Xue Han | Profiles RNS

Xue Han, PhD

Professor

Boston University College of Engineering

Biomedical Engineering

PhD, University of Wisconsin Madison
BS, Beijing University

Websites

	Han Lab
	Biomedical Engineering Faculty
	Google Scholar
	LinkedIn
	Twitter
	ResearchGate

Dr. Han received a Ph.D. from University of Wisconsin-Madison, and completed her Postdoctoral training with Dr. Bob Desimone at MIT, and Drs. Tirin Moore and Richard Tsien at Stanford University. Over the past decade, Dr. Han has trained 9 Ph.D. students, 5 postdoctoral fellows, and mentored over 70 undergraduate students for lab research. More than half of them are women or underrepresented minorities. She is currently mentoring 13 Ph.D. students, including one underrepresented minority and 8 women. She was awarded the Mentor of The Year award by Boston University Graduate Women in Science and Engineering. Dr. Han holds two granted patents with more pending and authored over 70 peer reviewed journal articles and conference proceedings. She and her students and postdoctoral trainees have given over 100 oral presentations. She has been recognized by many distinguished awards, including the Presidential Early Career Award for Scientists and Engineers (PECASE), the NIH New Innovator Award, the Pew Scholarship, the DARPA Young Faculty Award, the Alfred P. Sloan Fellowship and the Helen Hay Whitney Fellowship.

Dr. Xue Han’s seminal contribution to the field of neuroengineering centers on the invention and application of high impact molecular neurotechnologies to probe brain dynamics. She played an instrumental role in the development of optogenetic silencing molecules archaerhodopsins and halorhodopsins, enabling temporal precise silencing of specific neurons, some of the most widely used molecular tools in neuroscience, in use by thousands of research groups. Her contribution to optogenetics was crucial in establishing the new field of optogenetics, a field now being widely regarded as having revolutionized neuroscience research. In addition to her breakthrough discovery of the now widely used optogenetic molecular reagents, Dr. Han developed many other innovative technologies, including novel voltage imaging tools, cell type specific gene therapy viral vectors, drug releasing DNA origamis and mucosal based blood brain barrier penetrating strategies. Parallel to her neurotechnology innovation effort, Dr. Han has discovered key insights on the neural network mechanisms of neurological and psychiatric disorders, such as Parkinson’s disease and Alzheimer’s disease. Her current research focuses on inventing novel neurotechnologies and applying innovative approaches to probe the cellular and network mechanisms of brain disorders and brain stimulation therapies, with a goal of developing clinical biomarkers and a new generation of neuromodulation therapeutics.

Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

BU Research
NIH RePORTER Research

Targeting pathologic spike-ripples to isolate and disrupt epileptic dynamics
01/01/2021 - 11/30/2025 (Multi-PI)
PI: Xue Han, PhD
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NINDS
5R01NS119483-04

Collaborative Research: Dynamic interactions of individual neurons in supporting hippocampal network oscillations during behavior
10/01/2020 - 09/30/2025 (PI)
National Science Foundation
IOS-2002971

Optical voltage imaging analysis of the cellular and network mechanisms of deep brain stimulation
09/21/2022 - 08/31/2025 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1RF1NS129520-01

CIF: Medium: Discovering Changes in Networks: Fundamental Limits, Efficient Algorithms, and Large-Scale Neuroscience
07/01/2020 - 06/30/2025 (Multi-PI)
PI: Xue Han, PhD
National Science Foundation
CCF-1955981

Voltage imaging analysis of striatal network dynamics related to voluntary movement and Parkinsons disease
04/01/2020 - 03/31/2025 (PI)
NIH/National Institute of Neurological Disorders & Stroke
3R01NS115797-05S1

Multidimensional Optimization of Voltage Indicators for In Vivo Neural Activity Imaging
03/01/2020 - 01/31/2025 (PI)
NIH/National Institute of Mental Health
5R01MH122971-05

Designing low-cost, customizable high-density probes for acute and chronic neural recordings in rodents
09/01/2023 - 08/31/2024 (Subcontract PI)
Neural Dynamics Technologies NIH NIMH
6R44MH118155-04

