Andrew W. Taylor, PhD
Associate Dean of Research
Boston University School of Medicine

PhD, Ohio State University
MS, Ohio State University

A large part of our research effort has been to characterize the immunosuppressive and immunoregulating factors within the immune privileged eye. Through immunochemical and biological analysis of aqueous humor, the fluid filling the anterior chamber of the eye, and the soluble factors produced by retinal pigment epithelial cells. We have identified several potent immunoregulating and immunosuppressing neuropeptides that:
1. Suppress macrophage-mediated inflammation.
2. Induce activation of myeloid suppressor cells
3. Alter phagocytic pathways within potential Antigen Presenting Cells.
4. Suppress the activation of effector T cells
5. Mediate the induction of antigen-specific regulatory T cells.

Our research has found constitutively present neuropeptides in the immune-privileged eye, alpha-melanocyte stimulating hormone (a-MSH), vasoactive intestinal peptide, calcitonin gene related peptide, and somatostatin. Collectively, the neuropeptides in aqueous humor suppress activation of delayed-type hypersensitivity of adaptive immunity and endotoxin activation of macrophages in innate immunity. Individually, the neuropeptides target different cells at different stages in the induction of immune responses within the immune-privileged eye.

We are finding that the activation of macrophages to pathogens within the ocular microenvironment does not promote inflammation but promotes suppressor functionality in the macrophages. These macrophages respond to pathogens without mediating inflammation or activating T cells. Moreover, the macrophages produce anti-inflammatory cytokines, suppress activation of effector T cells while promoting Treg cell activity.

As we continue to examine the mechanisms of ocular immune privilege, we further promote the importance of the interactions between the nervous and the immune systems and how we can use these interactions therapeutically to manipulate immunity to suppress autoimmune disease.

Boston University School of Medicine

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

Manipulation of Immunity to Treat Uveitis
03/01/2020 - 02/29/2024 (PI)
NIH/National Eye Institute

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 05/31/2023 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, Inc.

Initial Mechanism of Action for The Therapeutic Application of Melanocortin Receptor Agonists to Reset Immune Tolerance in EAU
10/01/2019 - 09/30/2022 (PI)
Palatin Technologies, Inc.

The role of Wnt signaling in treating glucocorticoid-induced glaucoma
09/30/2021 - 07/31/2022 (Subcontract PI)
Trustees of Indiana University NIH NEI

Manipulation of Immunity to Treat Uveitis
03/01/2016 - 02/29/2020 (PI)
NIH/National Eye Institute

Initial Mechanism of Action for The Therapeutic Application of Melanocortin Receptor Agonists to Suppress EAU
06/01/2018 - 12/31/2019 (PI)
Palatin Technologies, Inc.

The MC1R protein palmitoylation in melanoma development
09/19/2018 - 11/30/2019 (PI)
NIH/National Cancer Institute

Initial Mechanism Of Action For The Therapeutic Application Of A Melanocortin Receptor Agonists To Attenuate Retinal Damage in Diabetic Retinopathy
06/01/2017 - 12/31/2018 (PI)
Palatin Technologies, Inc.

Initial Mechanism Of Action For The Therapeutic Application Of A Melanocortin Receptor Agonists To Supress EAU
02/10/2014 - 06/30/2016 (PI)
Palatin Technologies, Inc.


