Nelson Lau | Profiles RNS

Nelson Lau, PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Biochemistry & Cell Biology

PhD, Massachusetts Institute of Technology
BS, State University of New York at Albany

Websites

	Lau Lab Website
	Biochemistry Faculty
	ResearchGate
	LinkedIn
	Twitter

ORCID : 0000-0001-9907-1404

Director of Genome Institute
Boston University
Dean’s Office

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research

Transposable Element (TE) RNA regulation via small RNA pathways in aging cells and neurodegeneration.
09/15/2022 - 05/31/2027 (PI)
NIH/National Institute on Aging
5R01AG078930-02

Small RNA interactions with transgenes in genetically modified mosquito lines
07/01/2023 - 06/30/2026 (Subcontract PI)
University of North Texas NIH NIAID
1R15AI171800-01A1

Transposable elements in the keratinocyte genome and their regulation during skin development and epidermal differentiation
03/16/2021 - 01/31/2026 (Multi-PI)
PI: Nelson Lau, PhD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R01AR078306-03

The interplay between transposons and piRNA pathways
08/10/2020 - 04/30/2024 (PI)
NIH/National Institute of General Medical Sciences
3R01GM135215-04S1

Transposon landscapes and transcriptome diversity in aging neurons
01/01/2018 - 03/31/2022 (PI)
NIH/National Institute on Aging
5R01AG052465-06

THE IMPACT OF PIWI ASSOCIATED TRANSCRIPTS IN XENOPUS GERM CELL DEVELOPMENT
09/12/2017 - 05/31/2020 (PI)
NIH/National Institute of Child Health & Human Development
5R21HD088792-03

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Yabaji SM, Zhernovkov V, Araveti PB, Lata S, Rukhlenko OS, Abdullatif SA, Alekseev Y, Ma Q, Dayama G, Lau NC, Bishai WR, Crossland NA, Campbell JD, Kholodenko BN, Gimelbrant AA, Kobzik L, Kramnik I. Myc Dysregulation in Activated Macrophages Initiates Iron-Mediated Lipid Peroxidation that Fuels Type I Interferon and Compromises TB Resistance. bioRxiv. 2024 Mar 10.View Related Profiles.

Kramnik, Igor
Lau, Nelson
Crossland, Nicholas
Araveti, Prasanna

PMID: 38496444; PMCID: PMC10942339; DOI: 10.1101/2024.03.05.583602;

Ma Q, Srivastav SP, Gamez S, Dayama G, Feitosa-Suntheimer F, Patterson EI, Johnson RM, Matson EM, Gold AS, Brackney DE, Connor JH, Colpitts TM, Hughes GL, Rasgon JL, Nolan T, Akbari OS, Lau NC. Corrigendum: A mosquito small RNA genomics resource reveals dynamic evolution and host responses to viruses and transposons. Genome Res. 2024 Feb 07; 34(1):160.View Related Profiles.

Connor, John
Lau, Nelson
Colpitts, Tonya

PMID: 38326031; PMCID: PMC10903936; DOI: 10.1101/gr.278898.123;

Henderson C, Brustolin M, Hegde S, Dayama G, Lau N, Hughes GL, Bergey C, Rasgon JL. Transcriptomic and small RNA response to Mayaro virus infection in Anopheles stephensi mosquitoes. PLoS Negl Trop Dis. 2022 Jun; 16(6):e0010507. PMID: 35763539; PMCID: PMC9273063; DOI: 10.1371/journal.pntd.0010507;

Feitosa-Suntheimer F, Zhu Z, Mameli E, Dayama G, Gold AS, Broos-Caldwell A, Troupin A, Rippee-Brooks M, Corley RB, Lau NC, Colpitts TM, Londoño-Renteria B. Dengue Virus-2 Infection Affects Fecundity and Elicits Specific Transcriptional Changes in the Ovaries of Aedes aegypti Mosquitoes. Front Microbiol. 2022; 13:886787.View Related Profiles.