Voltage imaging during spike ripples in a cortical mouse model of epilepsy
07/01/2023 - 06/30/2024 (Key Person / Mentor)
American Epilepsy Society

Unveiling the mechanisms of ultrasound neuromodulation via spatially confined stimulation and temporally resolved recording
09/30/2018 - 06/30/2024 (Multi-PI)
PI: Xue Han, PhD
NIH/National Institute of Neurological Disorders & Stroke
3R01NS109794-05S1

Mechanistic study of the role of autism spectrum disorder risk genes in hippocampal CA1 population dynamics during learning and memory
01/01/2021 - 02/28/2023 (Key Person / Mentor)
NIH/National Institute of Mental Health
5F31MH123008-03

Showing 10 of 39 results. Show All Results

Title

Yr	Title	Project-Sub Proj
2024	Voltage Imaging Analysis of Striatal Network Dynamics Related to Movement, Parkinson's Disease and Deep Brain Stimulation	3R01NS115797-05S1
2024	Voltage Imaging Analysis of Striatal Network Dynamics Related to Movement, Parkinson's Disease and Deep Brain Stimulation	5R01NS115797-05
2024	Multidimensional Optimization of Voltage Indicators for In Vivo Neural Activity Imaging	5R01MH122971-05
2023	Voltage Imaging Analysis of Striatal Network Dynamics Related to Movement, Parkinson's Disease and Deep Brain Stimulation	5R01NS115797-04
2023	Voltage Imaging Analysis of Striatal Network Dynamics Related to Movement, Parkinson's Disease and Deep Brain Stimulation	3R01NS115797-04S1
2023	Multidimensional Optimization of Voltage Indicators for In Vivo Neural Activity Imaging	5R01MH122971-04
2022	Optical voltage imaging analysis of the cellular and network mechanisms of deep brain stimulation	1RF1NS129520-01
2022	Voltage imaging analysis of striatal network dynamics related to movement, Parkinson's disease and deep brain stimulation	5R01NS115797-03
2022	Multidimensional Optimization of Voltage Indicators for In Vivo Neural Activity Imaging	5R01MH122971-03
2022	Unveiling the mechanisms of ultrasound neuromodulation via spatially confined stimulation and temporally resolved recording	3R01NS109794-04S1

Showing 10 of 38 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Shi W, Zemel D, Sridhar S, Mount RA, Richardson RM, Eden UT, Han X, Kramer MA, Chu CJ. Spike ripples in striatum correlate with seizure risk in two mouse models. Epilepsy Behav Rep. 2022; 18:100529. PMID: 35274094; PMCID: PMC8902602; DOI: 10.1016/j.ebr.2022.100529;

Zemel D, Gritton H, Cheung C, Shankar S, Kramer M, Han X. Dopamine depletion selectively disrupts interactions between striatal neuron subtypes and LFP oscillations. Cell Rep. 2022 01 18; 38(3):110265. PMID: 35045299; PMCID: PMC8820590; DOI: 10.1016/j.celrep.2021.110265;

Xiao S, Lowet E, Gritton HJ, Fabris P, Wang Y, Sherman J, Mount RA, Tseng HA, Man HY, Straub C, Piatkevich KD, Boyden ES, Mertz J, Han X. Large-scale voltage imaging in behaving mice using targeted illumination. iScience. 2021 Nov 19; 24(11):103263.View Related Profiles.

Man, Hengye
Mertz, Jerome
Han, Xue

PMID: 34761183; PMCID: PMC8567393; DOI: 10.1016/j.isci.2021.103263;

Tseng HA, Sherman J, Bortz E, Mohammed A, Gritton HJ, Bensussen S, Tang RP, Zemel D, Szabo T, Han X. Region-specific effects of ultrasound on individual neurons in the awake mammalian brain. iScience. 2021 Sep 24; 24(9):102955. PMID: 34458703; PMCID: PMC8379692; DOI: 10.1016/j.isci.2021.102955;

Nadalin JK, Eden UT, Han X, Richardson RM, Chu CJ, Kramer MA. Application of a convolutional neural network for fully-automated detection of spike ripples in the scalp electroencephalogram. J Neurosci Methods. 2021 08 01; 360:109239. PMID: 34090917; PMCID: PMC8324553; DOI: 10.1016/j.jneumeth.2021.109239;

