Xue Han, PhD
Assistant Professor
Boston University College of Engineering
Dept of Biomedical Engineering

PhD, University of Wisconsin Madison




Dr. Han’s research interests include neurotechnology, optical neural modulation, optogenetics, neural prosthetics, neural network dynamics, brain rhythms, neurological and psychiatric diseases, and cognition.

Current Research:

Brain disorders represent the biggest unmet medical need, with many disorders being untreatable, and most treatments presenting serious side effects. Accordingly, we are discovering design principles for novel neuromodulation therapies. We invent and apply a variety of genetic, molecular, pharmacological, optical, and electrical tools to correct neural circuits that go awry within the brain. As an example, we have pioneered several technologies for silencing specific cells in the brain using pulses of light. We have also recently participated the first pre-clinical testing of a novel neurotechnology, optical neural modulation. Using these novel neurotechnologies and classical ones such as deep brain stimulation (DBS), we modulate the function of neural circuits to establish causal links between neural dynamics and behavioral phenomena (e.g., movement, attention, memory, and decision making). One of our current interests is the investigation of how neural synchrony arises within and across brain regions, and how synchronous activity contributes to normal cognition and pathology.

Assistant Professor
Boston University School of Medicine
Pharmacology & Experimental Therapeutics




Unveiling the mechanisms of ultrasound neuromodulation via spatially confined stimulation and temporally resolved recording
09/30/2018 - 06/30/2023 (Multi-PI)
PI: Xue Han, PhD
NIH/National Institute of Neurological Disorders & Stroke
5R01NS109794-02

RAISE Integrating machine learning and biological neural networks
10/01/2018 - 09/30/2021 (PI)
National Science Foundation
CBET-1848029

NCS-FO: Unraveling Cortical Circuits for Auditory Scene Analysis
10/01/2018 - 09/30/2021 (Co-PI)
National Science Foundation
IIS-1835270

NRT UtB: Neurophotonics
09/01/2016 - 08/31/2021 (Co-PI)
National Science Foundation
DGE-1633516

Cortical Spatial Processing for Solving the Cocktail Party Problem
05/15/2019 - 03/31/2021 (Multi-PI)
PI: Xue Han, PhD
NIH/National Institute of Neurological Disorders & Stroke
1R34NS111742-01

Sanaya Shroff Billing Agreement AY 19-20
07/01/2019 - 06/30/2020 (PI)
Massachusetts Institute of Technology


MIT Billing Agreement-An Accessible Toolbox for Comprehensive Analysis of Neural Tissue (Seth Bensussen)
09/01/2018 - 08/31/2019 (Subcontract PI)
Massachusetts Institute of Technology NIH NIMH
5R01MH114031-02

MIT Billing Agreement- RNA Scaffolds for Cell Specific Multiplexed Neural Observation (Sanaya Shroff)
09/01/2018 - 08/31/2019 (Subcontract PI)
Massachusetts Institute of Technology NIH NIMH
5R01MH114031-02

Charaterize functional connectivitiy of hippocampal adult born neurogenesis during critical period
04/15/2016 - 03/31/2019 (PI)
NIH/National Institute of Mental Health
5R21MH109941-02

New Tools and Principles for Understanding the Biophysical Mechanisms of Ultrasound Neuromodulation
09/15/2015 - 09/14/2018 (PI)
Department of Defense/DARPA


Showing 10 of 27 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2020 Voltage imaging analysis of striatal network dynamics related to movement, Parkinson's disease and deep brain stimulation 1R01NS115797-01
2020 Voltage imaging analysis of striatal network dynamics related to movement, Parkinson's disease and deep brain stimulation 1R01NS115797-01
2020 Multidimensional Optimization of Voltage Indicators for In Vivo Neural Activity Imaging 1R01MH122971-01A1
2020 Multidimensional Optimization of Voltage Indicators for In Vivo Neural Activity Imaging 1R01MH122971-01A1
2019 Cortical Spatial Processing for Solving the Cocktail Party Problem 1R34NS111742-01
2019 Unveiling the mechanisms of ultrasound neuromodulation via spatially confined stimulation and temporally resolved recording 5R01NS109794-02 2
2018 Unveiling the mechanisms of ultrasound neuromodulation via spatially confined stimulation and temporally resolved recording 1R01NS109794-01 2
2017 Characterize the functional connectivity of hippocampal adult neurogenesis during critical period 5R21MH109941-02 1
2017 Light-Actuatable NanoRobots for Molecular Uncaging 4DP2NS082126-02 14
2016 Characterize the functional connectivity of hippocampal adult neurogenesis during critical period 1R21MH109941-01 1
Showing 10 of 24 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Kohman RE, Han X. Light sensitization of DNA nanostructures via incorporation of photo-cleavable spacers. Chem Commun (Camb). 2015 Apr 4; 51(26):5747-50.View Related Profiles. PMID: 25720373; PMCID: PMC4394657; DOI: 10.1039/c5cc00082c;
     
