Dr. Joyce-Brady is Associate Professor in the Department of Medicine. He is an Attending Physician for the Medical Intensive Care Unit and the Pulmonary Consultation Service at Boston Medical Center . He is also the Director of Pulmonary, Respiratory Therapy and Ventilator Care Services at The Radius Specialty Hospital-Boston and Quincy.
Dr. Joyce-Brady’s research is focused on the response of the developing and the adult lung to oxidant stress. His focus is on glutathione and glutathione metabolism, particularly in the lung lining fluid that baths the surface of the lung. His laboratory has characterized the key enzyme in glutathione metabolism, gamma-glutamyl transferase (GGT), and a mouse model of GGT deficiency, the GGTenu1 mouse. This work has revealed the presence of glutathione metabolism in LLF and a novel target that can augment lung lining fluid glutathione content under oxidant stress associated with inflammatory lung disease.
His laboratory has also utilized several tools to study gene expression in the developing lung, including suppression subtractive hybridization, differential display and microarrays. Selected genes that are developmentally regulated in the perintal period are now under study in adult lung to decipher their role in repair following injury. One such gene, fibulin-5, is a regulator of elastogenesis and severe emphysema develops with fibulin-5 deficiency in the knock out lung. Fibulin-5 is a matrix protein that also functions in antioxidant defense and current studies are aimed at integrating the loss of elastogenesis with oxidant stress.
Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences
2007 Office of Technology Transfer, Boston University:
Publications listed below are automatically derived from MEDLINE/PubMed and other
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Jean JC, Brown LAS, Joyce-Brady M. "Perinatal Lung development: The Lung at Birth". In H Aly and H Abdel-Hady (eds), Respiratory Management of Newborns. InTech. Croatia. 2016; 119-138. View Publication
Epstein SK, Joyce-Brady MF. “Management of the difficult-to-wean adult patient in the intensive care unit”. In Polly E Parsons and Geraldine Finlay (eds), UpToDate. 2016.
Tuzova M, Jean JC, Hughey RP, Brown LA, Cruikshank WW, Hiratake J, Joyce-Brady M. Inhibiting lung lining fluid glutathione metabolism with GGsTop as a novel treatment for asthma. Front Pharmacol. 2014; 5:179.View Related Profiles. PMID: 25132819; DOI: 10.3389/fphar.2014.00179;
Sulis CA, Walkey AJ, Abadi Y, Campbell Reardon C, Joyce-Brady M. Outcomes of a ventilator-associated pneumonia bundle on rates of ventilator-associated pneumonia and other health care-associated infections in a long-term acute care hospital setting. Am J Infect Control. 2014 May; 42(5):536-8.View Related Profiles. PMID: 24773791; DOI: 10.1016/j.ajic.2014.01.020;
Joyce-Brady M, Hiratake J. Inhibiting Glutathione Metabolism in Lung Lining Fluid as a Strategy to Augment Antioxidant Defense. Curr Enzym Inhib. 2011 Jul; 7(2):71-78. PMID: 22485086
Martin Joyce-Brady, William W Cruikshank, Susan R. Doctrow. Antioxidant Strategies in the Treatment of Bronchial Asthma. Bronchial Asthma-Emerging Therapeutic Strategies (Dr. Liz Sapey, Ed). 2011. View Publication
Klings ES, Lowry MH, Li G, Jean JC, Fernandez BO, Garcia-Saura MF, Feelisch M, Joyce-Brady M. Hyperoxia-induced lung injury in gamma-glutamyl transferase deficiency is associated with alterations in nitrosative and nitrative stress. Am J Pathol. 2009 Dec; 175(6):2309-18.View Related Profiles. PMID: 19850887; PMCID: PMC2789614; DOI: 10.2353/ajpath.2009.081017;
Walkey AJ, Reardon CC, Sulis CA, Nace RN, Joyce-Brady M. Epidemiology of ventilator-associated pneumonia in a long-term acute care hospital. Infect Control Hosp Epidemiol. 2009 Apr; 30(4):319-24.View Related Profiles. PMID: 19245314; DOI: 10.1086/596103;
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