Mount RA, Sridhar S, Hansen KR, Mohammed AI, Abdulkerim M, Kessel R, Nazer B, Gritton HJ, Han X. Distinct neuronal populations contribute to trace conditioning and extinction learning in the hippocampal CA1. Elife. 2021 04 12; 10. PMID: 33843589; PMCID: PMC8064758; DOI: 10.7554/eLife.56491;

Tseng HA, Han X. Distinct Spiking Patterns of Excitatory and Inhibitory Neurons and LFP Oscillations in Prefrontal Cortex During Sensory Discrimination. Front Physiol. 2021; 12:618307. PMID: 33679434; PMCID: PMC7928411; DOI: 10.3389/fphys.2021.618307;

Tsang JM, Gritton HJ, Das SL, Weber TD, Chen CS, Han X, Mertz J. Fast, multiplane line-scan confocal microscopy using axially distributed slits. Biomed Opt Express. 2021 Mar 01; 12(3):1339-1350.View Related Profiles.

Chen, Christopher
Mertz, Jerome
Han, Xue

PMID: 33796357; PMCID: PMC7984773; DOI: 10.1364/BOE.417286;

Keaveney MK, Rahsepar B, Tseng HA, Fernandez FR, Mount RA, Ta T, White JA, Berg J, Han X. CaMKIIa-Positive Interneurons Identified via a microRNA-Based Viral Gene Targeting Strategy. J Neurosci. 2020 12 09; 40(50):9576-9588.View Related Profiles.

Fernandez, Fernando
White, John
Han, Xue

PMID: 33158963; PMCID: PMC7726537; DOI: 10.1523/JNEUROSCI.2570-19.2020;

Xiao S, Gritton H, Tseng HA, Zemel D, Han X, Mertz J. High-contrast multifocus microscopy with a single camera and z-splitter prism. Optica. 2020 Nov 20; 7(11):1477-1486.View Related Profiles.

Mertz, Jerome
Han, Xue

PMID: 34532564; PMCID: PMC8443084; DOI: 10.1364/optica.404678;

Showing 10 of 67 results. Show More

Bensussen S, Shankar S, Ching KH, Zemel D, Ta TL, Mount RA, Shroff SN, Gritton HJ, Fabris P, Vanbenschoten H, Beck C, Man HY, Han X. A Viral Toolbox of Genetically Encoded Fluorescent Synaptic Tags. iScience. 2020 Jul 24; 23(7):101330.View Related Profiles.

Man, Hengye
Han, Xue

PMID: 32674057; PMCID: PMC7363701; DOI: 10.1016/j.isci.2020.101330;

Shemesh OA, Linghu C, Piatkevich KD, Goodwin D, Celiker OT, Gritton HJ, Romano MF, Gao R, Yu CJ, Tseng HA, Bensussen S, Narayan S, Yang CT, Freifeld L, Siciliano CA, Gupta I, Wang J, Pak N, Yoon YG, Ullmann JFP, Guner-Ataman B, Noamany H, Sheinkopf ZR, Park WM, Asano S, Keating AE, Trimmer JS, Reimer J, Tolias AS, Bear MF, Tye KM, Han X, Ahrens MB, Boyden ES. Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator. Neuron. 2020 08 05; 107(3):470-486.e11.View Related Profiles.

Romano, Michael
Han, Xue

PMID: 32592656; PMCID: PMC7415598; DOI: 10.1016/j.neuron.2020.05.029;

What is the Key Conceptual or Methodological Bottleneck to Controlling Neural Biology? Cell Syst. 2020 06 24; 10(6):461-462. PMID: 32585154; DOI: 10.1016/j.cels.2020.06.001;

Shroff SN, Das SL, Tseng HA, Noueihed J, Fernandez F, White JA, Chen CS, Han X. Voltage Imaging of Cardiac Cells and Tissue Using the Genetically Encoded Voltage Sensor Archon1. iScience. 2020 Apr 24; 23(4):100974.View Related Profiles.