Yr Title Project-Sub Proj Pubs
2022 Manipulation of Immuity to Treat Uveitis 5R01EY025961-07
2021 Manipulation of Immuity to Treat Uveitis 5R01EY025961-06 6
2020 Manipulation of Immuity to Treat Uveitis 2R01EY025961-05 6
2019 The MC1R protein palmitoylation in melanoma development 5R01CA224432-02
2019 Manipulation of Immunity to Treat Uveitis 5R01EY025961-04 6
2018 Manipulation of Immunity to Treat Uveitis 5R01EY025961-03 6
2017 Manipulation of Immunity to Treat Uveitis 5R01EY025961-02 6
2016 Manipulation of Immunity to Treat Uveitis 1R01EY025961-01A1 6
2011 Neuroimmunomodulation within the eye 5R01EY010752-15 43
2010 Neuroimmunomodulation within the eye 7R01EY010752-14 43
Showing 10 of 30 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Goit RK, Taylor AW, Lo ACY. The central melanocortin system as a treatment target for obesity and diabetes: A brief overview. Eur J Pharmacol. 2022 Jun 05; 924:174956. PMID: 35430211
  2. Goit RK, Taylor AW, Lo ACY. Anti-inflammatory a-Melanocyte-Stimulating Hormone Protects Retina After Ischemia/Reperfusion Injury in Type I Diabetes. Front Neurosci. 2022; 16:799739. PMID: 35281489; PMCID: PMC8914517; DOI: 10.3389/fnins.2022.799739;
  3. Ng TF, Dawit K, Taylor AW. Melanocortin receptor agonists suppress experimental autoimmune uveitis. Exp Eye Res. 2022 May; 218:108986.View Related Profiles. PMID: 35196505; PMCID: PMC9050930; DOI: 10.1016/j.exer.2022.108986;
  4. Lužnik Marzidovšek Z, Blanco T, Sun Z, Alemi H, Ortiz G, Nakagawa H, Chauhan SK, Taylor AW, Jurkunas UV, Yin J, Dana R. The Neuropeptide Alpha-Melanocyte-Stimulating Hormone Is Critical for Corneal Endothelial Cell Protection and Graft Survival after Transplantation. Am J Pathol. 2022 02; 192(2):270-280. PMID: 34774519; PMCID: PMC8908049; DOI: 10.1016/j.ajpath.2021.10.016;
  5. Goit RK, Ng TC, Tam KC, Tsang JKW, Taylor AW, Lo ACY. Neuropeptide a-Melanocyte-Stimulating Hormone Promotes Neurological Recovery and Repairs Cerebral Ischemia/Reperfusion Injury in Type 1 Diabetes. Neurochem Res. 2022 Feb; 47(2):394-408. PMID: 34586586
  6. Lee DJ, Xu H, Taylor AW. Editorial: Retinal Immunobiology and Retinopathy. Front Immunol. 2021; 12:758375. PMID: 34539681; PMCID: PMC8440985; DOI: 10.3389/fimmu.2021.758375;
  7. Taylor AW, Hsu S, Ng TF. The Role of Retinal Pigment Epithelial Cells in Regulation of Macrophages/Microglial Cells in Retinal Immunobiology. Front Immunol. 2021; 12:724601.View Related Profiles. PMID: 34484232; PMCID: PMC8414138; DOI: 10.3389/fimmu.2021.724601;
  8. Taylor AW. Tailoring immune cell behavior to stop autoimmune disease. EBioMedicine. 2021 08; 70:103516. PMID: 34364167; PMCID: PMC8350449; DOI: 10.1016/j.ebiom.2021.103516;
  9. Sanjiv N, Osathanugrah P, Fraser E, Ng TF, Taylor AW. Extracellular Soluble Membranes from Retinal Pigment Epithelial Cells Mediate Apoptosis in Macrophages. Cells. 2021 05 13; 10(5).View Related Profiles. PMID: 34068205; PMCID: PMC8153131; DOI: 10.3390/cells10051193;
  10. Ng TF, Manhapra A, Cluckey D, Choe Y, Vajram S, Taylor AW. Melanocortin 5 Receptor Expression and Recovery of Ocular Immune Privilege after Uveitis. Ocul Immunol Inflamm. 2022 May 19; 30(4):876-886.View Related Profiles. PMID: 33617397; PMCID: PMC8380264; DOI: 10.1080/09273948.2020.1849735;
Showing 10 of 105 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 105 publications over 33 distinct years, with a maximum of 8 publications in 2000


2019-2024 Association for Research In Vision and Ophthalmology (ARVO): Elected Immunology Member of the Board of Trustees
2019 Association of American Medical Colleges (AAMC): GRAND Steering Committee Member
2015 Association for Research In Vision and Ophthalmology (ARVO): Gold Fellow, an honor to recognize individual members accomplishments, and leadership
2014-2018 NIH: DPVS Study Section Member
2011-2011 Association for Research In Vision and Ophthalmology (ARVO): Elected position for 3 years on the Annual Program Committee for the ARVO annual meeting representin
2010-2015 Association for Research In Vision and Ophthalmology (ARVO): Silver Fellow, an honor established to recognize current ARVO members for their individual accomplis

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72 E. Concord St Instructional (L)
Boston MA 02118
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