Joseph Goodliffe, PhD
Scientist II, Discovery
Decibel Therapeutics




Experienced Scientist with a demonstrated history of working with rodent models of neurodegeneration and neurological disorders. Skilled in cellular and molecular techniques, as well as rodent stereotaxic survival surgeries and ex vivo electrophysiology. Strong background in human, primate and mouse neuroanatomy. Proficient science communicator, writer, and mentor.

Predoctoral Trainee (previously held)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Anatomy & Neurobiology


Predoctoral Trainee (previously held)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Cell & Molecular Biology Program


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Goodliffe J, Rubakovic A, Chang W, Pathak D, Luebke J. Correction: Structural and functional features of medium spiny neurons in the BACHD?N17 mouse model of Huntington's Disease. PLoS One. 2025; 20(7):e0327837.View Related Profiles. PMID: 40638557; PMCID: PMC12244604; DOI: 10.1371/journal.pone.0327837;
     
  2. Tsolias A, Mojica CA, Yamani R, Khanna SD, Abdullatif SA, Snyder BJ, Chang W, Guillamon-Vivancos T, Goodliffe J, Capriglione AL, Palanca ILT, Martinez J, Campbell JD, Luebke JI, Zeldich E, Medalla M. Transcriptional and functional profiles of muscarinic receptor-expressing neurons in primate lateral prefrontal and anterior cingulate cortices. bioRxiv. 2025 May 23.View Related Profiles. PMID: 40475401; PMCID: PMC12139755; DOI: 10.1101/2025.05.23.655820;
     
  3. Kim Y, Chung Y, Kim JA, Han KH, Kang KW, Tran NT, Kim MY, Yi E, Jung S, Kim BJ, Artinian QA, Koehler SD, Pan N, Gibson TM, Becker L, Goodliffe JW, Kalker M, Barnes M, Shaheen LA, Drummond MC, Valayannopoulos V, Choi BY. Otof gene transfer in DFNB9 mice carrying human founder non-truncating alleles. Genes Dis. 2025 Sep; 12(5):101590. PMID: 40485982; PMCID: PMC12142502; DOI: 10.1016/j.gendis.2025.101590;
     
  4. Goodliffe J, Rubakovic A, Chang W, Pathak D, Luebke J. Structural and functional features of medium spiny neurons in the BACHD?N17 mouse model of Huntington's Disease. PLoS One. 2020; 15(6):e0234394.View Related Profiles. PMID: 32574176; PMCID: PMC7310706; DOI: 10.1371/journal.pone.0234394;
     
  5. Medalla M, Chang W, Calderazzo SM, Go V, Tsolias A, Goodliffe JW, Pathak D, De Alba D, Pessina M, Rosene DL, Buller B, Moore TL. Treatment with Mesenchymal-Derived Extracellular Vesicles Reduces Injury-Related Pathology in Pyramidal Neurons of Monkey Perilesional Ventral Premotor Cortex. J Neurosci. 2020 04 22; 40(17):3385-3407.View Related Profiles. PMID: 32241837; PMCID: PMC7178914; DOI: 10.1523/JNEUROSCI.2226-19.2020;
     
  6. Goodliffe JW, Song H, Rubakovic A, Chang W, Medalla M, Weaver CM, Luebke JI. Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington's Disease. PLoS One. 2018; 13(8):e0200626.View Related Profiles. PMID: 30118496; PMCID: PMC6097649; DOI: 10.1371/journal.pone.0200626;
     
  7. Goodliffe JW, Olmos-Serrano JL, Aziz NM, Pennings JL, Guedj F, Bianchi DW, Haydar TF. Absence of Prenatal Forebrain Defects in the Dp(16)1Yey/+ Mouse Model of Down Syndrome. J Neurosci. 2016 Mar 9; 36(10):2926-44.View Related Profiles. PMID: 26961948; PMCID: PMC4783496; DOI: 10.1523/JNEUROSCI.2513-15.2016;
     
  8. Olmos-Serrano JL, Kang HJ, Tyler WA, Silbereis JC, Cheng F, Zhu Y, Pletikos M, Jankovic-Rapan L, Cramer NP, Galdzicki Z, Goodliffe J, Peters A, Sethares C, Delalle I, Golden JA, Haydar TF, Sestan N. Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination. Neuron. 2016 Mar 16; 89(6):1208-22.View Related Profiles. PMID: 26924435; PMCID: PMC4795969; DOI: 10.1016/j.neuron.2016.01.042;
     

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 8 publications over 4 distinct years, with a maximum of 3 publications in 2025

YearPublications
20162
20181
20202
20253

Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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617.638.4200
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