Shelley Russek | Profiles RNS

Shelley J. Russek, PhD

Professor

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

PhD, Boston University
MS, Stony Brook University
BA, University of California, San Diego

Websites

	Pharmacology & Experimental Therapeutics Faculty
	Biology Faculty
	Center for Systems Neuroscience
	Graduate Program for Neuroscience
	ResearchGate
	LinkedIn
	Twitter
	Loop Frontiers

ORCID : 0000-0001-7547-3089

Research Interests of the Russek Laboratory: Dysregulated Plasticity of the Nervous System

The plasticity of a neuron’s receptor systems at the membrane is a key feature of the brain that enables its development as well as its function throughout life, creating and responding to an ever-changing external and internal world. A glorious biological feature of existence, however, also contributes to mankind’s most devastating disorders. Dysregulated plasticity takes multiple forms, from the unrelenting seizures of an infant that later emerges with brain damage, to the manifestation of autism and schizophrenia, all begging for curative therapies. Our chief interests in the laboratory surround a desire to understand the genetic and epigenetic basis of neurotransmitter and neurotrophin receptor regulation. We believe that such an understanding will enable us to contribute to the future development of therapeutics that can tackle these complex human problems where plasticity has lost its balance in controlling brain inhibition and excitation.

We employ a variety of proteomic and transcriptomic techniques, including confocal fluorescence immunohistochemistry, western blot, proximity ligation assays, siRNA silencing, RNA and chromatin immunoprecipitation (ChIP) high density sequencing, methylation genome analysis, proximity ligation analysis, primary neuronal cultures, and in vivo models (rodent and zebrafish) to test hypotheses of disease etiology and potential strategies for novel molecular therapeutics using novel chemical libraries and re-purposed therapeutics.

Director
Boston University
Graduate Program for Neuroscience

Member
Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Graduate Program for Neuroscience
07/01/2023 - 06/30/2028 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5T32NS131178-02

The STAT3 response of excitatory neurons to epileptogenic brain injury
05/01/2022 - 04/30/2027 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS122385-02

Development of Novel JAK/STAT Inhibitors for Epilepsy Prevention and Treatment
01/01/2014 - 09/16/2024 (Multi-PI)
PI: Shelley J. Russek, PhD
Regents of the University of Colorado, on behalf of The University of Colorado Denver NIH NINDS
5R21NS083057-02

The STAT3 response of excitatory neurons to epileptogenic brain injury
05/15/2020 - 04/30/2022 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1R56NS117141-01

Mapping the Transcriptome of Age-Related Hippocampal Trisynaptic Circuit Dysfunction in a Rat Model for Alzheimer's Disease
02/01/2019 - 01/31/2022 (Multi-PI)
PI: Shelley J. Russek, PhD
NIH/National Institute on Aging
5R21AG061553-02

Modeling Multi-scale Sleep EEG Dynamics as a Framework for Biomarker Discovery
07/01/2021 - 08/31/2021 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NINDS
5R01NS096177-06

Rapid removal of Amyloid-B aggregates using superparamagnetic nanoparticles immunotherapy (Billing Agreement for Shen Ning)
07/01/2019 - 06/30/2021 (Subcontract PI)
Massachusetts General Hospital NIH NIA
1R01AG062547-01

Does REST make you resilient?
05/07/2018 - 03/31/2021 (Multi-PI)
PI: Shelley J. Russek, PhD
NIH/National Institute of Mental Health
5R21MH113128-02

GABA(A) Receptor Subunit Regulation in Epileptogenesis
09/01/2015 - 06/30/2020 (Multi-PI)
PI: Shelley J. Russek, PhD
Regents of the University of Colorado, on behalf of The University of Colorado Denver NIH NINDS
5R01NS051710-14

Student Billing agreement for Shen Ning
07/01/2018 - 06/30/2019 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NIA
1RF1AG048080-01

Showing 10 of 16 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2024	Graduate Program for Neuroscience	5T32NS131178-02
2024	The STAT3 Response of Excitatory Neurons to Epileptogenic Brain Injury	5R01NS122385-03
2023	Graduate Program for Neuroscience	1T32NS131178-01
2023	The STAT3 Response of Excitatory Neurons to Epileptogenic Brain Injury	5R01NS122385-02
2022	The STAT3 response of excitatory neurons to epileptogenic brain injury	1R01NS122385-01A1
2020	The STAT3 response of excitatory neurons to epileptogenic brain injury	1R56NS117141-01
2020	Mapping the Transcriptome of Age-Related Hippocampal Trisynaptic Circuit Dysfunction in a Rat Model for Alzheimer's Disease	5R21AG061553-02
2019	Mapping the Transcriptome of Age-Related Hippocampal Trisynaptic Circuit Dysfunction in a Rat Model for Alzheimer's Disease	1R21AG061553-01
2019	Does REST make you resilient?	5R21MH113128-02	1
2018	Does REST make you resilient?	1R21MH113128-01A1	1

Showing 10 of 35 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Phan BN, Ray MH, Xue X, Fu C, Fenster RJ, Kohut SJ, Bergman J, Haber SN, McCullough KM, Fish MK, Glausier JR, Su Q, Tipton AE, Lewis DA, Freyberg Z, Tseng GC, Russek SJ, Alekseyev Y, Ressler KJ, Seney ML, Pfenning AR, Logan RW. Single nuclei transcriptomics in human and non-human primate striatum in opioid use disorder. Nat Commun. 2024 Jan 31; 15(1):878.View Related Profiles.

