Paul J. Maglione, MD, PhD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD/PhD, Albert Einstein College of Medicine

Paul J. (PJ) Maglione, MD, PhD is an Assistant Professor of Medicine in the Section of Pulmonary, Allergy, Sleep & Critical Care Medicine at the Boston University School of Medicine. He is a physician-scientist with expertise in the clinical care of primary immunodeficiencies and runs a laboratory in the Pulmonary Center at the Boston University Medical Campus. Before arriving at the university, Dr. Maglione was an attending physician and researcher at the Icahn School of Medicine at Mount Sinai. He completed his MD/PhD training at the Albert Einstein College of Medicine and internal medicine residency at Mount Sinai Hospital in New York. Also at Mount Sinai, Dr. Maglione undertook fellowship training in clinical immunology and post-doctoral research under the mentorship of Charlotte Cunningham-Rundles, MD, PhD, a renowned expert in common variable immunodeficiency.

Clinical Focus:
Dr. Maglione is an attending physician at Boston Medical Center where he focuses on the diagnosis and treatment of primary immunodeficiency disorders, with special expertise in the care of common variable immunodeficiency and its complications. He also attends on the inpatient allergy/immunology service. Dr. Maglione is involved in the teaching of allergy/immunology clinical fellows in the Boston University School of Medicine program. He has been invited to speak to patient audiences on numerous occasions by the Immune Deficiency Foundation, including their national conference, and cares for patients with immune deficiency disorders from around the country.

Research Focus:
Dr. Maglione studies human B cell biology through the lens of primary immunodeficiency. Dr. Maglione's clinical focus on antibody deficiency syndromes dovetails with his research focus on mechanisms of B cell dysfunction in humans. For numerous years, he has been investigating mechanisms underlying non-infectious complications of the most prevalent form of symptomatic primary antibody deficiency, common variable immunodeficiency (CVID). Recent work has focused upon the pathogenesis of interstitial lung disease affecting CVID patients, particularly upon the biology of B cell dysfunction in this disease. Dr. Maglione has helped devise therapeutic strategies to treat gastrointestinal and pulmonary complications of common variable immunodeficiency. His research utilizes high throughput strategies that include seromics, antibody arrays, genomics, and RNA sequencing coupled with cell culture, biopsies, and information from the medical record to define how B cell defects shape human disease.

Boston University
Pulmonary Center

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

2019-2022 AAAAI Foundation Faculty Development Award
2018 Schneider-Lesser Fellowship
2015 Icahn School of Medicine at Mount Sinai: Allergy/Immunology Teaching Award
2015 Burroughs Wellcome Fund: Finalist, Career Award for Medical Scientists
2014 Icahn School of Medicine Consortium for Graduate Medical Education: Best Poster
2013 Icahn School of Medicine at Mount Sinai: Best Poster, Child Health Research Day
2013 Clinical Immunology Society: Senior Fellowship Award
2013 Clemens von Pirquet Award for Best Research
2012 Thrasher Research Fund Early Career Award
2007 Keystone Symposia Scholarship
2006 AMA Foundation Seed Grant
2001 University of Rochester: GEBS Research Fellowship
1998-2002 University of Rochester: Rush Rhees Scholarship

How B cell developmental defects shape manifestations of common variable immunodeficiency
07/01/2019 - 06/30/2023 (PI)
American Academy of Allergy, Asthma, and Immunology

Immunomodulatory role of IgG replacement therapy in common variable immunodeficiency
04/29/2019 - 04/29/2023 (PI)
Shire, Inc.

Role of B cell activating factor in non-infectious complications of common variable immunodeficiency
02/01/2019 - 01/31/2023 (PI)
NIH/National Institute of Allergy & Infectious Diseases

Mechanisms of immune dysregulation due to NFKB1 mutation in common variable immunodeficiency
03/01/2020 - 02/28/2022 (PI)
NIH/National Institute of Allergy & Infectious Diseases

B cell maturation antigen in the diagnosis and management of antibody deficiency
09/01/2020 - 09/01/2021 (PI)
Immune Deficiency Foundation Inc.