Chen, Christopher
Fernandez, Fernando
Noueihed, Jad
White, John
Han, Xue

PMID: 32299055; PMCID: PMC7160579; DOI: 10.1016/j.isci.2020.100974;

Jiang Y, Lee HJ, Lan L, Tseng HA, Yang C, Man HY, Han X, Cheng JX. Optoacoustic brain stimulation at submillimeter spatial precision. Nat Commun. 2020 02 14; 11(1):881.View Related Profiles.

Man, Hengye
Cheng, Ji-Xin
Han, Xue

PMID: 32060282; PMCID: PMC7021819; DOI: 10.1038/s41467-020-14706-1;

Piatkevich KD, Bensussen S, Tseng HA, Shroff SN, Lopez-Huerta VG, Park D, Jung EE, Shemesh OA, Straub C, Gritton HJ, Romano MF, Costa E, Sabatini BL, Fu Z, Boyden ES, Han X. Population imaging of neural activity in awake behaving mice. Nature. 2019 10; 574(7778):413-417.View Related Profiles.

Romano, Michael
Han, Xue

PMID: 31597963; PMCID: PMC6858559; DOI: 10.1038/s41586-019-1641-1;

Romano M, Bucklin M, Gritton H, Mehrotra D, Kessel R, Han X. A Teensy microcontroller-based interface for optical imaging camera control during behavioral experiments. J Neurosci Methods. 2019 05 15; 320:107-115.View Related Profiles.

Bucklin, Mark
Romano, Michael
Han, Xue

PMID: 30946877; PMCID: PMC6510265; DOI: 10.1016/j.jneumeth.2019.03.019;

Badon A, Bensussen S, Gritton HJ, Awal MR, Gabel CV, Han X, Mertz J. Video-rate large-scale imaging with Multi-Z confocal microscopy. Optica. 2019 Apr 20; 6(4):389-395.View Related Profiles.

Gabel, Christopher
Mertz, Jerome
Awal, Mehraj
Han, Xue

PMID: 34504902; PMCID: PMC8425499; DOI: 10.1364/optica.6.000389;

Gritton HJ, Howe WM, Romano MF, DiFeliceantonio AG, Kramer MA, Saligrama V, Bucklin ME, Zemel D, Han X. Unique contributions of parvalbumin and cholinergic interneurons in organizing striatal networks during movement. Nat Neurosci. 2019 04; 22(4):586-597.View Related Profiles.

Bucklin, Mark
Romano, Michael
Han, Xue

PMID: 30804530; PMCID: PMC6744276; DOI: 10.1038/s41593-019-0341-3;

Nocera AL, Mueller SK, Stephan JR, Hing L, Seifert P, Han X, Lin DT, Amiji MM, Libermann T, Bleier BS. Exosome swarms eliminate airway pathogens and provide passive epithelial immunoprotection through nitric oxide. J Allergy Clin Immunol. 2019 04; 143(4):1525-1535.e1. PMID: 30442371; DOI: 10.1016/j.jaci.2018.08.046;

James NM, Gritton HJ, Kopell N, Sen K, Han X. Muscarinic receptors regulate auditory and prefrontal cortical communication during auditory processing. Neuropharmacology. 2019 01; 144:155-171.View Related Profiles.

Sen, Kamal
Kopell, Nancy
Han, Xue

PMID: 30352212; PMCID: PMC6400225; DOI: 10.1016/j.neuropharm.2018.10.027;

Shen SP, Tseng HA, Hansen KR, Wu R, Gritton HJ, Si J, Han X. Automatic Cell Segmentation by Adaptive Thresholding (ACSAT) for Large-Scale Calcium Imaging Datasets. eNeuro. 2018 Sep-Oct; 5(5). PMID: 30221189; PMCID: PMC6135987; DOI: 10.1523/ENEURO.0056-18.2018;

Keaveney MK, Tseng HA, Ta TL, Gritton HJ, Man HY, Han X. A MicroRNA-Based Gene-Targeting Tool for Virally Labeling Interneurons in the Rodent Cortex. Cell Rep. 2018 07 10; 24(2):294-303.View Related Profiles.

