Alan Cyril Jacques Wacquiez, PhD
Postdoctoral Associate
Boston University Chobanian & Avedisian School of Medicine
Biochemistry & Cell Biology




Dr. Wacquiez is currently a Postdoctoral Associate in the Saeed Lab located at the National Emerging Infectious Diseases Laboratories (NEIDL) of Boston University. Born in the city of Nantes in France, he obtained a Ph.D. degree from the University of Tours, France, in 2020. His research during this time investigated the molecular interactions between the influenza virus non-structural protein 1 (NS1) and double-stranded RNA molecules.

After his Ph.D., Dr. Wacquiez joined the “Respiratory Infection and Immunity” research team in the laboratory of Dr. Mustapha Si-Tahar at the Research Center for Respiratory Diseases (CEPR) in Tours, France, for a short postdoctoral stint. There, he studied the role of succinylation, a post-translational protein modification, in influenza virus infection and its involvement in anti-viral immunity. In the August of 2022, he joined the laboratory of Dr. Mohsan Saeed, where he is currently exploring the role of viral and host protease in shaping virus-host interactions.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Cezard A, Brea-Diakite D, Vasseur V, Wacquiez A, Gonzalez L, Le Goffic R, Da Costa B, Tinard A, Fouquenet D, Heumel S, Machelart A, Hoffmann E, Brodin P, Trottein F, Mathieu C, Canus L, Jacolin F, Vidalain PO, Perrin-Cocon L, Lotteau V, Burlaud-Gaillard J, Tertigas D, Surette MG, Legras A, Sizaret D, Baranek T, Paget C, Guillon A, Si-Tahar M. Cis-aconitate therapy protects against influenza mortality by dual targeting of viral polymerase and ERK/AKT/NF-?B signaling. EMBO Mol Med. 2026 Mar; 18(3):1023-1053. PMID: 41699259; PMCID: PMC12988032; DOI: 10.1038/s44321-026-00379-8;
     
  2. Sharafi M, Teh WP, Green J, Charifson PS, Wang J, Pemberton OA, Nevins AM, Lye M, Liu X, Varca AC, Owen CD, Morsheimer K, Wacquiez A, Dawson C, Steuber C, Smith J, Girardi NM, Magin RS, Marto JA, Saeed M, Davey RA, Hardee D, Ng TI, Namchuk MN, Buhrlage SJ. Structure-Guided Design of Potent and Selective Covalent Inhibitors Targeting the SARS-CoV-2 Papain-like Protease. J Med Chem. 2026 Feb 12; 69(3):2197-2214.View Related Profiles. PMID: 41557701
     
  3. Kenney D, Matsuo M, Unali G, Wacquiez A, Saeed M, Douam F. Comprehensive Analysis of the Impact of Weight Loss Thresholds on Mouse Models of Fatal Viral Infection. Viruses. 2025 Sep 07; 17(9).View Related Profiles. PMID: 41012653; PMCID: PMC12474137; DOI: 10.3390/v17091225;
     
  4. Caobi A, Su CM, Beusch CM, Kenney D, Darling TL, Feng S, Semaan M, Wacquiez A, Sanders NL, Tully ES, Chen DY, Evdokimova M, Ding Z, Jones D, Alysandratos KD, Mizgerd JP, Kirchdoerfer RN, Kotton DN, Douam F, Crossland NA, Boon ACM, Gordon DE, Baker SC, Saeed M. SARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses. Proc Natl Acad Sci U S A. 2025 Jun 17; 122(24):e2426528122.View Related Profiles. PMID: 40504150; PMCID: PMC12184426; DOI: 10.1073/pnas.2426528122;
     
  5. Keiser PT, Zhang W, Ricca M, Wacquiez A, Grimins A, Cencic R, Patten JJ, Shah P, Padilha E, Connor JH, Pelletier J, Lyons SM, Saeed M, Brown LE, Porco JA, Davey RA. Amidino-rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis. Antiviral Res. 2024 Oct; 230:105976.View Related Profiles. PMID: 39117283; PMCID: PMC11434215; DOI: 10.1016/j.antiviral.2024.105976;
     
  6. Guillon A, Brea-Diakite D, Cezard A, Wacquiez A, Baranek T, Bourgeais J, Picou F, Vasseur V, Meyer L, Chevalier C, Auvet A, Carballido JM, Nadal Desbarats L, Dingli F, Turtoi A, Le Gouellec A, Fauvelle F, Donchet A, Crépin T, Hiemstra PS, Paget C, Loew D, Herault O, Naffakh N, Le Goffic R, Si-Tahar M. Host succinate inhibits influenza virus infection through succinylation and nuclear retention of the viral nucleoprotein. EMBO J. 2022 06 14; 41(12):e108306. PMID: 35506364; PMCID: PMC9194747; DOI: 10.15252/embj.2021108306;
     
  7. Wacquiez A, Coste F, Kut E, Gaudon V, Trapp S, Castaing B, Marc D. Structure and Sequence Determinants Governing the Interactions of RNAs with Influenza A Virus Non-Structural Protein NS1. Viruses. 2020 08 27; 12(9). PMID: 32867106; PMCID: PMC7552008; DOI: 10.3390/v12090947;
     
  8. Trapp S, Soubieux D, Lidove A, Esnault E, Lion A, Guillory V, Wacquiez A, Kut E, Quéré P, Larcher T, Ledevin M, Nadan V, Camus-Bouclainville C, Marc D. Major contribution of the RNA-binding domain of NS1 in the pathogenicity and replication potential of an avian H7N1 influenza virus in chickens. Virol J. 2018 03 27; 15(1):55. PMID: 29587792; PMCID: PMC5870492; DOI: 10.1186/s12985-018-0960-4;
     

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 8 publications over 6 distinct years, with a maximum of 2 publications in 2025 and 2026

YearPublications
20181
20201
20221
20241
20252
20262

Contact for Mentoring:

72 E. Concord Street
Boston MA 02118
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