Neil Ganem | Profiles RNS

Neil J. Ganem, PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

PhD, Geisel School of Medicine
BS, University of New Hampshire

Websites

Ganem Lab

ORCID : 0000-0003-0269-6585

Dr. Ganem’s laboratory uses a combination of high-resolution microscopy, genome-wide RNAi screening, cell biology, and bioinformatics to study the causes and consequences of genome instability in human cancer. Dr. Ganem’s lab seeks to define the tumor suppression mechanisms that limit the proliferation of highly abnormal aneuploid cells, as well as to identify the common genetic adaptations made by cancer cells to overcome these growth barriers.

Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Hematology & Medical Oncology

Member
Boston University
BU-BMC Cancer Center

Member
Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Mechanisms of cell proliferation in whole-genome doubled cells
05/01/2022 - 04/30/2026 (PI)
NIH/National Cancer Institute
3R01CA274743-03S1

Defining the tumor suppressive mechanism of the kinase STK25
01/17/2024 - 01/16/2026 (Key Person / Mentor)
NIH/National Cancer Institute
1F31CA278588-01A1

Defining Gene Dependencies in Whole-Genome Doubled Esophageal Adenocarcinomas
10/01/2021 - 09/30/2024 (PI)
DeGregorio Foundation

Identifying Gene Dependencies in High-Ploidy Lung Cancers
01/01/2023 - 06/30/2024 (PI)
Johnson & Johnson Enterprise Innovation, Inc.

Chromatin bridge resolution and generation of unstable genomes
10/20/2020 - 10/19/2023 (PI)
Universitat Autonoma de Barcelona

Defining Novel Mechanisms of Genome Instability in BRAF-mutant Melanoma
05/01/2018 - 04/30/2023 (Key Person / Mentor)
PI: Marc Vittoria
NIH/National Cancer Institute
5F30CA228388-05

Defining the role of the Hippo tumor suppressor pathway in limiting melanomagenesis
05/20/2020 - 11/19/2022 (PI)
Harry J. Lloyd Charitable Trust

Maintenance of Chromosome Stability by the Hippo Tumor Suppressor Pathway
09/23/2016 - 06/30/2022 (PI)
NIH/National Institute of General Medical Sciences
5R01GM117150-05

PEP-Therapy Contract
10/08/2019 - 06/30/2021 (PI)
PEP-Therapy SAS

Maintenance of Chromosome Stability by the Hippo Tumor Suppressor Pathway
07/01/2016 - 06/30/2020 (PI)
American Cancer Society, Inc.

Showing 10 of 17 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2024	Mechanisms of cell proliferation in whole-genome doubled cells	5R01CA274743-03
2024	Mechanisms of cell proliferation in whole-genome doubled cells	3R01CA274743-03S1
2023	Mechanisms of cell proliferation in whole-genome doubled cells	3R01CA274743-02S1
2023	Mechanisms of cell proliferation in whole-genome doubled cells	5R01CA274743-02
2022	Mechanisms of cell proliferation in whole-genome doubled cells	1R01CA274743-01
2020	Maintenance of Chromosome Stability by the Hippo Tumor Suppressor Pathway	5R01GM117150-05	5
2019	Maintenance of Chromosome Stability by the Hippo Tumor Suppressor Pathway	5R01GM117150-04	5
2018	Maintenance of Chromosome Stability by the Hippo Tumor Suppressor Pathway	5R01GM117150-03	5
2017	Maintenance of Chromosome Stability by the Hippo Tumor Suppressor Pathway	5R01GM117150-02	5
2016	Maintenance of Chromosome Stability by the Hippo Tumor Suppressor Pathway	1R01GM117150-01A1	5

Showing 10 of 15 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Vittoria MA, Quinton RJ, Ganem NJ. Whole-genome doubling in tissues and tumors. Trends Genet. 2023 Dec; 39(12):954-967.View Related Profiles.

Vittoria, Marc
Ganem, Neil
Quinton, Ryan

PMID: 37714734; PMCID: PMC10840902; DOI: 10.1016/j.tig.2023.08.004;

Vedula CP, Ganem NJ. CIP2A and TOPBP1: Molecular lassos that herd pulverized micronuclear chromosomes. Mol Cell. 2023 Jun 15; 83(12):1964-1966. PMID: 37327773

Laroche FJF, Li S, Shen N, Hwang SK, Nguyen G, Yu W, Wong CK, Quinton RJ, Berman JN, Liu CT, Singh A, Ganem NJ, Thiagalingam S, Feng H. S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720. Cells. 2023 Mar 23; 12(7).View Related Profiles.

