Giovanni Ligresti | Profiles RNS

Giovanni Ligresti,PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Rheumatology

PhD, University of Trieste
MS, University of Trieste
BS, University of Trieste

Websites

	Pulmonary Center
	LinkedIn
	ResearchGate
	Google Scholar

ORCID : 0000-0002-3375-8665

My laboratory focuses on lung repair and pulmonary fibrosis. We are currently investigating molecular mechanisms implicated in the differentiation of lung fibroblasts into myofibroblasts during lung fibrosis, with particular emphasis on transcriptional and epigenetic mechanisms driving persistent fibrogenesis in idiopathic pulmonary fibrosis (IPF). We have recently discovered that in the lung, myofibroblast differentiation occurs through the engagement of chromatin modifier enzymes and epigenetic readers. We found that the histone methyltransferase G9a and the epigenetic reader CBX5 play a critical role in lung fibroblast activation, and that targeting these epigenetic modifiers enhanced mitochondrial function, blocked ECM protein secretion, and attenuated lung fibrogenesis.
In addition, my laboratory is interested in investigating the impact of aging on the development of pulmonary fibrosis. We have recently discovered that the endothelium of aged mouse lungs is dysfunctional and this abnormality leads to capillary loss and persistent lung fibrosis following injury. Using a multi-omics approach (RNA-seq, ATAC-seq, and scRNA-seq) we have identified transcriptional programs in lung endothelial cells orchestrating lung vascular repair and whose abnormal activation with aging leads to persistent lung fibrosis.

Member
Boston University
Pulmonary Center

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research

Targeting the alveolar vascular niche to promote fibrosis resolution
07/01/2025 - 06/30/2027 (Key Person / Mentor)
PI: Ahmed A. Raslan, PhD
American Lung Association

Heterogeneity and Regulation of the DNA Methylome in IPF Mesenchymal Cells
02/01/2023 - 11/30/2026 (Subcontract PI)
Regents of the University of Michigan NIH NHLBI
5R01HL162963-03

Targeting vascular dysfunction to promote lung repair and fibrosis resolution
03/05/2022 - 02/28/2026 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL158733-04

Targeting pathogenic venous endothelial cells in pulmonary fibrosis
02/05/2024 - 02/05/2026 (PI)
Ono Pharmaceutical Co Ltd (Japan)

Epigenetic gene repression in pulmonary fibrosis
09/18/2019 - 06/30/2024 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL142596-05

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Website Copy PMIDs To Clipboard

Antar SA, Mensah E, Dahlka J, Aziz M, Halouani A, Imani S, Parashar A, Raslan AA, Benezra R, Fraidenraich D, Ligresti G, Sassi Y. A Simultaneous Inhibition of ID1 and ID3 Protects Against Pulmonary Fibrosis. bioRxiv. 2025 Jul 26.View Related Profiles.

Raslan, Ahmed
Ligresti, Giovanni

PMID: 40777426; PMCID: PMC12330687; DOI: 10.1101/2025.07.24.665373;

Dinc MT, El-Adili F, Lui JK, Kripesh S, York M, Trojanowski M, Ligresti G, Lafyatis R, Trojanowska M, Bujor AM. Transcriptomic profiling of scleroderma monocytes reveals links with cardiovascular complications, implicating Notch and interferon pathways. J Scleroderma Relat Disord. 2025 Jul 25; 23971983251356123.View Related Profiles.

Bujor, Andreea
Ligresti, Giovanni
Lui, Justin
Trojanowski, Marcin
Trojanowska, Maria
Dinc, Mehmed
Lafyatis, Robert

PMID: 40735732; PMCID: PMC12301231; DOI: 10.1177/23971983251356123;

Hong J, Pham TX, Lee J, Raslan AA, Nicolas K, Sharov A, Meridew JA, Urrutia RA, Lomberk G, Huang SK, Ligresti G. Targeting the Epigenetic Regulator CBX5 Promotes Fibroblast Metabolic Reprogramming and Inhibits Lung Fibrosis. Am J Respir Cell Mol Biol. 2025 Jun; 72(6):627-642.View Related Profiles.

