Andrew Taylor | Profiles RNS

Andrew W. Taylor, PhD

Associate Dean of Research

Boston University Chobanian & Avedisian School of Medicine

PhD, Ohio State University
MS, Ohio State University
BS, University of Wisconsin Madison

Pronouns: he/him/his

Websites

	BUSM Research
	Ophthalmology Faculty
	Immunology Training Program Faculty
	LinkedIn
	ResearchGate

ORCID : 0000-0002-0330-8591

A large part of our research effort has been to characterize the immunosuppressive and immunoregulating factors within the immune privileged eye. Through immunochemical and biological analysis of aqueous humor, the fluid filling the anterior chamber of the eye, and the soluble factors produced by retinal pigment epithelial cells. We have identified several potent immunoregulating and immunosuppressing neuropeptides that:
1. Suppress macrophage-mediated inflammation.
2. Induce activation of myeloid suppressor cells
3. Alter phagocytic pathways within potential Antigen Presenting Cells.
4. Suppress the activation of effector T cells
5. Mediate the induction of antigen-specific regulatory T cells.

Our research has found constitutively present neuropeptides in the immune-privileged eye, alpha-melanocyte stimulating hormone (a-MSH), vasoactive intestinal peptide, calcitonin gene related peptide, and somatostatin. Collectively, the neuropeptides in aqueous humor suppress activation of delayed-type hypersensitivity of adaptive immunity and endotoxin activation of macrophages in innate immunity. Individually, the neuropeptides target different cells at different stages in the induction of immune responses within the immune-privileged eye.

We are finding that the activation of macrophages to pathogens within the ocular microenvironment does not promote inflammation but promotes suppressor functionality in the macrophages. These macrophages respond to pathogens without mediating inflammation or activating T cells. Moreover, the macrophages produce anti-inflammatory cytokines, suppress activation of effector T cells while promoting Treg cell activity.

As we continue to examine the mechanisms of ocular immune privilege, we further promote the importance of the interactions between the nervous and the immune systems and how we can use these interactions therapeutically to manipulate immunity to suppress autoimmune disease.

Diversity, Equity, Inclusion and Accessibility

In science, each researcher brings their unique intellectual curiosity to a project needed for discovery to move into new directions, have strong results, and achieve benefits for all. As a scientist leading a lab and a medical school leader, I extend this to how I conduct myself to train students and fellows and work with my colleagues and collaborators and in my personal life. I firmly believe that we should strive to build communities of individuals with diverse backgrounds and life experiences, free of discrimination based on racial, ethnic, gender, sexual orientation, or social economic status. Also, it means that I want to work within and for a diverse and inclusive research environment and academic institution and work to sustain this creative environment.

As Associate Dean for Research, I have been able to contribute to building our diverse and inclusive medical school by sponsoring two Mid-Career Faculty Leadership Programs that evaluated and provided recommendations on faculty understanding of resources for under-representative groups in research and on what resources we can create and improve to sustain our inclusive environment. The result has been for my office to work with the Faculty Affairs Office to establish two new career development programs that include matching faculty with mentors and resources for faculty that identify as a member of an under-representative group in research. We hope this new initiative will grow and encompass all faculty to have the resources to thrive and be successful with the knowledge that we all belong, free of bias and discrimination.

Sarkis J. Kechejian, MD Professor
Boston University Chobanian & Avedisian School of Medicine
Ophthalmology

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Study of the potential therapeutic use of Purified Cortrophin Gel for uveitis
05/08/2023 - 05/07/2024 (PI)
ANI Pharmaceuticals, Inc.

Manipulation of Immunity to Treat Uveitis
03/01/2020 - 02/29/2024 (PI)
NIH/National Eye Institute
5R01EY025961-08

Initial Mechanism of Action for The Therapeutic Application of Melanocortin Receptor Agonists to Reset Immune Tolerance in EAU
10/01/2019 - 12/31/2023 (PI)
Palatin Technologies, Inc.

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 08/31/2023 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, Inc.

The role of Wnt signaling in treating glucocorticoid-induced glaucoma
09/30/2021 - 07/31/2023 (Subcontract PI)
Trustees of Indiana University NIH NEI
5R01EY031700-02

Manipulation of Immunity to Treat Uveitis
03/01/2016 - 02/29/2020 (PI)
NIH/National Eye Institute
5R01EY025961-04

Initial Mechanism of Action for The Therapeutic Application of Melanocortin Receptor Agonists to Suppress EAU
06/01/2018 - 12/31/2019 (PI)
Palatin Technologies, Inc.

