Elena Klimtchuk, PdD
Research Associate
Boston University School of Medicine
Amyloidosis Center

Postdoctoral Fellow (Previously held)
Boston University School of Medicine

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Peterle D, Klimtchuk ES, Wales TE, Georgescauld F, Connors LH, Engen JR, Gursky O. A Conservative Point Mutation in a Dynamic Antigen-binding Loop of Human Immunoglobulin ?6 Light Chain Promotes Pathologic Amyloid Formation. J Mol Biol. 2021 Oct 19; 433(24):167310.View Related Profiles. PMID: 34678302
  2. Klimtchuk ES, Prokaeva T, Frame NM, Abdullahi HA, Spencer B, Dasari S, Cui H, Berk JL, Kurtin PJ, Connors LH, Gursky O. Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease. Proc Natl Acad Sci U S A. 2018 07 10; 115(28):E6428-E6436.View Related Profiles. PMID: 29941560; PMCID: PMC6048550; DOI: 10.1073/pnas.1802977115;
  3. Klimtchuk ES, Prokaeva TB, Spencer BH, Gursky O, Connors LH. In vitro co-expression of human amyloidogenic immunoglobulin light and heavy chain proteins: a relevant cell-based model of AL amyloidosis. Amyloid. 2017 Jun; 24(2):115-122.View Related Profiles. PMID: 28632419; PMCID: PMC5580339; DOI: 10.1080/13506129.2017.1336996;
  4. Greene MJ, Klimtchuk ES, Seldin DC, Berk JL, Connors LH. Cooperative stabilization of transthyretin by clusterin and diflunisal. Biochemistry. 2015 Jan 20; 54(2):268-78.View Related Profiles. PMID: 25478940; PMCID: PMC4303310; DOI: 10.1021/bi5011249;
  5. Cai J, Lücke C, Chen Z, Qiao Y, Klimtchuk E, Hamilton JA. Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited. Biophys J. 2012 Jun 6; 102(11):2585-94.View Related Profiles. PMID: 22713574; PMCID: PMC3368126; DOI: 10.1016/j.bpj.2012.04.039;
  6. Klimtchuk ES, Gursky O, Patel RS, Laporte KL, Connors LH, Skinner M, Seldin DC. The critical role of the constant region in thermal stability and aggregation of amyloidogenic immunoglobulin light chain. Biochemistry. 2010 Nov 16; 49(45):9848-57.View Related Profiles. PMID: 20936823; PMCID: PMC4080313; DOI: 10.1021/bi101351c;
  7. Kingsbury JS, Laue TM, Klimtchuk ES, Théberge R, Costello CE, Connors LH. The modulation of transthyretin tetramer stability by cysteine 10 adducts and the drug diflunisal. Direct analysis by fluorescence-detected analytical ultracentrifugation. J Biol Chem. 2008 May 2; 283(18):11887-96.View Related Profiles. PMID: 18326041; PMCID: PMC2335343; DOI: 10.1074/jbc.M709638200;
  8. Kingsbury JS, Klimtchuk ES, Théberge R, Costello CE, Connors LH. Expression, purification, and in vitro cysteine-10 modification of native sequence recombinant human transthyretin. Protein Expr Purif. 2007 Jun; 53(2):370-7.View Related Profiles. PMID: 17317215; PMCID: PMC2696000; DOI: 10.1016/j.pep.2007.01.004;
  9. Kirk W, Klimtchuk E. Photophysics of ANS. III: Circular dichroism of ANS and anilinonaphthalene in I-FABP. Biophys Chem. 2007 Jan; 125(1):24-31. PMID: 16949725
  10. Klimtchuk E, Venyaminov S, Kurian E, Wessels W, Kirk W, Prendergast FG. Photophysics of ANS. I. Protein-ANS complexes: Intestinal fatty acid binding protein and single-trp mutants. Biophys Chem. 2007 Jan; 125(1):1-12. PMID: 16978762
Showing 10 of 19 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 19 publications over 15 distinct years, with a maximum of 3 publications in 2006


Contact for Mentoring:

72 E. Concord St Silvio Conte (K)
Boston MA 02118
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