Raslan, Ahmed
Sharov, Andrei
Ligresti, Giovanni
Hong, Jeongmin
Pham, Tho

PMID: 39642371; PMCID: PMC12143411; DOI: 10.1165/rcmb.2024-0255OC;

Gianì F, Roos BB, Link PA, Somasundram B, Dresler SR, Sciacca E, Vancheri C, Javeed N, Ligresti G, Tschumperlin DJ, Caporarello N. Vascular protection by young circulating extracellular vesicles ameliorates aging-related pulmonary fibrosis. Am J Physiol Cell Physiol. 2025 Jul 01; 329(1):C159-C169. PMID: 40411768

Aplin AC, Ligresti G, Nicosia RF. Serum-Free Mouse Aortic Ring Assay of Angiogenesis. Methods Mol Biol. 2025; 2956:97-110. PMID: 40859078

Yamashita T, Kaplan U, Chakraborty A, Marden G, Gritli S, Roh D, Bujor A, Trojanowski M, Ligresti G, Browning JL, Trojanowska M. ERG Regulates Lymphatic Vessel Specification Genes and Its Deficiency Impairs Wound Healing-Associated Lymphangiogenesis. Arthritis Rheumatol. 2024 Nov; 76(11):1645-1657.View Related Profiles.

Chakraborty, Adri
Bujor, Andreea
Ligresti, Giovanni
Browning, Jeffrey
Trojanowski, Marcin
Trojanowska, Maria

PMID: 38965683; PMCID: PMC11521767; DOI: 10.1002/art.42944;

Raslan AA, Pham TX, Lee J, Kontodimas K, Tilston-Lunel A, Schmottlach J, Hong J, Dinc T, Bujor AM, Caporarello N, Thiriot A, von Andrian UH, Huang SK, Nicosia RF, Trojanowska M, Varelas X, Ligresti G. Lung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis. Nat Commun. 2024 Jun 27; 15(1):5449.View Related Profiles.

Raslan, Ahmed
Bujor, Andreea
Tilston-Lunel, Andrew
Ligresti, Giovanni
Hong, Jeongmin
Trojanowska, Maria
Pham, Tho
Varelas, Xaralabos

PMID: 38937456; PMCID: PMC11211333; DOI: 10.1038/s41467-024-49545-x;

Wang X, Li X, Zhao J, Li Y, Shin SR, Ligresti G, Ng AHM, Bromberg JS, Church G, Lemos DR, Abdi R. Rapid Generation of hPSC-Derived High Endothelial Venule Organoids with In Vivo Ectopic Lymphoid Tissue Capabilities. Adv Mater. 2024 Apr; 36(15):e2308760. PMID: 38306610; PMCID: PMC11009051; DOI: 10.1002/adma.202308760;

Chakraborty A, Kim A, AlAbdullatif S, Campbell JD, Alekseyev YO, Kaplan U, Dambal V, Ligresti G, Trojanowska M. Endothelial Erg Regulates Expression of Pulmonary Lymphatic Junctional and Inflammation Genes in Mouse Lungs Impacting Lymphatic Transport. Res Sq. 2024 Jan 24.View Related Profiles.

Ligresti, Giovanni
Campbell, Joshua
Trojanowska, Maria
Alekseyev, Yuriy

PMID: 38343832; PMCID: PMC10854286; DOI: 10.21203/rs.3.rs-3808970/v1;

Liang J, Ligresti G. Aging Delays Lung Repair: Insights from Omics Analysis in Mice with Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2023 Oct; 69(4):376-377. PMID: 37437301; PMCID: PMC10557920; DOI: 10.1165/rcmb.2023-0171ED;

Showing 10 of 70 results. Show More

Banerji R, Grifno GN, Shi L, Smolen D, LeBourdais R, Muhvich J, Eberman C, Hiller BE, Lee J, Regan K, Zheng S, Zhang S, Jiang J, Raslan AA, Breda JC, Pihl R, Traber K, Mazzilli S, Ligresti G, Mizgerd JP, Suki B, Nia HT. Crystal ribcage: a platform for probing real-time lung function at cellular resolution. Nat Methods. 2023 Nov; 20(11):1790-1801.View Related Profiles.

