David A. Boas, PhD
Professor
Boston University College of Engineering
Dept of Biomedical Engineering

PhD, University of Pennsylvania




David Boas, Ph.D. (Professor, Biomedical Engineering) is Director of the Neurophotonics Center at Boston University. He received his BS in Physics at Rensselear Polytechnic Institute and PhD in Physics at the University of Pennsylvania. During his academic career, he has supervised 44 students and post-doctoral fellows, and he has published over 250 papers that have received over 30,000 citations and an h-index of 101. He is the founding President of the Society for Functional Near Infrared Spectroscopy and founding Editor-in-Chief of the journal Neurophotonics published by SPIE. Dr. Boas was awarded the Britton Chance Award in Biomedical Optics in 2016 for his development of several novel, high-impact biomedical optical technologies in the neurosciences, as well as following through with impactful application studies, and fostering the widespread adoption of these technologies. He was elected a Fellow of AIMBE, SPIE, and OSA in 2017.

As Director of the Neurophotonics Center, he facilitates the development and application of novel optical methods to address a broad range of neuroscience questions from basic science to clinical translation. His own research efforts focus on neurovascular coupling, cerebral oxygen delivery and consumption, functional near infrared spectroscopy (fNIRS), and physiological modeling. Studies are done in rodents and humans, invasively and non-invasively, microscopically and macroscopically, providing a powerful ability to translate findings from animals to humans, and conversely to address in animals questions raised during human studies. One example of this that will tie together many of Dr. Boas’ activities is studying functional brain recovery in survivors of stroke. Human neuroimaging by fMRI and fNIRS measures hemodynamic functional recovery but it is not known if neuro-vascular coupling differs in these patients compared to healthy subjects. Animal studies will answer this question enabling more quantitative interpretation of the human neuroimaging studies.

Director
Neurophotonics Center




The impact of microvascular (dys)regulation on cerebral flow and oxygen heterogeneity
09/01/2018 - 05/31/2023 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS108472-02

Imaging and Analysis Techniques to Construct a Cell Census Atlas of the Human Brain
08/22/2018 - 05/31/2023 (Subcontract PI)
Massachusetts General Hospital NIH NIMH
5U01MH117023-02

Establishing an fNIRS Ecosystem for Open Software-Hardware Dissemination
01/01/2018 - 12/31/2021 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R24NS104096-02

NRT UtB: Neurophotonics
09/01/2016 - 08/31/2021 (Co-PI)
National Science Foundation
DGE-1633516

Improving human FMRI through modeling and imaging microvascular dynamics
11/01/2017 - 07/31/2021 (Subcontract PI)
Massachusetts General Hospital NIH NIMH
5R01MH111419-04

Microscopic foundation of multimodal human imaging
06/01/2017 - 05/31/2021 (Subcontract PI)
University of California, San Diego NIH NIMH
5R01MH111359-04

A Computational Miniature Mesoscope for Large-Scale Brain Mapping in Behaving Mice
04/01/2019 - 03/31/2021 (Multi-PI)
PI: David A. Boas, PhD
NIH/National Eye Institute
1R21EY030016-01

Gated Diffuse Correlation Spectroscopy for functional imaging of the human brain
09/25/2017 - 07/31/2020 (Subcontract PI)
General Hospital Corp d/b/a Massachusetts General Hospital NIH NIBIB
5R01EB025145-02

Microscopic imaging of tissue oxygen delivery altered by microvascular changes
09/01/2017 - 06/30/2020 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
3R01EB021018-04S2

Noninvasive fast optical correlates of neural and neurovascular activity
05/07/2019 - 05/19/2020 (PI)
Facebook Technologies, LLC


