My career goal is to apply my knowledge in veterinary medicine to most effectively use animal models to develop therapies that can significant translational potential and potential to impact patient outcomes. I have a career-long interest in hematology research, which emerged from my experience treating canine patients with hematological malignancies. My major research focus is hematopoietic stem cell biology and the de-regulation of those processes in malignancy. My current project explores the potential to target stem cells in myeloproliferative neoplasms driven by the JAK2V617F mutation through integrins. Given the experience accumulated on therapeutic targeting of integrins, I am excited by the significant translational potential of this project.
I graduated School of Veterinary Medicine and completed Residency in Internal Medicine at the University of São Paulo (USP), Brazil. My training in research consists of a graduate degree at the University of Tokyo, Japan, under the guidance of Dr. Hajime Tsujimoto, and postdoctoral training at the laboratories of Dr. Dong-Er Zhang at the Scripps Research Institute and at the University of California, San Diego under a F32 award, and Dr. Katya Ravid at Boston University. I was promoted Instructor of Medicine at the Boston University Chobanian and Avedisian School of Medicine in 2016 and Assistant Professor in 2021. I am a PI of the career development SERCA K01 award, from the Office of Research Infrastructure (ORIP)/NIH, a training mechanism specifically designed for veterinarians pursuing basic research.
Diversity, Equity, Inclusion and Accessibility
As a Japanese immigrant that grew up in Brazil, diversity and inclusion became part of my identity. Professionally, I also find myself as a minority of DVM graduate among PhD and MDs. Those experiences helped shape my commitment to enhance diversity and inclusion in the society and in the workplace, to give a fair chance to all individuals, regardless of their background and social status. An institutional culture that values diversity and inclusion are a foundation for a resilient and vibrant workplace, driving innovation and excellence through challenging of ideas, action, and rewarding on results, not entitlement.
Targeting the JAK2V617F Hematopoietic Stem Cell Through Integrins-Based Combination Therapy
03/01/2023 - 03/01/2025 (PI)MPN Research Foundation
Targeting JAK2V617F stem cells in primary myelofibrosis
12/15/2022 - 11/30/2024 (PI)NIH/Office of the Director1R03OD031959-01A1
The bone marrow extracellular matrix: scaffold of hematopoiesis
02/01/2019 - 01/31/2024 (PI)NIH/Office of the Director3K01OD025290-05S1
Targeting the JAK2V617F Hematopoietic Stem Cell through Integrins-Based Combination Therapy
03/01/2023 - 02/28/2025 (PI)
MPN Research Foundation and the Leukemia & Lymphoma Society
Role of JAK2 in cerebrovascular and microglial dysfunction in Alzhemeir’s disease
02/01/2023 - 01/31/2024 (Co-PI)
Boston University Chobanian and Avedisian School of Medicine
Exploring Integrin-targeting biologics for primary myelofibrosis
07/01/2022 - 06/30/2023 (PI)
Mechanistically Interrogate at the Gene Expression Level the effect of Anti-b1 Integrin Antibody on JAK2V617F+ Stem Cells
05/01/2022 - 12/31/2022 (PI)
BU CAMED Genome Science Institute
Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
to make corrections and additions.
Showing 10 of 37 results.
Matsuura S, Thompson CR, Belghasem ME, Bekendam RH, Piasecki A, Leiva O, Ray A, Italiano J, Yang M, Merill-Skoloff G, Chitalia VC, Flaumenhaft R, Ravid K. Platelet Dysfunction and Thrombosis in JAK2V617F-Mutated Primary Myelofibrotic Mice. Arterioscler Thromb Vasc Biol. 2020 10; 40(10):e262-e272.View Related Profiles. PMID: 32814440; PMCID: PMC7605151; DOI: 10.1161/ATVBAHA.120.314760;
Matsuura S, Thompson CR, Ng SK, Ward CM, Karagianni A, Mazzeo C, Malara A, Balduini A, Ravid K. Adhesion to fibronectin via a5ß1 integrin supports expansion of the megakaryocyte lineage in primary myelofibrosis. Blood. 2020 06 18; 135(25):2286-2291.View Related Profiles. PMID: 32294178; PMCID: PMC7316217; DOI: 10.1182/blood.2019004230;
Sano S, Wang Y, Yura Y, Sano M, Oshima K, Yang Y, Katanasaka Y, Min KD, Matsuura S, Ravid K, Mohi G, Walsh K. JAK2V617F -Mediated Clonal Hematopoiesis Accelerates Pathological Remodeling in Murine Heart Failure. JACC Basic Transl Sci. 2019 Oct; 4(6):684-697.View Related Profiles. PMID: 31709318; PMCID: PMC6834960; DOI: 10.1016/j.jacbts.2019.05.013;
Kolachalama VB, Shashar M, Alousi F, Shivanna S, Rijal K, Belghasem ME, Walker J, Matsuura S, Chang GH, Gibson CM, Dember LM, Francis JM, Ravid K, Chitalia VC. Uremic Solute-Aryl Hydrocarbon Receptor-Tissue Factor Axis Associates with Thrombosis after Vascular Injury in Humans. J Am Soc Nephrol. 2018 03; 29(3):1063-1072.View Related Profiles. PMID: 29343519; PMCID: PMC5827608; DOI: 10.1681/ASN.2017080929;
Shashar M, Belghasem ME, Matsuura S, Walker J, Richards S, Alousi F, Rijal K, Kolachalama VB, Balcells M, Odagi M, Nagasawa K, Henderson JM, Gautam A, Rushmore R, Francis J, Kirchhofer D, Kolandaivelu K, Sherr DH, Edelman ER, Ravid K, Chitalia VC. Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk. Sci Transl Med. 2017 Nov 22; 9(417).View Related Profiles. PMID: 29167396; PMCID: PMC5854487; DOI: 10.1126/scitranslmed.aam8475;
This graph shows the total number of publications by year, by first, middle/unknown,
or last author.
2015 American Society of Biochemistry and Molecular Biology (ASBMB):
Best Thematic Poster Award
2010 Annual Meeting of the American Society of Hematology (ASH):
2007 Federation of American Societies for Experimental Biology (FASEB), :
Best Poster Award
2005 Japanese College of Veterinary Internal Medicine:
Best Science Presentation Award
Available to Mentor as: (Review Mentor Role Definitions)
I believe that an individual mentoring experience is essential for research education.
I have experience in undergraduate and graduate mentoring. My teaching philosophy is to create an inquisitive environment to nurture curiosity and learning.