Raslan, Ahmed
Hiller, Bradley
Ligresti, Giovanni
Nia, Hadi
Mizgerd, Joseph
Traber, Katrina
Mazzilli, Sarah

PMID: 37710017; PMCID: PMC10860663; DOI: 10.1038/s41592-023-02004-9;

Caporarello N, Ligresti G. Vascular Contribution to Lung Repair and Fibrosis. Am J Respir Cell Mol Biol. 2023 Aug; 69(2):135-146. PMID: 37126595; PMCID: PMC10399144; DOI: 10.1165/rcmb.2022-0431TR;

Ruaro B, Tavano S, Confalonieri P, Pozzan R, Hughes M, Braga L, Volpe MC, Ligresti G, Andrisano AG, Lerda S, Geri P, Biolo M, Baratella E, Confalonieri M, Salton F. Transbronchial lung cryobiopsy and pulmonary fibrosis: A never-ending story? Heliyon. 2023 Apr; 9(4):e14768. PMID: 37025914; PMCID: PMC10070648; DOI: 10.1016/j.heliyon.2023.e14768;

Raslan AA, Pham TX, Lee J, Hong J, Schmottlach J, Nicolas K, Dinc T, Bujor AM, Caporarello N, Thiriot A, von Andrian UH, Huang SK, Nicosia RF, Trojanowska M, Varelas X, Ligresti G. Single Cell Transcriptomics of Fibrotic Lungs Unveils Aging-associated Alterations in Endothelial and Epithelial Cell Regeneration. bioRxiv. 2023 Jan 20.View Related Profiles.

Raslan, Ahmed
Bujor, Andreea
Ligresti, Giovanni
Trojanowska, Maria
Pham, Tho
Varelas, Xaralabos

PMID: 36712020; PMCID: PMC9882122; DOI: 10.1101/2023.01.17.523179;

Ligresti G, Raslan AA, Hong J, Caporarello N, Confalonieri M, Huang SK. Mesenchymal cells in the Lung: Evolving concepts and their role in fibrosis. Gene. 2023 Apr 05; 859:147142.View Related Profiles.

Raslan, Ahmed
Ligresti, Giovanni
Hong, Jeongmin

PMID: 36603696; PMCID: PMC10068350; DOI: 10.1016/j.gene.2022.147142;

Betageri KR, Link PA, Haak AJ, Ligresti G, Tschumperlin DJ, Caporarello N. The matricellular protein CCN3 supports lung endothelial homeostasis and function. Am J Physiol Lung Cell Mol Physiol. 2023 Feb 01; 324(2):L154-L168. PMID: 36573684; PMCID: PMC9925165; DOI: 10.1152/ajplung.00248.2022;

Ribatti D, Ligresti G, Nicosia RF. Kidney endothelial cell heterogeneity, angiocrine activity and paracrine regulatory mechanisms. Vascul Pharmacol. 2023 Feb; 148:107139. PMID: 36539108; PMCID: PMC10828957; DOI: 10.1016/j.vph.2022.107139;

Gao AY, Diaz Espinosa AM, Gianì F, Pham TX, Carver CM, Aravamudhan A, Bartman CM, Ligresti G, Caporarello N, Schafer MJ, Haak AJ. Pim-1 kinase is a positive feedback regulator of the senescent lung fibroblast inflammatory secretome. Am J Physiol Lung Cell Mol Physiol. 2022 Dec 01; 323(6):L685-L697.View Related Profiles.

Ligresti, Giovanni
Pham, Tho

PMID: 36223640; PMCID: PMC9744654; DOI: 10.1152/ajplung.00023.2022;

Caporarello N, Lee J, Pham TX, Jones DL, Guan J, Link PA, Meridew JA, Marden G, Yamashita T, Osborne CA, Bhagwate AV, Huang SK, Nicosia RF, Tschumperlin DJ, Trojanowska M, Ligresti G. Author Correction: Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis. Nat Commun. 2022 Sep 28; 13(1):5687.View Related Profiles.

Ligresti, Giovanni
Trojanowska, Maria
Pham, Tho

PMID: 36171208; PMCID: PMC9519969; DOI: 10.1038/s41467-022-33197-w;

Caporarello N, Lee J, Pham TX, Jones DL, Guan J, Link PA, Meridew JA, Marden G, Yamashita T, Osborne CA, Bhagwate AV, Huang SK, Nicosia RF, Tschumperlin DJ, Trojanowska M, Ligresti G. Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis. Nat Commun. 2022 Jul 25; 13(1):4170.View Related Profiles.

Ligresti, Giovanni
Trojanowska, Maria
Pham, Tho

PMID: 35879310; PMCID: PMC9314350; DOI: 10.1038/s41467-022-31890-4;

Ligresti G, Pham TX, Sanders YY. Circular RNA Methylation: A New Twist in Lung Fibrosis. Am J Respir Cell Mol Biol. 2022 May; 66(5):471-472.View Related Profiles.

