David A. Boas, PhD
Professor
Boston University College of Engineering
Dept of Biomedical Engineering

PhD, University of Pennsylvania




David Boas, Ph.D. (Professor, Biomedical Engineering) is Director of the Neurophotonics Center at Boston University. He received his BS in Physics at Rensselear Polytechnic Institute and PhD in Physics at the University of Pennsylvania. During his academic career, he has supervised 44 students and post-doctoral fellows, and he has published over 250 papers that have received over 30,000 citations and an h-index of 101. He is the founding President of the Society for Functional Near Infrared Spectroscopy and founding Editor-in-Chief of the journal Neurophotonics published by SPIE. Dr. Boas was awarded the Britton Chance Award in Biomedical Optics in 2016 for his development of several novel, high-impact biomedical optical technologies in the neurosciences, as well as following through with impactful application studies, and fostering the widespread adoption of these technologies. He was elected a Fellow of AIMBE, SPIE, and OSA in 2017.

As Director of the Neurophotonics Center, he facilitates the development and application of novel optical methods to address a broad range of neuroscience questions from basic science to clinical translation. His own research efforts focus on neurovascular coupling, cerebral oxygen delivery and consumption, functional near infrared spectroscopy (fNIRS), and physiological modeling. Studies are done in rodents and humans, invasively and non-invasively, microscopically and macroscopically, providing a powerful ability to translate findings from animals to humans, and conversely to address in animals questions raised during human studies. One example of this that will tie together many of Dr. Boas’ activities is studying functional brain recovery in survivors of stroke. Human neuroimaging by fMRI and fNIRS measures hemodynamic functional recovery but it is not known if neuro-vascular coupling differs in these patients compared to healthy subjects. Animal studies will answer this question enabling more quantitative interpretation of the human neuroimaging studies.

Director
Neurophotonics Center




Computational Miniature Mesoscope for Cortex-wide, Cellular resolution Ca2+ Imaging in Freely Behaving Mice
04/01/2022 - 03/31/2027 (Co-Investigator)
NIH/National Institute of Neurological Disorders & Stroke
1R01NS126596-01

The Neuroscience of Everyday World- A novel wearable system for continuous measurement of brain function
09/22/2020 - 05/31/2025 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
5U01EB029856-02

Time-Gated Diffuse Correlation Spectroscopy for functional imaging of the human brain
09/21/2019 - 06/30/2024 (Subcontract PI)
Massachusetts General Hospital NIH NIBIB
5U01EB028660-03

The impact of microvascular (dys)regulation on cerebral flow and oxygen heterogeneity
09/01/2018 - 05/31/2023 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS108472-05

Imaging and Analysis Techniques to Construct a Cell Census Atlas of the Human Brain
08/22/2018 - 05/31/2023 (Subcontract PI)
Massachusetts General Hospital NIH NIMH
5U01MH117023-04

Establishing an fNIRS Ecosystem for Open Software-Hardware Dissemination
01/01/2018 - 12/31/2022 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R24NS104096-04

Comparing laser speckle contract and diffuse correlation spectroscopy measurements in human brain function
04/20/2021 - 12/13/2022 (PI)
Facebook Technologies, LLC


NRT UtB: Neurophotonics
09/01/2016 - 08/31/2022 (Multi-PI)
PI: David A. Boas, PhD
National Science Foundation
DGE-1633516

A Computational Miniature Mesoscope for Large-Scale Brain Mapping in Behaving Mice
04/01/2019 - 03/31/2022 (Multi-PI)
PI: David A. Boas, PhD
NIH/National Eye Institute
1R21EY030016-01

Improving human FMRI through modeling and imaging microvascular dynamics
11/01/2017 - 07/31/2021 (Subcontract PI)
Massachusetts General Hospital NIH NIMH
5R01MH111419-05

Showing 10 of 20 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2022 The Neuroscience of Everyday World- A novel wearable system for continuous measurement of brain function 5U01EB029856-03
2022 The impact of microvascular (dys)regulation on cerebral flow and oxygen heterogeneity 5R01NS108472-05
2022 Imaging and Analysis Techniques to Construct a Cell Census Atlas of the Human Brain 5U01MH117023-05
2021 The Neuroscience of Everyday World- A novel wearable system for continuous measurement of brain function 5U01EB029856-02
2021 The Neuroscience of Everyday World- A novel wearable system for continuous measurement of brain function 3U01EB029856-02S1
2021 The impact of microvascular (dys)regulation on cerebral flow and oxygen heterogeneity 5R01NS108472-04 4
2021 Imaging and Analysis Techniques to Construct a Cell Census Atlas of the Human Brain Admin Supplement 3U01MH117023-04S1 5
2021 Imaging and Analysis Techniques to Construct a Cell Census Atlas of the Human Brain 5U01MH117023-04 5
2021 Establishing an fNIRS Ecosystem for Open Software-Hardware Dissemination 5R24NS104096-04 1
2020 The Neuroscience of Everyday World- A novel wearable system for continuous measurement of brain function 1U01EB029856-01
Showing 10 of 101 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Ortega-Martinez A, Von Lühmann A, Farzam P, Rogers D, Mugler EM, Boas DA, Yücel MA. Multivariate Kalman filter regression of confounding physiological signals for real-time classification of fNIRS data. Neurophotonics. 2022 Apr; 9(2):025003.View Related Profiles. PMID: 35692628; PMCID: PMC9174890; DOI: 10.1117/1.NPh.9.2.025003;
     
