).View Related Profiles. PMID: 29130578; PMCID: PMC5771400; DOI: 10.1111/acel.12679;
  4. Park KS, Kim MK, Seo Y, Ha T, Yoo K, Hyeon SJ, Hwang YJ, Lee J, Ryu H, Choo H, Chong Y. A Difluoroboron ß-Diketonate Probe Shows "Turn-on" Near-Infrared Fluorescence Specific for Tau Fibrils. ACS Chem Neurosci. 2017 Oct 18; 8(10):2124-2131.View Related Profiles. PMID: 28737890
  5. Lee J, Hwang YJ, Kim Y, Lee MY, Hyeon SJ, Lee S, Kim DH, Jang SJ, Im H, Min SJ, Choo H, Pae AN, Kim DJ, Cho KS, Kowall NW, Ryu H. Remodeling of heterochromatin structure slows neuropathological progression and prolongs survival in an animal model of Huntington's disease. Acta Neuropathol. 2017 Nov; 134(5):729-748.View Related Profiles. PMID: 28593442
  6. Seo JS, Lee S, Shin JY, Hwang YJ, Cho H, Yoo SK, Kim Y, Lim S, Kim YK, Hwang EM, Kim SH, Kim CH, Hyeon SJ, Yun JY, Kim J, Kim Y, Alvarez VE, Stein TD, Lee J, Kim DJ, Kim JI, Kowall NW, Ryu H, McKee AC. Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy. Exp Mol Med. 2017 05 19; 49(5):e333.View Related Profiles. PMID: 28524178; PMCID: PMC5454448; DOI: 10.1038/emm.2017.56;
  7. Lee J, Hyeon SJ, Im H, Ryu H, Kim Y, Ryu H. Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS. Exp Neurobiol. 2016 Oct; 25(5):233-240.View Related Profiles. PMID: 27790057; PMCID: PMC5081469; DOI: 10.5607/en.2016.25.5.233;
  8. Seo Y, Park KS, Ha T, Kim MK, Hwang YJ, Lee J, Ryu H, Choo H, Chong Y. A Smart Near-Infrared Fluorescence Probe for Selective Detection of Tau Fibrils in Alzheimer's Disease. ACS Chem Neurosci. 2016 Nov 16; 7(11):1474-1481.View Related Profiles. PMID: 27576176
  9. Lee CJ, Ahn H, Lee SB, Shin JY, Park WY, Kim JI, Lee J, Ryu H, Kim S. Integrated analysis of omics data using microRNA-target mRNA network and PPI network reveals regulation of Gnai1 function in the spinal cord of Ews/Ewsr1 KO mice. BMC Med Genomics. 2016 Aug 12; 9 Suppl 1:33.View Related Profiles. PMID: 27534535; PMCID: PMC4989891; DOI: 10.1186/s12920-016-0195-4;
  10. Kim Y, Lee J, Ryu H. Modulation of autophagy by miRNAs. BMB Rep. 2015 Jul; 48(7):371-2.View Related Profiles. PMID: 26129673; PMCID: PMC4577285; DOI: 10.5483/BMBRep.2015.48.7.121;
Showing 10 of 52 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 52 publications over 21 distinct years, with a maximum of 6 publications in 2013


2018 RO1 Grant Award from NINDS
2011 Boston University: BU-CMD Ignition Award
2008 Les Turner Amyotrophic Lateral Sclerosis (ALS) Foundation: Research Grant Award
2004 Alzheimer’s Disease Core Center (ADC): Young Investigator Pilot Award
2000 Korea Science and Engineering Foundation: Postdoc Fellowship Award
Contact for Mentoring:

150 S Huntington Avenue
Jamaica Plain MA 02130
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