Ligresti, Giovanni
Pham, Tho

PMID: 35238732; PMCID: PMC9116359; DOI: 10.1165/rcmb.2022-0044ED;

Pham TX, Lee J, Guan J, Caporarello N, Meridew JA, Jones DL, Tan Q, Huang SK, Tschumperlin DJ, Ligresti G. Transcriptional analysis of lung fibroblasts identifies PIM1 signaling as a driver of aging-associated persistent fibrosis. JCI Insight. 2022 Mar 22; 7(6).View Related Profiles.

Ligresti, Giovanni
Pham, Tho

PMID: 35167499; PMCID: PMC8986080; DOI: 10.1172/jci.insight.153672;

Ring NAR, Volpe MC, Stepišnik T, Mamolo MG, Panov P, Kocev D, Vodret S, Fortuna S, Calabretti A, Rehman M, Colliva A, Marchesan P, Camparini L, Marcuzzo T, Bussani R, Scarabellotto S, Confalonieri M, Pham TX, Ligresti G, Caporarello N, Loffredo FS, Zampieri D, Džeroski S, Zacchigna S. Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis through inhibition of myofibroblast differentiation. Cell Death Dis. 2021 12 17; 13(1):2.View Related Profiles.

Ligresti, Giovanni
Pham, Tho

PMID: 34916483; PMCID: PMC8677786; DOI: 10.1038/s41419-021-04439-4;

Nicosia RF, Ligresti G, Caporarello N, Akilesh S, Ribatti D. COVID-19 Vasculopathy: Mounting Evidence for an Indirect Mechanism of Endothelial Injury. Am J Pathol. 2021 08; 191(8):1374-1384. PMID: 34033751; PMCID: PMC8141344; DOI: 10.1016/j.ajpath.2021.05.007;

Jones DL, Meridew JA, Link PA, Ducharme MT, Lydon KL, Choi KM, Caporarello N, Tan Q, Diaz Espinosa AM, Xiong Y, Lee JH, Ye Z, Yan H, Ordog T, Ligresti G, Varelas X, Tschumperlin DJ. ZNF416 is a pivotal transcriptional regulator of fibroblast mechanoactivation. J Cell Biol. 2021 05 03; 220(5).View Related Profiles.

Ligresti, Giovanni
Varelas, Xaralabos
Xiong, Yiqin (“E-chin”)

PMID: 33625469; PMCID: PMC7918622; DOI: 10.1083/jcb.202007152;

Tan Q, Link PA, Meridew JA, Pham TX, Caporarello N, Ligresti G, Tschumperlin DJ. Spontaneous Lung Fibrosis Resolution Reveals Novel Antifibrotic Regulators. Am J Respir Cell Mol Biol. 2021 04; 64(4):453-464.View Related Profiles.

Ligresti, Giovanni
Pham, Tho

PMID: 33493091; PMCID: PMC8008802; DOI: 10.1165/rcmb.2020-0396OC;

Fortier SM, Penke LR, King D, Pham TX, Ligresti G, Peters-Golden M. Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions. JCI Insight. 2021 03 22; 6(6).View Related Profiles.

Ligresti, Giovanni
Pham, Tho

PMID: 33561015; PMCID: PMC8026183; DOI: 10.1172/jci.insight.144799;

Ji S, Traini C, Mischopoulou M, Gibbons SJ, Ligresti G, Faussone-Pellegrini MS, Sha L, Farrugia G, Vannucchi MG, Cipriani G. Muscularis macrophages establish cell-to-cell contacts with telocytes/PDGFRa-positive cells and smooth muscle cells in the human and mouse gastrointestinal tract. Neurogastroenterol Motil. 2021 03; 33(3):e13993. PMID: 33020982; PMCID: PMC7902307; DOI: 10.1111/nmo.13993;

Vivarelli S, Falzone L, Ligresti G, Candido S, Garozzo A, Magro GG, Bonavida B, Libra M. Role of the Transcription Factor Yin Yang 1 and Its Selectively Identified Target Survivin in High-Grade B-Cells Non-Hodgkin Lymphomas: Potential Diagnostic and Therapeutic Targets. Int J Mol Sci. 2020 Sep 03; 21(17). PMID: 32899428; PMCID: PMC7504013; DOI: 10.3390/ijms21176446;

Caporarello N, Meridew JA, Aravamudhan A, Jones DL, Austin SA, Pham TX, Haak AJ, Moo Choi K, Tan Q, Haresi A, Huang SK, Katusic ZS, Tschumperlin DJ, Ligresti G. Vascular dysfunction in aged mice contributes to persistent lung fibrosis. Aging Cell. 2020 08; 19(8):e13196.View Related Profiles.

