My career goal is to apply my knowledge in veterinary medicine to most effectively use animal models to develop therapies that can significant translational potential and potential to impact patient outcomes. I have a career-long interest in hematology research, which emerged from my experience treating canine patients with hematological malignancies. My major research focus is hematopoietic stem cell biology and the de-regulation of those processes in malignancy. My current project explores the potential to target stem cells in myeloproliferative neoplasms driven by the JAK2V617F mutation through integrins. Given the experience accumulated on therapeutic targeting of integrins, I am excited by the significant translational potential of this project.
I graduated School of Veterinary Medicine and completed Residency in Internal Medicine at the University of São Paulo (USP), Brazil. My training in research consists of a graduate degree at the University of Tokyo, Japan, under the guidance of Dr. Hajime Tsujimoto, and postdoctoral training at the laboratories of Dr. Dong-Er Zhang at the Scripps Research Institute and at the University of California, San Diego under a F32 award, and Dr. Katya Ravid at Boston University. I was promoted Instructor of Medicine at the Boston University Chobanian and Avedisian School of Medicine in 2016 and Assistant Professor in 2021. I am a PI of the career development SERCA K01 award, from the Office of Research Infrastructure (ORIP)/NIH, a training mechanism specifically designed for veterinarians pursuing basic research.
Diversity, Equity, Inclusion and Accessibility
As a Japanese immigrant that grew up in Brazil, diversity and inclusion became part of my identity. Professionally, I also find myself as a minority of DVM graduate among PhD and MDs. Those experiences helped shape my commitment to enhance diversity and inclusion in the society and in the workplace, to give a fair chance to all individuals, regardless of their background and social status. An institutional culture that values diversity and inclusion are a foundation for a resilient and vibrant workplace, driving innovation and excellence through challenging of ideas, action, and rewarding on results, not entitlement.
This tab shows grant data from BMC Sponsored Research. It includes:
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- Data is sorted by project end date, and updated monthly.
This tab shows grant data from BU Sponsored Research. It includes:
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- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
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- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
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- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data from the Boston VA. We are only showing grant title, and only for people in the role of PI.
Targeting the JAK2V617F Hematopoietic Stem Cell Through Integrins-Based Combination Therapy03/01/2023 - 03/01/2025 (PI)
MPN Research Foundation
Targeting JAK2V617F stem cells in primary myelofibrosis12/15/2022 - 11/30/2024 (PI)
NIH/Office of the Director1R03OD031959-01A1
The bone marrow extracellular matrix: scaffold of hematopoiesis02/01/2019 - 01/31/2024 (PI)
NIH/Office of the Director5K01OD025290-05
Targeting the JAK2V617F Hematopoietic Stem Cell through Integrins-Based Combination Therapy03/01/2023 - 02/28/2025 (PI)
MPN Research Foundation and the Leukemia & Lymphoma Society
Role of JAK2 in cerebrovascular and microglial dysfunction in Alzhemeir’s disease02/01/2023 - 01/31/2024 (Co-PI)
Boston University Chobanian and Avedisian School of Medicine
Exploring Integrin-targeting biologics for primary myelofibrosis07/01/2022 - 06/30/2023 (PI)
BU CTSIUL1 TR001430
Mechanistically Interrogate at the Gene Expression Level the effect of Anti-b1 Integrin Antibody on JAK2V617F+ Stem Cells05/01/2022 - 12/31/2022 (PI)
BU CAMED Genome Science Institute
Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
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Matsuura S, Thompson CR, Belghasem ME, Bekendam RH, Piasecki A, Leiva O, Ray A, Italiano J, Yang M, Merill-Skoloff G, Chitalia VC, Flaumenhaft R, Ravid K. Platelet Dysfunction and Thrombosis in JAK2V617F-Mutated Primary Myelofibrotic Mice. Arterioscler Thromb Vasc Biol. 2020 10; 40(10):e262-e272.View Related Profiles. PMID: 32814440; PMCID: PMC7605151; DOI: 10.1161/ATVBAHA.120.314760;
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Matsuura S, Thompson CR, Ng SK, Ward CM, Karagianni A, Mazzeo C, Malara A, Balduini A, Ravid K. Adhesion to fibronectin via a5ß1 integrin supports expansion of the megakaryocyte lineage in primary myelofibrosis. Blood. 2020 06 18; 135(25):2286-2291.View Related Profiles. PMID: 32294178; PMCID: PMC7316217; DOI: 10.1182/blood.2019004230;
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Sano S, Wang Y, Yura Y, Sano M, Oshima K, Yang Y, Katanasaka Y, Min KD, Matsuura S, Ravid K, Mohi G, Walsh K. JAK2V617F -Mediated Clonal Hematopoiesis Accelerates Pathological Remodeling in Murine Heart Failure. JACC Basic Transl Sci. 2019 Oct; 4(6):684-697.View Related Profiles. PMID: 31709318; PMCID: PMC6834960; DOI: 10.1016/j.jacbts.2019.05.013;
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Kolachalama VB, Shashar M, Alousi F, Shivanna S, Rijal K, Belghasem ME, Walker J, Matsuura S, Chang GH, Gibson CM, Dember LM, Francis JM, Ravid K, Chitalia VC. Uremic Solute-Aryl Hydrocarbon Receptor-Tissue Factor Axis Associates with Thrombosis after Vascular Injury in Humans. J Am Soc Nephrol. 2018 03; 29(3):1063-1072.View Related Profiles. PMID: 29343519; PMCID: PMC5827608; DOI: 10.1681/ASN.2017080929;
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Shashar M, Belghasem ME, Matsuura S, Walker J, Richards S, Alousi F, Rijal K, Kolachalama VB, Balcells M, Odagi M, Nagasawa K, Henderson JM, Gautam A, Rushmore R, Francis J, Kirchhofer D, Kolandaivelu K, Sherr DH, Edelman ER, Ravid K, Chitalia VC. Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk. Sci Transl Med. 2017 Nov 22; 9(417).View Related Profiles. PMID: 29167396; PMCID: PMC5854487; DOI: 10.1126/scitranslmed.aam8475;
Showing 10 of 37 results.
