I am an Associate Professor of Medicine in the Section of Rheumatology at Boston University School of Medicine, specializing in scleroderma translational research and in the care of patients with scleroderma.
My research focuses on the interplay between myeloid cells and fibroblasts in scleroderma-associated cardiac fibrosis. Our project investigating the role of the transcription factor Fli1 in myeloid cells has received funding from the NIH, American Heart Association, and Rheumatology Research Foundation. Additionally, we are exploring a method called spatial frequency domain imaging as a non-invasive tool for assessing skin fibrosis in scleroderma patients, a project supported by the Scleroderma Clinical Trials Consortium and National Scleroderma Foundation.
Beyond research, I am deeply committed to mentoring and education. As the Associate Program Director for the Rheumatology Fellowship, I have mentored trainees at all levels, and received an Outstanding Mentor Award from UROP. I regularly lecture on scleroderma and rheumatology and lead board review sessions for fellows. In recognition of my contributions to clinical care and research, I was honored as one of Boston’s Top Doctors in 2024 and 2025.
Diversity, Equity, Inclusion and Accessibility
2020-2021 Clinical preceptor for two Rheumatology fellows from underrepresented minorities
2022- Research mentor for a Rheumatology fellows from underrepresented minorities
2021- Faculty mentor for our monthly JEDI “Justice, equity, diversity and inclusion” sessions, Division of Rheumatology, BUMC, Boston, MA
Associate Program Director
Boston University
Arthritis & Autoimmune Diseases Research Center
Rheumatology Fellowship Program
Member
Boston University
Evans Center for Interdisciplinary Biomedical Research
This tab shows grant data from BMC Sponsored Research. It includes:
- Grant title
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- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data from BU Sponsored Research. It includes:
- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data that did not automatically get imported into Profiles
from BU or BMC sources.
- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data from the Boston VA. We are only showing grant title, and only for people in the role of PI.
Collaborative, National Quality and Efficacy Registry for Tracking Disease Progression in Systemic Sclerosis (Scleroderma)08/13/2024 - 02/28/2029 (PI)
Scleroderma Foundation
The role of FLI1 in myeloid cells and its contribution to cardiac fibrosis09/15/2021 - 06/30/2026 (PI)
NIH/National Heart, Lung, and Blood Institute5R01HL155955-04
Spatial frequency domain imaging as a new method to quantify skin changes in scleroderma04/01/2023 - 03/31/2025 (PI)
Scleroderma Foundation
Spacial frequency domain imaging as a new method to quantify skin changes in Scleroderma07/01/2022 - 06/30/2023 (PI)
Scleroderma Clinical Trials Consortium
The role of myeloid Fli1 in organ fibrosis in systemic sclerosis07/01/2020 - 12/31/2021 (PI)
Rheumatology Research Foundation
Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
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to make corrections and additions.
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Darbousset R, Senkpeil L, Kuehn J, Balu S, Miglani D, Dillon E, Fromson C, Elahee M, Jarrot PA, Montesi SB, Rao DA, Ware J, Wagner DD, Bujor AM, Gutierrez-Arcelus M, Nigrovic PA. A GPVI-platelet-neutrophil-NET axis drives systemic sclerosis. bioRxiv. 2025 Jan 24. PMID: 39896646; PMCID: PMC11785050; DOI: 10.1101/2025.01.21.634123;
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Lui JK, Cozzolino M, Winburn M, Trojanowski MA, Soylemez Wiener R, LaValley MP, Bujor AM, Gopal DM, Klings ES. Clustering regional patterns of left ventricular longitudinal strain in systemic sclerosis-related pulmonary hypertension. Int J Cardiol. 2025 Feb 15; 421:132891.View Related Profiles. PMID: 39662748; PMCID: PMC11747944; DOI: 10.1016/j.ijcard.2024.132891;