  2. Aykan SA, Xie H, Zheng Y, Chung DY, Kura S, Han Lai J, Erdogan TD, Morais A, Tamim I, Yagmur D, Ishikawa H, Arai K, Abbas Yaseen M, Boas DA, Sakadzic S, Ayata C. Rho-Kinase Inhibition Improves the Outcome of Focal Subcortical White Matter Lesions. Stroke. 2022 Jul; 53(7):2369-2376. PMID: 35656825
     
  3. Yang J, Chang S, Chen IA, Kura S, Rosen GA, Saltiel NA, Huber BR, Varadarajan D, Balbastre Y, Magnain C, Chen SC, Fischl B, Mckee AC, Boas D, Wang H. Volumetric characterization of microvasculature in ex vivo human brain samples by serial sectioning optical coherence tomography. IEEE Trans Biomed Eng. 2022 May 13; PP.View Related Profiles. PMID: 35560084
     
  4. Varadarajan D, Magnain C, Fogarty M, Boas DA, Fischl B, Wang H. A novel algorithm for multiplicative speckle noise reduction in ex vivo human brain OCT images. Neuroimage. 2022 Aug 15; 257:119304. PMID: 35568350
     
  5. Abdelfattah AS, Ahuja S, Akkin T, Allu SR, Brake J, Boas DA, Buckley EM, Campbell RE, Chen AI, Cheng X, Cižmár T, Costantini I, De Vittorio M, Devor A, Doran PR, El Khatib M, Emiliani V, Fomin-Thunemann N, Fainman Y, Fernandez-Alfonso T, Ferri CGL, Gilad A, Han X, Harris A, Hillman EMC, Hochgeschwender U, Holt MG, Ji N, Kiliç K, Lake EMR, Li L, Li T, Mächler P, Miller EW, Mesquita RC, Nadella KMNS, Nägerl UV, Nasu Y, Nimmerjahn A, Ondrácková P, Pavone FS, Perez Campos C, Peterka DS, Pisano F, Pisanello F, Puppo F, Sabatini BL, Sadegh S, Sakadzic S, Shoham S, Shroff SN, Silver RA, Sims RR, Smith SL, Srinivasan VJ, Thunemann M, Tian L, Tian L, Troxler T, Valera A, Vaziri A, Vinogradov SA, Vitale F, Wang LV, Uhlírová H, Xu C, Yang C, Yang MH, Yellen G, Yizhar O, Zhao Y. Neurophotonic tools for microscopic measurements and manipulation: status report. Neurophotonics. 2022 Jan; 9(Suppl 1):013001.View Related Profiles. PMID: 35493335; PMCID: PMC9047450; DOI: 10.1117/1.NPh.9.S1.013001;
     
  6. Cheng X, Chen H, Sie EJ, Marsili F, Boas DA. Development of a Monte Carlo-wave model to simulate time domain diffuse correlation spectroscopy measurements from first principles. J Biomed Opt. 2022 02; 27(8). PMID: 35199501; PMCID: PMC8866418; DOI: 10.1117/1.JBO.27.8.083009;
     
  7. Chang S, Varadarajan D, Yang J, Chen IA, Kura S, Magnain C, Augustinack JC, Fischl B, Greve DN, Boas DA, Wang H. Scalable mapping of myelin and neuron density in the human brain with micrometer resolution. Sci Rep. 2022 01 10; 12(1):363. PMID: 35013441; PMCID: PMC8748995; DOI: 10.1038/s41598-021-04093-y;
     
  8. Liu CJ, Ammon W, Jones RJ, Nolan J, Wang R, Chang S, Frosch MP, Yendiki A, Boas DA, Magnain C, Fischl B, Wang H. Refractive-index matching enhanced polarization sensitive optical coherence tomography quantification in human brain tissue. Biomed Opt Express. 2022 Jan 01; 13(1):358-372. PMID: 35154876; PMCID: PMC8803034; DOI: 10.1364/BOE.443066;
     
  9. Aykan SA, Xie H, Lai JH, Zheng Y, Chung DY, Kura S, Anzabi M, Sugimoto K, McAllister LM, Yaseen MA, Boas DA, Whalen MJ, Sakadzic S, Ayata C. Focal Subcortical White Matter Lesions Disrupt Resting State Cortical Interhemispheric Functional Connectivity in Mice. Cereb Cortex. 2021 10 01; 31(11):4958-4969. PMID: 34037216; PMCID: PMC8491690; DOI: 10.1093/cercor/bhab134;
     
  10. Gilmore N, Yücel MA, Li X, Boas DA, Kiran S. Investigating Language and Domain-General Processing in Neurotypicals and Individuals With Aphasia - A Functional Near-Infrared Spectroscopy Pilot Study. Front Hum Neurosci. 2021; 15:728151.View Related Profiles. PMID: 34602997; PMCID: PMC8484538; DOI: 10.3389/fnhum.2021.728151;
     
Showing 10 of 342 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 342 publications over 29 distinct years, with a maximum of 23 publications in 2009

YearPublications
19941
19952
19962
19974
19983
19992
20005
20014
20026
200314
20048
200519
200610
200711
200820
200923
201019
201116
201211
201317
201412
201517
201622
201721
201815
201913
202021
202117
20227
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Boston MA 02215
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