Jeffrey L. Browning, PhD
Research Professor
Boston University School of Medicine
Dept of Microbiology

PhD, University of Wisconsin Madison




My interests focus on understanding how the immune system interacts with stromal elements to form the specialized structures that orchestrate immunological encounters in lymphoid organs. On a different plane, the barriers to effective quantitation of disease are formidable in some autoimmune diseases especially those with considerable unmet need such as lupus and scleroderma. I am interested in bringing new views onto the human immune system to improve clinical studies.

Mesenchymal cell differentiation pathways are intimately interwoven with pathological processes e.g. compromised vascular integrity, aberrant tissue remodeling and fibrosis and tumor-stromal interactions. In lymphoid organs, the lymphotoxin pathway, a TNF family member, is one mechanism by which both innate and adaptive lymphoid cells communicate with their stromal microenvironments. The maintenance of a differentiated follicular dendritic cell network to scaffold the B cell follicle is a well-studied example of this communication. More recently, it is clear that another network, the fibroblastoid reticular cell network, is a differentiated form of mural cells, e.g. pericytes or vascular smooth muscle cells. The precise role of the lymphotoxin pathway in controlling this structure is an area of investigation. As lymph nodes can undergo massive expansion in response to danger following by involution, they form an intriguing model of physiological tissue remodeling. Using this foundation, we have been studying the stromal underpinnings of the perivascular adventitial compartment. this compartment is considered crucial to harbor stem cells, tissue resident leucocytes and sense and initiate repair/remodelling efforts after injury. Human skin has provided an excellent tool to observe these stromal perivascular networks.

Research Professor
Boston University School of Medicine
Medicine
Rheumatology

Member
Boston University
Arthritis & Autoimmune Diseases Research Center


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Fibroblast activation foretells leukocyte infiltration and autoimmune attack on non-lymphoid organs
09/01/2018 - 08/31/2019 (PI)
The American Association of Immunologists


Modulation of DCLK1 and Related Pathways as Targets in Lupus Nephritis
08/21/2017 - 02/28/2019 (PI)
F. Hoffmann-La Roche, Ltd.


Biomarker based prediction models for response to treatment in systemic sclerosis related interstitial lung disease
09/15/2016 - 09/14/2018 (Subcontract PI)
University of Texas Health Science Center, Houston DOD Army Med Resrch




Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Skaug B, Khanna D, Swindell WR, Hinchcliff ME, Frech TM, Steen VD, Hant FN, Gordon JK, Shah AA, Zhu L, Zheng WJ, Browning JL, Barron AMS, Wu M, Visvanathan S, Baum P, Franks JM, Whitfield ML, Shanmugam VK, Domsic RT, Castelino FV, Bernstein EJ, Wareing N, Lyons MA, Ying J, Charles J, Mayes MD, Assassi S. Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile. Ann Rheum Dis. 2020 03; 79(3):379-386. PMID: 31767698
     
  2. Ho JD, Chung HJ, Ms Barron A, Ho DA, Sahni D, Browning JL, Bhawan J. Extensive CD34-to-CD90 Fibroblast Transition Defines Regions of Cutaneous Reparative, Hypertrophic, and Keloidal Scarring. Am J Dermatopathol. 2019 Jan; 41(1):16-28.View Related Profiles. PMID: 30320623
     
  3. Barron AMS, Mantero JC, Ho JD, Nazari B, Horback KL, Bhawan J, Lafyatis R, Lam C, Browning JL. Perivascular Adventitial Fibroblast Specialization Accompanies T Cell Retention in the Inflamed Human Dermis. J Immunol. 2019 01 01; 202(1):56-68.View Related Profiles. PMID: 30510068
     