Lau, Nelson
Corley, Ronald
Colpitts, Tonya
Zhu, Zheng

PMID: 35814655; PMCID: PMC9260120; DOI: 10.3389/fmicb.2022.886787;

Yang N, Srivastav SP, Rahman R, Ma Q, Dayama G, Li S, Chinen M, Lei EP, Rosbash M, Lau NC. Transposable element landscapes in aging Drosophila. PLoS Genet. 2022 03; 18(3):e1010024.View Related Profiles.

Yang, Nachen
Lau, Nelson

PMID: 35239675; PMCID: PMC8893327; DOI: 10.1371/journal.pgen.1010024;

Dayama G, Bulekova K, Lau NC. Extending and Running the Mosquito Small RNA Genomics Resource Pipeline. Methods Mol Biol. 2022; 2509:341-352.View Related Profiles.

Bulekova, Katia
Lau, Nelson

PMID: 35796973; PMCID: PMC10100135; DOI: 10.1007/978-1-0716-2380-0_20;

Bandyopadhyay S, Douglass J, Kapell S, Khan N, Feitosa-Suntheimer F, Klein JA, Temple J, Brown-Culbertson J, Tavares AH, Saeed M, Lau NC. DNA templates with blocked long 3' end single-stranded overhangs (BL3SSO) promote bona fide Cas9-stimulated homology-directed repair of long transgenes into endogenous gene loci. G3 (Bethesda). 2021 08 07; 11(8).View Related Profiles.

Klein, Jenny
Saeed, Mohsan
Khan, Nazimuddin
Lau, Nelson
Bandyopadhyay, Saptaparni
Kapell, Sebastian

PMID: 33989385; PMCID: PMC8496256; DOI: 10.1093/g3journal/jkab169;

Ma Q, Srivastav SP, Gamez S, Dayama G, Feitosa-Suntheimer F, Patterson EI, Johnson RM, Matson EM, Gold AS, Brackney DE, Connor JH, Colpitts TM, Hughes GL, Rasgon JL, Nolan T, Akbari OS, Lau NC. A mosquito small RNA genomics resource reveals dynamic evolution and host responses to viruses and transposons. Genome Res. 2021 03; 31(3):512-528.View Related Profiles.

Connor, John
Lau, Nelson
Colpitts, Tonya

PMID: 33419731; PMCID: PMC7919454; DOI: 10.1101/gr.265157.120;

Gamez S, Srivastav S, Akbari OS, Lau NC. Diverse Defenses: A Perspective Comparing Dipteran Piwi-piRNA Pathways. Cells. 2020 09 27; 9(10). PMID: 32992598; PMCID: PMC7601171; DOI: 10.3390/cells9102180;

Srivastav SP, Rahman R, Ma Q, Pierre J, Bandyopadhyay S, Lau NC. Har-P, a short P-element variant, weaponizes P-transposase to severely impair Drosophila development. Elife. 2019 12 17; 8.View Related Profiles.

Lau, Nelson
Bandyopadhyay, Saptaparni

PMID: 31845649; PMCID: PMC6917496; DOI: 10.7554/eLife.49948;

Showing 10 of 47 results. Show More

Zeldich E, Chen CD, Boden E, Howat B, Nasse JS, Zeldich D, Lambert AG, Yuste A, Cherry JD, Mathias RM, Ma Q, Lau NC, McKee AC, Hatzipetros T, Abraham CR. Klotho Is Neuroprotective in the Superoxide Dismutase (SOD1G93A) Mouse Model of ALS. J Mol Neurosci. 2019 Oct; 69(2):264-285.View Related Profiles.

McKee, Ann
Abraham, Carmela
Chen, Ci-Di
Zeldich, Ella
Nasse, Jason
Cherry, Jonathan
Lau, Nelson

PMID: 31250273; PMCID: PMC7008951; DOI: 10.1007/s12031-019-01356-2;

Gushchanskaia ES, Esse R, Ma Q, Lau NC, Grishok A. Interplay between small RNA pathways shapes chromatin landscapes in C. elegans. Nucleic Acids Res. 2019 06 20; 47(11):5603-5616.View Related Profiles.

