Shelley J. Russek, PhD
Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

PhD, Boston University
MS, Stony Brook University
BA, University of California, San Diego



Research Interests of the Russek Laboratory: Dysregulated Plasticity of the Nervous System

The plasticity of a neuron’s receptor systems at the membrane is a key feature of the brain that enables its development as well as its function throughout life, creating and responding to an ever-changing external and internal world. A glorious biological feature of existence, however, also contributes to mankind’s most devastating disorders. Dysregulated plasticity takes multiple forms, from the unrelenting seizures of an infant that later emerges with brain damage, to the manifestation of autism and schizophrenia, all begging for curative therapies. Our chief interests in the laboratory surround a desire to understand the genetic and epigenetic basis of neurotransmitter and neurotrophin receptor regulation. We believe that such an understanding will enable us to contribute to the future development of therapeutics that can tackle these complex human problems where plasticity has lost its balance in controlling brain inhibition and excitation.

We employ a variety of proteomic and transcriptomic techniques, including confocal fluorescence immunohistochemistry, western blot, proximity ligation assays, siRNA silencing, RNA and chromatin immunoprecipitation (ChIP) high density sequencing, methylation genome analysis, proximity ligation analysis, primary neuronal cultures, and in vivo models (rodent and zebrafish) to test hypotheses of disease etiology and potential strategies for novel molecular therapeutics using novel chemical libraries and re-purposed therapeutics.

Director
Boston University
Graduate Program for Neuroscience


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Graduate Program for Neuroscience
07/01/2023 - 06/30/2028 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1T32NS131178-01

The STAT3 response of excitatory neurons to epileptogenic brain injury
05/01/2022 - 04/30/2027 (Multi-PI)
PI: Shelley J. Russek, PhD
NIH/National Institute of Neurological Disorders & Stroke
5R01NS122385-02

The STAT3 response of excitatory neurons to epileptogenic brain injury
05/15/2020 - 04/30/2022 (Multi-PI)
PI: Shelley J. Russek, PhD
NIH/National Institute of Neurological Disorders & Stroke
1R56NS117141-01

Mapping the Transcriptome of Age-Related Hippocampal Trisynaptic Circuit Dysfunction in a Rat Model for Alzheimer's Disease
02/01/2019 - 01/31/2022 (Multi-PI)
PI: Shelley J. Russek, PhD
NIH/National Institute on Aging
5R21AG061553-02

Modeling Multi-scale Sleep EEG Dynamics as a Framework for Biomarker Discovery
07/01/2021 - 08/31/2021 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NINDS
5R01NS096177-06

Rapid removal of Amyloid-B aggregates using superparamagnetic nanoparticles immunotherapy (Billing Agreement for Shen Ning)
07/01/2019 - 06/30/2021 (Subcontract PI)
Massachusetts General Hospital NIH NIA
1R01AG062547-01

Does REST make you resilient?
05/07/2018 - 03/31/2021 (Multi-PI)
PI: Shelley J. Russek, PhD
NIH/National Institute of Mental Health
5R21MH113128-02

GABA(A) Receptor Subunit Regulation in Epileptogenesis
09/01/2015 - 06/30/2020 (Multi-PI)
PI: Shelley J. Russek, PhD
Regents of the University of Colorado, on behalf of The University of Colorado Denver NIH NINDS
5R01NS051710-14

Student Billing agreement for Shen Ning
07/01/2018 - 06/30/2019 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NIA
1RF1AG048080-01

Development of Novel JAK/STAT Inhibitors for Epilepsy Prevention and Treatment
01/01/2014 - 09/16/2016 (Multi-PI)
PI: Shelley J. Russek, PhD
Regents of the University of Colorado, on behalf of The University of Colorado Denver NIH NINDS
5R21NS083057-02

Showing 10 of 16 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2024 The STAT3 Response of Excitatory Neurons to Epileptogenic Brain Injury 5R01NS122385-03
2023 Graduate Program for Neuroscience 1T32NS131178-01
2023 The STAT3 Response of Excitatory Neurons to Epileptogenic Brain Injury 5R01NS122385-02
2022 The STAT3 response of excitatory neurons to epileptogenic brain injury 1R01NS122385-01A1
2020 The STAT3 response of excitatory neurons to epileptogenic brain injury 1R56NS117141-01
2020 Mapping the Transcriptome of Age-Related Hippocampal Trisynaptic Circuit Dysfunction in a Rat Model for Alzheimer's Disease 5R21AG061553-02
2019 Mapping the Transcriptome of Age-Related Hippocampal Trisynaptic Circuit Dysfunction in a Rat Model for Alzheimer's Disease 1R21AG061553-01
2019 Does REST make you resilient? 5R21MH113128-02 1
2018 Does REST make you resilient? 1R21MH113128-01A1 1
2018 GABA(A) Receptor Subunit Regulation in Epileptogenesis 5R01NS051710-14 19
Showing 10 of 34 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Phan BN, Ray MH, Xue X, Fu C, Fenster RJ, Kohut SJ, Bergman J, Haber SN, McCullough KM, Fish MK, Glausier JR, Su Q, Tipton AE, Lewis DA, Freyberg Z, Tseng GC, Russek SJ, Alekseyev Y, Ressler KJ, Seney ML, Pfenning AR, Logan RW. Single nuclei transcriptomics in human and non-human primate striatum in opioid use disorder. Nat Commun. 2024 Jan 31; 15(1):878.View Related Profiles. PMID: 38296993; PMCID: PMC10831093; DOI: 10.1038/s41467-024-45165-7;
     