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Yamashita T, Kaplan U, Chakraborty A, Marden G, Gritli S, Roh D, Bujor A, Trojanowski M, Ligresti G, Browning JL, Trojanowska M. ERG Regulates Lymphatic Vessel Specification Genes and Its Deficiency Impairs Wound Healing-Associated Lymphangiogenesis. Arthritis Rheumatol. 2024 Nov; 76(11):1645-1657.View Related Profiles. PMID: 38965683; PMCID: PMC11521767; DOI: 10.1002/art.42944;
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Raslan AA, Pham TX, Lee J, Kontodimas K, Tilston-Lunel A, Schmottlach J, Hong J, Dinc T, Bujor AM, Caporarello N, Thiriot A, von Andrian UH, Huang SK, Nicosia RF, Trojanowska M, Varelas X, Ligresti G. Lung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis. Nat Commun. 2024 Jun 27; 15(1):5449.View Related Profiles. PMID: 38937456; PMCID: PMC11211333; DOI: 10.1038/s41467-024-49545-x;
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Lui JK, Sangani RA, Gillmeyer KR, Vakhshoorzadeh J, Trojanowski MA, Bujor AM, Gopal DM, Wiener RS, LaValley MP, Klings ES. Correction to: Hemodynamic Response to Oral Vasodilator Therapy in Systemic Sclerosis-Related Pulmonary Hypertension. Cardiovasc Drugs Ther. 2024 Jun; 38(3):657.View Related Profiles. PMID: 36662449; PMCID: PMC11528702; DOI: 10.1007/s10557-023-07431-6;
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Lui JK, Gillmeyer KR, Sangani RA, Smyth RJ, Gopal DM, Trojanowski MA, Bujor AM, Soylemez Wiener R, LaValley MP, Klings ES. A Clinical Decision Tool for Risk Stratifying Patients with Systemic Sclerosis-Related Pulmonary Hypertension. Lung. 2023 Dec; 201(6):565-569.View Related Profiles. PMID: 37957388; PMCID: PMC11037922; DOI: 10.1007/s00408-023-00646-2;
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El-Adili F, Lui JK, Najem M, Farina G, Trojanowska M, Sam F, Bujor AM. Correction: Periostin overexpression in scleroderma cardiac tissue and its utility as a marker for disease complications. Arthritis Res Ther. 2023 Jan 23; 25(1):11.View Related Profiles. PMID: 36691037; PMCID: PMC9869504; DOI: 10.1186/s13075-023-02993-0;
Showing 10 of 43 results.
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Raslan AA, Pham TX, Lee J, Hong J, Schmottlach J, Nicolas K, Dinc T, Bujor AM, Caporarello N, Thiriot A, von Andrian UH, Huang SK, Nicosia RF, Trojanowska M, Varelas X, Ligresti G. Single Cell Transcriptomics of Fibrotic Lungs Unveils Aging-associated Alterations in Endothelial and Epithelial Cell Regeneration. bioRxiv. 2023 Jan 20.View Related Profiles. PMID: 36712020; PMCID: PMC9882122; DOI: 10.1101/2023.01.17.523179;
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Lui JK, Gillmeyer KR, Sangani RA, Smyth RJ, Gopal DM, Trojanowski MA, Bujor AM, Soylemez Wiener R, LaValley MP, Klings ES. A Multimodal Prediction Model for Diagnosing Pulmonary Hypertension in Systemic Sclerosis. Arthritis Care Res (Hoboken). 2023 Jul; 75(7):1462-1468.View Related Profiles. PMID: 35678779; PMCID: PMC9732142; DOI: 10.1002/acr.24969;
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Lui JK, Sangani RA, Gillmeyer KR, Vakhshoorzadeh J, Trojanowski MA, Bujor AM, Gopal DM, Wiener RS, LaValley MP, Klings ES. Hemodynamic Response to Oral Vasodilator Therapy in Systemic Sclerosis-Related Pulmonary Hypertension. Cardiovasc Drugs Ther. 2024 Jun; 38(3):651-656.View Related Profiles. PMID: 36607535; PMCID: PMC10666735; DOI: 10.1007/s10557-022-07420-1;
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Sanges S, Rice L, Tu L, Valenzi E, Cracowski JL, Montani D, Mantero JC, Ternynck C, Marot G, Bujor AM, Hachulla E, Launay D, Humbert M, Guignabert C, Lafyatis R. Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary arterial hypertension by serum proteome analysis. Ann Rheum Dis. 2023 Mar; 82(3):365-373.View Related Profiles. PMID: 36600187; PMCID: PMC9918672; DOI: 10.1136/ard-2022-223237;