Grishok, Alla
Gushchanskaia, Ekaterina
Lau, Nelson

PMID: 31216042; PMCID: PMC6582410; DOI: 10.1093/nar/gkz275;

Kozeretska IA, Shulha VI, Serga SV, Rozhok AI, Protsenko OV, Lau NC. A rapid change in P-element-induced hybrid dysgenesis status in Ukrainian populations of Drosophila melanogaster. Biol Lett. 2018 08; 14(8). PMID: 30135116; PMCID: PMC6127123; DOI: 10.1098/rsbl.2018.0184;

Clark JP, Rahman R, Yang N, Yang LH, Lau NC. Drosophila PAF1 Modulates PIWI/piRNA Silencing Capacity. Curr Biol. 2017 Sep 11; 27(17):2718-2726.e4.View Related Profiles.

Yang, Nachen
Lau, Nelson

PMID: 28844648; PMCID: PMC5611886; DOI: 10.1016/j.cub.2017.07.052;

Toombs JA, Sytnikova YA, Chirn GW, Ang I, Lau NC, Blower MD. Xenopus Piwi proteins interact with a broad proportion of the oocyte transcriptome. RNA. 2017 Apr; 23(4):504-520.View Related Profiles.

Blower, Michael
Lau, Nelson

PMID: 28031481; PMCID: PMC5340914; DOI: 10.1261/rna.058859.116;

Madison-Villar MJ, Sun C, Lau NC, Settles ML, Mueller RL. Small RNAs from a Big Genome: The piRNA Pathway and Transposable Elements in the Salamander Species Desmognathus fuscus. J Mol Evol. 2016 Oct; 83(3-4):126-136. PMID: 27743003; DOI: 10.1007/s00239-016-9759-3;

Chirn GW, Rahman R, Sytnikova YA, Matts JA, Zeng M, Gerlach D, Yu M, Berger B, Naramura M, Kile BT, Lau NC. Conserved piRNA Expression from a Distinct Set of piRNA Cluster Loci in Eutherian Mammals. PLoS Genet. 2015 Nov; 11(11):e1005652. PMID: 26588211; PMCID: PMC4654475; DOI: 10.1371/journal.pgen.1005652;

Rahman R, Chirn GW, Kanodia A, Sytnikova YA, Brembs B, Bergman CM, Lau NC. Unique transposon landscapes are pervasive across Drosophila melanogaster genomes. Nucleic Acids Res. 2015 Dec 15; 43(22):10655-72. PMID: 26578579; PMCID: PMC4678822; DOI: 10.1093/nar/gkv1193;

Post C, Clark JP, Sytnikova YA, Chirn GW, Lau NC. The capacity of target silencing by Drosophila PIWI and piRNAs. RNA. 2014 Dec; 20(12):1977-86. PMID: 25336588; PMCID: PMC4238361; DOI: 10.1261/rna.046300.114;

Sytnikova YA, Rahman R, Chirn GW, Clark JP, Lau NC. Transposable element dynamics and PIWI regulation impacts lncRNA and gene expression diversity in Drosophila ovarian cell cultures. Genome Res. 2014 Dec; 24(12):1977-90. PMID: 25267525; PMCID: PMC4248314; DOI: 10.1101/gr.178129.114;

Arnold CD, Gerlach D, Spies D, Matts JA, Sytnikova YA, Pagani M, Lau NC, Stark A. Quantitative genome-wide enhancer activity maps for five Drosophila species show functional enhancer conservation and turnover during cis-regulatory evolution. Nat Genet. 2014 Jul; 46(7):685-92. PMID: 24908250; PMCID: PMC4250274; DOI: 10.1038/ng.3009;

Ghiretti AE, Moore AR, Brenner RG, Chen LF, West AE, Lau NC, Van Hooser SD, Paradis S. Rem2 is an activity-dependent negative regulator of dendritic complexity in vivo. J Neurosci. 2014 Jan 08; 34(2):392-407. PMID: 24403140; PMCID: PMC3870928; DOI: 10.1523/JNEUROSCI.1328-13.2014;