Wong, Chen Khuan
Liu, Ching-Ti
Feng, Hui
Ganem, Neil
Quinton, Ryan
Thiagalingam, Sam

PMID: 37048053; PMCID: PMC10093541; DOI: 10.3390/cells12070980;

Darp R, Vittoria MA, Ganem NJ, Ceol CJ. Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis. Nat Commun. 2022 Jul 15; 13(1):4109.View Related Profiles.

Vittoria, Marc
Ganem, Neil

PMID: 35840569; PMCID: PMC9287415; DOI: 10.1038/s41467-022-31899-9;

Vittoria MA, Kingston N, Kotynkova K, Xia E, Hong R, Huang L, McDonald S, Tilston-Lunel A, Darp R, Campbell JD, Lang D, Xu X, Ceol CJ, Varelas X, Ganem NJ. Inactivation of the Hippo tumor suppressor pathway promotes melanoma. Nat Commun. 2022 Jun 29; 13(1):3732.View Related Profiles.

Tilston-Lunel, Andrew
Lang, Deborah
Xia, Eric
Campbell, Joshua
Kotynkova, Kristyna
Vittoria, Marc
Ganem, Neil
Varelas, Xaralabos

PMID: 35768444; PMCID: PMC9243107; DOI: 10.1038/s41467-022-31399-w;

Floro J, Dai A, Metzger A, Mora-Martin A, Ganem NJ, Cifuentes D, Wu CS, Dalal J, Lyons SM, Labadorf A, Flynn RL. SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing. Nucleic Acids Res. 2021 09 20; 49(16):9424-9443.View Related Profiles.

Labadorf, Adam
Cifuentes, Daniel
Ganem, Neil
Flynn, Rachel
Lyons, Shawn

PMID: 34365507; PMCID: PMC8450105; DOI: 10.1093/nar/gkab647;

Quinton RJ, DiDomizio A, Vittoria MA, Kotýnková K, Ticas CJ, Patel S, Koga Y, Vakhshoorzadeh J, Hermance N, Kuroda TS, Parulekar N, Taylor AM, Manning AL, Campbell JD, Ganem NJ. Publisher Correction: Whole-genome doubling confers unique genetic vulnerabilities on tumour cells. Nature. 2021 May; 593(7860):E15.View Related Profiles.

Vakhshoorzadeh, Jasmine
Vittoria, Marc
Ganem, Neil
Quinton, Ryan

PMID: 33976417

Quinton RJ, DiDomizio A, Vittoria MA, Kotýnková K, Ticas CJ, Patel S, Koga Y, Vakhshoorzadeh J, Hermance N, Kuroda TS, Parulekar N, Taylor AM, Manning AL, Campbell JD, Ganem NJ. Whole-genome doubling confers unique genetic vulnerabilities on tumour cells. Nature. 2021 02; 590(7846):492-497.View Related Profiles.

Vakhshoorzadeh, Jasmine
Campbell, Joshua
Vittoria, Marc
Ganem, Neil
Quinton, Ryan

PMID: 33505027; PMCID: PMC7889737; DOI: 10.1038/s41586-020-03133-3;

Gan W, Dai X, Dai X, Xie J, Yin S, Zhu J, Wang C, Liu Y, Guo J, Wang M, Liu J, Hu J, Quinton RJ, Ganem NJ, Liu P, Asara JM, Pandolfi PP, Yang Y, He Z, Gao G, Wei W. LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control. Nat Cell Biol. 2020 02; 22(2):246-256.View Related Profiles.

Ganem, Neil
Quinton, Ryan

PMID: 32015438; PMCID: PMC7076906; DOI: 10.1038/s41556-020-0463-6;

Lim S, Hermance N, Mudianto T, Mustaly HM, Mauricio IPM, Vittoria MA, Quinton RJ, Howell BW, Cornils H, Manning AL, Ganem NJ. Identification of the kinase STK25 as an upstream activator of LATS signaling. Nat Commun. 2019 04 04; 10(1):1547.View Related Profiles.

