Beth Bragdon, PhD
Postdoctoral Fellow
Boston University School of Medicine
Dept of Orthopaedic Surgery

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I am interested in the effects of trauma and repair as it pertains to the musculoskeletal system with an emphasis on stem/progenitor cell recruitment, differentiation, and formation of bone tissue and the signaling pathways involved with these processes. Currently, the stem cell population(s) that drives heterotopic ossification (HO) due to trauma or even fracture repair is unknown. My work focuses on 1) the identification and isolation of the stem/progenitor cell populations that contribute to post-natal bone formation (HO and fracture) and 2) compare the transcriptome of these different populations for similarities and identify key signaling pathways that could be used as targets for future therapy.

2017 Orthopaedic Research Society: Alice L. Jee Award
2017 ORS 47th International Musculoskeletal Biology Workshop : Blue Ribbon Poster Presentation
2017 Orthopaedic Research Society Regional Meeting / University of Rochester NY: Center for Musculoskeletal Research Poster Award
2015 American Society for Bone and Mineral Research: John Haddad Young Investigator Award
2007 University of Maine: Dysart Travel Award
2007 University of Maine: Chemical BioPhysics Symposium Graduate Student Travel Award


The Characterization of the Skeletogenic Stem Cells that Contribute to Post Natal Axial Skeletal Tissue Repair
06/06/2016 - 05/31/2018 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5K99AR068582-02

Defining the Tissue Origin of DBM Responsive Sketelogenic Stem Cells
02/01/2015 - 03/31/2018 (PI)
Musculoskeletal Transplant Foundation




Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Bragdon BC, Bahney CS. Origin of Reparative Stem Cells in Fracture Healing. Curr Osteoporos Rep. 2018 Aug; 16(4):490-503. PMID: 29959723.
     
  2. Bragdon B, Lam S, Aly S, Femia A, Clark A, Hussein A, Morgan EF, Gerstenfeld LC. Earliest phases of chondrogenesis are dependent upon angiogenesis during ectopic bone formation in mice. Bone. 2017 Aug; 101:49-61.View Related Profiles. PMID: 28412469; DOI: 10.1016/j.bone.2017.04.002;.
     
  3. Ko FC, Martins JS, Reddy P, Bragdon B, Hussein AI, Gerstenfeld LC, Demay MB. Acute Phosphate Restriction Impairs Bone Formation and Increases Marrow Adipose Tissue in Growing Mice. J Bone Miner Res. 2016 Dec; 31(12):2204-2214.View Related Profiles. PMID: 27324177; DOI: 10.1002/jbmr.2891;.
     
  4. Bragdon B, Lybrand K, Gerstenfeld L. Overview of biological mechanisms and applications of three murine models of bone repair: closed fracture with intramedullary fixation, distraction osteogenesis, and marrow ablation by reaming. Curr Protoc Mouse Biol. 2015; 5(1):21-34.View Related Profiles. PMID: 25727198; PMCID: PMC4358754; DOI: 10.1002/9780470942390.mo140166;.
     
  5. Lybrand K, Bragdon B, Gerstenfeld L. Mouse models of bone healing: fracture, marrow ablation, and distraction osteogenesis. Curr Protoc Mouse Biol. 2015; 5(1):35-49.View Related Profiles. PMID: 25727199; PMCID: PMC4380295; DOI: 10.1002/9780470942390.mo140161;.
     
  6. Bragdon B, Burns R, Baker AH, Belkina AC, Morgan EF, Denis GV, Gerstenfeld LC, Schlezinger JJ. Intrinsic Sex-Linked Variations in Osteogenic and Adipogenic Differentiation Potential of Bone Marrow Multipotent Stromal Cells. J Cell Physiol. 2015 Feb; 230(2):296-307.View Related Profiles. PMID: 24962433; PMCID: PMC4317374; DOI: 10.1002/jcp.24705;.
     
  7. Akkiraju H, Bonor J, Olli K, Bowen C, Bragdon B, Coombs H, Donahue LR, Duncan R, Nohe A. Systemic injection of CK2.3, a novel peptide acting downstream of bone morphogenetic protein receptor BMPRIa, leads to increased trabecular bone mass. J Orthop Res. 2015 Feb; 33(2):208-15. PMID: 25331517; PMCID: PMC4304894; DOI: 10.1002/jor.22752;.
     
  8. Moseychuk O, Akkiraju H, Dutta J, D'Angelo A, Bragdon B, Duncan RL, Nohe A. Inhibition of CK2 binding to BMPRIa induces C2C12 differentiation into osteoblasts and adipocytes. J Cell Commun Signal. 2013 Dec; 7(4):265-78. PMID: 23637019; PMCID: PMC3889251; DOI: 10.1007/s12079-013-0199-1;.
     
  9. Saldanha S, Bragdon B, Moseychuk O, Bonor J, Dhurjati P, Nohe A. Caveolae regulate Smad signaling as verified by novel imaging and system biology approaches. J Cell Physiol. 2013 May; 228(5):1060-9. PMID: 23041979; DOI: 10.1002/jcp.24253;.
     
  10. Bragdon B, Bonor J, Shultz KL, Beamer WG, Rosen CJ, Nohe A. Bone morphogenetic protein receptor type Ia localization causes increased BMP2 signaling in mice exhibiting increased peak bone mass phenotype. J Cell Physiol. 2012 Jul; 227(7):2870-9. PMID: 22170575; PMCID: PMC3309108; DOI: 10.1002/jcp.23028;.
     
Showing 10 of 19 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 19 publications over 11 distinct years, with a maximum of 4 publications in 2011

YearPublications
20081
20091
20102
20114
20122
20132
20141
20153
20161
20171
20181
Contact for Mentoring:

72 E. Concord St Evans Building
Boston MA 02118
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