Ligresti, Giovanni
Pham, Tho

PMID: 32691484; PMCID: PMC7431829; DOI: 10.1111/acel.13196;

Aravamudhan A, Haak AJ, Choi KM, Meridew JA, Caporarello N, Jones DL, Tan Q, Ligresti G, Tschumperlin DJ. TBK1 regulates YAP/TAZ and fibrogenic fibroblast activation. Am J Physiol Lung Cell Mol Physiol. 2020 05 01; 318(5):L852-L863. PMID: 32159970; PMCID: PMC7272740; DOI: 10.1152/ajplung.00324.2019;

Liu W, Meridew JA, Aravamudhan A, Ligresti G, Tschumperlin DJ, Tan Q. Targeted regulation of fibroblast state by CRISPR-mediated CEBPA expression. Respir Res. 2019 Dec 11; 20(1):281. PMID: 31829168; PMCID: PMC6907247; DOI: 10.1186/s12931-019-1253-1;

Tan Q, Ma XY, Liu W, Meridew JA, Jones DL, Haak AJ, Sicard D, Ligresti G, Tschumperlin DJ. Nascent Lung Organoids Reveal Epithelium- and Bone Morphogenetic Protein-mediated Suppression of Fibroblast Activation. Am J Respir Cell Mol Biol. 2019 11; 61(5):607-619. PMID: 31050552; PMCID: PMC6827068; DOI: 10.1165/rcmb.2018-0390OC;

Haak AJ, Kostallari E, Sicard D, Ligresti G, Choi KM, Caporarello N, Jones DL, Tan Q, Meridew J, Diaz Espinosa AM, Aravamudhan A, Maiers JL, Britt RD, Roden AC, Pabelick CM, Prakash YS, Nouraie SM, Li X, Zhang Y, Kass DJ, Lagares D, Tager AM, Varelas X, Shah VH, Tschumperlin DJ. Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis. Sci Transl Med. 2019 10 30; 11(516).View Related Profiles.

Ligresti, Giovanni
Varelas, Xaralabos

PMID: 31666402; PMCID: PMC7066514; DOI: 10.1126/scitranslmed.aau6296;

Jones DL, Haak AJ, Caporarello N, Choi KM, Ye Z, Yan H, Varelas X, Ordog T, Ligresti G, Tschumperlin DJ. TGFß-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression. J Cell Sci. 2019 10 18; 132(20).View Related Profiles.

Ligresti, Giovanni
Varelas, Xaralabos

PMID: 31527052; PMCID: PMC6826010; DOI: 10.1242/jcs.233486;

Caporarello N, Meridew JA, Jones DL, Tan Q, Haak AJ, Choi KM, Manlove LJ, Prakash YS, Tschumperlin DJ, Ligresti G. PGC1a repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state. Thorax. 2019 08; 74(8):749-760. PMID: 31182654; PMCID: PMC6703129; DOI: 10.1136/thoraxjnl-2019-213064;

Ligresti G, Caporarello N, Meridew JA, Jones DL, Tan Q, Choi KM, Haak AJ, Aravamudhan A, Roden AC, Prakash YS, Lomberk G, Urrutia RA, Tschumperlin DJ. CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis. JCI Insight. 2019 05 16; 5. PMID: 31095524; PMCID: PMC6629126; DOI: 10.1172/jci.insight.127111;

Jones DL, Ligresti G. Survivin IPF: Targeting Cellular Metabolism to Promote Apoptosis in IPF Fibroblasts. Am J Respir Cell Mol Biol. 2019 01; 60(1):5-6. PMID: 30211627; PMCID: PMC6348721; DOI: 10.1165/rcmb.2018-0270ED;