  4. St Clair EW, Baer AN, Wei C, Noaiseh G, Parke A, Coca A, Utset TO, Genovese MC, Wallace DJ, McNamara J, Boyle K, Keyes-Elstein L, Browning JL, Franchimont N, Smith K, Guthridge JM, Sanz I, James JA. Clinical Efficacy and Safety of Baminercept, a Lymphotoxin ß Receptor Fusion Protein, in Primary Sjögren's Syndrome: Results From a Phase II Randomized, Double-Blind, Placebo-Controlled Trial. Arthritis Rheumatol. 2018 09; 70(9):1470-1480. PMID: 29604186
     
  5. Grzegorzewska AP, Seta F, Han R, Czajka CA, Makino K, Stawski L, Isenberg JS, Browning JL, Trojanowska M. Dimethyl Fumarate ameliorates pulmonary arterial hypertension and lung fibrosis by targeting multiple pathways. Sci Rep. 2017 02 02; 7:41605.View Related Profiles. PMID: 28150703; DOI: 10.1038/srep41605;
     
  6. Gardet A, Chou WC, Reynolds TL, Velez DB, Fu K, Czerkowicz JM, Bajko J, Ranger AM, Allaire N, Kerns HM, Ryan S, Legault HM, Dunstan RW, Lafyatis R, Lukashev M, Viney JL, Browning JL, Rabah D. Pristane-Accelerated Autoimmune Disease in (SWR X NZB) F1 Mice Leads to Prominent Tubulointerstitial Inflammation and Human Lupus Nephritis-Like Fibrosis. PLoS One. 2016; 11(10):e0164423.View Related Profiles. PMID: 27760209; DOI: 10.1371/journal.pone.0164423;
     
  7. Chia JJ, Zhu T, Chyou S, Dasoveanu DC, Carballo C, Tian S, Magro CM, Rodeo S, Spiera RF, Ruddle NH, McGraw TE, Browning JL, Lafyatis R, Gordon JK, Lu TT. Dendritic cells maintain dermal adipose-derived stromal cells in skin fibrosis. J Clin Invest. 2016 Nov 01; 126(11):4331-4345.View Related Profiles. PMID: 27721238; DOI: 10.1172/JCI85740;
     
  8. Nazari B, Rice LM, Stifano G, Barron AM, Wang YM, Korndorf T, Lee J, Bhawan J, Lafyatis R, Browning JL. Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90. Am J Pathol. 2016 Oct; 186(10):2650-64.View Related Profiles. PMID: 27565038; DOI: 10.1016/j.ajpath.2016.06.020;
     
  9. Mejías-Luque R, Zöller J, Anderl F, Loew-Gil E, Vieth M, Adler T, Engler DB, Urban S, Browning JL, Müller A, Gerhard M, Heikenwalder M. Lymphotoxin ß receptor signalling executes Helicobacter pylori-driven gastric inflammation in a T4SS-dependent manner. Gut. 2017 Aug; 66(8):1369-1381. PMID: 27196595; DOI: 10.1136/gutjnl-2015-310783;
     
  10. Seleznik G, Seeger H, Bauer J, Fu K, Czerkowicz J, Papandile A, Poreci U, Rabah D, Ranger A, Cohen CD, Lindenmeyer M, Chen J, Edenhofer I, Anders HJ, Lech M, Wüthrich RP, Ruddle NH, Moeller MJ, Kozakowski N, Regele H, Browning JL, Heikenwalder M, Segerer S. The lymphotoxin ß receptor is a potential therapeutic target in renal inflammation. Kidney Int. 2016 Jan; 89(1):113-26. PMID: 26398497; DOI: 10.1038/ki.2015.280;
     
Showing 10 of 121 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 121 publications over 32 distinct years, with a maximum of 9 publications in 1997

YearPublications
19862
19873
19881
19893
19903
19913
19924
19936
19944
19955
19966
19979
19986
19998
20005
20016
20024
20033
20053
20062
20081
20093
20102
20115
20124
20132
20146
20152
20165
20171
20182
20192

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

immune system
lupus
Systemic Sclerosis
perivascular adventitia

Available to Mentor as: (Review Mentor Role Definitions):
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  • Career Mentor
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  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
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