Vittoria, Marc
Ganem, Neil
Quinton, Ryan
Lim, Sanghee

PMID: 30948712; PMCID: PMC6449379; DOI: 10.1038/s41467-019-09597-w;

Showing 10 of 34 results. Show More

Quinton RJ, Ganem NJ. CRISPR-Mediated Approaches to Regulate YAP/TAZ Levels. Methods Mol Biol. 2019; 1893:203-214.View Related Profiles.

Ganem, Neil
Quinton, Ryan

PMID: 30565136; PMCID: PMC6533617; DOI: 10.1007/978-1-4939-8910-2_16;

Vittoria MA, Shenk EM, O'Rourke KP, Bolgioni AF, Lim S, Kacprzak V, Quinton RJ, Ganem NJ. A genome-wide microRNA screen identifies regulators of tetraploid cell proliferation. Mol Biol Cell. 2018 07 15; 29(13):1682-1692.View Related Profiles.

Bolgioni-Smith, Amanda
Vittoria, Marc
Ganem, Neil
Quinton, Ryan
Lim, Sanghee

PMID: 29791254; PMCID: PMC6080710; DOI: 10.1091/mbc.E18-02-0141;

Bolgioni AF, Vittoria MA, Ganem NJ. Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel. J Vis Exp. 2018 05 14; (135).View Related Profiles.

Bolgioni-Smith, Amanda
Vittoria, Marc
Ganem, Neil

PMID: 29806834; PMCID: PMC6101178; DOI: 10.3791/57383;

Henssen AG, Reed C, Jiang E, Garcia HD, von Stebut J, MacArthur IC, Hundsdoerfer P, Kim JH, de Stanchina E, Kuwahara Y, Hosoi H, Ganem NJ, Dela Cruz F, Kung AL, Schulte JH, Petrini JH, Kentsis A. Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors. Sci Transl Med. 2017 Nov 01; 9(414). PMID: 29093183; PMCID: PMC5683417; DOI: 10.1126/scitranslmed.aam9078;

Grant TJ, Mehta AK, Gupta A, Sharif AAD, Arora KS, Deshpande V, Ting DT, Bardeesy N, Ganem NJ, Hergovich A, Singh A. STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines. Oncotarget. 2017 Oct 03; 8(45):78556-78572.View Related Profiles.

Singh, Anurag
Ganem, Neil
Grant, Trevor

PMID: 29108249; PMCID: PMC5667982; DOI: 10.18632/oncotarget.20833;

Lim S, Quinton RJ, Ganem NJ. Nuclear envelope rupture drives genome instability in cancer. Mol Biol Cell. 2016 Nov 01; 27(21):3210-3213.View Related Profiles.

Ganem, Neil
Quinton, Ryan
Lim, Sanghee

PMID: 27799497; PMCID: PMC5170854; DOI: 10.1091/mbc.E16-02-0098;

Shenk EM, Ganem NJ. Generation and Purification of Tetraploid Cells. Methods Mol Biol. 2016; 1413:393-401. PMID: 27193862; PMCID: PMC5091649; DOI: 10.1007/978-1-4939-3542-0_24;

Bolgioni AF, Ganem NJ. The interplay between centrosomes and the Hippo tumor suppressor pathway. Chromosome Res. 2016 Jan; 24(1):93-104.View Related Profiles.

Bolgioni-Smith, Amanda
Ganem, Neil

PMID: 26582635; PMCID: PMC4726471; DOI: 10.1007/s10577-015-9502-8;

Russo A, Pacchierotti F, Cimini D, Ganem NJ, Genescà A, Natarajan AT, Pavanello S, Valle G, Degrassi F. Genomic instability: Crossing pathways at the origin of structural and numerical chromosome changes. Environ Mol Mutagen. 2015 Aug; 56(7):563-80. PMID: 25784636; DOI: 10.1002/em.21945;

Flynn RL, Cox KE, Jeitany M, Wakimoto H, Bryll AR, Ganem NJ, Bersani F, Pineda JR, Suvà ML, Benes CH, Haber DA, Boussin FD, Zou L. Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors. Science. 2015 Jan 16; 347(6219):273-7.View Related Profiles.