Man, Hengye
Han, Xue

PMID: 29996091; PMCID: PMC6095194; DOI: 10.1016/j.celrep.2018.06.049;

Xiao S, Tseng HA, Gritton H, Han X, Mertz J. Video-rate volumetric neuronal imaging using 3D targeted illumination. Sci Rep. 2018 05 21; 8(1):7921.View Related Profiles.

Mertz, Jerome
Han, Xue

PMID: 29784920; PMCID: PMC5962542; DOI: 10.1038/s41598-018-26240-8;

Pittman-Polletta BR, Quach A, Mohammed AI, Romano M, Kondabolu K, Kopell NJ, Han X, McCarthy MM. Striatal cholinergic receptor activation causes a rapid, selective and state-dependent rise in cortico-striatal ß activity. Eur J Neurosci. 2018 10; 48(8):2857-2868.View Related Profiles.

Quach, Allison
Romano, Michael
Kopell, Nancy
Han, Xue

PMID: 29528521

Hansen KR, DeWalt GJ, Mohammed AI, Tseng HA, Abdulkerim ME, Bensussen S, Saligrama V, Nazer B, Eldred WD, Han X. Mild Blast Injury Produces Acute Changes in Basal Intracellular Calcium Levels and Activity Patterns in Mouse Hippocampal Neurons. J Neurotrauma. 2018 07 01; 35(13):1523-1536. PMID: 29343209; PMCID: PMC5998839; DOI: 10.1089/neu.2017.5029;

Shain WJ, Vickers NA, Li J, Han X, Bifano T, Mertz J. Axial localization with modulated-illumination extended-depth-of-field microscopy. Biomed Opt Express. 2018 Apr 01; 9(4):1771-1782.View Related Profiles.

Mertz, Jerome
Han, Xue

PMID: 29675318; PMCID: PMC5905922; DOI: 10.1364/BOE.9.001771;

Kodandaramaiah SB, Flores FJ, Holst GL, Singer AC, Han X, Brown EN, Boyden ES, Forest CR. Multi-neuron intracellular recording in vivo via interacting autopatching robots. Elife. 2018 01 03; 7. PMID: 29297466; PMCID: PMC5812718; DOI: 10.7554/eLife.24656;

Wang G, Li S, Gilbert J, Gritton HJ, Wang Z, Li Z, Han X, Selkoe DJ, Man HY. Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory. Cell Rep. 2017 08 08; 20(6):1335-1347.View Related Profiles.

Man, Hengye
Han, Xue

PMID: 28793258; PMCID: PMC5584878; DOI: 10.1016/j.celrep.2017.07.030;

Nocera AL, Miyake MM, Seifert P, Han X, Bleier BS. Exosomes mediate interepithelial transfer of functional P-glycoprotein in chronic rhinosinusitis with nasal polyps. Laryngoscope. 2017 09; 127(9):E295-E300. PMID: 28485529; DOI: 10.1002/lary.26614;

Kunkhyen T, McCarthy EA, Korzan WJ, Doctor D, Han X, Baum MJ, Cherry JA. Optogenetic Activation of Accessory Olfactory Bulb Input to the Forebrain Differentially Modulates Investigation of Opposite versus Same-Sex Urinary Chemosignals and Stimulates Mating in Male Mice. eNeuro. 2017 Mar-Apr; 4(2). PMID: 28374006; PMCID: PMC5362934; DOI: 10.1523/ENEURO.0010-17.2017;

Zhuo JM, Tseng HA, Desai M, Bucklin ME, Mohammed AI, Robinson NT, Boyden ES, Rangel LM, Jasanoff AP, Gritton HJ, Han X. Young adult born neurons enhance hippocampal dependent performance via influences on bilateral networks. Elife. 2016 Dec 03; 5.View Related Profiles.

Bucklin, Mark
Han, Xue

PMID: 27914197; PMCID: PMC5156524; DOI: 10.7554/eLife.22429;

Nocera AL, Meurer AT, Miyake MM, Sadow PM, Han X, Bleier BS. Secreted P-glycoprotein is a noninvasive biomarker of chronic rhinosinusitis. Laryngoscope. 2017 01; 127(1):E1-E4. PMID: 27577924; DOI: 10.1002/lary.26249;

Kondabolu K, Roberts EA, Bucklin M, McCarthy MM, Kopell N, Han X. Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):E3159-68.View Related Profiles.

