Xue Han, PhD
Professor
Boston University College of Engineering
Dept of Biomedical Engineering

PhD, University of Wisconsin Madison



Dr. Han received a Ph.D. from University of Wisconsin-Madison, and completed her Postdoctoral training with Dr. Bob Desimone at MIT, and Drs. Tirin Moore and Richard Tsien at Stanford University. Over the past decade, Dr. Han has trained 9 Ph.D. students, 5 postdoctoral fellows, and mentored over 70 undergraduate students for lab research. More than half of them are women or underrepresented minorities. She is currently mentoring 13 Ph.D. students, including one underrepresented minority and 8 women. She was awarded the Mentor of The Year award by Boston University Graduate Women in Science and Engineering. Dr. Han holds two granted patents with more pending and authored over 70 peer reviewed journal articles and conference proceedings. She and her students and postdoctoral trainees have given over 100 oral presentations. She has been recognized by many distinguished awards, including the Presidential Early Career Award for Scientists and Engineers (PECASE), the NIH New Innovator Award, the Pew Scholarship, the DARPA Young Faculty Award, the Alfred P. Sloan Fellowship and the Helen Hay Whitney Fellowship.

Dr. Xue Han’s seminal contribution to the field of neuroengineering centers on the invention and application of high impact molecular neurotechnologies to probe brain dynamics. She played an instrumental role in the development of optogenetic silencing molecules archaerhodopsins and halorhodopsins, enabling temporal precise silencing of specific neurons, some of the most widely used molecular tools in neuroscience, in use by thousands of research groups. Her contribution to optogenetics was crucial in establishing the new field of optogenetics, a field now being widely regarded as having revolutionized neuroscience research. In addition to her breakthrough discovery of the now widely used optogenetic molecular reagents, Dr. Han developed many other innovative technologies, including novel voltage imaging tools, cell type specific gene therapy viral vectors, drug releasing DNA origamis and mucosal based blood brain barrier penetrating strategies. Parallel to her neurotechnology innovation effort, Dr. Han has discovered key insights on the neural network mechanisms of neurological and psychiatric disorders, such as Parkinson’s disease and Alzheimer’s disease. Her current research focuses on inventing novel neurotechnologies and applying innovative approaches to probe the cellular and network mechanisms of brain disorders and brain stimulation therapies, with a goal of developing clinical biomarkers and a new generation of neuromodulation therapeutics.

Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology & Experimental Therapeutics




Targeting pathologic spike-ripples to isolate and disrupt epileptic dynamics
01/01/2021 - 11/30/2025 (Multi-PI)
PI: Xue Han, PhD
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NINDS
5R01NS119483-02

Collaborative Research: Dynamic interactions of individual neurons in supporting hippocampal network oscillations during behavior
10/01/2020 - 09/30/2025 (PI)
National Science Foundation
IOS-2002971

Voltage imaging analysis of striatal network dynamics related to voluntary movement and Parkinsons disease
04/01/2020 - 08/31/2025 (PI)
NIH/National Institute of Neurological Disorders & Stroke
3R01NS115797-03S1

Multidimensional Optimization of Voltage Indicators for In Vivo Neural Activity Imaging
03/01/2020 - 01/31/2025 (PI)
NIH/National Institute of Mental Health
5R01MH122971-03

CIF: Medium: Discovering Changes in Networks: Fundamental Limits, Efficient Algorithms, and Large-Scale Neuroscience
07/01/2020 - 06/30/2024 (Multi-PI)
PI: Xue Han, PhD
National Science Foundation
CCF-1955981

Mechanistic study of the role of autism spectrum disorder risk genes in hippocampal CA1 population dynamics during learning and memory
01/01/2021 - 12/31/2023 (Key Person / Mentor)
NIH/National Institute of Mental Health
5F31MH123008-02

Unveiling the mechanisms of ultrasound neuromodulation via spatially confined stimulation and temporally resolved recording
09/30/2018 - 06/30/2023 (Multi-PI)
PI: Xue Han, PhD
NIH/National Institute of Neurological Disorders & Stroke
3R01NS109794-04S1

Voltage imaging of striatal neuron activity during movement and reward
10/19/2019 - 12/20/2022 (Key Person / Mentor)
NIH/National Institute of Neurological Disorders & Stroke
5F31NS115421-03

NCS-FO: Unraveling Cortical Circuits for Auditory Scene Analysis
10/01/2018 - 09/30/2022 (Multi-PI)
PI: Xue Han, PhD
National Science Foundation
IIS-1835270

RAISE Integrating machine learning and biological neural networks
10/01/2018 - 09/30/2022 (Multi-PI)
PI: Xue Han, PhD
National Science Foundation
CBET-1848029

