Matthew Nayor, MD, MPH
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Cardiovascular Medicine

MD, New York University School of Medicine
MPH, Harvard School of Public Health
BA, University of Michigan at Ann Arbor



Dr. Nayor is a clinical-translational investigator and heart failure cardiologist. He received training in Internal Medicine at the Johns Hopkins Hospital Osler Medical Residency training program and Cardiology and Heart Failure and Transplantation training at Brigham and Women's Hospital. His research background includes basic science investigations, physiologic studies, and cardiovascular epidemiology focusing on the intersection of metabolic health and cardiovascular disease. His group and collaborators have studied: 1) the effect of exercise on metabolism via assaying >500 circulating metabolites; 2) physiologic determinants of fitness; 3) novel protein biomarkers of heart failure risk through broad proteomic profiling; 4) and lifestyle contributors to cardiometabolic disease and heart failure, among other topics.

Dr. Nayor has worked closely with the Framingham Heart Study for the last 8 years and currently leads community-based studies evaluating metabolic responses to discrete physiologic perturbations, such as exercise and a dietary intervention.

Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Preventive Medicine & Epidemiology



Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF Spectrum
04/05/2023 - 02/28/2027 (PI)
NIH/National Heart, Lung, and Blood Institute
2R01HL131029-05A1

Metabolic Responses to an Oral Mixed Meal Tolerance Test: Intra-individual changes, correlates, and prognostic significance
08/20/2021 - 06/30/2026 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL156975-03

NOVEL METABOLITE AND MICROBIOTA PATHWAYS FOR HYPERURICEMIA AND GOUT
03/01/2023 - 02/28/2026 (Subcontract PI)
Massachusetts General Hospital NIH NIAMS
5R01AR065944-07

Cardiovascular disease, metabolic syndrome, microbes and metabolites in FHS
02/01/2022 - 01/31/2026 (Subcontract PI)
Broad Institute, Inc., The NIH NHLBI
1R01HL157717-01A1

The San Antonio Heart and Mind Study
07/01/2023 - 03/31/2024 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NIA
1R01AG082360-01

Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise Training
08/05/2021 - 06/30/2023 (PI)
NIH/National Heart, Lung, and Blood Institute
7K23HL138260-07



Title


Yr Title Project-Sub Proj Pubs
2023 Metabolic Responses to an Oral Mixed Meal Tolerance Test: Intra-individual changes, correlates, and prognostic significance 5R01HL156975-03
2023 Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF Spectrum 2R01HL131029-05A1
2022 Metabolic Responses to an Oral Mixed Meal Tolerance Test: Intra-individual changes, correlates, and prognostic significance 5R01HL156975-02
2021 Metabolic Responses to an Oral Mixed Meal Tolerance Test: Intra-individual changes, correlates, and prognostic significance 1R01HL156975-01
2021 Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise Training 5K23HL138260-06 4
2021 Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise Training 7K23HL138260-07 4
2020 Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise Training 5K23HL138260-05 4
2019 Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise Training 5K23HL138260-04 4
2018 Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise Training 5K23HL138260-03 4
2017 Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise Training 7K23HL138260-02 4

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Shah RV, Zhong J, Massier L, Tanriverdi K, Hwang SJ, Haessler J, Nayor M, Zhao S, Perry AS, Wilkins JT, Shadyab AH, Manson JE, Martin L, Levy D, Kooperberg C, Freedman JE, Rydén M, Murthy VL. Targeted Proteomics Reveals Functional Targets for Early Diabetes Susceptibility in Young Adults. Circ Genom Precis Med. 2024 Feb; 17(1):e004192.View Related Profiles. PMID: 38323454
     
  2. Perry AS, Hadad N, Chatterjee E, Ramos MJ, Farber-Eger E, Roshani R, Stolze LK, Zhao S, Martens L, Kendall TJ, Thone T, Amancherla K, Bailin S, Gabriel CL, Koethe J, Carr JJ, Terry JG, Freedman J, Tanriverdi K, Alsop E, Keuren-Jensen KV, Sauld JFK, Mahajan G, Khan S, Colangelo L, Nayor M, Fisher-Hoch S, McCormick J, North KE, Below J, Wells Q, Abel D, Kalhan R, Scott C, Guilliams M, Fallowfield JA, Banovich NE, Das S, Shah R. A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver. medRxiv. 2024 Jan 29. PMID: 38352394
     
  3. Motiwala SR, Nayor M. Risk Stratification in Advanced Heart Failure: Can Simple Hemodynamic Indices Replace Comprehensive CPET? JACC Heart Fail. 2024 Feb; 12(2):272-274. PMID: 37999666
     