Optimizing efficacy of interferon-y therapy in primary immunodeficiency patients
05/09/2019 - 05/09/2021 (PI)
Horizon Pharma USA


Identifying B cell maturation defects that shape manifestations of common variable immunodeficiency
07/01/2019 - 06/30/2022 (PI)
American Academy of Allergy, Asthma, and Immunology

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Abyazi ML, Bell KA, Gyimesi G, Baker TS, Byun M, Ko HM, Cunningham-Rundles C, Feng F, Maglione PJ. Convergence of cytokine dysregulation and antibody deficiency in common variable immunodeficiency with inflammatory complications. J Allergy Clin Immunol. 2021 Jun 17.View Related Profiles. PMID: 34146579
  2. Wallace LJ, Ware MS, Cunningham-Rundles C, Fuleihan RL, Maglione PJ. Clinical disparity of primary antibody deficiency patients at a safety net hospital. J Allergy Clin Immunol Pract. 2021 07; 9(7):2923-2925.e1. PMID: 33766581; PMCID: PMC8277688; DOI: 10.1016/j.jaip.2021.03.021;
  3. Lee TK, Gereige JD, Maglione PJ. State-of-the-art diagnostic evaluation of common variable immunodeficiency. Ann Allergy Asthma Immunol. 2021 Jul; 127(1):19-27. PMID: 33716149
  4. Matson EM, Abyazi ML, Bell KA, Hayes KM, Maglione PJ. B Cell Dysregulation in Common Variable Immunodeficiency Interstitial Lung Disease. Front Immunol. 2020; 11:622114. PMID: 33613556; PMCID: PMC7892472; DOI: 10.3389/fimmu.2020.622114;
  5. Cowan J, Bonagura VR, Lugar PL, Maglione PJ, Patel NC, Vinh DC, Hofmann JH, Praus M, Rojavin MA. Safety and Tolerability of Manual Push Administration of Subcutaneous IgPro20 at High Infusion Rates in Patients with Primary Immunodeficiency: Findings from the Manual Push Administration Cohort of the HILO Study. J Clin Immunol. 2021 Jan; 41(1):66-75. PMID: 33025378; PMCID: PMC7846525; DOI: 10.1007/s10875-020-00876-6;
  6. Grasset EK, Chorny A, Casas-Recasens S, Gutzeit C, Bongers G, Thomsen I, Chen L, He Z, Matthews DB, Oropallo MA, Veeramreddy P, Uzzan M, Mortha A, Carrillo J, Reis BS, Ramanujam M, Sintes J, Magri G, Maglione PJ, Cunningham-Rundles C, Bram RJ, Faith J, Mehandru S, Pabst O, Cerutti A. Gut T cell-independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells. Sci Immunol. 2020 07 31; 5(49). PMID: 32737068
  7. Maglione PJ. Chronic Lung Disease in Primary Antibody Deficiency: Diagnosis and Management. Immunol Allergy Clin North Am. 2020 08; 40(3):437-459. PMID: 32654691; PMCID: PMC7366316; DOI: 10.1016/j.iac.2020.03.003;
  8. Gereige JD, Maglione PJ, Guenechea-Sola M. Delayed Diagnosis of Good Syndrome. J Allergy Clin Immunol Pract. 2020 04; 8(4):1396-1397.View Related Profiles. PMID: 31839563; PMCID: PMC7409509; DOI: 10.1016/j.jaip.2019.11.019;
  9. Gereige JD, Maglione PJ. Current Understanding and Recent Developments in Common Variable Immunodeficiency Associated Autoimmunity. Front Immunol. 2019; 10:2753. PMID: 31921101; PMCID: PMC6914703; DOI: 10.3389/fimmu.2019.02753;
  10. Maglione PJ, Ko HM, Tokuyama M, Gyimesi G, Soof C, Li M, Sanchez E, Chen H, Radigan L, Berenson J, Cunningham-Rundles C. Serum B-Cell Maturation Antigen (BCMA) Levels Differentiate Primary Antibody Deficiencies. J Allergy Clin Immunol Pract. 2020 01; 8(1):283-291.e1. PMID: 31430592; PMCID: PMC6980522; DOI: 10.1016/j.jaip.2019.08.012;
Showing 10 of 34 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 34 publications over 13 distinct years, with a maximum of 5 publications in 2015 and 2019


Available to Mentor as: (Review Mentor Role Definitions):
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  • Co-Mentor or Peer Mentor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:
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