Russek, Shelley
Alekseyev, Yuriy

PMID: 38296993; PMCID: PMC10831093; DOI: 10.1038/s41467-024-45165-7;

Tipton AE, Cruz Del Angel Y, Hixson K, Carlsen J, Strode D, Busquet N, Mesches MH, Gonzalez MI, Napoli E, Russek SJ, Brooks-Kayal AR. Selective Neuronal Knockout of STAT3 Function Inhibits Epilepsy Progression, Improves Cognition, and Restores Dysregulated Gene Networks in a Temporal Lobe Epilepsy Model. Ann Neurol. 2023 Jul; 94(1):106-122.View Related Profiles.

Hixson, Kathryn
Russek, Shelley

PMID: 36935347; PMCID: PMC10313781; DOI: 10.1002/ana.26644;

Hixson, Kathryn
Russek, Shelley

PMID: 36935347; PMCID: PMC10313781; DOI: 10.1002/ana.26644;

Tipton AE, Russek SJ. Regulation of Inhibitory Signaling at the Receptor and Cellular Level; Advances in Our Understanding of GABAergic Neurotransmission and the Mechanisms by Which It Is Disrupted in Epilepsy. Front Synaptic Neurosci. 2022; 14:914374. PMID: 35874848; PMCID: PMC9302637; DOI: 10.3389/fnsyn.2022.914374;

Tipton AE, George J, Ratner M, Farb D, Russek S. Data from single nuclei RNA-sequencing reveals a prodromal gene network response in excitatory neurons of a humanized rat Alzheimer's disease model. Alzheimers Dement. 2021 Dec; 17 Suppl 2:e058589.View Related Profiles.

Farb, David
George, Jonique
Ratner, Marcia
Russek, Shelley

PMID: 34971150; DOI: 10.1002/alz.058589;

Hixson KM, Cogswell M, Brooks-Kayal AR, Russek SJ. Evidence for a non-canonical JAK/STAT signaling pathway in the synthesis of the brain's major ion channels and neurotransmitter receptors. BMC Genomics. 2019 Aug 28; 20(1):677.View Related Profiles.

Hixson, Kathryn
Cogswell, Meaghan
Russek, Shelley

PMID: 31455240; PMCID: PMC6712773; DOI: 10.1186/s12864-019-6033-2;

Li Z, Cogswell M, Hixson K, Brooks-Kayal AR, Russek SJ. Nuclear Respiratory Factor 1 (NRF-1) Controls the Activity Dependent Transcription of the GABA-A Receptor Beta 1 Subunit Gene in Neurons. Front Mol Neurosci. 2018; 11:285.View Related Profiles.

Hixson, Kathryn
Russek, Shelley

PMID: 30186109; PMCID: PMC6113564; DOI: 10.3389/fnmol.2018.00285;

Ruan QT, Yazdani N, Beierle JA, Hixson KM, Hokenson KE, Apicco DJ, Luttik KP, Zheng K, Maziuk BF, Ash PEA, Szumlinski KK, Russek SJ, Wolozin B, Bryant CD. Changes in neuronal immunofluorescence in the C- versus N-terminal domains of hnRNP H following D1 dopamine receptor activation. Neurosci Lett. 2018 09 25; 684:109-114.View Related Profiles.

Wolozin, Benjamin
Bryant, Camron
Apicco, Daniel
Beierle, Jacob
Hixson, Kathryn
Hokenson, Kristen
Yazdani, Neema
Ash, Peter
Russek, Shelley

PMID: 30003938; PMCID: PMC6330092; DOI: 10.1016/j.neulet.2018.07.015;

Thomas AX, Cruz Del Angel Y, Gonzalez MI, Carrel AJ, Carlsen J, Lam PM, Hempstead BL, Russek SJ, Brooks-Kayal AR. Rapid Increases in proBDNF after Pilocarpine-Induced Status Epilepticus in Mice Are Associated with Reduced proBDNF Cleavage Machinery. eNeuro. 2016 Jan-Feb; 3(1). PMID: 27057559; PMCID: PMC4814566; DOI: 10.1523/ENEURO.0020-15.2016;

Huang S, Hokenson K, Bandyopadhyay S, Russek SJ, Kirkwood A. Brief Dark Exposure Reduces Tonic Inhibition in Visual Cortex. J Neurosci. 2015 Dec 2; 35(48):15916-20.View Related Profiles.

