Gregory A. Grillone, MD
Chair
Boston University School of Medicine
Dept of Otolaryngology-Head & Neck Surgery

MD, Mount Sinai School of Medicine




1. PROSPECTIVE RESEARCH:
a) Retrospective Review of Long Term Voice Quality Following Augmentation of the Vocal Fold with Cymetra Using the Minihole Laryngoplasty Technique. IRB approval obtained this year. Chart review in progress.
b) Feasibility of Using Manual Robotic Instrumentation for Microlaryngeal Surgery. The objective of this study is to evaluate effectiveness of a proprietary robotic instrument for use in microlaryngeal surgery. The first phase of this study will utilize a larynx model/mannequin. Subsequent phases will utilize animal and cadaver models. Study is in initial stage of planning.
c) Use of the DaVinci Robotic System in Pharyngeal and Laryngeal Endoscopic Surgery. The object of this study is to evaluate the usefulness of the DaVinci robotic system in performing endoscopic pharyngeal and laryngeal surgery. Currently such procedures are carried out using conventional endoscopic instrumentation. We are in the process of submitting IRB application.
d) Phase 2, Open-label Trial of the Safety and Biological Effect of Pre-operative Peri-lymphatic Ultralow Dose IRX-2 (with Cyclophosphamide, Indomethacin, and Zinc) in Patients with Resectable Cancer of the Head and Neck. This study is in initial planning stage.

2. FUNDED RESEARCH:
a) Spectroscopic Imaging and Diagnosis of Neoplasia
Source: National Institutes of Health (NCI) - 1R01CA097966
P.I.: Gregory Grillone, M.D., F.A.C.S.
This study is the basis of my triologic thesis. The objectives of this research are to develop and test a spectroscopic based algorithm for the evaluation of cancer or pre-cancerous changes in oral cavity epithelium. An in depth study of this approach is being carried out in the oral cavity as well as for a data set previously collected from the esophagus. This study is being carried out in collaboration with the spectroscopy laboratory at MIT. They have developed a portable, clinical device known as the Fast Excitation Emission Matrix (Fast-EEM), which collects reflectance and fluorescence spectra. This instrument is being used to collect spectroscopic data prior to biopsy of oral cavity lesions in patients with suspicious lesions of the oral cavity.

b) Laser Atraumatic Treatment of Ectasias on Vocal Cords
Source: National Institutes of Health (NIDCD) - 1R21DC006853001
PI: Zimmern Wang, M.D.
Our previous studies have shown the efficacy and safety of PDL as an alternative to routine surgeries (that result in more scarring) for treatment of laryngeal papilloma. Specific aims are (1) to further optimize PDL parameters in the cheek pouches of a hamster model; (2) to compare the treatment selectivity and safety between CO2 laser and PDL microvascular targeting (MVT) treatment, in the same model; and (3) to determine whether PDL will produce better and quicker voice improvement than the CO2 laser, in 12 patients with vocal fold small vascular lesions (ectasias).

c) Voice Preserving Treatment of Recurrent Laryngeal Papilloma (RLP)
Source: National Institutes of Health (NIDCD) – 1R01DC006617
P.I. Zimmern Wang, M.D.
This study is a continuation of our effort to develop a new, low cost and less invasive alternative to the currently traumatic surgeries for RLP. Our final objective is to provide a “voice preserving” and long-term effective therapy for RLP that can be delivered in the putpatient setting. This 2 year study will evaluate 30 adults with RLP, using traditional CO2 laser in 15 cases and new PDL-Celecoxib treatment in other 15 cases.

d) Voice Preserving Treatment of Laryngeal Papilloma in Children
Source: National Institutes of Health (NIDCD) – 1R01DC008287
P.I. Zimmern Wang, M.D.

e) Prediction of Cancer Chemoprevention Efficacy with Cell Imaging
Source: National Institutes of Health (NCI) – 1R21CA
P.I. Zimmern Wang, M.D.

f) Harvard Collaborative Oral Cancer Study
Source: National Institutes of Health - Grant #CA 78609
P.I.: Karl T. Kelsey, M.D., M.O.H.,
Site P.I.: Gregory Grillone, M.D., F.A.C.S.

g) Long-term General and Voice Related Quality of Life after Botulinum Toxin Injection for Adductor Spasmodic Dysphonia
Source: Alpha Omega Honor Society
P.I. Gregory A. Grillone, M.D., F.A.C.S.

