Matthew Nayor, MD, MPH
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Cardiovascular Medicine

MD, New York University School of Medicine
MPH, Harvard School of Public Health
BA, University of Michigan at Ann Arbor



Dr. Nayor is a clinical-translational investigator and heart failure cardiologist. He received training in Internal Medicine at the Johns Hopkins Hospital Osler Medical Residency training program and Cardiology and Heart Failure and Transplantation training at Brigham and Women's Hospital. His research background includes basic science investigations, physiologic studies, and cardiovascular epidemiology focusing on the intersection of metabolic health and cardiovascular disease. His group and collaborators have studied: 1) the effect of exercise on metabolism via assaying >500 circulating metabolites; 2) physiologic determinants of fitness; 3) novel protein biomarkers of heart failure risk through broad proteomic profiling; 4) and lifestyle contributors to cardiometabolic disease and heart failure, among other topics.

Dr. Nayor has worked closely with the Framingham Heart Study for the last 8 years and currently leads community-based studies evaluating metabolic responses to discrete physiologic perturbations, such as exercise and a dietary intervention.

Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Preventive Medicine & Epidemiology



PRIMER: Promoting Research In MEdical Residency
07/01/2024 - 06/30/2029 (Multi-PI)
PI: Matthew Nayor, MD, MPH
NIH/National Heart, Lung, and Blood Institute
2R38HL143584-05

Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF Spectrum
04/05/2023 - 02/28/2027 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL131029-06

Metabolic Responses to an Oral Mixed Meal Tolerance Test: Intra-individual changes, correlates, and prognostic significance
08/20/2021 - 06/30/2026 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL156975-03

NOVEL METABOLITE AND MICROBIOTA PATHWAYS FOR HYPERURICEMIA AND GOUT
03/01/2023 - 02/28/2026 (Subcontract PI)
Massachusetts General Hospital NIH NIAMS
5R01AR065944-07

Cardiovascular disease, metabolic syndrome, microbes and metabolites in FHS
02/01/2022 - 01/31/2026 (Subcontract PI)
Broad Institute, Inc., The NIH NHLBI
5R01HL157717-03

The San Antonio Heart and Mind Study
07/01/2023 - 03/31/2025 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NIA
5R01AG082360-02

Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise Training
08/05/2021 - 06/30/2023 (PI)
NIH/National Heart, Lung, and Blood Institute
7K23HL138260-07



Title


Yr Title Project-Sub Proj Pubs
2024 Effect of physical rehabilitation on molecular markers of frailty in heart failure 1R21AG086679-01
2024 Metabolic Responses to an Oral Mixed Meal Tolerance Test: Intra-individual changes, correlates, and prognostic significance 5R01HL156975-04
2024 PRIMER: Promoting Research In MEdical Residency 2R38HL143584-05
2024 Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF Spectrum 5R01HL131029-06
2023 Metabolic Responses to an Oral Mixed Meal Tolerance Test: Intra-individual changes, correlates, and prognostic significance 5R01HL156975-03
2023 Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF Spectrum 2R01HL131029-05A1
2022 Metabolic Responses to an Oral Mixed Meal Tolerance Test: Intra-individual changes, correlates, and prognostic significance 5R01HL156975-02
2021 Metabolic Responses to an Oral Mixed Meal Tolerance Test: Intra-individual changes, correlates, and prognostic significance 1R01HL156975-01
2021 Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise Training 5K23HL138260-06 4
2021 Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise Training 7K23HL138260-07 4
Showing 10 of 14 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Li JP, Slocum C, Sbarbaro J, Schoenike M, Campain J, Prasad C, Nayor MG, Lewis GD, Malhotra R. Percent Predicted Peak Exercise Oxygen Pulse Provides Insights Into Ventricular-Vascular Response and Prognosticates HFpEF. JACC Adv. 2024 Aug; 3(8):101101. PMID: 39105119; PMCID: PMC11299572; DOI: 10.1016/j.jacadv.2024.101101;
     
  2. Miller PE, Gajjar P, Mitchell GF, Khan SS, Vasan RS, Larson MG, Lewis GD, Shah RV, Nayor M. Clusters of multidimensional exercise response patterns and estimated heart failure risk in the Framingham Heart Study. ESC Heart Fail. 2024 Jun 28.View Related Profiles. PMID: 38943268
     
  3. Grech J, Nkambule BB, Thibord F, Chan M, Lachapelle A, Vasan R, Spartano N, Chen MH, Nayor M, Lewis GD, Johnson AD. Cardiorespiratory Fitness Is Associated with Decreased Platelet Reactivity. Med Sci Sports Exerc. 2024 Jun 24.View Related Profiles. PMID: 38913957
     