Oh RS, Haak AJ, Smith KMJ, Ligresti G, Choi KM, Xie T, Wang S, Walters PR, Thompson MA, Freeman MR, Manlove LJ, Chu VM, Feghali-Bostwick C, Roden AC, Schymeinsky J, Pabelick CM, Prakash YS, Vassallo R, Tschumperlin DJ. RNAi screening identifies a mechanosensitive ROCK-JAK2-STAT3 network central to myofibroblast activation. J Cell Sci. 2018 05 15; 131(10). PMID: 29678906; PMCID: PMC6031327; DOI: 10.1242/jcs.209932;

Paulitti A, Andreuzzi E, Bizzotto D, Pellicani R, Tarticchio G, Marastoni S, Pastrello C, Jurisica I, Ligresti G, Bucciotti F, Doliana R, Colladel R, Braghetta P, Poletto E, Di Silvestre A, Bressan G, Colombatti A, Bonaldo P, Mongiat M. The ablation of the matricellular protein EMILIN2 causes defective vascularization due to impaired EGFR-dependent IL-8 production affecting tumor growth. Oncogene. 2018 06; 37(25):3399-3414. PMID: 29483644

Tschumperlin DJ, Ligresti G, Hilscher MB, Shah VH. Mechanosensing and fibrosis. J Clin Invest. 2018 01 02; 128(1):74-84. PMID: 29293092; PMCID: PMC5749510; DOI: 10.1172/JCI93561;

Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D, Kisseleva T, Brenner DA, Urrutia R, Lomberk G, Gao Y, Ligresti G, Tschumperlin DJ, Revzin A, Cao S, Shah VH. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. JCI Insight. 2017 12 21; 2(24). PMID: 29263300; PMCID: PMC5752303; DOI: 10.1172/jci.insight.92821;

Abrams SL, Ruvolo PP, Ruvolo VR, Ligresti G, Martelli AM, Cocco L, Ratti S, Tafuri A, Steelman LS, Candido S, Libra M, McCubrey JA. Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells. Oncotarget. 2017 Sep 29; 8(44):76525-76557. PMID: 29100331; PMCID: PMC5652725; DOI: 10.18632/oncotarget.20408;

Dang LTH, Aburatani T, Marsh GA, Johnson BG, Alimperti S, Yoon CJ, Huang A, Szak S, Nakagawa N, Gomez I, Ren S, Read SK, Sparages C, Aplin AC, Nicosia RF, Chen C, Ligresti G, Duffield JS. Hyperactive FOXO1 results in lack of tip stalk identity and deficient microvascular regeneration during kidney injury. Biomaterials. 2017 Oct; 141:314-329. PMID: 28711779; PMCID: PMC5567800; DOI: 10.1016/j.biomaterials.2017.07.010;

Schafer MJ, White TA, Iijima K, Haak AJ, Ligresti G, Atkinson EJ, Oberg AL, Birch J, Salmonowicz H, Zhu Y, Mazula DL, Brooks RW, Fuhrmann-Stroissnigg H, Pirtskhalava T, Prakash YS, Tchkonia T, Robbins PD, Aubry MC, Passos JF, Kirkland JL, Tschumperlin DJ, Kita H, LeBrasseur NK. Cellular senescence mediates fibrotic pulmonary disease. Nat Commun. 2017 02 23; 8:14532. PMID: 28230051; PMCID: PMC5331226; DOI: 10.1038/ncomms14532;

Lemos DR, Marsh G, Huang A, Campanholle G, Aburatani T, Dang L, Gomez I, Fisher K, Ligresti G, Peti-Peterdi J, Duffield JS. Maintenance of vascular integrity by pericytes is essential for normal kidney function. Am J Physiol Renal Physiol. 2016 12 01; 311(6):F1230-F1242. PMID: 27335372; PMCID: PMC5210201; DOI: 10.1152/ajprenal.00030.2016;

Ligresti G, Nagao RJ, Xue J, Choi YJ, Xu J, Ren S, Aburatani T, Anderson SK, MacDonald JW, Bammler TK, Schwartz SM, Muczynski KA, Duffield JS, Himmelfarb J, Zheng Y. A Novel Three-Dimensional Human Peritubular Microvascular System. J Am Soc Nephrol. 2016 08; 27(8):2370-81. PMID: 26657868; PMCID: PMC4978055; DOI: 10.1681/ASN.2015070747;

Nakagawa N, Xin C, Roach AM, Naiman N, Shankland SJ, Ligresti G, Ren S, Szak S, Gomez IG, Duffield JS. Dicer1 activity in the stromal compartment regulates nephron differentiation and vascular patterning during mammalian kidney organogenesis. Kidney Int. 2015 Jun; 87(6):1125-40. PMID: 25651362; PMCID: PMC4449790; DOI: 10.1038/ki.2014.406;