M. Stuart Strong and Charles W. Vaughan Professor
Boston University School of Medicine
Otolaryngology-Head & Neck Surgery


Chief
Boston Medical Center
Otolaryngology-Head & Neck Surgery


Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Amyloidosis Center



2011-2011 Triological Society: Citation conferred by Dr Kenneth Grundfast, Vice President-Eastern Section of the Triological Societ
2010-2010 Boston Magazine-Castle-Connelly: Listed in Boston Magazine's list of Best Doctors in Boston for 2010


Spectroscopic Imaging and Diagnosis of Neoplasia
08/15/2003 - 05/31/2009 (PI)
Massachusetts Institute of Technology NIH NCI


Margin Guidance for Oral Cancer Resection Using Light Scattering Spectroscopy
12/14/2012 - 05/31/2016 (PI)
NIH-NIDCR
5R21DE023192-02

Patient Navigator
11/01/2005 - 10/31/2010 (PI)
Kohlberg Foundation


Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Plocienniczak MJ, Noordzij JP, Grillone G, Platt M, Brook C. Guidelines for Resident Participation in Otolaryngology Telehealth Clinics During the COVID-19 Pandemic. Otolaryngol Head Neck Surg. 2020 09; 163(3):498-500.View Related Profiles. PMID: 32482138
     
  2. Kim KN, Dyer MA, Qureshi MM, Shah NK, Grillone GA, Faden DL, Jalisi SM, Truong MT. Hypofractionated radiotherapy and surgery compared to standard radiotherapy in early glottic cancer. Am J Otolaryngol. 2020 Sep - Oct; 41(5):102544.View Related Profiles. PMID: 32505989
     
  3. Rubin SJ, Saunders SS, Kuperstock J, Gadaleta D, Burke PA, Grillone G, Moses JM, Murphy JP, Rodriguez G, Salama A, Platt MP. Quality improvement in tracheostomy care: A multidisciplinary approach to standardizing tracheostomy care to reduce complications. Am J Otolaryngol. 2020 Mar - Apr; 41(2):102376.View Related Profiles. PMID: 31924414
     
  4. Sax L, Wong K, Shetty KR, Devaiah AK, Levi J, Grillone GA. Investigating Patient Preferences in Medical Student Attire in the Outpatient Otolaryngology Setting. Ear Nose Throat J. 2019 Sep 30; 145561319871911.View Related Profiles. PMID: 31569983
     
  5. Shetty KR, Ward LM, Levi JR, Grillone G. Novel treatment for mild and moderate velopharyngeal insufficiency using implantable AlloDerm for posterior pharyngeal wall augmentation and review of surgical repair techniques. Am J Otolaryngol. 2019 Nov - Dec; 40(6):102274.View Related Profiles. PMID: 31444004
     
  6. Patel SA, Qureshi MM, Dyer MA, Jalisi S, Grillone G, Truong MT. Comparing surgical and nonsurgical larynx-preserving treatments with total laryngectomy for locally advanced laryngeal cancer. Cancer. 2019 Oct 01; 125(19):3367-3377.View Related Profiles. PMID: 31206637
     
  7. Shah NK, Qureshi MM, Dyer MA, Patel SA, Kim K, Everett PC, Grillone GA, Jalisi SM, Truong MT. Optimal sequencing of chemoradiotherapy for locally advanced laryngeal cancer. Laryngoscope. 2019 10; 129(10):2313-2320.View Related Profiles. PMID: 30628077
     
  8. Crimlisk JT, Krisciunas GP, Sipe MH, Winter MR, Gonzalez RM, Grillone GA. Emergency Airway Response Team (EART) Documentation: Criteria, Feasibility, and Usability. Crit Care Nurs Q. 2018 Oct/Dec; 41(4):426-438.View Related Profiles. PMID: 30153187
     
  9. Wong K, Yee HM, Xavier BA, Grillone GA. Applications of Augmented Reality in Otolaryngology: A Systematic Review. Otolaryngol Head Neck Surg. 2018 12; 159(6):956-967. PMID: 30126323
     
  10. Truong MT, Grillone G. Reluctant Induction Followed by Proton Beam Therapy, If Practicable. Int J Radiat Oncol Biol Phys. 2018 07 15; 101(4):761.View Related Profiles. PMID: 29976481
     
Showing 10 of 57 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 56 publications over 21 distinct years, with a maximum of 6 publications in 2015 and 2017

YearPublications
19921
19931
19941
19961
19971
19983
19993
20031
20041
20053
20064
20083
20093
20102
20123
20143
20156
20176
20183
20195
20202


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Contact for Mentoring:
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  • Assistant
         Name: Sophia Boulas
         Email: sophia.boulas@bmc.org
         Phone: 617-638-7934

830 Harrison Ave, Suite 1400
Boston MA 02118
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