Roberts, Erik
Bucklin, Mark
Kopell, Nancy
Han, Xue

PMID: 27185924; PMCID: PMC4896681; DOI: 10.1073/pnas.1605658113;

Kohman RE, Cha SS, Man HY, Han X. Light-Triggered Release of Bioactive Molecules from DNA Nanostructures. Nano Lett. 2016 Apr 13; 16(4):2781-5.View Related Profiles.

Kohman, Richard
Han, Xue

PMID: 26935839; PMCID: PMC4959465; DOI: 10.1021/acs.nanolett.6b00530;

Bleier BS, Kohman RE, Guerra K, Nocera AL, Ramanlal S, Kocharyan AH, Curry WT, Han X. Heterotopic Mucosal Grafting Enables the Delivery of Therapeutic Neuropeptides Across the Blood Brain Barrier. Neurosurgery. 2016 Mar; 78(3):448-57; discussion 457.View Related Profiles.

Kohman, Richard
Han, Xue

PMID: 26352099; DOI: 10.1227/NEU.0000000000001016;

Mohammed AI, Gritton HJ, Tseng HA, Bucklin ME, Yao Z, Han X. An integrative approach for analyzing hundreds of neurons in task performing mice using wide-field calcium imaging. Sci Rep. 2016 Feb 08; 6:20986.View Related Profiles.

Bucklin, Mark
Han, Xue

PMID: 26854041; PMCID: PMC4745097; DOI: 10.1038/srep20986;

Bleier BS, Singleton A, Nocera AL, Kocharyan A, Petkova V, Han X. P-glycoprotein regulates Staphylococcus aureus enterotoxin B-stimulated interleukin-5 and thymic stromal lymphopoietin secretion in organotypic mucosal explants. Int Forum Allergy Rhinol. 2016 Feb; 6(2):169-77. PMID: 26625351; DOI: 10.1002/alr.21566;

Rueckemann JW, DiMauro AJ, Rangel LM, Han X, Boyden ES, Eichenbaum H. Transient optogenetic inactivation of the medial entorhinal cortex biases the active population of hippocampal neurons. Hippocampus. 2016 Feb; 26(2):246-60.View Related Profiles.

Dimauro, Audrey
Han, Xue

PMID: 26299904; PMCID: PMC4718858; DOI: 10.1002/hipo.22519;

Lam A, Hoang JD, Singleton A, Han X, Bleier BS. Itraconazole and clarithromycin inhibit P-glycoprotein activity in primary human sinonasal epithelial cells. Int Forum Allergy Rhinol. 2015 Jun; 5(6):477-80. PMID: 25907295; DOI: 10.1002/alr.21454;

Sayeg MK, Weinberg BH, Cha SS, Goodloe M, Wong WW, Han X. Rationally Designed MicroRNA-Based Genetic Classifiers Target Specific Neurons in the Brain. ACS Synth Biol. 2015 Jul 17; 4(7):788-795.View Related Profiles.

Wong, Wilson
Han, Xue

PMID: 25848814; PMCID: PMC4547530; DOI: 10.1021/acssynbio.5b00040;

Kohman RE, Han X. Light sensitization of DNA nanostructures via incorporation of photo-cleavable spacers. Chem Commun (Camb). 2015 Apr 4; 51(26):5747-50.View Related Profiles.

Kohman, Richard
Han, Xue

PMID: 25720373; PMCID: PMC4394657; DOI: 10.1039/c5cc00082c;

Kondabolu K, Kowalski MM, Roberts EA, Han X. Optogenetics and deep brain stimulation neurotechnologies. Handb Exp Pharmacol. 2015; 228:441-50.View Related Profiles.