Kelly EJ, Wang Z, Voellinger JL, Yeung CK, Shen DD, Thummel KE, Zheng Y, Ligresti G, Eaton DL, Muczynski KA, Duffield JS, Neumann T, Tourovskaia A, Fauver M, Kramer G, Asp E, Himmelfarb J. Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system. Stem Cell Res Ther. 2013; 4 Suppl 1:S17. PMID: 24564863; PMCID: PMC4029535; DOI: 10.1186/scrt378;

Aplin AC, Ligresti G, Fogel E, Zorzi P, Smith K, Nicosia RF. Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors. Angiogenesis. 2014 Jan; 17(1):147-61. PMID: 24091496

Campanholle G, Ligresti G, Gharib SA, Duffield JS. Cellular mechanisms of tissue fibrosis. 3. Novel mechanisms of kidney fibrosis. Am J Physiol Cell Physiol. 2013 Apr 01; 304(7):C591-603. PMID: 23325411; PMCID: PMC3625718; DOI: 10.1152/ajpcell.00414.2012;

McCubrey JA, Steelman LS, Chappell WH, Sun L, Davis NM, Abrams SL, Franklin RA, Cocco L, Evangelisti C, Chiarini F, Martelli AM, Libra M, Candido S, Ligresti G, Malaponte G, Mazzarino MC, Fagone P, Donia M, Nicoletti F, Polesel J, Talamini R, Bäsecke J, Mijatovic S, Maksimovic-Ivanic D, Michele M, Tafuri A, Dulinska-Litewka J, Laidler P, D'Assoro AB, Drobot L, Umezawa D, Montalto G, Cervello M, Demidenko ZN. Advances in targeting signal transduction pathways. Oncotarget. 2012 Dec; 3(12):1505-21. PMID: 23455493; PMCID: PMC3681490; DOI: 10.18632/oncotarget.802;

Ligresti G, Aplin AC, Dunn BE, Morishita A, Nicosia RF. The acute phase reactant orosomucoid-1 is a bimodal regulator of angiogenesis with time- and context-dependent inhibitory and stimulatory properties. PLoS One. 2012; 7(8):e41387. PMID: 22916107; PMCID: PMC3419235; DOI: 10.1371/journal.pone.0041387;

McCubrey JA, Steelman LS, Abrams SL, Misaghian N, Chappell WH, Basecke J, Nicoletti F, Libra M, Ligresti G, Stivala F, Maksimovic-Ivanic D, Mijatovic S, Montalto G, Cervello M, Laidler P, Bonati A, Evangelisti C, Cocco L, Martelli AM. Targeting the cancer initiating cell: the ultimate target for cancer therapy. Curr Pharm Des. 2012; 18(13):1784-95. PMID: 22394167

Hafsi S, Pezzino FM, Candido S, Ligresti G, Spandidos DA, Soua Z, McCubrey JA, Travali S, Libra M. Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance (review). Int J Oncol. 2012 Mar; 40(3):639-44. PMID: 22200790

Lorenzon E, Colladel R, Andreuzzi E, Marastoni S, Todaro F, Schiappacassi M, Ligresti G, Colombatti A, Mongiat M. MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway. Oncogene. 2012 Jun 28; 31(26):3136-47. PMID: 22020326

Ligresti G, Aplin AC, Zorzi P, Morishita A, Nicosia RF. Macrophage-derived tumor necrosis factor-alpha is an early component of the molecular cascade leading to angiogenesis in response to aortic injury. Arterioscler Thromb Vasc Biol. 2011 May; 31(5):1151-9. PMID: 21372301; PMCID: PMC3113655; DOI: 10.1161/ATVBAHA.111.223917;

Nicosia RF, Zorzi P, Ligresti G, Morishita A, Aplin AC. Paracrine regulation of angiogenesis by different cell types in the aorta ring model. Int J Dev Biol. 2011; 55(4-5):447-53. PMID: 21858770

Mongiat M, Marastoni S, Ligresti G, Lorenzon E, Schiappacassi M, Perris R, Frustaci S, Colombatti A. The extracellular matrix glycoprotein elastin microfibril interface located protein 2: a dual role in the tumor microenvironment. Neoplasia. 2010 Apr; 12(4):294-304. PMID: 20360940; PMCID: PMC2847737; DOI: 10.1593/neo.91930;