  2. Tipton AE, Cruz Del Angel Y, Hixson K, Carlsen J, Strode D, Busquet N, Mesches MH, Gonzalez MI, Napoli E, Russek SJ, Brooks-Kayal AR. Selective Neuronal Knockout of STAT3 Function Inhibits Epilepsy Progression, Improves Cognition, and Restores Dysregulated Gene Networks in a Temporal Lobe Epilepsy Model. Ann Neurol. 2023 Jul; 94(1):106-122.View Related Profiles. PMID: 36935347; PMCID: PMC10313781; DOI: 10.1002/ana.26644;
     
  3. Tipton AE, Cruz Del Angel Y, Hixson K, Carlsen J, Strode D, Busquet N, Mesches MH, Gonzalez MI, Napoli E, Russek SJ, Brooks-Kayal AR. Selective Neuronal Knockout of STAT3 Function Inhibits Epilepsy Progression, Improves Cognition, and Restores Dysregulated Gene Networks in a Temporal Lobe Epilepsy Model. Ann Neurol. 2023 Mar 19.View Related Profiles. PMID: 36935347; PMCID: PMC10313781; DOI: 10.1002/ana.26644;
     
  4. Tipton AE, Russek SJ. Regulation of Inhibitory Signaling at the Receptor and Cellular Level; Advances in Our Understanding of GABAergic Neurotransmission and the Mechanisms by Which It Is Disrupted in Epilepsy. Front Synaptic Neurosci. 2022; 14:914374. PMID: 35874848; PMCID: PMC9302637; DOI: 10.3389/fnsyn.2022.914374;
     
  5. Tipton AE, George J, Ratner M, Farb D, Russek S. Data from single nuclei RNA-sequencing reveals a prodromal gene network response in excitatory neurons of a humanized rat Alzheimer's disease model. Alzheimers Dement. 2021 Dec; 17 Suppl 2:e058589.View Related Profiles. PMID: 34971150; DOI: 10.1002/alz.058589;
     
  6. Hixson KM, Cogswell M, Brooks-Kayal AR, Russek SJ. Evidence for a non-canonical JAK/STAT signaling pathway in the synthesis of the brain's major ion channels and neurotransmitter receptors. BMC Genomics. 2019 Aug 28; 20(1):677.View Related Profiles. PMID: 31455240; PMCID: PMC6712773; DOI: 10.1186/s12864-019-6033-2;
     
  7. Li Z, Cogswell M, Hixson K, Brooks-Kayal AR, Russek SJ. Nuclear Respiratory Factor 1 (NRF-1) Controls the Activity Dependent Transcription of the GABA-A Receptor Beta 1 Subunit Gene in Neurons. Front Mol Neurosci. 2018; 11:285.View Related Profiles. PMID: 30186109; PMCID: PMC6113564; DOI: 10.3389/fnmol.2018.00285;
     
  8. Ruan QT, Yazdani N, Beierle JA, Hixson KM, Hokenson KE, Apicco DJ, Luttik KP, Zheng K, Maziuk BF, Ash PEA, Szumlinski KK, Russek SJ, Wolozin B, Bryant CD. Changes in neuronal immunofluorescence in the C- versus N-terminal domains of hnRNP H following D1 dopamine receptor activation. Neurosci Lett. 2018 09 25; 684:109-114.View Related Profiles. PMID: 30003938; PMCID: PMC6330092; DOI: 10.1016/j.neulet.2018.07.015;
     
  9. Thomas AX, Cruz Del Angel Y, Gonzalez MI, Carrel AJ, Carlsen J, Lam PM, Hempstead BL, Russek SJ, Brooks-Kayal AR. Rapid Increases in proBDNF after Pilocarpine-Induced Status Epilepticus in Mice Are Associated with Reduced proBDNF Cleavage Machinery. eNeuro. 2016 Jan-Feb; 3(1). PMID: 27057559; PMCID: PMC4814566; DOI: 10.1523/ENEURO.0020-15.2016;
     
  10. Huang S, Hokenson K, Bandyopadhyay S, Russek SJ, Kirkwood A. Brief Dark Exposure Reduces Tonic Inhibition in Visual Cortex. J Neurosci. 2015 Dec 2; 35(48):15916-20.View Related Profiles. PMID: 26631472; PMCID: PMC4666916; DOI: 10.1523/JNEUROSCI.1813-15.2015;
     
Showing 10 of 63 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 62 publications over 30 distinct years, with a maximum of 5 publications in 2004 and 2006

YearPublications
19902
19921
19931
19941
19953
19981
19993
20002
20011
20021
20032
20045
20053
20065
20073
20084
20091
20101
20112
20124
20133
20143
20152
20161
20182
20191
20211
20221
20231
20241

2004 American Epilepsy Society: Innovative Research Award
2001 BU School of Medicine: Dean’s Distinguished Faculty Service Award
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Autism
Brain Inhibition
Epilepsy
Gene Regulation
Systems Biology
Contact for Mentoring:

72 E. Concord St Building A
Boston MA 02118
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