Neil J. Ganem, PhD
Assistant Professor
Boston University School of Medicine
Dept of Pharmacology & Experimental Therapeutics

PhD, Geisel School of Medicine



Dr. Ganem’s laboratory uses a combination of high-resolution microscopy, genome-wide RNAi screening, cell biology, and bioinformatics to study the causes and consequences of genome instability in human cancer. Dr. Ganem’s lab seeks to define the tumor suppression mechanisms that limit the proliferation of highly abnormal aneuploid cells, as well as to identify the common genetic adaptations made by cancer cells to overcome these growth barriers.

Assistant Professor
Boston University School of Medicine
Medicine
Hematology & Medical Oncology


2010 Andor “Insight Awards” Imaging Competition: First Place
2009 FASEB: Young Investigator Award
2006 Geisel School of Medicine at Dartmouth: John W. Strohbehn Medal for Excellence in Biomedical Research
2005 Geisel School of Medicine at Dartmouth: E. Lucille Smith Award for Excellence in Biochemistry
2004-2005 Norris Cotton Cancer Center: “Best Graduate Student Paper” Award
2004 American Society for Cell Biology: Travel Award
2002 Albert J. Ryan Predoctoral Fellowship
2000 University of New Hampshire: Presidential Scholar Award


Maintenance of Chromosome Stability by the Hippo Tumor Suppressor Pathway
09/23/2016 - 06/30/2021 (PI)
NIH/National Institute of General Medical Sciences
1R01GM117150-01A1

Maintenance of Chromosome Stability by the Hippo Tumor Suppressor Pathway
07/01/2016 - 06/30/2020 (PI)
American Cancer Society, Inc.


Maintenance of Chromosome Stability by the Hippo Pathway
07/01/2015 - 06/30/2018 (PI)
Searle Scholars Program


Maintenance of Genome Stability by the Hippo Tumor Suppressor Pathway
12/01/2014 - 06/30/2018 (PI)
The Medical Foundation/Richard and Susan Smith Family Foundation


Defining novel mechanisms of genome instability in human melanoma
05/01/2015 - 04/30/2018 (PI)
Melanoma Research Alliance


Defining Novel Pathways that Arrest Genetically Unstable Tetraploid Cells
09/01/2013 - 08/31/2017 (PI)
NIH/National Cancer Institute
5R00CA154531-05

Therapeutically targeting the hippo Pathway in Osteosarcoma
06/01/2015 - 05/31/2016 (PI)
Sarcoma Foundation of America


Defining novel mechanisms of Genome Instability in Melanoma
04/01/2015 - 03/31/2016 (PI)
The Skin Cancer Foundation


Defining Novel Mechanisms of Genomic Instability in Melanoma
02/01/2015 - 02/01/2016 (PI)
Melanoma Research Foundation, The





Yr Title Project-Sub Proj Pubs
2016 Maintenance of Chromosome Stability by the Hippo Tumor Suppressor Pathway 1R01GM117150-01A1 1
2015 Defining novel pathways that arrest genetically unstable tetraploid cells 5R00CA154531-05 3
2014 Defining novel pathways that arrest genetically unstable tetraploid cells 5R00CA154531-04 3
2013 Defining novel pathways that arrest genetically unstable tetraploid cells 4R00CA154531-03 3
2012 Defining novel pathways that arrest genetically unstable tetraploid cells 5K99CA154531-02 5
2011 Defining novel pathways that arrest genetically unstable tetraploid cells 1K99CA154531-01 5
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Henssen AG, Reed C, Jiang E, Garcia HD, von Stebut J, MacArthur IC, Hundsdoerfer P, Kim JH, de Stanchina E, Kuwahara Y, Hosoi H, Ganem NJ, Dela Cruz F, Kung AL, Schulte JH, Petrini JH, Kentsis A. Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors. Sci Transl Med. 2017 Nov 01; 9(414). PMID: 29093183.
     
  2. Grant TJ, Mehta AK, Gupta A, Sharif AAD, Arora KS, Deshpande V, Ting DT, Bardeesy N, Ganem NJ, Hergovich A, Singh A. STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines. Oncotarget. 2017 Oct 03; 8(45):78556-78572.View Related Profiles. PMID: 29108249.
     
  3. Lim S, Quinton RJ, Ganem NJ. Nuclear envelope rupture drives genome instability in cancer. Mol Biol Cell. 2016 Nov 01; 27(21):3210-3213.View Related Profiles. PMID: 27799497.
     
  4. Bolgioni AF, Ganem NJ. The interplay between centrosomes and the Hippo tumor suppressor pathway. Chromosome Res. 2016 Jan; 24(1):93-104.View Related Profiles. PMID: 26582635; PMCID: PMC4726471; DOI: 10.1007/s10577-015-9502-8;.
     
  5. Shenk EM, Ganem NJ. Generation and Purification of Tetraploid Cells. Methods Mol Biol. 2016; 1413:393-401. PMID: 27193862; DOI: 10.1007/978-1-4939-3542-0_24;.
     
  6. Russo A, Pacchierotti F, Cimini D, Ganem NJ, Genescà A, Natarajan AT, Pavanello S, Valle G, Degrassi F. Genomic instability: Crossing pathways at the origin of structural and numerical chromosome changes. Environ Mol Mutagen. 2015 Aug; 56(7):563-80. PMID: 25784636; DOI: 10.1002/em.21945;.
     
  7. Flynn RL, Cox KE, Jeitany M, Wakimoto H, Bryll AR, Ganem NJ, Bersani F, Pineda JR, Suvà ML, Benes CH, Haber DA, Boussin FD, Zou L. Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors. Science. 2015 Jan 16; 347(6219):273-7.View Related Profiles. PMID: 25593184; PMCID: PMC4358324; DOI: 10.1126/science.1257216;.
     
  8. Lim S, Ganem NJ. Tetraploidy and tumor development. Oncotarget. 2014 Nov 30; 5(22):10959-60.View Related Profiles. PMID: 25526024; PMCID: PMC4294366.
     
  9. Ganem NJ, Cornils H, Chiu SY, O'Rourke KP, Arnaud J, Yimlamai D, Théry M, Camargo FD, Pellman D. Cytokinesis failure triggers hippo tumor suppressor pathway activation. Cell. 2014 Aug 14; 158(4):833-48. PMID: 25126788; PMCID: PMC4136486; DOI: 10.1016/j.cell.2014.06.029;.
     
  10. Ganem NJ, Pellman D. Linking abnormal mitosis to the acquisition of DNA damage. J Cell Biol. 2012 Dec 10; 199(6):871-81. PMID: 23229895; PMCID: PMC3518222; DOI: 10.1083/jcb.201210040;.
     
Showing 10 of 21 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 21 publications over 11 distinct years, with a maximum of 3 publications in 2007 and 2016

YearPublications
20041
20051
20062
20073
20081
20092
20122
20142
20152
20163
20172

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72 E. Concord St Silvio Conte (K)
Boston MA 02118
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