Cheng Lin, PhD
Research Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Biochemistry & Cell Biology

PhD, Cornell University
MSc, Cornell University
BSc, Beijing University

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

High-Throughput De Novo Glycan Sequencing
09/01/2019 - 08/31/2024 (PI)
NIH/National Institute of General Medical Sciences

Characterization of glycan isomers by trapped ion mobility spectometry-electron activated dissociation tandem mass spectrometry
09/01/2016 - 08/31/2019 (PI)
NIH/National Institute of General Medical Sciences

Development of new approaches to FT-ICR mass spectometry
07/15/2016 - 07/14/2017 (Subcontract PI)
MassTech Inc. NIH NIGMS

Defining the Isoaspartome
06/01/2007 - 05/31/2012 (PI)
NIH/National Institute of General Medical Sciences
5 R01 GM78293 04

Defining the Isoaspartome
06/01/2007 - 05/31/2012 (PI)
NIH/National Institute of General Medical Sciences


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Pu Y, Ridgeway ME, Glaskin RS, Park MA, Costello CE, Lin C. Separation and Identification of Isomeric Glycans by Selected Accumulation-Trapped Ion Mobility Spectrometry-Electron Activated Dissociation Tandem Mass Spectrometry. Anal Chem. 2016 Apr 05; 88(7):3440-3.View Related Profiles. PMID: 26959868; PMCID: PMC4821751; DOI: 10.1021/acs.analchem.6b00041;
  2. Ji Y, Bachschmid MM, Costello CE, Lin C. S- to N-Palmitoyl Transfer During Proteomic Sample Preparation. J Am Soc Mass Spectrom. 2016 Apr; 27(4):677-85.View Related Profiles. PMID: 26729453; PMCID: PMC4794353; DOI: 10.1007/s13361-015-1319-3;
  3. Tykesson E, Mao Y, Maccarana M, Pu Y, Gao J, Lin C, Zaia J, Westergren-Thorsson G, Ellervik U, Malmström L, Malmström A. Deciphering the Mode of Action of the Processive Polysaccharide Modifying Enzyme Dermatan Sulfate Epimerase 1 by Hydrogen-Deuterium Exchange Mass Spectrometry. Chem Sci. 2016 Feb 01; 7(2):1447-1456.View Related Profiles. PMID: 26900446; PMCID: PMC4755500; DOI: 10.1039/c5sc03798k;
  4. Yu X, Sargaeva NP, Thompson CJ, Costello CE, Lin C. In-Source Decay Characterization of Isoaspartate and ß-Peptides. Int J Mass Spectrom. 2015 Nov 15; 390:101-109.View Related Profiles. PMID: 26644780; PMCID: PMC4669973; DOI: 10.1016/j.ijms.2015.07.013;
  5. Huang Y, Pu Y, Yu X, Costello CE, Lin C. Mechanistic Study on Electronic Excitation Dissociation of the Cellobiose-Na(+) Complex. J Am Soc Mass Spectrom. 2016 Feb; 27(2):319-28.View Related Profiles. PMID: 26432580; PMCID: PMC4724539; DOI: 10.1007/s13361-015-1277-9;
  6. Ji Y, Liu M, Bachschmid MM, Costello CE, Lin C. Surfactant-Induced Artifacts during Proteomic Sample Preparation. Anal Chem. 2015 Jun 2; 87(11):5500-4.View Related Profiles. PMID: 25945600; PMCID: PMC4574305; DOI: 10.1021/acs.analchem.5b00249;
  7. Huang Y, Mao Y, Zong C, Lin C, Boons GJ, Zaia J. Discovery of a heparan sulfate 3-O-sulfation specific peeling reaction. Anal Chem. 2015 Jan 6; 87(1):592-600.View Related Profiles. PMID: 25486437; PMCID: PMC4287833; DOI: 10.1021/ac503248k;
  8. Hu H, Huang Y, Mao Y, Yu X, Xu Y, Liu J, Zong C, Boons GJ, Lin C, Xia Y, Zaia J. A computational framework for heparan sulfate sequencing using high-resolution tandem mass spectra. Mol Cell Proteomics. 2014 Sep; 13(9):2490-502.View Related Profiles. PMID: 24925905; PMCID: PMC4159664; DOI: 10.1074/mcp.M114.039560;
  9. Huang Y, Pu Y, Yu X, Costello CE, Lin C. Mechanistic study on electron capture dissociation of the oligosaccharide-Mg²? complex. J Am Soc Mass Spectrom. 2014 Aug; 25(8):1451-60.View Related Profiles. PMID: 24845360; PMCID: PMC4108535; DOI: 10.1007/s13361-014-0921-0;
  10. Wu ZL, Robey MT, Tatge T, Lin C, Leymarie N, Zou Y, Zaia J. Detecting O-GlcNAc using in vitro sulfation. Glycobiology. 2014 Aug; 24(8):740-7.View Related Profiles. PMID: 24799377; PMCID: PMC4070980; DOI: 10.1093/glycob/cwu037;
Showing 10 of 40 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 40 publications over 16 distinct years, with a maximum of 7 publications in 2006


In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Mass Spectrometry, Proteomics, Glycomics, PTM characterization

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Research / Scholarly Mentor
Contact for Mentoring:

670 Albany St Biosquare III
Boston MA 02118
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