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Sangani RA, Lui JK, Gillmeyer KR, Trojanowski MA, Bujor AM, LaValley MP, Klings ES. Clinical characteristics and outcomes in pulmonary manifestations of systemic sclerosis: Contribution from pulmonary hypertension and interstitial lung disease severity. Pulm Circ. 2022 Oct; 12(4):e12117.View Related Profiles. PMID: 36238967; PMCID: PMC9535436; DOI: 10.1002/pul2.12117;
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Alotaibi M, Shao J, Pauciulo MW, Nichols WC, Hemnes AR, Malhotra A, Kim NH, Yuan JX, Fernandes T, Kerr KM, Alshawabkeh L, Desai AA, Bujor AM, Lafyatis R, Watrous JD, Long T, Cheng S, Chan SY, Jain M. Metabolomic Profiles Differentiate Scleroderma-PAH From Idiopathic PAH and Correspond With Worsened Functional Capacity. Chest. 2023 Jan; 163(1):204-215.View Related Profiles. PMID: 36087794; PMCID: PMC9899641; DOI: 10.1016/j.chest.2022.08.2230;
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Lui JK, Sangani RA, Chen CA, Bujor AM, Trojanowski MA, Gopal DM, LaValley MP, Soylemez Wiener R, Klings ES. Prognostic Value of Cardiac Axis Deviation in Systemic Sclerosis-Related Pulmonary Hypertension. Arthritis Care Res (Hoboken). 2022 Jul; 74(7):1219-1226.View Related Profiles. PMID: 34085410; PMCID: PMC8639831; DOI: 10.1002/acr.24724;
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Mazzotta C, Marden G, Farina A, Bujor A, Trojanowski MA, Trojanowska M. FLI1 and ERG protein degradation is regulated via Cathepsin B lysosomal pathway in human dermal microvascular endothelial cells. Microcirculation. 2021 01; 28(1):e12660.View Related Profiles. PMID: 32979864; PMCID: PMC7988617; DOI: 10.1111/micc.12660;
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Marden G, Wan Q, Wilks J, Nevin K, Feeney M, Wisniacki N, Trojanowski M, Bujor A, Stawski L, Trojanowska M. The role of the oncostatin M/OSM receptor ß axis in activating dermal microvascular endothelial cells in systemic sclerosis. Arthritis Res Ther. 2020 07 31; 22(1):179.View Related Profiles. PMID: 32736577; PMCID: PMC7393919; DOI: 10.1186/s13075-020-02266-0;
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Martirossian L, Bujor AM, Kissin E. Basic Calcium Phosphate Crystal Periarthritis Involving the Distal Interphalangeal Joints in a Patient with Systemic Lupus Erythematosus. Am J Case Rep. 2019 Aug 01; 20:1132-1137.View Related Profiles. PMID: 31366882; PMCID: PMC6690217; DOI: 10.12659/AJCR.916118;
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Christmann RB, Mathes A, Affandi AJ, Padilla C, Nazari B, Bujor AM, Stifano G, Lafyatis R. Thymic stromal lymphopoietin is up-regulated in the skin of patients with systemic sclerosis and induces profibrotic genes and intracellular signaling that overlap with those induced by interleukin-13 and transforming growth factor ß. Arthritis Rheum. 2013 May; 65(5):1335-46.View Related Profiles. PMID: 23335246; PMCID: PMC4437575; DOI: 10.1002/art.37859;
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Chan ES, Liu H, Fernandez P, Luna A, Perez-Aso M, Bujor AM, Trojanowska M, Cronstein BN. Adenosine A(2A) receptors promote collagen production by a Fli1- and CTGF-mediated mechanism. Arthritis Res Ther. 2013; 15(3):R58.View Related Profiles. PMID: 23663495; PMCID: PMC4060252; DOI: 10.1186/ar4229;
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Bujor AM, Haines P, Padilla C, Christmann RB, Junie M, Sampaio-Barros PD, Lafyatis R, Trojanowska M. Ciprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1. Int J Mol Med. 2012 Dec; 30(6):1473-80.View Related Profiles. PMID: 23041765; PMCID: PMC4035782; DOI: 10.3892/ijmm.2012.1150;
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Christmann RB, Mathes A, Affandi A, Padilla C, Nazari B, Bujor AM, Stifano G, Lafyatis R. The 2012 ACR/ARHP Conference. TSLP upregulation in human SSc skin and induction of overlapping profibrotic genes and intracelullar signaling with IL-13 and TGFß. Washington DC. 2012.
