Barbara Slack | Profiles RNS

Barbara E. Slack, PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Pathology & Laboratory Medicine

Other Pathology

PhD, Queen's University
MSc, Queen's University
BS, Queen's University

Websites

Pathology & Laboratory Medicine Faculty

ORCID : 0000-0002-7619-410X

Barbara Slack, PhD, is an Associate Professor of Pathology & Laboratory Medicine at the Chobanian and Avedisian School of Medicine.She has been a member of the faculty since 1995. Previously, Dr. Slack was a research and postdoctoral fellow at both MIT and Harvard University. Her laboratory studies signal transduction pathways coupled to G protein-coupled receptors.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Integrin Dependence of Muscarinic Receptor Signaling
08/10/2000 - 12/31/2005 (PI)
NIH/National Institute of Mental Health
5 R01 MH59775 05

Title

Yr	Title	Project-Sub Proj	Pubs
2003	INTEGRIN DEPENDENCE OF MUSCARINIC RECEPTOR SIGNALING	5R01MH059775-05	7
2002	INTEGRIN DEPENDENCE OF MUSCARINIC RECEPTOR SIGNALING	5R01MH059775-04	7
2001	INTEGRIN DEPENDENCE OF MUSCARINIC RECEPTOR SIGNALING	5R01MH059775-03	7
2001	MEMBRANE TURNOVER AND AMYLOID PRECURSOR PROTEIN RELEASE	5R01NS030791-07	11
2000	INTEGRIN DEPENDENCE OF MUSCARINIC RECEPTOR SIGNALING	7R01MH059775-02	7
2000	MEMBRANE TURNOVER AND AMYLOID PRECURSOR PROTEIN RELEASE	5R01NS030791-06	11
1999	MEMBRANE TURNOVER AND AMYLOID PRECURSOR PROTEIN RELEASE	2R01NS030791-05A3	11
1996	MEMBRANE TURNOVER AND AMYLOID PRECURSOR PROTEIN RELEASE	5R01NS030791-04	11
1995	MEMBRANE TURNOVER AND AMYLOID PRECURSOR PROTEIN RELEASE	5R01NS030791-03	11
1994	MEMBRANE TURNOVER AND AMYLOID PRECURSOR PROTEIN RELEASE	7R01NS030791-02	11

Showing 10 of 11 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Blusztajn JK, Slack BE. Accelerated Breakdown of Phosphatidylcholine and Phosphatidylethanolamine Is a Predominant Brain Metabolic Defect in Alzheimer's Disease. J Alzheimers Dis. 2023; 93(4):1285-1289.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 37182883; PMCID: PMC10885637; DOI: 10.3233/JAD-230061;

Blusztajn JK, Slack BE, Mellott TJ. Neuroprotective Actions of Dietary Choline. Nutrients. 2017 Jul 28; 9(8).View Related Profiles.

Slack, Barbara
Blusztajn, Jan
Mellott, Tiffany

PMID: 28788094; PMCID: PMC5579609; DOI: 10.3390/nu9080815;

Mellott TJ, Huleatt OM, Shade BN, Pender SM, Liu YB, Slack BE, Blusztajn JK. Correction: Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. PLoS One. 2017; 12(3):e0174875.View Related Profiles.

Slack, Barbara
Blusztajn, Jan
Mellott, Tiffany

PMID: 28334015; PMCID: PMC5363934; DOI: 10.1371/journal.pone.0174875;

Mellott TJ, Huleatt OM, Shade BN, Pender SM, Liu YB, Slack BE, Blusztajn JK. Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. PLoS One. 2017; 12(1):e0170450.View Related Profiles.

Slack, Barbara
Blusztajn, Jan
Mellott, Tiffany

PMID: 28103298; PMCID: PMC5245895; DOI: 10.1371/journal.pone.0170450;

Burke RM, Norman TA, Haydar TF, Slack BE, Leeman SE, Blusztajn JK, Mellott TJ. BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19567-72.View Related Profiles.

Slack, Barbara
Blusztajn, Jan
Burke, Rebecca
Leeman, Susan
Haydar, Tarik
Mellott, Tiffany
Norman, Timothy

PMID: 24218590; PMCID: PMC3845152; DOI: 10.1073/pnas.1319297110;

Akle V, Guelin E, Yu L, Brassard-Giordano H, Slack BE, Zhdanova IV. F-spondin/spon1b expression patterns in developing and adult zebrafish. PLoS One. 2012; 7(6):e37593.View Related Profiles.

