Neil Ganem | Profiles RNS

Neil J. Ganem, PhD

Assistant Professor

Boston University School of Medicine

Dept of Pharmacology & Experimental Therapeutics

PhD, Geisel School of Medicine

Websites

Pharmacology & Experimental Therapeutics Faculty

Dr. Ganem’s laboratory uses a combination of high-resolution microscopy, genome-wide RNAi screening, cell biology, and bioinformatics to study the causes and consequences of genome instability in human cancer. Dr. Ganem’s lab seeks to define the tumor suppression mechanisms that limit the proliferation of highly abnormal aneuploid cells, as well as to identify the common genetic adaptations made by cancer cells to overcome these growth barriers.

Assistant Professor
Boston University School of Medicine
Medicine
Hematology & Medical Oncology

2010 Andor “Insight Awards” Imaging Competition: First Place

2009 FASEB: Young Investigator Award

2006 Geisel School of Medicine at Dartmouth: John W. Strohbehn Medal for Excellence in Biomedical Research

2005 Geisel School of Medicine at Dartmouth: E. Lucille Smith Award for Excellence in Biochemistry

2004-2005 Norris Cotton Cancer Center: “Best Graduate Student Paper” Award

2004 American Society for Cell Biology: Travel Award

2002 Albert J. Ryan Predoctoral Fellowship

2000 University of New Hampshire: Presidential Scholar Award

BU Sponsored Research
NIH RePORTER Sponsored Research

MAINTENANCE OF CHROMOSOME STABILITY BY THE HIPPO TUMOR SUPPRESSOR PATHWAY
09/23/2016 - 06/30/2021 (PI)
NIH/National Institute of General Medical Sciences
5R01GM117150-03

MAINTENANCE OF CHROMOSOME STABILITY BY THE HIPPO TUMOR SUPPRESSOR PATHWAY
07/01/2016 - 06/30/2020 (PI)
American Cancer Society, Inc.

MAINTENANCE OF CHROMOSOME STABILITY BY THE HIPPO PATHWAY
07/01/2015 - 06/30/2018 (PI)
Searle Scholars Program

MAINTENANCE OF GENOME STABILITY BY THE HIPPO TUMOR SUPPRESSOR PATHWAY
12/01/2014 - 06/30/2018 (PI)
The Medical Foundation/Richard and Susan Smith Family Foundation

DEFINING NOVEL MECHANISMS OF GENOME INSTABILITY IN HUMAN MELANOMA
05/01/2015 - 04/30/2018 (PI)
Melanoma Research Alliance

DEFINING NOVEL PATHWAYS THAT ARREST GENETICALLY UNSTABLE TETRAPLOID CELLS
09/01/2013 - 08/31/2017 (PI)
NIH/National Cancer Institute
5R00CA154531-05

THERAPEUTICALLY TARGETING THE HIPPO PATHWAY IN OSTEOSARCOMA
06/01/2015 - 05/31/2016 (PI)
Sarcoma Foundation of America

DEFINING NOVEL MECHANISMS OF GENOME INSTABILITY IN MELANOMA
04/01/2015 - 03/31/2016 (PI)
The Skin Cancer Foundation

DEFINING NOVEL MECHANISMS OF GENOMIC INSTABILITY IN MELANOMA
02/01/2015 - 02/01/2016 (PI)
Melanoma Research Foundation, The

Yr	Title	Project-Sub Proj	Pubs
2018	Maintenance of Chromosome Stability by the Hippo Tumor Suppressor Pathway	5R01GM117150-03	2
2016	Maintenance of Chromosome Stability by the Hippo Tumor Suppressor Pathway	1R01GM117150-01A1	2
2015	Defining novel pathways that arrest genetically unstable tetraploid cells	5R00CA154531-05	3
2014	Defining novel pathways that arrest genetically unstable tetraploid cells	5R00CA154531-04	3
2013	Defining novel pathways that arrest genetically unstable tetraploid cells	4R00CA154531-03	3
2012	Defining novel pathways that arrest genetically unstable tetraploid cells	5K99CA154531-02	5
2011	Defining novel pathways that arrest genetically unstable tetraploid cells	1K99CA154531-01	5

