Gregory A. Grillone, MD

a) Retrospective Review of Long Term Voice Quality Following Augmentation of the Vocal Fold with Cymetra Using the Minihole Laryngoplasty Technique. IRB approval obtained this year. Chart review in progress.
b) Feasibility of Using Manual Robotic Instrumentation for Microlaryngeal Surgery. The objective of this study is to evaluate effectiveness of a proprietary robotic instrument for use in microlaryngeal surgery. The first phase of this study will utilize a larynx model/mannequin. Subsequent phases will utilize animal and cadaver models. Study is in initial stage of planning.
c) Use of the DaVinci Robotic System in Pharyngeal and Laryngeal Endoscopic Surgery. The object of this study is to evaluate the usefulness of the DaVinci robotic system in performing endoscopic pharyngeal and laryngeal surgery. Currently such procedures are carried out using conventional endoscopic instrumentation. We are in the process of submitting IRB application.
d) Phase 2, Open-label Trial of the Safety and Biological Effect of Pre-operative Peri-lymphatic Ultralow Dose IRX-2 (with Cyclophosphamide, Indomethacin, and Zinc) in Patients with Resectable Cancer of the Head and Neck. This study is in initial planning stage.

a) Spectroscopic Imaging and Diagnosis of Neoplasia
Source: National Institutes of Health (NCI) - 1R01CA097966
P.I.: Gregory Grillone, M.D., F.A.C.S.
This study is the basis of my triologic thesis. The objectives of this research are to develop and test a spectroscopic based algorithm for the evaluation of cancer or pre-cancerous changes in oral cavity epithelium. An in depth study of this approach is being carried out in the oral cavity as well as for a data set previously collected from the esophagus. This study is being carried out in collaboration with the spectroscopy laboratory at MIT. They have developed a portable, clinical device known as the Fast Excitation Emission Matrix (Fast-EEM), which collects reflectance and fluorescence spectra. This instrument is being used to collect spectroscopic data prior to biopsy of oral cavity lesions in patients with suspicious lesions of the oral cavity.

b) Laser Atraumatic Treatment of Ectasias on Vocal Cords
Source: National Institutes of Health (NIDCD) - 1R21DC006853001
PI: Zimmern Wang, M.D.
Our previous studies have shown the efficacy and safety of PDL as an alternative to routine surgeries (that result in more scarring) for treatment of laryngeal papilloma. Specific aims are (1) to further optimize PDL parameters in the cheek pouches of a hamster model; (2) to compare the treatment selectivity and safety between CO2 laser and PDL microvascular targeting (MVT) treatment, in the same model; and (3) to determine whether PDL will produce better and quicker voice improvement than the CO2 laser, in 12 patients with vocal fold small vascular lesions (ectasias).

c) Voice Preserving Treatment of Recurrent Laryngeal Papilloma (RLP)
Source: National Institutes of Health (NIDCD) – 1R01DC006617
P.I. Zimmern Wang, M.D.
This study is a continuation of our effort to develop a new, low cost and less invasive alternative to the currently traumatic surgeries for RLP. Our final objective is to provide a “voice preserving” and long-term effective therapy for RLP that can be delivered in the putpatient setting. This 2 year study will evaluate 30 adults with RLP, using traditional CO2 laser in 15 cases and new PDL-Celecoxib treatment in other 15 cases.

d) Voice Preserving Treatment of Laryngeal Papilloma in Children
Source: National Institutes of Health (NIDCD) – 1R01DC008287
P.I. Zimmern Wang, M.D.

e) Prediction of Cancer Chemoprevention Efficacy with Cell Imaging
Source: National Institutes of Health (NCI) – 1R21CA
P.I. Zimmern Wang, M.D.

f) Harvard Collaborative Oral Cancer Study
Source: National Institutes of Health - Grant #CA 78609
P.I.: Karl T. Kelsey, M.D., M.O.H.,
Site P.I.: Gregory Grillone, M.D., F.A.C.S.

g) Long-term General and Voice Related Quality of Life after Botulinum Toxin Injection for Adductor Spasmodic Dysphonia
Source: Alpha Omega Honor Society
P.I. Gregory A. Grillone, M.D., F.A.C.S.