Roberts, Erik
Han, Xue

PMID: 25977092; DOI: 10.1007/978-3-319-16522-6_15;

Bleier BS, Kocharyan A, Singleton A, Han X. Verapamil modulates interleukin-5 and interleukin-6 secretion in organotypic human sinonasal polyp explants. Int Forum Allergy Rhinol. 2015 Jan; 5(1):10-3. PMID: 25330767; DOI: 10.1002/alr.21436;

Kocharyan A, Feldman R, Singleton A, Han X, Bleier BS. P-glycoprotein inhibition promotes prednisone retention in human sinonasal polyp explants. Int Forum Allergy Rhinol. 2014 Sep; 4(9):734-8. PMID: 25145685; DOI: 10.1002/alr.21361;

Kohman RE, Han X, Bleier BS. Heterotopic mucosal engrafting procedure for direct drug delivery to the brain in mice. J Vis Exp. 2014; (89).View Related Profiles.

Kohman, Richard
Han, Xue

PMID: 25077554; PMCID: PMC4217501; DOI: 10.3791/51452;

Chuong AS, Miri ML, Busskamp V, Matthews GA, Acker LC, Sørensen AT, Young A, Klapoetke NC, Henninger MA, Kodandaramaiah SB, Ogawa M, Ramanlal SB, Bandler RC, Allen BD, Forest CR, Chow BY, Han X, Lin Y, Tye KM, Roska B, Cardin JA, Boyden ES. Noninvasive optical inhibition with a red-shifted microbial rhodopsin. Nat Neurosci. 2014 Aug; 17(8):1123-9. PMID: 24997763; PMCID: PMC4184214; DOI: 10.1038/nn.3752;

Bleier BS, Nocera AL, Iqbal H, Hoang JD, Alvarez U, Feldman RE, Han X. P-glycoprotein promotes epithelial T helper 2-associated cytokine secretion in chronic sinusitis with nasal polyps. Int Forum Allergy Rhinol. 2014 Jun; 4(6):488-94. PMID: 24599606; DOI: 10.1002/alr.21316;

Zhang XX, Lamanna CM, Kohman RE, McIntosh TJ, Han X, Grinstaff MW. Lipid-mediated DNA and siRNA Transfection Efficiency Depends on Peptide Headgroup. Soft Matter. 2013 May 05; 9(17).View Related Profiles.

Grinstaff, Mark
Kohman, Richard
Han, Xue

PMID: 24391676; PMCID: PMC3878819; DOI: 10.1039/C3SM27633C;

Bleier BS, Kohman RE, Feldman RE, Ramanlal S, Han X. Permeabilization of the blood-brain barrier via mucosal engrafting: implications for drug delivery to the brain. PLoS One. 2013; 8(4):e61694.View Related Profiles.

Kohman, Richard
Han, Xue

PMID: 23637885; PMCID: PMC3634848; DOI: 10.1371/journal.pone.0061694;

Bleier BS, Nocera AL, Iqbal H, Hoang JD, Feldman RE, Han X. P-glycoprotein functions as an immunomodulator in healthy human primary nasal epithelial cells. Int Forum Allergy Rhinol. 2013 Jun; 3(6):433-8. PMID: 23520057; DOI: 10.1002/alr.21166;

Han X. In vivo application of optogenetics for neural circuit analysis. ACS Chem Neurosci. 2012 Aug 15; 3(8):577-84. PMID: 22896801; PMCID: PMC3419447; DOI: 10.1021/cn300065j;

Madisen L, Mao T, Koch H, Zhuo JM, Berenyi A, Fujisawa S, Hsu YW, Garcia AJ, Gu X, Zanella S, Kidney J, Gu H, Mao Y, Hooks BM, Boyden ES, Buzsáki G, Ramirez JM, Jones AR, Svoboda K, Han X, Turner EE, Zeng H. A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. Nat Neurosci. 2012 May; 15(5):793-802. PMID: 22446880; PMCID: PMC3337962; DOI: 10.1038/nn.3078;

Han X. Optogenetics in the nonhuman primate. Prog Brain Res. 2012; 196:215-33. PMID: 22341328; PMCID: PMC3586218; DOI: 10.1016/B978-0-444-59426-6.00011-2;

Chow BY, Han X, Boyden ES. Genetically encoded molecular tools for light-driven silencing of targeted neurons. Prog Brain Res. 2012; 196:49-61. PMID: 22341320; PMCID: PMC3553588; DOI: 10.1016/B978-0-444-59426-6.00003-3;

McCarthy MM, Moore-Kochlacs C, Gu X, Boyden ES, Han X, Kopell N. Striatal origin of the pathologic beta oscillations in Parkinson's disease. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11620-5.View Related Profiles.