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

Quinton RJ, Ganem NJ. CRISPR-Mediated Approaches to Regulate YAP/TAZ Levels. Methods Mol Biol. 2019; 1893:203-214.View Related Profiles.
Ganem, Neil
Quinton, Ryan
PMID: 30565136.
Vittoria MA, Shenk EM, O'Rourke KP, Bolgioni AF, Lim S, Kacprzak V, Quinton RJ, Ganem NJ. A genome-wide microRNA screen identifies regulators of tetraploid cell proliferation. Mol Biol Cell. 2018 Jul 15; 29(13):1682-1692.View Related Profiles.
Bolgioni-Smith, Amanda
Vittoria, Marc
Ganem, Neil
Quinton, Ryan
Lim, Sanghee
PMID: 29791254.
Bolgioni AF, Vittoria MA, Ganem NJ. Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel. J Vis Exp. 2018 05 14; (135).View Related Profiles.
Bolgioni-Smith, Amanda
Vittoria, Marc
Ganem, Neil
PMID: 29806834.
Henssen AG, Reed C, Jiang E, Garcia HD, von Stebut J, MacArthur IC, Hundsdoerfer P, Kim JH, de Stanchina E, Kuwahara Y, Hosoi H, Ganem NJ, Dela Cruz F, Kung AL, Schulte JH, Petrini JH, Kentsis A. Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors. Sci Transl Med. 2017 Nov 01; 9(414). PMID: 29093183.
Grant TJ, Mehta AK, Gupta A, Sharif AAD, Arora KS, Deshpande V, Ting DT, Bardeesy N, Ganem NJ, Hergovich A, Singh A. STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines. Oncotarget. 2017 Oct 03; 8(45):78556-78572.View Related Profiles.
Singh, Anurag
Ganem, Neil
Grant, Trevor
PMID: 29108249.
Lim S, Quinton RJ, Ganem NJ. Nuclear envelope rupture drives genome instability in cancer. Mol Biol Cell. 2016 Nov 01; 27(21):3210-3213.View Related Profiles.
Ganem, Neil
Quinton, Ryan
Lim, Sanghee
PMID: 27799497.
Bolgioni AF, Ganem NJ. The interplay between centrosomes and the Hippo tumor suppressor pathway. Chromosome Res. 2016 Jan; 24(1):93-104.View Related Profiles.
Bolgioni-Smith, Amanda
Ganem, Neil
PMID: 26582635; PMCID: PMC4726471; DOI: 10.1007/s10577-015-9502-8;.
Shenk EM, Ganem NJ. Generation and Purification of Tetraploid Cells. Methods Mol Biol. 2016; 1413:393-401. PMID: 27193862; DOI: 10.1007/978-1-4939-3542-0_24;.
Russo A, Pacchierotti F, Cimini D, Ganem NJ, Genescà A, Natarajan AT, Pavanello S, Valle G, Degrassi F. Genomic instability: Crossing pathways at the origin of structural and numerical chromosome changes. Environ Mol Mutagen. 2015 Aug; 56(7):563-80. PMID: 25784636; DOI: 10.1002/em.21945;.
Flynn RL, Cox KE, Jeitany M, Wakimoto H, Bryll AR, Ganem NJ, Bersani F, Pineda JR, Suvà ML, Benes CH, Haber DA, Boussin FD, Zou L. Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors. Science. 2015 Jan 16; 347(6219):273-7.View Related Profiles.
Cox, Kelli
Ganem, Neil
Flynn, Rachel
PMID: 25593184; PMCID: PMC4358324; DOI: 10.1126/science.1257216;.