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Lam K, Muselman A, Du R, Yan M, Matsuura S, Zhang DE. Loss of RUNX1 function results in enhanced granulocyte-colony-stimulating factor-mediated mobilization. Blood Cancer J. 2016 Mar 25; 6:e407. PMID: 27015284; PMCID: PMC4817102; DOI: 10.1038/bcj.2016.20;
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Matsuura S, Mi R, Koupenova M, Eliades A, Patterson S, Toselli P, Thon J, Italiano JE, Trackman PC, Papadantonakis N, Ravid K. Lysyl oxidase is associated with increased thrombosis and platelet reactivity. Blood. 2016 Mar 17; 127(11):1493-501.View Related Profiles. PMID: 26755713; PMCID: PMC4797025; DOI: 10.1182/blood-2015-02-629667;
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Jing L, Tamplin OJ, Chen MJ, Deng Q, Patterson S, Kim PG, Durand EM, McNeil A, Green JM, Matsuura S, Ablain J, Brandt MK, Schlaeger TM, Huttenlocher A, Daley GQ, Ravid K, Zon LI. Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. J Exp Med. 2015 May 4; 212(5):649-63.View Related Profiles. PMID: 25870200; PMCID: PMC4419349; DOI: 10.1084/jem.20141528;
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Kawarai S, Hisasue M, Matsuura S, Ito T, Inoue Y, Neo S, Fujii Y, Madarame H, Shirota K, Tsuchiya R. Canine pemphigus foliaceus with concurrent immune-mediated thrombocytopenia. J Am Anim Hosp Assoc. 2015 Jan-Feb; 51(1):56-63. PMID: 25415212; DOI: 10.5326/JAAHA-MS-6044;
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Lam K, Muselman A, Du R, Harada Y, Scholl AG, Yan M, Matsuura S, Weng S, Harada H, Zhang DE. Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice. Blood. 2014 Oct 2; 124(14):2203-12. PMID: 25150295; PMCID: PMC4183983; DOI: 10.1182/blood-2014-02-554543;
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Kawarai S, Matsuura S, Yamamoto S, Kiuchi A, Kanemaki N, Madarame H, Shirota K. A case of cutaneous sterile pyogranuloma/granuloma syndrome in a maltese. J Am Anim Hosp Assoc. 2014 Jul-Aug; 50(4):278-83. PMID: 24855086; DOI: 10.5326/JAAHA-MS-6009;
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Komeno Y, Yan M, Matsuura S, Lam K, Lo MC, Huang YJ, Tenen DG, Downing JR, Zhang DE. Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice. Blood. 2014 Jun 12; 123(24):3760-9. PMID: 24771859; PMCID: PMC4055923; DOI: 10.1182/blood-2013-08-521252;
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Sher N, Von Stetina JR, Bell GW, Matsuura S, Ravid K, Orr-Weaver TL. Fundamental differences in endoreplication in mammals and Drosophila revealed by analysis of endocycling and endomitotic cells. Proc Natl Acad Sci U S A. 2013 Jun 4; 110(23):9368-73.View Related Profiles. PMID: 23613587; PMCID: PMC3677442; DOI: 10.1073/pnas.1304889110;
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Ahn EE, Higashi T, Yan M, Matsuura S, Hickey CJ, Lo MC, Shia WJ, DeKelver RC, Zhang DE. SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster. J Biol Chem. 2013 Feb 22; 288(8):5381-8. PMID: 23322776; PMCID: PMC3581430; DOI: 10.1074/jbc.M112.447227;
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Matsuura S, Komeno Y, Stevenson KE, Biggs JR, Lam K, Tang T, Lo MC, Cong X, Yan M, Neuberg DS, Zhang DE. Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome. Blood. 2012 Nov 8; 120(19):4028-37. PMID: 22919028; PMCID: PMC3496957; DOI: 10.1182/blood-2012-01-404533;
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Lo MC, Peterson LF, Yan M, Cong X, Jin F, Shia WJ, Matsuura S, Ahn EY, Komeno Y, Ly M, Ommen HB, Chen IM, Hokland P, Willman CL, Ren B, Zhang DE. Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML. Blood. 2012 Aug 16; 120(7):1473-84. PMID: 22740448; PMCID: PMC3423785; DOI: 10.1182/blood-2011-12-395335;