Slack, Barbara
Zhdanova, Irina
Yu, Lili

PMID: 22768035; PMCID: PMC3387172; DOI: 10.1371/journal.pone.0037593;

Cissé M, Duplan E, Guillot-Sestier MV, Rumigny J, Bauer C, Pagès G, Orzechowski HD, Slack BE, Checler F, Vincent B. The extracellular regulated kinase-1 (ERK1) controls regulated alpha-secretase-mediated processing, promoter transactivation, and mRNA levels of the cellular prion protein. J Biol Chem. 2011 Aug 19; 286(33):29192-206. PMID: 21586567; PMCID: PMC3190726; DOI: 10.1074/jbc.M110.208249;

Carey RM, Blusztajn JK, Slack BE. Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin. BMC Cell Biol. 2011; 12:20.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 21586144; PMCID: PMC3118186; DOI: 10.1186/1471-2121-12-20;

Kishi S, Slack BE, Uchiyama J, Zhdanova IV. Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates--a mini-review. Gerontology. 2009; 55(4):430-41.View Related Profiles.

Slack, Barbara
Zhdanova, Irina

PMID: 19654474; PMCID: PMC2820570; DOI: 10.1159/000228892;

Slack BE, Blusztajn JK. Differential regulation of mTOR-dependent S6 phosphorylation by muscarinic acetylcholine receptor subtypes. J Cell Biochem. 2008 Aug 1; 104(5):1818-31.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 18348264; DOI: 10.1002/jcb.21745;

Showing 10 of 46 results. Show More

Alfa Cissé M, Louis K, Braun U, Mari B, Leitges M, Slack BE, Fisher A, Auberger P, Checler F, Vincent B. Isoform-specific contribution of protein kinase C to prion processing. Mol Cell Neurosci. 2008 Nov; 39(3):400-10. PMID: 18722532; DOI: 10.1016/j.mcn.2008.07.013;

Alfa Cissé M, Sunyach C, Slack BE, Fisher A, Vincent B, Checler F. M1 and M3 muscarinic receptors control physiological processing of cellular prion by modulating ADAM17 phosphorylation and activity. J Neurosci. 2007 Apr 11; 27(15):4083-92. PMID: 17428986; PMCID: PMC6672535; DOI: 10.1523/JNEUROSCI.5293-06.2007;

Slack BE, Siniaia MS, Blusztajn JK. Collagen type I selectively activates ectodomain shedding of the discoidin domain receptor 1: involvement of Src tyrosine kinase. J Cell Biochem. 2006 Jun 1; 98(3):672-84.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 16440311; PMCID: PMC2593136; DOI: 10.1002/jcb.20812;

Lopez-Coviella I, Mellott TM, Kovacheva VP, Berse B, Slack BE, Zemelko V, Schnitzler A, Blusztajn JK. Developmental pattern of expression of BMP receptors and Smads and activation of Smad1 and Smad5 by BMP9 in mouse basal forebrain. Brain Res. 2006 May 9; 1088(1):49-56.View Related Profiles.

Slack, Barbara
Berse, Brygida
Blusztajn, Jan

PMID: 16626664

Carey RM, Balcz BA, Lopez-Coviella I, Slack BE. Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein. BMC Cell Biol. 2005; 6:30. PMID: 16095541; PMCID: PMC1208872; DOI: 10.1186/1471-2121-6-30;

Slack BE, Siniaia MS. Adhesion-dependent redistribution of MAP kinase and MEK promotes muscarinic receptor-mediated signaling to the nucleus. J Cell Biochem. 2005 May 15; 95(2):366-78. PMID: 15779001; PMCID: PMC2593131; DOI: 10.1002/jcb.20431;

Lopez-Coviella I, Follettie MT, Mellott TJ, Kovacheva VP, Slack BE, Diesl V, Berse B, Thies RS, Blusztajn JK. Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6984-9.View Related Profiles.

