Jeffrey L. Browning, PhD
Research Professor
Boston University Chobanian & Avedisian School of Medicine
Virology, Immunology & Microbiology

PhD, University of Wisconsin Madison
BS, Michigan State University



My interests focus on understanding how the immune system interacts with stromal elements to form the specialized structures that orchestrate immunological encounters in lymphoid organs. On a different plane, the barriers to effective quantitation of disease are formidable in some autoimmune diseases especially those with considerable unmet need such as lupus and scleroderma. I am interested in bringing new views onto the human immune system to improve clinical studies.

Mesenchymal cell differentiation pathways are intimately interwoven with pathological processes e.g. compromised vascular integrity, aberrant tissue remodeling and fibrosis and tumor-stromal interactions. In lymphoid organs, the lymphotoxin pathway, a TNF family member, is one mechanism by which both innate and adaptive lymphoid cells communicate with their stromal microenvironments. The maintenance of a differentiated follicular dendritic cell network to scaffold the B cell follicle is a well-studied example of this communication. More recently, it is clear that another network, the fibroblastoid reticular cell network, is a differentiated form of mural cells, e.g. pericytes or vascular smooth muscle cells. The precise role of the lymphotoxin pathway in controlling this structure is an area of investigation. As lymph nodes can undergo massive expansion in response to danger following by involution, they form an intriguing model of physiological tissue remodeling. Using this foundation, we have been studying the stromal underpinnings of the perivascular adventitial compartment. this compartment is considered crucial to harbor stem cells, tissue resident leucocytes and sense and initiate repair/remodelling efforts after injury. Human skin has provided an excellent tool to observe these stromal perivascular networks.

Research Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Rheumatology

Member
Boston University
Arthritis & Autoimmune Diseases Research Center


Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




To optimise and perform immunofluorescence staining on Mestag's serial sections
04/10/2024 - 04/01/2026 (PI)
Mestag Therapeutics Limited


Fibroblast activation foretells leukocyte infiltration and autoimmune attack on non-lymphoid organs
09/01/2018 - 08/31/2019 (PI)
The American Association of Immunologists


Modulation of DCLK1 and Related Pathways as Targets in Lupus Nephritis
08/21/2017 - 02/28/2019 (PI)
F. Hoffmann-La Roche, Ltd.


Biomarker based prediction models for response to treatment in systemic sclerosis related interstitial lung disease
09/15/2016 - 09/14/2018 (Subcontract PI)
University of Texas Health Science Center, Houston DOD Army Med Resrch




Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Website       Copy PMIDs To Clipboard

  1. Adamski S, Ahn M, Barbeau PS, Belov V, Bernardi I, Bock C, Bolozdynya A, Bouabid R, Browning J, Cabrera-Palmer B, Cedarblade-Jones N, Colón Rivera AI, Conley E, da Silva V, Daughhetee J, Detwiler J, Ding K, Durand MR, Efremenko Y, Elliott SR, Erlandson A, Fabris L, Galindo-Uribarri A, Green MP, Hakenmüller J, Heath MR, Hedges S, Jeong H, Johnson BA, Johnson T, Jones H, Khromov A, Kim D, Konovalov A, Kozlova E, Kumpan A, Kyzylova O, Lee Y, Li G, Li L, Link JM, Liu J, Luxnat M, Major A, Mann K, Markoff DM, Mattingly J, Moye J, Mueller PE, Newby J, Ogoi N, O'Reilly J, Parno DS, Pérez-Loureiro D, Pershey D, Prior CG, Queen J, Rapp R, Ray H, Razuvaeva O, Reyna D, Rich GC, Rudik D, Runge J, Salvat DJ, Sander J, Scholberg K, Shakirov A, Simakov G, Snow WM, Sosnovtsev V, Stringer M, Subedi T, Suh B, Sur B, Tayloe R, Tellez-Giron-Flores K, Tsai YT, van Nieuwenhuizen EE, Virtue CJ, Visser G, Walkup K, Ward EM, Wongjirad T, Yang Y, Yoo J, Yu CH, Zaalishvili A. Evidence of Coherent Elastic Neutrino-Nucleus Scattering with COHERENT's Germanium Array. Phys Rev Lett. 2025 Jun 13; 134(23):231801. PMID: 40577756
     
  2. Modanwal G, Dhamdhere R, Khera A, de Lemos JA, Peshock R, Browning J, Joshi P, Neeland I, Al-Kindi S, Madabhushi A. QuLF-CT: A Radiomics-Based Tool for Quantification of Liver Fat Fraction on Cardiac CT. JACC Adv. 2024 Sep; 3(9):101175. PMID: 39372483; PMCID: PMC11450860; DOI: 10.1016/j.jacadv.2024.101175;
     
  3. Yamashita T, Kaplan U, Chakraborty A, Marden G, Gritli S, Roh D, Bujor A, Trojanowski M, Ligresti G, Browning JL, Trojanowska M. ERG Regulates Lymphatic Vessel Specification Genes and Its Deficiency Impairs Wound Healing-Associated Lymphangiogenesis. Arthritis Rheumatol. 2024 Nov; 76(11):1645-1657.View Related Profiles. PMID: 38965683; PMCID: PMC11521767; DOI: 10.1002/art.42944;
     
  4. Etesami NS, Barker KA, Shenoy AT, De Ana CL, Arafa EI, Grifno GN, Matschulat AM, Vannini ME, Pihl RMF, Breen MP, Soucy AM, Goltry WN, Ha CT, Betsuyaku H, Browning JL, Varelas X, Traber KE, Jones MR, Quinton LJ, Maglione PJ, Nia HT, Belkina AC, Mizgerd JP. B cells in the pneumococcus-infected lung are heterogeneous and require CD4+ T cell help including CD40L to become resident memory B cells. Front Immunol. 2024; 15:1382638.View Related Profiles. PMID: 38715601; PMCID: PMC11074383; DOI: 10.3389/fimmu.2024.1382638;
     