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Shia WJ, Okumura AJ, Yan M, Sarkeshik A, Lo MC, Matsuura S, Komeno Y, Zhao X, Nimer SD, Yates JR, Zhang DE. PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential. Blood. 2012 May 24; 119(21):4953-62. PMID: 22498736; PMCID: PMC3367897; DOI: 10.1182/blood-2011-04-347476;
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Matsuura S, Yan M, Lo MC, Ahn EY, Weng S, Dangoor D, Matin M, Higashi T, Feng GS, Zhang DE. Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia. Blood. 2012 Mar 29; 119(13):3155-63. PMID: 22223820; PMCID: PMC3321875; DOI: 10.1182/blood-2011-04-350694;
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Ahn EY, DeKelver RC, Lo MC, Nguyen TA, Matsuura S, Boyapati A, Pandit S, Fu XD, Zhang DE. SON controls cell-cycle progression by coordinated regulation of RNA splicing. Mol Cell. 2011 Apr 22; 42(2):185-98. PMID: 21504830; PMCID: PMC3137374; DOI: 10.1016/j.molcel.2011.03.014;
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Kawarai S, Masuda K, Ohmori K, Matsuura S, Yasuda N, Nagata M, Sakaguchi M, Tsujimoto H. Cultivation and characterization of canine skin-derived mast cells. J Vet Med Sci. 2010 Feb; 72(2):131-40. PMID: 19940396
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Ide K, Matsuura S, Fujino Y, Ohno K, Tsujimoto H. Investigation of various methods for the cryopreservation of canine bone marrow-derived CD34(+) cells. J Vet Med Sci. 2008 Nov; 70(11):1211-7. PMID: 19057140
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Takeuchi Y, Matsuura S, Fujino Y, Nakajima M, Takahashi M, Nakashima K, Sakai Y, Uetsuka K, Ohno K, Nakayama H, Tsujimoto H. Hypereosinophilic syndrome in two cats. J Vet Med Sci. 2008 Oct; 70(10):1085-9. PMID: 18981665
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Kitamura Y, Koto H, Matsuura S, Kawabata T, Tsuchiya H, Kusuhara H, Tsujimoto H, Sugiyama Y. Modest effect of impaired P-glycoprotein on the plasma concentrations of fexofenadine, quinidine, and loperamide following oral administration in collies. Drug Metab Dispos. 2008 May; 36(5):807-10. PMID: 18299336; DOI: 10.1124/dmd.107.017624;
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Matsuura S, Koto H, Ide K, Fujino Y, Setoguchi-Mukai A, Ohno K, Tsujimoto H. Induction of chemoresistance in a cultured canine cell line by retroviral transduction of the canine multidrug resistance 1 gene. Am J Vet Res. 2007 Jan; 68(1):95-100. PMID: 17199425
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Fukushima K, Okai Y, Matsuura S, Tsujimoto H, Endo Y. Molecular cloning of feline lung resistance-related protein (LRP) cDNA and its expression in a feline lymphoma cell line and adriamycin-resistant subline. J Vet Med Sci. 2006 Aug; 68(8):885-90. PMID: 16953094
This graph shows the total number of publications by year, by first, middle/unknown,
or last author.
| Year | Publications |
|---|
| 2006 | 1 |
| 2007 | 1 |
| 2008 | 3 |
| 2009 | 1 |
| 2011 | 1 |
| 2012 | 6 |
| 2013 | 3 |
| 2014 | 4 |
| 2015 | 1 |
| 2016 | 4 |
| 2017 | 3 |
| 2018 | 1 |
| 2019 | 2 |
| 2020 | 2 |
| 2021 | 3 |
| 2022 | 1 |
2015 American Society of Biochemistry and Molecular Biology (ASBMB):
Best Thematic Poster Award
2010 Annual Meeting of the American Society of Hematology (ASH):
Travel Award
2007 Federation of American Societies for Experimental Biology (FASEB), :
Best Poster Award
2005 Japanese College of Veterinary Internal Medicine:
Best Science Presentation Award
I believe that an individual mentoring experience is essential for research education.
I have experience in undergraduate and graduate mentoring. My teaching philosophy is to create an inquisitive environment to nurture curiosity and learning.
Available to Mentor as: (Review Mentor Role Definitions):
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Diversity Mentor
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Education Mentor
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Project Mentor