Slack, Barbara
Berse, Brygida
Blusztajn, Jan
Mellott, Tiffany

PMID: 15870197; PMCID: PMC1088172; DOI: 10.1073/pnas.0502097102;

Slack BE, Ma LK, Seah CC. Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme. Biochem J. 2001 Aug 1; 357(Pt 3):787-94. PMID: 11463349; PMCID: PMC1222008

Farber SA, Slack BE, Blusztajn JK. Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease. FASEB J. 2000 Nov; 14(14):2198-206.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 11053240

Slack BE. The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase. Biochem J. 2000 Jun 1; 348 Pt 2:381-7. PMID: 10816433; PMCID: PMC1221077

Slack BE. Tyrosine phosphorylation of paxillin and focal adhesion kinase by activation of muscarinic m3 receptors is dependent on integrin engagement by the extracellular matrix. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7281-6. PMID: 9636140; PMCID: PMC22590

Slack BE, Breu J, Muchnicki L, Wurtman RJ. Rapid stimulation of amyloid precursor protein release by epidermal growth factor: role of protein kinase C. Biochem J. 1997 Oct 1; 327 ( Pt 1):245-9. PMID: 9355759; PMCID: PMC1218787

Li H, Leeman SE, Slack BE, Hauser G, Saltsman WS, Krause JE, Blusztajn JK, Boyd ND. A substance P (neurokinin-1) receptor mutant carboxyl-terminally truncated to resemble a naturally occurring receptor isoform displays enhanced responsiveness and resistance to desensitization. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):9475-80.View Related Profiles.

Slack, Barbara
Blusztajn, Jan
Leeman, Susan

PMID: 9256507; PMCID: PMC23228

Petryniak MA, Wurtman RJ, Slack BE. Elevated intracellular calcium concentration increases secretory processing of the amyloid precursor protein by a tyrosine phosphorylation-dependent mechanism. Biochem J. 1996 Dec 15; 320 ( Pt 3):957-63. PMID: 9003386; PMCID: PMC1218021

Farber SA, Savci V, Wei A, Slack BE, Wurtman RJ. Choline's phosphorylation in rat striatal slices is regulated by the activity of cholinergic neurons. Brain Res. 1996 Jun 3; 723(1-2):90-9. PMID: 8813385

Slack BE, Breu J, Petryniak MA, Srivastava K, Wurtman RJ. Tyrosine phosphorylation-dependent stimulation of amyloid precursor protein secretion by the m3 muscarinic acetylcholine receptor. J Biol Chem. 1995 Apr 7; 270(14):8337-44. PMID: 7713942

Slack BE, Breu J, Livneh E, Eldar H, Wurtman RJ. Phorbol ester stimulates choline uptake in Swiss 3T3 fibroblasts following introduction of the gene encoding protein kinase C alpha. Biochem J. 1995 Jan 15; 305 ( Pt 2):621-6. PMID: 7832781; PMCID: PMC1136407

Nitsch RM, Slack BE, Farber SA, Schulz JG, Deng M, Kim C, Borghesani PR, Korver W, Wurtman RJ, Growdon JH. Regulation of proteolytic processing of the amyloid beta-protein precursor of Alzheimer's disease in transfected cell lines and in brain slices. J Neural Transm Suppl. 1994; 44:21-7. PMID: 7897393

Slack BE, Nitsch RM, Livneh E, Kunz GM, Breu J, Eldar H, Wurtman RJ. Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts overexpressing protein kinase C alpha. J Biol Chem. 1993 Oct 5; 268(28):21097-101. PMID: 8407946

Nitsch RM, Slack BE, Farber SA, Borghesani PR, Schulz JG, Kim C, Felder CC, Growdon JH, Wurtman RJ. Receptor-coupled amyloid precursor protein processing. Ann N Y Acad Sci. 1993 Sep 24; 695:122-7. PMID: 8239269

Slack BE, Nitsch RM, Livneh E, Kunz GM, Eldar H, Wurtman RJ. Regulation of amyloid precursor protein release by protein kinase C in Swiss 3T3 fibroblasts. Ann N Y Acad Sci. 1993 Sep 24; 695:128-31. PMID: 8239270

Nitsch RM, Slack BE, Wurtman RJ, Growdon JH. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science. 1992 Oct 9; 258(5080):304-7. PMID: 1411529

Slack BE, Richardson UI, Nitsch RM, Wurtman RJ. Dioctanoylglycerol stimulates accumulation of [methyl-14C]choline and its incorporation into acetylcholine and phosphatidylcholine in a human cholinergic neuroblastoma cell line. Brain Res. 1992 Jul 10; 585(1-2):169-76. PMID: 1511298

