Shinobu Matsuura, DVM, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Cardiovascular Medicine

PhD, University of Tokyo
DVM, Universidade de São Paulo

Pronouns: she/her/hers



My career goal is to apply my knowledge in veterinary medicine to most effectively use animal models to develop therapies that can significant translational potential and potential to impact patient outcomes. I have a career-long interest in hematology research, which emerged from my experience treating canine patients with hematological malignancies. My major research focus is hematopoietic stem cell biology and the de-regulation of those processes in malignancy. My current project explores the potential to target stem cells in myeloproliferative neoplasms driven by the JAK2V617F mutation through integrins. Given the experience accumulated on therapeutic targeting of integrins, I am excited by the significant translational potential of this project.

I graduated School of Veterinary Medicine and completed Residency in Internal Medicine at the University of São Paulo (USP), Brazil. My training in research consists of a graduate degree at the University of Tokyo, Japan, under the guidance of Dr. Hajime Tsujimoto, and postdoctoral training at the laboratories of Dr. Dong-Er Zhang at the Scripps Research Institute and at the University of California, San Diego under a F32 award, and Dr. Katya Ravid at Boston University. I was promoted Instructor of Medicine at the Boston University Chobanian and Avedisian School of Medicine in 2016 and Assistant Professor in 2021. I am a PI of the career development SERCA K01 award, from the Office of Research Infrastructure (ORIP)/NIH, a training mechanism specifically designed for veterinarians pursuing basic research.

Diversity, Equity, Inclusion and Accessibility

As a Japanese immigrant that grew up in Brazil, diversity and inclusion became part of my identity. Professionally, I also find myself as a minority of DVM graduate among PhD and MDs. Those experiences helped shape my commitment to enhance diversity and inclusion in the society and in the workplace, to give a fair chance to all individuals, regardless of their background and social status. An institutional culture that values diversity and inclusion are a foundation for a resilient and vibrant workplace, driving innovation and excellence through challenging of ideas, action, and rewarding on results, not entitlement.


Targeting the JAK2V617F Hematopoietic Stem Cell Through Integrins-Based Combination Therapy
03/01/2023 - 03/01/2025 (PI)
MPN Research Foundation


The bone marrow extracellular matrix: scaffold of hematopoiesis
02/01/2019 - 01/31/2025 (PI)
NIH/Office of the Director
3K01OD025290-05S1

Targeting JAK2V617F stem cells in primary myelofibrosis
12/15/2022 - 11/30/2024 (PI)
NIH/Office of the Director
5R03OD031959-02



Title

Targeting the JAK2V617F Hematopoietic Stem Cell through Integrins-Based Combination Therapy
03/01/2023 - 02/28/2025 (PI)
MPN Research Foundation and the Leukemia & Lymphoma Society

Role of JAK2 in cerebrovascular and microglial dysfunction in Alzhemeir’s disease
02/01/2023 - 01/31/2024 (Co-PI)
Boston University Chobanian and Avedisian School of Medicine

Exploring Integrin-targeting biologics for primary myelofibrosis
07/01/2022 - 06/30/2023 (PI)
BU CTSI
UL1 TR001430

Mechanistically Interrogate at the Gene Expression Level the effect of Anti-b1 Integrin Antibody on JAK2V617F+ Stem Cells
05/01/2022 - 12/31/2022 (PI)
BU CAMED Genome Science Institute


Yr Title Project-Sub Proj Pubs
2024 Targeting beta1 integrin in JAK2V617F+ stem cells 5R03OD031959-02
2023 Targeting beta1 integrin in JAK2V617F+ stem cells 1R03OD031959-01A1
2023 The bone marrow extracellular matrix: scaffold of hematopoiesis 5K01OD025290-05
2023 The bone marrow extracellular matrix: scaffold of hematopoiesis 3K01OD025290-05S1
2022 The bone marrow extracellular matrix: scaffold of hematopoiesis 5K01OD025290-04
2021 The bone marrow extracellular matrix: scaffold of hematopoiesis 5K01OD025290-03 1
2020 The bone marrow extracellular matrix: scaffold of hematopoiesis 5K01OD025290-02 1
2019 The bone marrow extracellular matrix: scaffold of hematopoiesis 1K01OD025290-01A1 1
2010 Novel molecular targets of RUNX in hematopoietic stem/progenitor cells 5F32HL091641-04 9
2009 Novel molecular targets of RUNX in hematopoietic stem/progenitor cells 5F32HL091641-03 9
Showing 10 of 11 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Karagianni A, Karkempetzaki AI, Brooks D, Matsuura S, Dambal V, Trackman PC, Ravid K. Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner. Blood. 2024 Jun 20; 143(25):2666-2670.View Related Profiles. PMID: 38635757; PMCID: PMC11196861; DOI: 10.1182/blood.2024024620;
     