Cox, Kelli
Ganem, Neil
Flynn, Rachel

PMID: 25593184; PMCID: PMC4358324; DOI: 10.1126/science.1257216;

Lim S, Ganem NJ. Tetraploidy and tumor development. Oncotarget. 2014 Nov 30; 5(22):10959-60.View Related Profiles.

Ganem, Neil
Lim, Sanghee

PMID: 25526024; PMCID: PMC4294366; DOI: 10.18632/oncotarget.2790;

Ganem NJ, Cornils H, Chiu SY, O'Rourke KP, Arnaud J, Yimlamai D, Théry M, Camargo FD, Pellman D. Cytokinesis failure triggers hippo tumor suppressor pathway activation. Cell. 2014 Aug 14; 158(4):833-48. PMID: 25126788; PMCID: PMC4136486; DOI: 10.1016/j.cell.2014.06.029;

Ganem NJ, Pellman D. Linking abnormal mitosis to the acquisition of DNA damage. J Cell Biol. 2012 Dec 10; 199(6):871-81. PMID: 23229895; PMCID: PMC3518222; DOI: 10.1083/jcb.201210040;

Crasta K, Ganem NJ, Dagher R, Lantermann AB, Ivanova EV, Pan Y, Nezi L, Protopopov A, Chowdhury D, Pellman D. DNA breaks and chromosome pulverization from errors in mitosis. Nature. 2012 Feb 2; 482(7383):53-8. PMID: 22258507; PMCID: PMC3271137; DOI: 10.1038/nature10802;

Rhodes J, Amsterdam A, Sanda T, Moreau LA, McKenna K, Heinrichs S, Ganem NJ, Ho KW, Neuberg DS, Johnston A, Ahn Y, Kutok JL, Hromas R, Wray J, Lee C, Murphy C, Radtke I, Downing JR, Fleming MD, MacConaill LE, Amatruda JF, Gutierrez A, Galinsky I, Stone RM, Ross EA, Pellman DS, Kanki JP, Look AT. Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression. Mol Cell Biol. 2009 Nov; 29(21):5911-22. PMID: 19704007; PMCID: PMC2772726; DOI: 10.1128/MCB.00558-09;

Ganem NJ, Godinho SA, Pellman D. A mechanism linking extra centrosomes to chromosomal instability. Nature. 2009 Jul 9; 460(7252):278-82. PMID: 19506557; PMCID: PMC2743290; DOI: 10.1038/nature08136;

Kwon M, Godinho SA, Chandhok NS, Ganem NJ, Azioune A, Thery M, Pellman D. Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev. 2008 Aug 15; 22(16):2189-203. PMID: 18662975; PMCID: PMC2518815; DOI: 10.1101/gad.1700908;

Ganem NJ, Pellman D. Limiting the proliferation of polyploid cells. Cell. 2007 Nov 2; 131(3):437-40. PMID: 17981108

Manning AL, Ganem NJ, Bakhoum SF, Wagenbach M, Wordeman L, Compton DA. The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells. Mol Biol Cell. 2007 Aug; 18(8):2970-9. PMID: 17538014; PMCID: PMC1949365; DOI: 10.1091/mbc.E07-02-0110;

Ganem NJ, Storchova Z, Pellman D. Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev. 2007 Apr; 17(2):157-62. PMID: 17324569

Ganem NJ, Compton DA. Functional roles of poleward microtubule flux during mitosis. Cell Cycle. 2006 Mar; 5(5):481-5. PMID: 16552178

Couch RD, Ganem NJ, Zhou M, Popov VM, Honda T, Veenstra TD, Sporn MB, Anderson AC. 2-cyano-3,12-dioxooleana-1,9(11)-diene-28-oic acid disrupts microtubule polymerization: a possible mechanism contributing to apoptosis. Mol Pharmacol. 2006 Apr; 69(4):1158-65. PMID: 16407469

Ganem NJ, Upton K, Compton DA. Efficient mitosis in human cells lacking poleward microtubule flux. Curr Biol. 2005 Oct 25; 15(20):1827-32. PMID: 16243029

Ganem NJ, Compton DA. The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK. J Cell Biol. 2004 Aug 16; 166(4):473-8. PMID: 15302853; PMCID: PMC2172212

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 34 publications over 17 distinct years, with a maximum of 3 publications in 2007 and 2016 and 2021 and 2023