M. Stuart Strong and Charles W. Vaughan Professor
Boston University School of Medicine
Otolaryngology-Head & Neck Surgery

Boston Medical Center
Otolaryngology-Head & Neck Surgery

Active Staff Privileges
Boston Medical Center

2011-2011 Triological Society: Citation conferred by Dr Kenneth Grundfast, Vice President-Eastern Section of the Triological Societ
2010-2010 Boston Magazine-Castle-Connelly: Listed in Boston Magazine's list of Best Doctors in Boston for 2010

Spectroscopic Imaging and Diagnosis of Neoplasia
08/15/2003 - 05/31/2009 (PI)
Massachusetts Institute of Technology NIH NCI

Margin Guidance for Oral Cancer Resection Using Light Scattering Spectroscopy
12/14/2012 - 05/31/2016 (PI)

Patient Navigator
11/01/2005 - 10/31/2010 (PI)
Kohlberg Foundation

Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Shah NK, Qureshi MM, Dyer MA, Patel SA, Kim K, Everett PC, Grillone GA, Jalisi SM, Truong MT. Optimal sequencing of chemoradiotherapy for locally advanced laryngeal cancer. Laryngoscope. 2019 Jan 09.View Related Profiles. PMID: 30628077.
  2. Crimlisk JT, Krisciunas GP, Sipe MH, Winter MR, Gonzalez RM, Grillone GA. Emergency Airway Response Team (EART) Documentation: Criteria, Feasibility, and Usability. Crit Care Nurs Q. 2018 Oct/Dec; 41(4):426-438.View Related Profiles. PMID: 30153187.
  3. Wong K, Yee HM, Xavier BA, Grillone GA. Applications of Augmented Reality in Otolaryngology: A Systematic Review. Otolaryngol Head Neck Surg. 2018 Dec; 159(6):956-967. PMID: 30126323.
  4. Truong MT, Grillone G. Reluctant Induction Followed by Proton Beam Therapy, If Practicable. Int J Radiat Oncol Biol Phys. 2018 07 15; 101(4):761.View Related Profiles. PMID: 29976481.
  5. Kamran SC, Qureshi MM, Jalisi S, Salama A, Grillone G, Truong MT. Primary surgery versus primary radiation-based treatment for locally advanced oropharyngeal cancer. Laryngoscope. 2018 06; 128(6):1353-1364.View Related Profiles. PMID: 28988426.
  6. Crimlisk JT, Krisciunas GP, Grillone GA, Gonzalez RM, Winter MR, Griever SC, Fernandes E, Medzon R, Blansfield JS, Blumenthal A. Emergency Airway Response Team Simulation Training: A Nursing Perspective. Dimens Crit Care Nurs. 2017 Sep/Oct; 36(5):290-297.View Related Profiles. PMID: 28777116.
  7. Grillone GA, Wang Z, Krisciunas GP, Tsai AC, Kannabiran VR, Pistey RW, Zhao Q, Rodriguez-Diaz E, A'Amar OM, Bigio IJ. The color of cancer: Margin guidance for oral cancer resection using elastic scattering spectroscopy. Laryngoscope. 2017 Sep; 127 Suppl 4:S1-S9.View Related Profiles. PMID: 28752518.
  8. Jalisi S, Jamal BT, Grillone GA. Surgical Management of Long-standing Eagle's Syndrome. Ann Maxillofac Surg. 2017 Jul-Dec; 7(2):232-236.View Related Profiles. PMID: 29264291.
  9. Russell KA, Brook CD, Platt MP, Grillone GA, Aliphas A, Noordzij JP. The Benefits and Limitations of Targeted Training in Flexible Transnasal Laryngoscopy Diagnosis. JAMA Otolaryngol Head Neck Surg. 2017 Jul 01; 143(7):707-711.View Related Profiles. PMID: 28472351.
  10. Jamal BT, Grillone GA, Jalisi S. Chemoresponse Assay in Head and Neck Cancer Patients: A Three-Year Follow Up. J Clin Diagn Res. 2017 May; 11(5):XC01-XC03.View Related Profiles. PMID: 28658890.
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Bar chart showing 50 publications over 20 distinct years, with a maximum of 6 publications in 2015 and 2017


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