  4. Lau ES, Roshandelpoor A, Zarbafian S, Wang D, Guseh JS, Allen N, Varadarajan V, Nayor M, Shah RV, Lima JAC, Shah SJ, Yu B, Alotaibi M, Cheng S, Jain M, Lewis GD, Ho JE. Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction. Nat Commun. 2023 Nov 20; 14(1):7557. PMID: 37985769; PMCID: PMC10662264; DOI: 10.1038/s41467-023-43363-3;
     
  5. Li Y, Wang M, Liu X, Rong J, Miller PE, Joehanes R, Huan T, Guo X, Rotter JI, Smith JA, Yu B, Nayor M, Levy D, Liu C, Ma J. Circulating metabolites may illustrate relationship of alcohol consumption with cardiovascular disease. BMC Med. 2023 Nov 16; 21(1):443.View Related Profiles. PMID: 37968697; PMCID: PMC10652547; DOI: 10.1186/s12916-023-03149-2;
     
  6. Shah RV, Hwang SJ, Murthy VL, Zhao S, Tanriverdi K, Gajjar P, Duarte K, Schoenike M, Farrell R, Brooks LC, Gopal DM, Ho JE, Girerd N, Vasan RS, Levy D, Freedman JE, Lewis GD, Nayor M. Proteomics and Precise Exercise Phenotypes in Heart Failure With Preserved Ejection Fraction: A Pilot Study. J Am Heart Assoc. 2023 Nov 07; 12(21):e029980.View Related Profiles. PMID: 37889181; PMCID: PMC10727424; DOI: 10.1161/JAHA.122.029980;
     
  7. Nayor M, Gajjar P, Miller P, Murthy VL, Shah RV, Houstis NE, Velagaleti RS, Larson MG, Vasan RS, Lewis GD, Mitchell GF. Arterial Stiffness and Cardiorespiratory Fitness Impairment in the Community. J Am Heart Assoc. 2023 Nov 07; 12(21):e029619.View Related Profiles. PMID: 37850464; PMCID: PMC10727403; DOI: 10.1161/JAHA.123.029619;
     
  8. Mi MY, Gajjar P, Walker ME, Miller P, Xanthakis V, Murthy VL, Larson MG, Vasan RS, Shah RV, Lewis GD, Nayor M. Association of healthy dietary patterns and cardiorespiratory fitness in the community. Eur J Prev Cardiol. 2023 Oct 10; 30(14):1450-1461.View Related Profiles. PMID: 37164358; PMCID: PMC10562138; DOI: 10.1093/eurjpc/zwad113;
     
  9. Perry AS, Zhao S, Gajjar P, Murthy VL, Lehallier B, Miller P, Nair S, Neill C, Carr JJ, Fearon W, Kapadia S, Kumbhani D, Gillam L, Lindenfeld J, Farrell L, Marron MM, Tian Q, Newman AB, Murabito J, Gerszten RE, Nayor M, Elmariah S, Lindman BR, Shah R. Proteomic architecture of frailty across the spectrum of cardiovascular disease. Aging Cell. 2023 Nov; 22(11):e13978.View Related Profiles. PMID: 37731195; PMCID: PMC10652351; DOI: 10.1111/acel.13978;
     
  10. Ramirez MF, Lau ES, Parekh JK, Pan AS, Owunna N, Wang D, McNeill JN, Malhotra R, Nayor M, Lewis GD, Ho JE. Obesity-Related Biomarkers Are Associated With Exercise Intolerance and HFpEF. Circ Heart Fail. 2023 Nov; 16(11):e010618. PMID: 37703087; PMCID: PMC10698557; DOI: 10.1161/CIRCHEARTFAILURE.123.010618;
     
Showing 10 of 72 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 72 publications over 13 distinct years, with a maximum of 15 publications in 2023

YearPublications
20102
20111
20141
20155
20161
20173
20187
20192
202010
202114
20229
202315
20242

2021 Boston University School of Medicine: Aram Chobanian Assistant Professor of Medicine
2021 Boston University Medical Center: Boston University School of Medicine Department of Medicine Career Development Award
2018-2020 National Institutes of Health: Loan Repayment Program
2016 Brigham and Women's Hospital, Cardiovascular Medicine Division: Richard Gorlin Fellowship in Cardiovascular Medicine
2012 Johns Hopkins Hospital Osler Medical Residency: Frank L. Coulson, Jr. Award for Clinical Excellence
2009 NYU School of Medicine: Clerkship Award for Outstanding Essay in the Philosophy of Medicine
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Epidemiology, Molecular
Exercise, Physical
Metabolomics
Proteomics
Heart Failure, Diastolic
Heart Failure, Systolic
Metabolic Cardiovascular Syndrome

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