  2. Arimoto KI, Zhang Y, Matsuura S, Miyauchi S, Zhang DE. Hypersensitivity to type I interferon as a cause of hydrocephalus development. Brain Res. 2024 Jun 10; 1840:149082. PMID: 38866307
     
  3. Abbonante V, Karkempetzaki AI, Leon C, Krishnan A, Huang N, Di Buduo CA, Cattaneo D, Ward CM, Matsuura S, Guinard I, Weber J, De Acutis A, Vozzi G, Iurlo A, Ravid K, Balduini A. Newly identified roles for PIEZO1 mechanosensor in controlling normal megakaryocyte development and in primary myelofibrosis. Am J Hematol. 2024 Mar; 99(3):336-349.View Related Profiles. PMID: 38165047; PMCID: PMC10922533; DOI: 10.1002/ajh.27184;
     
  4. Karagianni A, Matsuura S, Gerstenfeld LC, Ravid K. Inhibition of Osteoblast Differentiation by JAK2V617F Megakaryocytes Derived From Male Mice With Primary Myelofibrosis. Front Oncol. 2022; 12:929498.View Related Profiles. PMID: 35880162; PMCID: PMC9307716; DOI: 10.3389/fonc.2022.929498;
     
  5. Matsuura S, Balduini A, Onisto M. Editorial: Mechanisms of Cell Adhesion in Hematopoietic Stem Cells. Front Cell Dev Biol. 2021; 9:826554. PMID: 34993206; PMCID: PMC8724261; DOI: 10.3389/fcell.2021.826554;
     
  6. Yang X, Chitalia SV, Matsuura S, Ravid K. Integrins and their role in megakaryocyte development and function. Exp Hematol. 2022 02; 106:31-39.View Related Profiles. PMID: 34910941; PMCID: PMC8795491; DOI: 10.1016/j.exphem.2021.11.007;
     
  7. Lim KH, Matsuura S, Xu B. Editorial: Novel Treatment Strategies for Myeloproliferative Neoplasms. Front Oncol. 2021; 11:762928. PMID: 34604100; PMCID: PMC8479092; DOI: 10.3389/fonc.2021.762928;
     
  8. Matsuura S, Thompson CR, Belghasem ME, Bekendam RH, Piasecki A, Leiva O, Ray A, Italiano J, Yang M, Merill-Skoloff G, Chitalia VC, Flaumenhaft R, Ravid K. Platelet Dysfunction and Thrombosis in JAK2V617F-Mutated Primary Myelofibrotic Mice. Arterioscler Thromb Vasc Biol. 2020 10; 40(10):e262-e272.View Related Profiles. PMID: 32814440; PMCID: PMC7605151; DOI: 10.1161/ATVBAHA.120.314760;
     
  9. Matsuura S, Thompson CR, Ng SK, Ward CM, Karagianni A, Mazzeo C, Malara A, Balduini A, Ravid K. Adhesion to fibronectin via a5ß1 integrin supports expansion of the megakaryocyte lineage in primary myelofibrosis. Blood. 2020 06 18; 135(25):2286-2291.View Related Profiles. PMID: 32294178; PMCID: PMC7316217; DOI: 10.1182/blood.2019004230;
     
  10. Leiva O, Ng SK, Matsuura S, Chitalia V, Lucero H, Findlay A, Turner C, Jarolimek W, Ravid K. Novel lysyl oxidase inhibitors attenuate hallmarks of primary myelofibrosis in mice. Int J Hematol. 2019 Dec; 110(6):699-708.View Related Profiles. PMID: 31637674; PMCID: PMC7503219; DOI: 10.1007/s12185-019-02751-6;
     
Showing 10 of 40 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 40 publications over 17 distinct years, with a maximum of 6 publications in 2012

YearPublications
20061
20071
20083
20091
20111
20126
20133
20144
20151
20164
20173
20181
20192
20202
20213
20221
20243


2015 American Society of Biochemistry and Molecular Biology (ASBMB): Best Thematic Poster Award
2010 Annual Meeting of the American Society of Hematology (ASH): Travel Award
2007 Federation of American Societies for Experimental Biology (FASEB), : Best Poster Award
2005 Japanese College of Veterinary Internal Medicine: Best Science Presentation Award

I believe that an individual mentoring experience is essential for research education.
I have experience in undergraduate and graduate mentoring. My teaching philosophy is to create an inquisitive environment to nurture curiosity and learning.

Available to Mentor as: (Review Mentor Role Definitions):
  • Diversity Mentor
  • Education Mentor
  • Project Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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