Clark JP, Lau NC. Piwi Proteins and piRNAs step onto the systems biology stage. Adv Exp Med Biol. 2014; 825:159-97. PMID: 25201106; PMCID: PMC4248790; DOI: 10.1007/978-1-4939-1221-6_5;

Ow MC, Lau NC, Hall SE. Small RNA library cloning procedure for deep sequencing of specific endogenous siRNA classes in Caenorhabditis elegans. Methods Mol Biol. 2014; 1173:59-70. PMID: 24920360; PMCID: PMC5328689; DOI: 10.1007/978-1-4939-0931-5_6;

Matts JA, Sytnikova Y, Chirn GW, Igloi GL, Lau NC. Small RNA library construction from minute biological samples. Methods Mol Biol. 2014; 1093:123-36. PMID: 24178561; PMCID: PMC4036803; DOI: 10.1007/978-1-62703-694-8_10;

Zeng M, Kuzirian MS, Harper L, Paradis S, Nakayama T, Lau NC. Organic small hairpin RNAs (OshR): a do-it-yourself platform for transgene-based gene silencing. Methods. 2013 Sep 15; 63(2):101-9. PMID: 23707624; PMCID: PMC3966114; DOI: 10.1016/j.ymeth.2013.05.007;

Sytnikova Y, Lau NC. Does the APC/C Mark MIWI and piRNAs for a final farewell? Dev Cell. 2013 Jan 28; 24(2):119-20. PMID: 23369709; PMCID: PMC4036799; DOI: 10.1016/j.devcel.2013.01.005;

Hall SE, Chirn GW, Lau NC, Sengupta P. RNAi pathways contribute to developmental history-dependent phenotypic plasticity in C. elegans. RNA. 2013 Mar; 19(3):306-19. PMID: 23329696; PMCID: PMC3677242; DOI: 10.1261/rna.036418.112;

Lau NC. Small RNAs in the animal gonad: guarding genomes and guiding development. Int J Biochem Cell Biol. 2010 Aug; 42(8):1334-47. PMID: 20227517; PMCID: PMC2902580; DOI: 10.1016/j.biocel.2010.03.005;

Wu Q, Luo Y, Lu R, Lau N, Lai EC, Li WX, Ding SW. Virus discovery by deep sequencing and assembly of virus-derived small silencing RNAs. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1606-11. PMID: 20080648; PMCID: PMC2824396; DOI: 10.1073/pnas.0911353107;

Robine N, Lau NC, Balla S, Jin Z, Okamura K, Kuramochi-Miyagawa S, Blower MD, Lai EC. A broadly conserved pathway generates 3'UTR-directed primary piRNAs. Curr Biol. 2009 Dec 29; 19(24):2066-76.View Related Profiles.

Blower, Michael
Lau, Nelson

PMID: 20022248; PMCID: PMC2812478; DOI: 10.1016/j.cub.2009.11.064;

Lau NC, Ohsumi T, Borowsky M, Kingston RE, Blower MD. Systematic and single cell analysis of Xenopus Piwi-interacting RNAs and Xiwi. EMBO J. 2009 Oct 07; 28(19):2945-58.View Related Profiles.

Blower, Michael
Lau, Nelson

PMID: 19713941; PMCID: PMC2760114; DOI: 10.1038/emboj.2009.237;

Lau NC, Robine N, Martin R, Chung WJ, Niki Y, Berezikov E, Lai EC. Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line. Genome Res. 2009 Oct; 19(10):1776-85. PMID: 19541914; PMCID: PMC2765285; DOI: 10.1101/gr.094896.109;

Lau NC. Analysis of small endogenous RNAs. Curr Protoc Mol Biol. 2008 Jan; Chapter 26:Unit26.7. PMID: 18231982; DOI: 10.1002/0471142727.mb2607s81;