Showing 10 of 36 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2022 Optical voltage imaging analysis of the cellular and network mechanisms of deep brain stimulation 1RF1NS129520-01
2022 Voltage imaging analysis of striatal network dynamics related to movement, Parkinson's disease and deep brain stimulation 5R01NS115797-03
2022 Multidimensional Optimization of Voltage Indicators for In Vivo Neural Activity Imaging 5R01MH122971-03
2022 Dissemination of a fiber-based optoacoustic neurostimulation device 3R01NS109794-05S1
2022 Unveiling the mechanisms of ultrasound neuromodulation via spatially confined stimulation and temporally resolved recording 5R01NS109794-05
2022 Unveiling the mechanisms of ultrasound neuromodulation via spatially confined stimulation and temporally resolved recording 3R01NS109794-04S1
2021 Voltage imaging analysis of striatal network dynamics related to movement, Parkinson's disease and deep brain stimulation 5R01NS115797-02
2021 Multidimensional Optimization of Voltage Indicators for In Vivo Neural Activity Imaging 5R01MH122971-02
2021 Unveiling the mechanisms of ultrasound neuromodulation via spatially confined stimulation and temporally resolved recording 5R01NS109794-04 2
2020 Voltage imaging analysis of striatal network dynamics related to movement, Parkinson's disease and deep brain stimulation 1R01NS115797-01
Showing 10 of 32 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Shi W, Zemel D, Sridhar S, Mount RA, Richardson RM, Eden UT, Han X, Kramer MA, Chu CJ. Spike ripples in striatum correlate with seizure risk in two mouse models. Epilepsy Behav Rep. 2022; 18:100529. PMID: 35274094; PMCID: PMC8902602; DOI: 10.1016/j.ebr.2022.100529;
     
  2. Zemel D, Gritton H, Cheung C, Shankar S, Kramer M, Han X. Dopamine depletion selectively disrupts interactions between striatal neuron subtypes and LFP oscillations. Cell Rep. 2022 01 18; 38(3):110265. PMID: 35045299; PMCID: PMC8820590; DOI: 10.1016/j.celrep.2021.110265;
     
  3. Xiao S, Lowet E, Gritton HJ, Fabris P, Wang Y, Sherman J, Mount RA, Tseng HA, Man HY, Straub C, Piatkevich KD, Boyden ES, Mertz J, Han X. Large-scale voltage imaging in behaving mice using targeted illumination. iScience. 2021 Nov 19; 24(11):103263.View Related Profiles. PMID: 34761183; PMCID: PMC8567393; DOI: 10.1016/j.isci.2021.103263;
     
  4. Tseng HA, Sherman J, Bortz E, Mohammed A, Gritton HJ, Bensussen S, Tang RP, Zemel D, Szabo T, Han X. Region-specific effects of ultrasound on individual neurons in the awake mammalian brain. iScience. 2021 Sep 24; 24(9):102955. PMID: 34458703; PMCID: PMC8379692; DOI: 10.1016/j.isci.2021.102955;
     
  5. Nadalin JK, Eden UT, Han X, Richardson RM, Chu CJ, Kramer MA. Application of a convolutional neural network for fully-automated detection of spike ripples in the scalp electroencephalogram. J Neurosci Methods. 2021 08 01; 360:109239. PMID: 34090917; PMCID: PMC8324553; DOI: 10.1016/j.jneumeth.2021.109239;
     
  6. Mount RA, Sridhar S, Hansen KR, Mohammed AI, Abdulkerim M, Kessel R, Nazer B, Gritton HJ, Han X. Distinct neuronal populations contribute to trace conditioning and extinction learning in the hippocampal CA1. Elife. 2021 04 12; 10. PMID: 33843589; PMCID: PMC8064758; DOI: 10.7554/eLife.56491;
     
  7. Tseng HA, Han X. Distinct Spiking Patterns of Excitatory and Inhibitory Neurons and LFP Oscillations in Prefrontal Cortex During Sensory Discrimination. Front Physiol. 2021; 12:618307. PMID: 33679434; PMCID: PMC7928411; DOI: 10.3389/fphys.2021.618307;
     
  8. Tsang JM, Gritton HJ, Das SL, Weber TD, Chen CS, Han X, Mertz J. Fast, multiplane line-scan confocal microscopy using axially distributed slits. Biomed Opt Express. 2021 Mar 01; 12(3):1339-1350.View Related Profiles. PMID: 33796357; PMCID: PMC7984773; DOI: 10.1364/BOE.417286;
     
  9. Keaveney MK, Rahsepar B, Tseng HA, Fernandez FR, Mount RA, Ta T, White JA, Berg J, Han X. CaMKIIa-Positive Interneurons Identified via a microRNA-Based Viral Gene Targeting Strategy. J Neurosci. 2020 12 09; 40(50):9576-9588.View Related Profiles. PMID: 33158963; PMCID: PMC7726537; DOI: 10.1523/JNEUROSCI.2570-19.2020;
     
  10. Xiao S, Gritton H, Tseng HA, Zemel D, Han X, Mertz J. High-contrast multifocus microscopy with a single camera and z-splitter prism. Optica. 2020 Nov 20; 7(11):1477-1486.View Related Profiles. PMID: 34532564; PMCID: PMC8443084; DOI: 10.1364/optica.404678;
     
Showing 10 of 67 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 67 publications over 19 distinct years, with a maximum of 9 publications in 2018

YearPublications
20041
20051
20061
20071
20081
20093
20102
20112
20124
20133
20145
20156
20166
20173
20189
20194
20207
20216
20222

2022 Elected Fellow, American Institute for Medical and Biological Engineering (AIMBE)
2015 DARPA Young Investigator Award
2014 Boston University GWISE, Mentor of the Year Award
2013 Presidential Early Career Award for Scientists and Engineers (PECASE)
2012-2018 NIH New Innovator Award
2012-2016 Pew Scholar Award
2010-2011 Boston University Photonic Center Young Investigator Award
2007-2008 MIT McGovern Institute Neurotechnology Award
2005 UW-Madison Jerzy Rose Neuroscience Thesis Award
2002 UW-Madison Vilas Travel Award
2000-2001 UW-Madison Cremer Fellowship
Contact for Mentoring:

44 Cummington St
Boston MA 02215
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