Showing 10 of 24 results. Show More

Lim S, Ganem NJ. Tetraploidy and tumor development. Oncotarget. 2014 Nov 30; 5(22):10959-60.View Related Profiles.
Ganem, Neil
Lim, Sanghee
PMID: 25526024; PMCID: PMC4294366.
Ganem NJ, Cornils H, Chiu SY, O'Rourke KP, Arnaud J, Yimlamai D, Théry M, Camargo FD, Pellman D. Cytokinesis failure triggers hippo tumor suppressor pathway activation. Cell. 2014 Aug 14; 158(4):833-48. PMID: 25126788; PMCID: PMC4136486; DOI: 10.1016/j.cell.2014.06.029;.
Ganem NJ, Pellman D. Linking abnormal mitosis to the acquisition of DNA damage. J Cell Biol. 2012 Dec 10; 199(6):871-81. PMID: 23229895; PMCID: PMC3518222; DOI: 10.1083/jcb.201210040;.
Crasta K, Ganem NJ, Dagher R, Lantermann AB, Ivanova EV, Pan Y, Nezi L, Protopopov A, Chowdhury D, Pellman D. DNA breaks and chromosome pulverization from errors in mitosis. Nature. 2012 Feb 2; 482(7383):53-8. PMID: 22258507; PMCID: PMC3271137; DOI: 10.1038/nature10802;.
Rhodes J, Amsterdam A, Sanda T, Moreau LA, McKenna K, Heinrichs S, Ganem NJ, Ho KW, Neuberg DS, Johnston A, Ahn Y, Kutok JL, Hromas R, Wray J, Lee C, Murphy C, Radtke I, Downing JR, Fleming MD, MacConaill LE, Amatruda JF, Gutierrez A, Galinsky I, Stone RM, Ross EA, Pellman DS, Kanki JP, Look AT. Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression. Mol Cell Biol. 2009 Nov; 29(21):5911-22. PMID: 19704007; PMCID: PMC2772726; DOI: 10.1128/MCB.00558-09;.
Ganem NJ, Godinho SA, Pellman D. A mechanism linking extra centrosomes to chromosomal instability. Nature. 2009 Jul 9; 460(7252):278-82. PMID: 19506557; PMCID: PMC2743290; DOI: 10.1038/nature08136;.
Kwon M, Godinho SA, Chandhok NS, Ganem NJ, Azioune A, Thery M, Pellman D. Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev. 2008 Aug 15; 22(16):2189-203. PMID: 18662975; PMCID: PMC2518815; DOI: 10.1101/gad.1700908;.
Ganem NJ, Pellman D. Limiting the proliferation of polyploid cells. Cell. 2007 Nov 2; 131(3):437-40. PMID: 17981108.
Manning AL, Ganem NJ, Bakhoum SF, Wagenbach M, Wordeman L, Compton DA. The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells. Mol Biol Cell. 2007 Aug; 18(8):2970-9. PMID: 17538014; PMCID: PMC1949365.
Ganem NJ, Storchova Z, Pellman D. Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev. 2007 Apr; 17(2):157-62. PMID: 17324569.
Ganem NJ, Compton DA. Functional roles of poleward microtubule flux during mitosis. Cell Cycle. 2006 Mar; 5(5):481-5. PMID: 16552178.
Couch RD, Ganem NJ, Zhou M, Popov VM, Honda T, Veenstra TD, Sporn MB, Anderson AC. 2-cyano-3,12-dioxooleana-1,9(11)-diene-28-oic acid disrupts microtubule polymerization: a possible mechanism contributing to apoptosis. Mol Pharmacol. 2006 Apr; 69(4):1158-65. PMID: 16407469.
Ganem NJ, Upton K, Compton DA. Efficient mitosis in human cells lacking poleward microtubule flux. Curr Biol. 2005 Oct 25; 15(20):1827-32. PMID: 16243029.
Ganem NJ, Compton DA. The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK. J Cell Biol. 2004 Aug 16; 166(4):473-8. PMID: 15302853; PMCID: PMC2172212.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 24 publications over 13 distinct years, with a maximum of 3 publications in 2007 and 2016