Miska EA, Alvarez-Saavedra E, Abbott AL, Lau NC, Hellman AB, McGonagle SM, Bartel DP, Ambros VR, Horvitz HR. Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genet. 2007 Dec; 3(12):e215. PMID: 18085825; PMCID: PMC2134938; DOI: 10.1371/journal.pgen.0030215;

Seto AG, Kingston RE, Lau NC. The coming of age for Piwi proteins. Mol Cell. 2007 Jun 08; 26(5):603-9. PMID: 17560367; DOI: 10.1016/j.molcel.2007.05.021;

Lau NC, Seto AG, Kim J, Kuramochi-Miyagawa S, Nakano T, Bartel DP, Kingston RE. Characterization of the piRNA complex from rat testes. Science. 2006 Jul 21; 313(5785):363-7. PMID: 16778019; DOI: 10.1126/science.1130164;

Abbott AL, Alvarez-Saavedra E, Miska EA, Lau NC, Bartel DP, Horvitz HR, Ambros V. The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Dev Cell. 2005 Sep; 9(3):403-14. PMID: 16139228; PMCID: PMC3969732; DOI: 10.1016/j.devcel.2005.07.009;

Li M, Jones-Rhoades MW, Lau NC, Bartel DP, Rougvie AE. Regulatory mutations of mir-48, a C. elegans let-7 family MicroRNA, cause developmental timing defects. Dev Cell. 2005 Sep; 9(3):415-22. PMID: 16139229; DOI: 10.1016/j.devcel.2005.08.002;

Lau NC, Lai EC. Diverse roles for RNA in gene regulation. Genome Biol. 2005; 6(4):315. PMID: 15833133; PMCID: PMC1088955; DOI: 10.1186/gb-2005-6-4-315;

Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS, Johnson JM. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 2005 Feb 17; 433(7027):769-73. PMID: 15685193; DOI: 10.1038/nature03315;

Landthaler M, Lau NC, Shub DA. Group I intron homing in Bacillus phages SPO1 and SP82: a gene conversion event initiated by a nicking homing endonuclease. J Bacteriol. 2004 Jul; 186(13):4307-14. PMID: 15205433; PMCID: PMC421625; DOI: 10.1128/JB.186.13.4307-4314.2004;

Bergman NH, Lau NC, Lehnert V, Westhof E, Bartel DP. The three-dimensional architecture of the class I ligase ribozyme. RNA. 2004 Feb; 10(2):176-84. PMID: 14730016; PMCID: PMC1370529

Lau NC, Bartel DP. Censors of the genome. Sci Am. 2003 Aug; 289(2):34-41. PMID: 12884536

Lim LP, Lau NC, Weinstein EG, Abdelhakim A, Yekta S, Rhoades MW, Burge CB, Bartel DP. The microRNAs of Caenorhabditis elegans. Genes Dev. 2003 Apr 15; 17(8):991-1008. PMID: 12672692; PMCID: PMC196042; DOI: 10.1101/gad.1074403;

Landthaler M, Begley U, Lau NC, Shub DA. Two self-splicing group I introns in the ribonucleotide reductase large subunit gene of Staphylococcus aureus phage Twort. Nucleic Acids Res. 2002 May 01; 30(9):1935-43. PMID: 11972330; PMCID: PMC113830

Lau NC, Lim LP, Weinstein EG, Bartel DP. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science. 2001 Oct 26; 294(5543):858-62. PMID: 11679671; DOI: 10.1126/science.1065062;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 47 publications over 21 distinct years, with a maximum of 7 publications in 2014

Bar chart showing 47 publications over 21 distinct years, with a maximum of 7 publications in 2014

Year	Publications
2001	1
2002	1
2003	2
2004	2
2005	4
2006	1
2007	2
2008	1
2009	3
2010	2
2013	3
2014	7
2015	2
2016	2
2017	1
2018	1
2019	3
2020	1
2021	2
2022	4
2024	2

2010-2012 Searle Scholar: Nelson Lau

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

PIWI Subfamily of Argonaute Proteins
Piwi-Interacting RNA

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