Kopell, Nancy
Han, Xue

PMID: 21697509; PMCID: PMC3136295; DOI: 10.1073/pnas.1107748108;

Han X, Chow BY, Zhou H, Klapoetke NC, Chuong A, Rajimehr R, Yang A, Baratta MV, Winkle J, Desimone R, Boyden ES. A high-light sensitivity optical neural silencer: development and application to optogenetic control of non-human primate cortex. Front Syst Neurosci. 2011; 5:18. PMID: 21811444; PMCID: PMC3082132; DOI: 10.3389/fnsys.2011.00018;

Lindskog M, Li L, Groth RD, Poburko D, Thiagarajan TC, Han X, Tsien RW. Postsynaptic GluA1 enables acute retrograde enhancement of presynaptic function to coordinate adaptation to synaptic inactivity. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21806-11. PMID: 21098665; PMCID: PMC3003060; DOI: 10.1073/pnas.1016399107;

Chow BY, Han X, Dobry AS, Qian X, Chuong AS, Li M, Henninger MA, Belfort GM, Lin Y, Monahan PE, Boyden ES. High-performance genetically targetable optical neural silencing by light-driven proton pumps. Nature. 2010 Jan 7; 463(7277):98-102. PMID: 20054397; PMCID: PMC2939492; DOI: 10.1038/nature08652;

Han X, Qian X, Stern P, Chuong AS, Boyden ES. Informational lesions: optical perturbation of spike timing and neural synchrony via microbial opsin gene fusions. Front Mol Neurosci. 2009; 2:12. PMID: 19753326; PMCID: PMC2742664; DOI: 10.3389/neuro.02.012.2009;

Han X, Xian SX, Moore T. Dynamic sensitivity of area V4 neurons during saccade preparation. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):13046-51. PMID: 19622736; PMCID: PMC2722339; DOI: 10.1073/pnas.0902412106;

Han X, Qian X, Bernstein JG, Zhou HH, Franzesi GT, Stern P, Bronson RT, Graybiel AM, Desimone R, Boyden ES. Millisecond-timescale optical control of neural dynamics in the nonhuman primate brain. Neuron. 2009 Apr 30; 62(2):191-8. PMID: 19409264; PMCID: PMC2830644; DOI: 10.1016/j.neuron.2009.03.011;

Bernstein JG, Han X, Henninger MA, Ko EY, Qian X, Franzesi GT, McConnell JP, Stern P, Desimone R, Boyden ES. Prosthetic systems for therapeutic optical activation and silencing of genetically-targeted neurons. Proc SPIE Int Soc Opt Eng. 2008; 6854:68540H. PMID: 18458792; PMCID: PMC2366937; DOI: 10.1117/12.768798;

Han X, Boyden ES. Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution. PLoS One. 2007; 2(3):e299. PMID: 17375185; PMCID: PMC1808431; DOI: 10.1371/journal.pone.0000299;

Han X, Jackson MB. Structural transitions in the synaptic SNARE complex during Ca2+-triggered exocytosis. J Cell Biol. 2006 Jan 16; 172(2):281-93. PMID: 16418536; PMCID: PMC2063557; DOI: 10.1083/jcb.200510012;

Han X, Jackson MB. Electrostatic interactions between the syntaxin membrane anchor and neurotransmitter passing through the fusion pore. Biophys J. 2005 Mar; 88(3):L20-2. PMID: 15653732; PMCID: PMC1305285; DOI: 10.1529/biophysj.104.056739;

Han X, Wang CT, Bai J, Chapman ER, Jackson MB. Transmembrane segments of syntaxin line the fusion pore of Ca2+-triggered exocytosis. Science. 2004 Apr 9; 304(5668):289-92. PMID: 15016962; DOI: 10.1126/science.1095801;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 67 publications over 19 distinct years, with a maximum of 9 publications in 2018