Nitsch RM, Blusztajn JK, Pittas AG, Slack BE, Growdon JH, Wurtman RJ. Evidence for a membrane defect in Alzheimer disease brain. Proc Natl Acad Sci U S A. 1992 Mar 1; 89(5):1671-5.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 1311847; PMCID: PMC48514

Slack BE, Breu J, Wurtman RJ. Production of diacylglycerol by exogenous phospholipase C stimulates CTP:phosphocholine cytidylyltransferase activity and phosphatidylcholine synthesis in human neuroblastoma cells. J Biol Chem. 1991 Dec 25; 266(36):24503-8. PMID: 1662212

Nitsch R, Pittas A, Blusztajn JK, Slack BE, Growdon JH, Wurtman RJ. Alterations of phospholipid metabolites in postmortem brain from patients with Alzheimer's disease. Ann N Y Acad Sci. 1991; 640:110-3.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 1663712

Wurtman RJ, Blusztajn JK, Ulus IH, Coviella IL, Buyukuysal RL, Growdon JH, Slack BE. Choline metabolism in cholinergic neurons: implications for the pathogenesis of neurodegenerative diseases. Adv Neurol. 1990; 51:117-25.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 2403709

Slack BE, Liscovitch M, Blusztajn JK, Wurtman RJ. Uptake of exogenous phosphatidylserine by human neuroblastoma cells stimulates the incorporation of [methyl-14C]choline into phosphatidylcholine. J Neurochem. 1989 Aug; 53(2):472-81.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 2746233

Liscovitch M, Slack B, Blusztajn JK, Wurtman RJ. Differential regulation of phosphatidylcholine biosynthesis by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol in NG108-15 neuroblastoma x glioma hybrid cells. J Biol Chem. 1987 Dec 25; 262(36):17487-91.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 3693364

Slack BE. Pre- and postsynaptic actions of noradrenaline and clonidine on myenteric neurons. Neuroscience. 1986 Dec; 19(4):1303-9. PMID: 2434878

Slack BE, Bell JE, Benos DJ. Inositol-1,4,5-trisphosphate injection mimics fertilization potentials in sea urchin eggs. Am J Physiol. 1986 Feb; 250(2 Pt 1):C340-4. PMID: 3485384

North RA, Slack BE, Surprenant A. Muscarinic M1 and M2 receptors mediate depolarization and presynaptic inhibition in guinea-pig enteric nervous system. J Physiol. 1985 Nov; 368:435-52. PMID: 4078746; PMCID: PMC1192606

Downie JW, Slack BE. Sensitivity to indomethacin of tetrodotoxin-resistant contractions of smooth muscle from the base of rabbit bladder. Br J Pharmacol. 1983 Jun; 79(2):334-6. PMID: 6652332; PMCID: PMC2044857

Slack BE, Downie JW. Pharmacological analysis of the responses of the feline urethra to autonomic nerve stimulation. J Auton Nerv Syst. 1983 Jun; 8(2):141-60. PMID: 6619512

Slack BE, Downie JW, Elbadawi A. Paradoxical resistance to adrenolytic agents of field-stimulated bladder base of rabbit. J Pharmacol Exp Ther. 1982 Jan; 220(1):216-22. PMID: 7053418

Slack BE, Boegman RJ, Downie JW, Jasmin G. Cardiac membrane cholesterol in dystrophic and verapamil-treated hamsters. J Mol Cell Cardiol. 1980 Feb; 12(2):179-85. PMID: 7365803

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 46 publications over 28 distinct years, with a maximum of 3 publications in 1992 and 1993 and 2005 and 2017

Bar chart showing 46 publications over 28 distinct years, with a maximum of 3 publications in 1992 and 1993 and 2005 and 2017

Year	Publications
1980	1
1982	1
1983	2
1985	1
1986	2
1987	1
1989	1
1990	1
1991	2
1992	3
1993	3
1994	1
1995	2
1996	2
1997	2
1998	1
2000	2
2001	1
2005	3
2006	2
2007	1
2008	2
2009	1
2011	2
2012	1
2013	1
2017	3
2023	1

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72 E. Concord St Instructional (L)
Boston MA 02118
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