  5. Akimov D, An P, Awe C, Barbeau PS, Becker B, Belov V, Bernardi I, Blackston MA, Bock C, Bolozdynya A, Browning J, Cabrera-Palmer B, Chernyak D, Conley E, Daughhetee J, Detwiler J, Ding K, Durand MR, Efremenko Y, Elliott SR, Fabris L, Febbraro M, Gallo Rosso A, Galindo-Uribarri A, Green MP, Heath MR, Hedges S, Hoang D, Hughes M, Johnson T, Khromov A, Konovalov A, Kozlova E, Kumpan A, Li L, Link JM, Liu J, Mann K, Markoff DM, Mastroberti J, Mueller PE, Newby J, Parno DS, Penttila SI, Pershey D, Rapp R, Raybern J, Razuvaeva O, Reyna D, Rich GC, Ross J, Rudik D, Runge J, Salvat DJ, Salyapongse AM, Sander J, Scholberg K, Shakirov A, Simakov G, Sinev G, Snow WM, Sosnovtsev V, Suh B, Tayloe R, Tellez-Giron-Flores K, Tolstukhin I, Ujah E, Vanderwerp J, Varner RL, Virtue CJ, Visser G, Wongjirad T, Yen YR, Yoo J, Yu CH, Zettlemoyer J. First Probe of Sub-GeV Dark Matter beyond the Cosmological Expectation with the COHERENT CsI Detector at the SNS. Phys Rev Lett. 2023 Feb 03; 130(5):051803. PMID: 36800477
     
  6. Browning JL, Bhawan J, Tseng A, Crossland N, Bujor AM, Akassoglou K, Assassi S, Skaug B, Ho J. Extensive and Persistent Extravascular Dermal Fibrin Deposition Characterizes Systemic Sclerosis. bioRxiv. 2023 Jan 19.View Related Profiles. PMID: 36711912; PMCID: PMC9882194; DOI: 10.1101/2023.01.16.523256;
     
  7. Akimov D, An P, Awe C, Barbeau PS, Becker B, Belov V, Bernardi I, Blackston MA, Bock C, Bolozdynya A, Browning J, Cabrera-Palmer B, Chernyak D, Conley E, Daughhetee J, Detwiler J, Ding K, Durand MR, Efremenko Y, Elliott SR, Fabris L, Febbraro M, Gallo Rosso A, Galindo-Uribarri A, Green MP, Heath MR, Hedges S, Hoang D, Hughes M, Johnson T, Khromov A, Konovalov A, Kozlova E, Kumpan A, Li L, Link JM, Liu J, Mann K, Markoff DM, Mastroberti J, Mueller PE, Newby J, Parno DS, Penttila SI, Pershey D, Rapp R, Ray H, Raybern J, Razuvaeva O, Reyna D, Rich GC, Ross J, Rudik D, Runge J, Salvat DJ, Salyapongse AM, Scholberg K, Shakirov A, Simakov G, Sinev G, Snow WM, Sosnovstsev V, Suh B, Tayloe R, Tellez-Giron-Flores K, Tolstukhin I, Ujah E, Vanderwerp J, Varner RL, Virtue CJ, Visser G, Wongjirad T, Yen YR, Yoo J, Yu CH, Zettlemoyer J. Measurement of the Coherent Elastic Neutrino-Nucleus Scattering Cross Section on CsI by COHERENT. Phys Rev Lett. 2022 Aug 19; 129(8):081801. PMID: 36053683
     
  8. Nayar S, Pontarini E, Campos J, Berardicurti O, Smith CG, Asam S, Gardner DH, Colafrancesco S, Lucchesi D, Coleby R, Chung MM, Iannizzotto V, Hunter K, Bowman SJ, Carlesso G, Herbst R, McGettrick HM, Browning J, Buckley CD, Fisher BA, Bombardieri M, Barone F. Immunofibroblasts regulate LTa3 expression in tertiary lymphoid structures in a pathway dependent on ICOS/ICOSL interaction. Commun Biol. 2022 May 04; 5(1):413. PMID: 35508704; PMCID: PMC9068764; DOI: 10.1038/s42003-022-03344-6;
     
  9. Gommerman JL, Browning JL. Queen's Gambit: B Cell to Follicle. J Immunol. 2021 08 01; 207(3):753-754. PMID: 34321285
     
  10. Barker KA, Etesami NS, Shenoy AT, Arafa EI, Lyon de Ana C, Smith NM, Martin IM, Goltry WN, Barron AM, Browning JL, Kathuria H, Belkina AC, Guillon A, Zhong X, Crossland NA, Jones MR, Quinton LJ, Mizgerd JP. Lung-resident memory B cells protect against bacterial pneumonia. J Clin Invest. 2021 06 01; 131(11).View Related Profiles. PMID: 34060477; PMCID: PMC8159694; DOI: 10.1172/JCI141810;
     
Showing 10 of 132 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 132 publications over 38 distinct years, with a maximum of 9 publications in 1997

YearPublications
19862
19873
19881
19893
19903
19913
19924
19936
19944
19955
19966
19979
19986
19998
20005
20016
20024
20033
20053
20062
20081
20093
20102
20115
20124
20132
20146
20152
20165
20171
20182
20192
20201
20212
20222
20232
20243
20251

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

immune system
lupus
Systemic Sclerosis
perivascular adventitia

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
Google Map

617.638.3979
Download vCard

Browning's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
See all (649) concept(s)
_
Co-Authors
See all (26) people
_
Similar People
See all (60) people
_
Same Department
Search Department