Castellano G, Torrisi E, Ligresti G, Nicoletti F, Malaponte G, Traval S, McCubrey JA, Canevari S, Libra M. Yin Yang 1 overexpression in diffuse large B-cell lymphoma is associated with B-cell transformation and tumor progression. Cell Cycle. 2010 Feb 01; 9(3):557-63. PMID: 20081364

Castellano G, Torrisi E, Ligresti G, Malaponte G, Militello L, Russo AE, McCubrey JA, Canevari S, Libra M. The involvement of the transcription factor Yin Yang 1 in cancer development and progression. Cell Cycle. 2009 May 01; 8(9):1367-72. PMID: 19342874

Ligresti G, Militello L, Steelman LS, Cavallaro A, Basile F, Nicoletti F, Stivala F, McCubrey JA, Libra M. PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches. Cell Cycle. 2009 May 01; 8(9):1352-8. PMID: 19305151; PMCID: PMC3781181; DOI: 10.4161/cc.8.9.8255;

Misaghian N, Ligresti G, Steelman LS, Bertrand FE, Bäsecke J, Libra M, Nicoletti F, Stivala F, Milella M, Tafuri A, Cervello M, Martelli AM, McCubrey JA. Targeting the leukemic stem cell: the Holy Grail of leukemia therapy. Leukemia. 2009 Jan; 23(1):25-42. PMID: 18800146; PMCID: PMC2627788; DOI: 10.1038/leu.2008.246;

McCubrey JA, Abrams SL, Ligresti G, Misaghian N, Wong EW, Steelman LS, Bäsecke J, Troppmair J, Libra M, Nicoletti F, Molton S, McMahon M, Evangelisti C, Martelli AM. Involvement of p53 and Raf/MEK/ERK pathways in hematopoietic drug resistance. Leukemia. 2008 Nov; 22(11):2080-90. PMID: 18685611

Ligresti G, Libra M, Militello L, Clementi S, Donia M, Imbesi R, Malaponte G, Cappellani A, McCubrey JA, Stivala F. Breast cancer: Molecular basis and therapeutic strategies (Review). Mol Med Rep. 2008 Jul-Aug; 1(4):451-8. PMID: 21479431

McCubrey JA, Sokolosky ML, Lehmann BD, Taylor JR, Navolanic PM, Chappell WH, Abrams SL, Stadelman KM, Wong EW, Misaghian N, Horn S, Bäsecke J, Libra M, Stivala F, Ligresti G, Tafuri A, Milella M, Zarzycki M, Dzugaj A, Chiarini F, Evangelisti C, Martelli AM, Terrian DM, Franklin RA, Steelman LS. Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy. Adv Enzyme Regul. 2008; 48:113-35. PMID: 18423407; PMCID: PMC2583357; DOI: 10.1016/j.advenzreg.2008.02.006;

Marastoni S, Ligresti G, Lorenzon E, Colombatti A, Mongiat M. Extracellular matrix: a matter of life and death. Connect Tissue Res. 2008; 49(3):203-6. PMID: 18661343

Doliana R, Veljkovic V, Prljic J, Veljkovic N, De Lorenzo E, Mongiat M, Ligresti G, Marastoni S, Colombatti A. EMILINs interact with anthrax protective antigen and inhibit toxin action in vitro. Matrix Biol. 2008 Mar; 27(2):96-106. PMID: 17988845

Mongiat M, Ligresti G, Marastoni S, Lorenzon E, Doliana R, Colombatti A. Regulation of the extrinsic apoptotic pathway by the extracellular matrix glycoprotein EMILIN2. Mol Cell Biol. 2007 Oct; 27(20):7176-87. PMID: 17698584; PMCID: PMC2168889; DOI: 10.1128/MCB.00696-07;

Libra M, Malaponte G, Bevelacqua V, Siciliano R, Castrogiovanni P, Fulvi A, Micali G, Ligresti G, Mazzarino MC, Stivala F, Travali S, McCubrey JA. Absence of BRAF gene mutation in non-melanoma skin tumors. Cell Cycle. 2006 May; 5(9):968-70. PMID: 16687919

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 70 publications over 19 distinct years, with a maximum of 7 publications in 2019 and 2022