  4. Zhang Y, Wang X, Pathiravasan CH, Spartano NL, Lin H, Borrelli B, Benjamin EJ, McManus DD, Larson MG, Vasan RS, Shah RV, Lewis GD, Liu C, Murabito JM, Nayor M. Association of Smartwatch-Based Heart Rate and Physical Activity With Cardiorespiratory Fitness Measures in the Community: Cohort Study. J Med Internet Res. 2024 Jun 13; 26:e56676.View Related Profiles. PMID: 38870519; PMCID: PMC11216017; DOI: 10.2196/56676;
     
  5. Perry AS, Farber-Eger E, Gonzales T, Tanaka T, Robbins JM, Murthy VL, Stolze LK, Zhao S, Huang S, Colangelo LA, Deng S, Hou L, Lloyd-Jones DM, Walker KA, Ferrucci L, Watts EL, Barber JL, Rao P, Mi MY, Gabriel KP, Hornikel B, Sidney S, Houstis N, Lewis GD, Liu GY, Thyagarajan B, Khan SS, Choi B, Washko G, Kalhan R, Wareham N, Bouchard C, Sarzynski MA, Gerszten RE, Brage S, Wells QS, Nayor M, Shah RV. Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks. Nat Med. 2024 Jun; 30(6):1711-1721. PMID: 38834850; PMCID: PMC11186767; DOI: 10.1038/s41591-024-03039-x;
     
  6. Kosyakovsky LB, Liu EE, Wang JK, Myers L, Parekh JK, Knauss H, Lewis GD, Malhotra R, Nayor M, Robbins JM, Gerszten RE, Hamburg NM, McNeill JN, Lau ES, Ho JE. Uncovering Unrecognized Heart Failure With Preserved Ejection Fraction Among Individuals With Obesity and Dyspnea. Circ Heart Fail. 2024 May; 17(5):e011366.View Related Profiles. PMID: 38742409; PMCID: PMC11214582; DOI: 10.1161/CIRCHEARTFAILURE.123.011366;
     
  7. Murthy VL, Mosley JD, Perry AS, Jacobs DR, Tanriverdi K, Zhao S, Sawicki KT, Carnethon M, Wilkins JT, Nayor M, Das S, Abel ED, Freedman JE, Clish CB, Shah RV. Metabolic liability for weight gain in early adulthood. Cell Rep Med. 2024 May 21; 5(5):101548. PMID: 38703763; PMCID: PMC11148768; DOI: 10.1016/j.xcrm.2024.101548;
     
  8. Ravichandran S, Gajjar P, Walker ME, Prescott B, Tsao CW, Jha M, Rao P, Miller P, Larson MG, Vasan RS, Shah RV, Xanthakis V, Lewis GD, Nayor M. Life's Essential 8 Cardiovascular Health Score and Cardiorespiratory Fitness in the Community. J Am Heart Assoc. 2024 May 07; 13(9):e032944.View Related Profiles. PMID: 38700001; PMCID: PMC11179926; DOI: 10.1161/JAHA.123.032944;
     
  9. Perry AS, Zhang K, Murthy VL, Choi B, Zhao S, Gajjar P, Colangelo LA, Hou L, Rice MB, Carr JJ, Carson AP, Nigra AE, Vasan RS, Gerszten RE, Khan SS, Kalhan R, Nayor M, Shah RV. Proteomics, Human Environmental Exposure, and Cardiometabolic Risk. Circ Res. 2024 Jun 21; 135(1):138-154. PMID: 38662804; PMCID: PMC11189739; DOI: 10.1161/CIRCRESAHA.124.324559;
     
  10. Perry AS, Piaggi P, Huang S, Nayor M, Freedman J, North K, Below J, Clish C, Murthy VL, Krakoff J, Shah RV. Human metabolic chambers reveal a coordinated metabolic-physiologic response to nutrition. medRxiv. 2024 Apr 10. PMID: 38645000; PMCID: PMC11030300; DOI: 10.1101/2024.04.08.24305087;
     
Showing 10 of 82 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 82 publications over 13 distinct years, with a maximum of 15 publications in 2023

YearPublications
20102
20111
20141
20155
20161
20173
20187
20192
202010
202114
20229
202315
202412

2021 Boston University School of Medicine: Aram Chobanian Assistant Professor of Medicine
2021 Boston University Medical Center: Boston University School of Medicine Department of Medicine Career Development Award
2018-2020 National Institutes of Health: Loan Repayment Program
2016 Brigham and Women's Hospital, Cardiovascular Medicine Division: Richard Gorlin Fellowship in Cardiovascular Medicine
2012 Johns Hopkins Hospital Osler Medical Residency: Frank L. Coulson, Jr. Award for Clinical Excellence
2009 NYU School of Medicine: Clerkship Award for Outstanding Essay in the Philosophy of Medicine
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Epidemiology, Molecular
Exercise, Physical
Metabolomics
Proteomics
Heart Failure, Diastolic
Heart Failure, Systolic
Metabolic Cardiovascular Syndrome

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