Hokenson, Kristen
Russek, Shelley

PMID: 26631472; PMCID: PMC4666916; DOI: 10.1523/JNEUROSCI.1813-15.2015;

Showing 10 of 63 results. Show More

Raible DJ, Frey LC, Del Angel YC, Carlsen J, Hund D, Russek SJ, Smith B, Brooks-Kayal AR. JAK/STAT pathway regulation of GABAA receptor expression after differing severities of experimental TBI. Exp Neurol. 2015 Sep; 271:445-56. PMID: 26172316; PMCID: PMC5969808; DOI: 10.1016/j.expneurol.2015.07.001;

Grabenstatter HL, Cogswell M, Cruz Del Angel Y, Carlsen J, Gonzalez MI, Raol YH, Russek SJ, Brooks-Kayal AR. Effect of spontaneous seizures on GABAA receptor a4 subunit expression in an animal model of temporal lobe epilepsy. Epilepsia. 2014 Nov; 55(11):1826-33. PMID: 25223733; PMCID: PMC4596257; DOI: 10.1111/epi.12771;

Smith CC, Martin SC, Sugunan K, Russek SJ, Gibbs TT, Farb DH. A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation. Mol Pharmacol. 2014 Oct; 86(4):390-8.View Related Profiles.

Farb, David
Sugunan, Kavitha
Russek, Shelley
Martin, Stella

PMID: 25057049; PMCID: PMC4164982; DOI: 10.1124/mol.114.094128;

Grabenstatter HL, Carlsen J, Raol YH, Yang T, Hund D, Cruz Del Angel Y, White AM, Gonzalez MI, Longo FM, Russek SJ, Brooks-Kayal AR. Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus. J Neurosci Res. 2014 Oct; 92(10):1307-18. PMID: 24801281; PMCID: PMC4134742; DOI: 10.1002/jnr.23402;

Grabenstatter HL, Del Angel YC, Carlsen J, Wempe MF, White AM, Cogswell M, Russek SJ, Brooks-Kayal AR. The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy. Neurobiol Dis. 2014 Feb; 62:73-85. PMID: 24051278; PMCID: PMC3908775; DOI: 10.1016/j.nbd.2013.09.003;

Saha S, Hu Y, Martin SC, Bandyopadhyay S, Russek SJ, Farb DH. Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity. BMC Pharmacol Toxicol. 2013; 14:37.View Related Profiles.

Farb, David
Russek, Shelley
Martin, Stella

PMID: 23879974; PMCID: PMC3734045; DOI: 10.1186/2050-6511-14-37;

Kostakis E, Smith C, Jang MK, Martin SC, Richards KG, Russek SJ, Gibbs TT, Farb DH. The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism. Mol Pharmacol. 2013 Aug; 84(2):261-74.View Related Profiles.

Farb, David
Russek, Shelley
Martin, Stella
Gibbs, Terrell

PMID: 23716622; PMCID: PMC3716320; DOI: 10.1124/mol.113.085696;

Grabenstatter HL, Russek SJ, Brooks-Kayal AR. Molecular pathways controlling inhibitory receptor expression. Epilepsia. 2012 Dec; 53 Suppl 9:71-8. PMID: 23216580; PMCID: PMC3776022; DOI: 10.1111/epi.12036;

Ahn S, Huang CL, Ozkumur E, Zhang X, Chinnala J, Yalcin A, Bandyopadhyay S, Russek S, Unlü MS, DeLisi C, Irani RJ. TATA binding proteins can recognize nontraditional DNA sequences. Biophys J. 2012 Oct 3; 103(7):1510-7. PMID: 23062343; PMCID: PMC3471470; DOI: 10.1016/j.bpj.2012.08.030;

Raible DJ, Frey LC, Cruz Del Angel Y, Russek SJ, Brooks-Kayal AR. GABA(A) receptor regulation after experimental traumatic brain injury. J Neurotrauma. 2012 Nov 1; 29(16):2548-54. PMID: 22827467; PMCID: PMC3495117; DOI: 10.1089/neu.2012.2483;

Brooks-Kayal AR, Russek SJ. Regulation of GABA-A Receptor Gene Expression and Epilepsy. Jasper's Basic Mechanisms of the Epilepsies. National Center for Biotechnology Information. Bethesda, MD. 2012. View Publication

Kim JH, Roberts DS, Hu Y, Lau GC, Brooks-Kayal AR, Farb DH, Russek SJ. Brain-derived neurotrophic factor uses CREB and Egr3 to regulate NMDA receptor levels in cortical neurons. J Neurochem. 2012 Jan; 120(2):210-9.View Related Profiles.

Year	Publications
1990	2
1992	1
1993	1
1994	1
1995	3
1998	1
1999	3
2000	2
2001	1
2002	1
2003	2
2004	5
2005	3
2006	5
2007	3
2008	4
2009	1
2010	1
2011	2
2012	4
2013	3
2014	3
2015	2
2016	1
2018	2
2019	1
2021	1
2022	1
2023	1
2024	1