  2. Bleier BS, Kocharyan A, Singleton A, Han X. Verapamil modulates interleukin-5 and interleukin-6 secretion in organotypic human sinonasal polyp explants. Int Forum Allergy Rhinol. 2015 Jan; 5(1):10-3. PMID: 25330767; DOI: 10.1002/alr.21436;
     
  3. Kocharyan A, Feldman R, Singleton A, Han X, Bleier BS. P-glycoprotein inhibition promotes prednisone retention in human sinonasal polyp explants. Int Forum Allergy Rhinol. 2014 Sep; 4(9):734-8. PMID: 25145685; DOI: 10.1002/alr.21361;
     
  4. Kohman RE, Han X, Bleier BS. Heterotopic mucosal engrafting procedure for direct drug delivery to the brain in mice. J Vis Exp. 2014; (89).View Related Profiles. PMID: 25077554; DOI: 10.3791/51452;
     
  5. Chuong AS, Miri ML, Busskamp V, Matthews GA, Acker LC, Sørensen AT, Young A, Klapoetke NC, Henninger MA, Kodandaramaiah SB, Ogawa M, Ramanlal SB, Bandler RC, Allen BD, Forest CR, Chow BY, Han X, Lin Y, Tye KM, Roska B, Cardin JA, Boyden ES. Noninvasive optical inhibition with a red-shifted microbial rhodopsin. Nat Neurosci. 2014 Aug; 17(8):1123-9. PMID: 24997763; PMCID: PMC4184214; DOI: 10.1038/nn.3752;
     
  6. Bleier BS, Nocera AL, Iqbal H, Hoang JD, Alvarez U, Feldman RE, Han X. P-glycoprotein promotes epithelial T helper 2-associated cytokine secretion in chronic sinusitis with nasal polyps. Int Forum Allergy Rhinol. 2014 Jun; 4(6):488-94. PMID: 24599606; DOI: 10.1002/alr.21316;
     
  7. Zhang XX, Lamanna CM, Kohman RE, McIntosh TJ, Han X, Grinstaff MW. Lipid-mediated DNA and siRNA Transfection Efficiency Depends on Peptide Headgroup. Soft Matter. 2013 May 05; 9(17).View Related Profiles. PMID: 24391676; DOI: 10.1039/C3SM27633C;
     
  8. Bleier BS, Kohman RE, Feldman RE, Ramanlal S, Han X. Permeabilization of the blood-brain barrier via mucosal engrafting: implications for drug delivery to the brain. PLoS One. 2013; 8(4):e61694.View Related Profiles. PMID: 23637885; PMCID: PMC3634848; DOI: 10.1371/journal.pone.0061694;
     
  9. Sun L, Li J, Zhou K, Zhang M, Yang J, Li Y, Ji B, Zhang Z, Zhu H, Yang L, He G, Gao L, Wei Z, Wang K, Han X, Liu W, Tan L, Yu Y, He L, Wan C. Metabolomic analysis reveals metabolic disturbance in the cortex and hippocampus of subchronic MK-801 treated rats. PLoS One. 2013; 8(4):e60598. PMID: 23577129; PMCID: PMC3618452; DOI: 10.1371/journal.pone.0060598;
     
  10. Bleier BS, Nocera AL, Iqbal H, Hoang JD, Feldman RE, Han X. P-glycoprotein functions as an immunomodulator in healthy human primary nasal epithelial cells. Int Forum Allergy Rhinol. 2013 Jun; 3(6):433-8. PMID: 23520057; DOI: 10.1002/alr.21166;
     
Showing 10 of 24 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 24 publications over 12 distinct years, with a maximum of 5 publications in 2014

YearPublications
20041
20051
20061
20071
20081
20092
20101
20112
20124
20134
20145
20151
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44 Cummington St
Boston MA 02215
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