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Bujor AM, Asano Y, Haines P, Lafyatis R, Trojanowska M. The c-Abl tyrosine kinase controls protein kinase Cd-induced Fli-1 phosphorylation in human dermal fibroblasts. Arthritis Rheum. 2011 Jun; 63(6):1729-37.View Related Profiles. PMID: 21321929; PMCID: PMC3381734; DOI: 10.1002/art.30284;
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Samuel GH, Bujor AM, Nakerakanti SS, Hant FN, Trojanowska M. Autocrine transforming growth factor ß signaling regulates extracellular signal-regulated kinase 1/2 phosphorylation via modulation of protein phosphatase 2A expression in scleroderma fibroblasts. Fibrogenesis Tissue Repair. 2010; 3:25.View Related Profiles. PMID: 21134273; PMCID: PMC3008687; DOI: 10.1186/1755-1536-3-25;
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Bu S, Asano Y, Bujor A, Highland K, Hant F, Trojanowska M. Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels. Arthritis Rheum. 2010 Jul; 62(7):2117-26.View Related Profiles. PMID: 20309867; PMCID: PMC3034368; DOI: 10.1002/art.27463;
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Bujor AM, Haines P, Lafyatis R, Trojanowska M. Caveolin-1 overexpression in a subset of SSc dermal fibroblasts promotes TGF beta/Smad1 signaling and contributes to MMPI down-regulation. Clinical and experimental rheumatology. 2010; 28(5):S60.
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Buhaescu I, Lafyatis R, Trojanowska M, Bujor AM. The role of PTEN down-regulation on PPM1A expression in scleroderma fibroblasts. Clinical and experimental rheumatology. 2010; 28(5):S60.
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Bujor AM, Pannu J, Bu S, Smith EA, Muise-Helmericks RC, Trojanowska M. Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts. J Invest Dermatol. 2008 Aug; 128(8):1906-14.View Related Profiles. PMID: 18323784; DOI: 10.1038/jid.2008.39;
This graph shows the total number of publications by year, by first, middle/unknown,
or last author.
Year | Publications |
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2008 | 1 |
2010 | 6 |
2011 | 4 |
2012 | 5 |
2013 | 2 |
2019 | 2 |
2020 | 3 |
2021 | 1 |
2022 | 5 |
2023 | 9 |
2024 | 4 |
2025 | 1 |
2021 Boston University:
Outstanding Mentor Award, UROP
2020 Rheumatology Research Foundation:
Tobé and Stephen E. Malawista, MD, Endowment in Academic Rheumatology
2020 American Heart Association:
Career Development Award
2019 16th International Workshop on Scleroderma Research:
SCTC Travel Award
2010 Scleroderma Foundation:
Walter A. Coyle Memorial Research Grant Award
2006 9th International Workshop in SSc, Boston, MA:
Young Investigator Travel Award
2006 Arthritis Foundation:
Postdoctoral Fellowship Award
As an Associate Professor of Rheumatology and Associate Program Director for the Rheumatology Fellowship, I have a deep commitment to mentoring and developing the next generation of physician-scientists in rheumatology, with a particular focus on scleroderma research. My expertise lies in the molecular mechanisms of fibrosis, particularly in scleroderma and cardiac fibrosis, and I bring this knowledge to bear in my mentoring relationships.
I have successfully mentored numerous trainees, including undergraduate and medical students, residents, rheumatology fellows, and postdoctoral research fellows, guiding them through research projects and supporting their career development. My mentoring philosophy centers on nurturing each individual's unique strengths and interests, helping them to align their research and clinical pursuits with their personal goals and values.
Ultimately, my goal as a mentor is to foster independence, critical thinking, and scientific curiosity in my mentees. I aim to help them develop the skills and confidence necessary to become successful physician and/or scientists, capable of making significant contributions to the field of rheumatology and, more broadly, to improving patient care through innovative research.
Available to Mentor as: (Review Mentor Role Definitions):
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Advisor
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Career Mentor
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Co-Mentor or Peer Mentor
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Education Mentor
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Project Mentor
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Research / Scholarly Mentor