Showing 10 of 13 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2020 Establishing an fNIRS Ecosystem for Open Software-Hardware Dissemination 5R24NS104096-03 1
2019 A Computational Miniature Mesoscope for Large-Scale Brain Mapping in Behaving Mice 1R21EY030016-01
2019 The impact of microvascular (dys)regulation on cerebral flow and oxygen heterogeneity 5R01NS108472-02 4
2019 Imaging and Analysis Techniques to Construct a Cell Census Atlas of the Human Brain 5U01MH117023-02 5
2019 Establishing an fNIRS Ecosystem for Open Software-Hardware Dissemination 5R24NS104096-02 1
2019 Establishing an fNIRS Ecosystem for Open Software-Hardware Dissemination 5R24NS104096-02 1
2018 Microscopic imaging of tissue oxygen delivery altered by microvascular changes 3R01EB021018-04S2 23
2018 The impact of microvascular (dys)regulation on cerebral flow and oxygen heterogeneity 1R01NS108472-01 4
2018 Imaging and Analysis Techniques to Construct a Cell Census Atlas of the Human Brain 1U01MH117023-01 5
2018 Establishing an fNIRS Ecosystem for Open Software-Hardware Dissemination 1R24NS104096-01 1
Showing 10 of 92 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Chung DY, Oka F, Jin G, Harriott A, Kura S, Aykan SA, Qin T, Iii WJE, Lee H, Yaseen MA, Sakadžic S, Boas DA, Whalen MJ, Ayata C. Subarachnoid hemorrhage leads to early and persistent functional connectivity and behavioral changes in mice. J Cereb Blood Flow Metab. 2020 Sep 16; 271678X20940152. PMID: 32936728
     
  2. Kiliç K, Tang J, Erdener SE, Sunil S, Giblin JT, Lee BS, Postnov DD, Chen A, Boas DA. Chronic Imaging of Mouse Brain: From Optical Systems to Functional Ultrasound. Curr Protoc Neurosci. 2020 09; 93(1):e98. PMID: 32584495
     
  3. Li X, Krol MA, Jahani S, Boas DA, Tager-Flusberg H, Yücel MA. Brain correlates of motor complexity during observed and executed actions. Sci Rep. 2020 Jul 03; 10(1):10965.View Related Profiles. PMID: 32620887
     
  4. Sencan I, Esipova T, Kiliç K, Li B, Desjardins M, Yaseen MA, Wang H, Porter JE, Kura S, Fu B, Secomb TW, Boas DA, Vinogradov SA, Devor A, Sakadžic S. Optical measurement of microvascular oxygenation and blood flow responses in awake mouse cortex during functional activation. J Cereb Blood Flow Metab. 2020 Jun 09; 271678X20928011. PMID: 32515672
     
  5. Celaya-Alcala JT, Lee GV, Smith AF, Li B, Sakadžic S, Boas DA, Secomb TW. Simulation of oxygen transport and estimation of tissue perfusion in extensive microvascular networks: Application to cerebral cortex. J Cereb Blood Flow Metab. 2020 Jun 05; 271678X20927100. PMID: 32501155
     
  6. Cheng X, Sadegh S, Zilpelwar S, Devor A, Tian L, Boas DA. Comparing the fundamental imaging depth limit of two-photon, three-photon, and non-degenerate two-photon microscopy. Opt Lett. 2020 May 15; 45(10):2934-2937. PMID: 32412504
     
  7. Robinson MB, Carp SA, Peruch A, Boas DA, Franceschini MA, Sakadžic S. Characterization of continuous wave ultrasound for acousto-optic modulated diffuse correlation spectroscopy (AOM-DCS). Biomed Opt Express. 2020 Jun 01; 11(6):3071-3090. PMID: 32637242
     
  8. Tamborini D, Franceschini MA, Stephens KA, Wu MM, Farzam P, Siegel AM, Shatrovoy O, Blackwell M, Boas DA, Carp SA. Corrections to "Portable System for Time-Domain Diffuse Correlation Spectroscopy". IEEE Trans Biomed Eng. 2020 Apr; 67(4):1229. PMID: 32203016
     
  9. Erdener SE, Tang J, Kiliç K, Postnov D, Giblin JT, Kura S, Chen IA, Vayisoglu T, Sakadžic S, Schaffer CB, Boas DA. Dynamic capillary stalls in reperfused ischemic penumbra contribute to injury: A hyperacute role for neutrophils in persistent traffic jams. J Cereb Blood Flow Metab. 2020 Apr 01; 271678X20914179. PMID: 32237951
     
  10. Jones R, Grisot G, Augustinack J, Magnain C, Boas DA, Fischl B, Wang H, Yendiki A. Insight into the fundamental trade-offs of diffusion MRI from polarization-sensitive optical coherence tomography in ex vivo human brain. Neuroimage. 2020 07 01; 214:116704. PMID: 32151760
     
Showing 10 of 310 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 310 publications over 27 distinct years, with a maximum of 23 publications in 2009

YearPublications
19941
19952
19962
19974
19983
19992
20005
20014
20026
200314
20048
200519
200610
200711
200820
200923
201019
201116
201211
201317
201412
201517
201622
201721
201815
201913
202013

Contact for Mentoring:

610 Commonwealth Ave, CILSE Room 804
Boston MA 02215
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