Elena Klimtchuk, PdD
Research Associate
Boston University Chobanian & Avedisian School of Medicine
Amyloidosis Center




Postdoctoral Fellow (Previously held)
Boston University Chobanian & Avedisian School of Medicine


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Klimtchuk ES, Peterle D, Bullitt E, Connors LH, Engen JR, Gursky O. Role of complementarity-determining regions 1 and 3 in pathologic amyloid formation by human immunoglobulin ?1 light chains. Amyloid. 2023 Dec; 30(4):364-378.View Related Profiles. PMID: 37216473; PMCID: PMC10663386; DOI: 10.1080/13506129.2023.2212397;
     
  2. Klimtchuk ES, Peterle D, Bullitt EA, Connors LH, Engen JR, Gursky O. Role of Complementarity-Determining Regions 1 and 3 in Pathologic Amyloid Formation by Human Immunoglobulin ?1 Light Chains. bioRxiv. 2023 Feb 03.View Related Profiles. PMID: 36778378; PMCID: PMC9915687; DOI: 10.1101/2023.02.01.526662;
     
  3. Prokaeva T, Klimtchuk ES, Feschenko P, Spencer B, Cui H, Burks EJ, Aslebagh R, Muneeruddin K, Shaffer SA, Varghese E, Berk JL, Connors LH. An additive destabilising effect of compound T60I and V122I substitutions in ATTRv amyloidosis. Amyloid. 2023 Jun; 30(2):141-152.View Related Profiles. PMID: 36286264
     
  4. Prokaeva T, Joshi T, Klimtchuk ES, Gibson VM, Spencer B, Siddiqi O, Nedelkov D, Hu Y, Berk JL, Cuddy SAM, Dasari S, Chiu A, Choate LA, McPhail ED, Cui H, Chen H, Burks EJ, Sanchorawala V, Connors LH. A novel substitution of proline (P32L) destabilises ß2-microglobulin inducing hereditary systemic amyloidosis. Amyloid. 2022 Dec; 29(4):255-262.View Related Profiles. PMID: 35575118; DOI: 10.1080/13506129.2022.2072199;
     
  5. Peterle D, Klimtchuk ES, Wales TE, Georgescauld F, Connors LH, Engen JR, Gursky O. A Conservative Point Mutation in a Dynamic Antigen-binding Loop of Human Immunoglobulin ?6 Light Chain Promotes Pathologic Amyloid Formation. J Mol Biol. 2021 12 03; 433(24):167310.View Related Profiles. PMID: 34678302; PMCID: PMC8627465; DOI: 10.1016/j.jmb.2021.167310;
     
  6. Klimtchuk ES, Prokaeva T, Frame NM, Abdullahi HA, Spencer B, Dasari S, Cui H, Berk JL, Kurtin PJ, Connors LH, Gursky O. Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease. Proc Natl Acad Sci U S A. 2018 07 10; 115(28):E6428-E6436.View Related Profiles. PMID: 29941560; PMCID: PMC6048550; DOI: 10.1073/pnas.1802977115;
     
  7. Klimtchuk ES, Prokaeva TB, Spencer BH, Gursky O, Connors LH. In vitro co-expression of human amyloidogenic immunoglobulin light and heavy chain proteins: a relevant cell-based model of AL amyloidosis. Amyloid. 2017 Jun; 24(2):115-122.View Related Profiles. PMID: 28632419; PMCID: PMC5580339; DOI: 10.1080/13506129.2017.1336996;
     
  8. Greene MJ, Klimtchuk ES, Seldin DC, Berk JL, Connors LH. Cooperative stabilization of transthyretin by clusterin and diflunisal. Biochemistry. 2015 Jan 20; 54(2):268-78.View Related Profiles. PMID: 25478940; PMCID: PMC4303310; DOI: 10.1021/bi5011249;
     
  9. Cai J, Lücke C, Chen Z, Qiao Y, Klimtchuk E, Hamilton JA. Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited. Biophys J. 2012 Jun 6; 102(11):2585-94.View Related Profiles. PMID: 22713574; PMCID: PMC3368126; DOI: 10.1016/j.bpj.2012.04.039;
     
  10. Klimtchuk ES, Gursky O, Patel RS, Laporte KL, Connors LH, Skinner M, Seldin DC. The critical role of the constant region in thermal stability and aggregation of amyloidogenic immunoglobulin light chain. Biochemistry. 2010 Nov 16; 49(45):9848-57.View Related Profiles. PMID: 20936823; PMCID: PMC4080313; DOI: 10.1021/bi101351c;
     
Showing 10 of 23 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 23 publications over 17 distinct years, with a maximum of 3 publications in 2006

YearPublications
19881
19892
19921
19961
20021
20042
20063
20071
20081
20101
20121
20141
20171
20181
20211
20222
20232

Contact for Mentoring:

72 E. Concord St Silvio Conte (K)
Boston MA 02118
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