Giovanni Ligresti,PhD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Rheumatology

PhD, University of Trieste
MS, University of Trieste




My laboratory focuses on lung repair and pulmonary fibrosis. We are currently investigating molecular mechanisms implicated in the differentiation of lung fibroblasts into myofibroblasts during lung fibrosis, with particular emphasis on transcriptional and epigenetic mechanisms driving persistent fibrogenesis in idiopathic pulmonary fibrosis (IPF). We have recently discovered that in the lung, myofibroblast differentiation occurs through the engagement of chromatin modifier enzymes and epigenetic readers. We found that the histone methyltransferase G9a and the epigenetic reader CBX5 play a critical role in lung fibroblast activation, and that targeting these epigenetic modifiers enhanced mitochondrial function, blocked ECM protein secretion, and attenuated lung fibrogenesis.
In addition, my laboratory is interested in investigating the impact of aging on the development of pulmonary fibrosis. We have recently discovered that the endothelium of aged mouse lungs is dysfunctional and this abnormality leads to capillary loss and persistent lung fibrosis following injury. Using a multi-omics approach (RNA-seq, ATAC-seq, and scRNA-seq) we have identified transcriptional programs in lung endothelial cells orchestrating lung vascular repair and whose abnormal activation with aging leads to persistent lung fibrosis.

Member
Boston University
Pulmonary Center


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Targeting vascular dysfunction to promote lung repair and fibrosis resolution
03/05/2022 - 02/28/2026 (PI)
NIH/National Heart, Lung, and Blood Institute
1R01HL158733-01A1

Epigenetic gene repression in pulmonary fibrosis
09/18/2019 - 06/30/2023 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL142596-04



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Caporarello N, Lee J, Pham TX, Jones DL, Guan J, Link PA, Meridew JA, Marden G, Yamashita T, Osborne CA, Bhagwate AV, Huang SK, Nicosia RF, Tschumperlin DJ, Trojanowska M, Ligresti G. Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis. Nat Commun. 2022 Jul 25; 13(1):4170.View Related Profiles. PMID: 35879310; PMCID: PMC9314350; DOI: 10.1038/s41467-022-31890-4;
     
  2. Ligresti G, Pham TX, Sanders YY. Circular RNA Methylation: A New Twist in Lung Fibrosis. Am J Respir Cell Mol Biol. 2022 May; 66(5):471-472.View Related Profiles. PMID: 35238732; PMCID: PMC9116359; DOI: 10.1165/rcmb.2022-0044ED;
     
  3. Pham TX, Lee J, Guan J, Caporarello N, Meridew JA, Jones DL, Tan Q, Huang SK, Tschumperlin DJ, Ligresti G. Transcriptional analysis of lung fibroblasts identifies PIM1 signaling as a driver of aging-associated persistent fibrosis. JCI Insight. 2022 Mar 22; 7(6).View Related Profiles. PMID: 35167499; PMCID: PMC8986080; DOI: 10.1172/jci.insight.153672;
     
  4. Ring NAR, Volpe MC, Stepišnik T, Mamolo MG, Panov P, Kocev D, Vodret S, Fortuna S, Calabretti A, Rehman M, Colliva A, Marchesan P, Camparini L, Marcuzzo T, Bussani R, Scarabellotto S, Confalonieri M, Pham TX, Ligresti G, Caporarello N, Loffredo FS, Zampieri D, Džeroski S, Zacchigna S. Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis through inhibition of myofibroblast differentiation. Cell Death Dis. 2021 12 17; 13(1):2.View Related Profiles. PMID: 34916483; PMCID: PMC8677786; DOI: 10.1038/s41419-021-04439-4;
     
  5. Nicosia RF, Ligresti G, Caporarello N, Akilesh S, Ribatti D. COVID-19 Vasculopathy: Mounting Evidence for an Indirect Mechanism of Endothelial Injury. Am J Pathol. 2021 08; 191(8):1374-1384. PMID: 34033751; PMCID: PMC8141344; DOI: 10.1016/j.ajpath.2021.05.007;
     
  6. Jones DL, Meridew JA, Link PA, Ducharme MT, Lydon KL, Choi KM, Caporarello N, Tan Q, Diaz Espinosa AM, Xiong Y, Lee JH, Ye Z, Yan H, Ordog T, Ligresti G, Varelas X, Tschumperlin DJ. ZNF416 is a pivotal transcriptional regulator of fibroblast mechanoactivation. J Cell Biol. 2021 05 03; 220(5).View Related Profiles. PMID: 33625469; PMCID: PMC7918622; DOI: 10.1083/jcb.202007152;
     
  7. Tan Q, Link PA, Meridew JA, Pham TX, Caporarello N, Ligresti G, Tschumperlin DJ. Spontaneous Lung Fibrosis Resolution Reveals Novel Antifibrotic Regulators. Am J Respir Cell Mol Biol. 2021 04; 64(4):453-464.View Related Profiles. PMID: 33493091; PMCID: PMC8008802; DOI: 10.1165/rcmb.2020-0396OC;
     
  8. Fortier SM, Penke LR, King D, Pham TX, Ligresti G, Peters-Golden M. Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions. JCI Insight. 2021 03 22; 6(6).View Related Profiles. PMID: 33561015; PMCID: PMC8026183; DOI: 10.1172/jci.insight.144799;
     
  9. Ji S, Traini C, Mischopoulou M, Gibbons SJ, Ligresti G, Faussone-Pellegrini MS, Sha L, Farrugia G, Vannucchi MG, Cipriani G. Muscularis macrophages establish cell-to-cell contacts with telocytes/PDGFRa-positive cells and smooth muscle cells in the human and mouse gastrointestinal tract. Neurogastroenterol Motil. 2021 03; 33(3):e13993. PMID: 33020982; PMCID: PMC7902307; DOI: 10.1111/nmo.13993;
     
  10. Vivarelli S, Falzone L, Ligresti G, Candido S, Garozzo A, Magro GG, Bonavida B, Libra M. Role of the Transcription Factor Yin Yang 1 and Its Selectively Identified Target Survivin in High-Grade B-Cells Non-Hodgkin Lymphomas: Potential Diagnostic and Therapeutic Targets. Int J Mol Sci. 2020 Sep 03; 21(17). PMID: 32899428; PMCID: PMC7504013; DOI: 10.3390/ijms21176446;
     
Showing 10 of 51 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 51 publications over 16 distinct years, with a maximum of 7 publications in 2019

YearPublications
20061
20072
20085
20092
20102
20114
20123
20133
20152
20161
20174
20183
20197
20204
20215
20223
Contact for Mentoring:

72 East Concord Street
Boston MA 02118
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