The MC1R protein palmitoylation in melanoma development
09/19/2018 - 11/30/2019 (PI)
NIH/National Cancer Institute
5R01CA224432-02

Initial Mechanism Of Action For The Therapeutic Application Of A Melanocortin Receptor Agonists To Attenuate Retinal Damage in Diabetic Retinopathy
06/01/2017 - 12/31/2018 (PI)
Palatin Technologies, Inc.

Initial Mechanism Of Action For The Therapeutic Application Of A Melanocortin Receptor Agonists To Supress EAU
02/10/2014 - 06/30/2016 (PI)
Palatin Technologies, Inc.

Title

Yr	Title	Project-Sub Proj	Pubs
2023	Manipulation of Immuity to Treat Uveitis	5R01EY025961-08
2022	Manipulation of Immuity to Treat Uveitis	5R01EY025961-07
2021	Manipulation of Immuity to Treat Uveitis	5R01EY025961-06	6
2020	Manipulation of Immuity to Treat Uveitis	2R01EY025961-05	6
2019	The MC1R protein palmitoylation in melanoma development	5R01CA224432-02
2019	Manipulation of Immunity to Treat Uveitis	5R01EY025961-04	6
2018	Manipulation of Immunity to Treat Uveitis	5R01EY025961-03	6
2017	Manipulation of Immunity to Treat Uveitis	5R01EY025961-02	6
2016	Manipulation of Immunity to Treat Uveitis	1R01EY025961-01A1	6
2011	Neuroimmunomodulation within the eye	5R01EY010752-15	43

Showing 10 of 31 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Tao Q, Zhang C, Mercier G, Lunetta K, Ang TFA, Akhter-Khan S, Zhang Z, Taylor A, Killiany RJ, Alosco M, Mez J, Au R, Zhang X, Farrer LA, Qiu WWQ. Identification of an APOE e4-specific blood-based molecular pathway for Alzheimer's disease risk. Alzheimers Dement (Amst). 2023; 15(4):e12490.View Related Profiles.

Taylor, Andrew
Mercier, Gustavo
Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Alosco, Michael
Tao, Qiushan
Au, Rhoda
Ang, Ting Fang Alvin

PMID: 37854772; PMCID: PMC10579631; DOI: 10.1002/dad2.12490;

Rinne P, Taylor AW, Montero-Melendez T. Editorial: Melanocortins and melanocortin receptors in the regulation of inflammation: mechanisms and novel therapeutic strategies. Front Immunol. 2023; 14:1226886. PMID: 37325641; PMCID: PMC10265466; DOI: 10.3389/fimmu.2023.1226886;

Ng TF, Taylor AW. Stimulating the Melanocortin System in Uveitis and Diabetes Preserves the Structure and Anti-Inflammatory Activity of the Retina. Int J Mol Sci. 2023 Apr 08; 24(8). PMID: 37108092; PMCID: PMC10138492; DOI: 10.3390/ijms24086928;

Goit RK, Taylor AW, Lo ACY. The central melanocortin system as a treatment target for obesity and diabetes: A brief overview. Eur J Pharmacol. 2022 Jun 05; 924:174956. PMID: 35430211

Goit RK, Taylor AW, Lo ACY. Anti-inflammatory a-Melanocyte-Stimulating Hormone Protects Retina After Ischemia/Reperfusion Injury in Type I Diabetes. Front Neurosci. 2022; 16:799739. PMID: 35281489; PMCID: PMC8914517; DOI: 10.3389/fnins.2022.799739;

Ng TF, Dawit K, Taylor AW. Melanocortin receptor agonists suppress experimental autoimmune uveitis. Exp Eye Res. 2022 May; 218:108986.View Related Profiles.

Taylor, Andrew
Dawit, Kaleb
Ng, Tatfong

PMID: 35196505; PMCID: PMC9050930; DOI: 10.1016/j.exer.2022.108986;

Lužnik Marzidovšek Z, Blanco T, Sun Z, Alemi H, Ortiz G, Nakagawa H, Chauhan SK, Taylor AW, Jurkunas UV, Yin J, Dana R. The Neuropeptide Alpha-Melanocyte-Stimulating Hormone Is Critical for Corneal Endothelial Cell Protection and Graft Survival after Transplantation. Am J Pathol. 2022 02; 192(2):270-280. PMID: 34774519; PMCID: PMC8908049; DOI: 10.1016/j.ajpath.2021.10.016;

Goit RK, Ng TC, Tam KC, Tsang JKW, Taylor AW, Lo ACY. Neuropeptide a-Melanocyte-Stimulating Hormone Promotes Neurological Recovery and Repairs Cerebral Ischemia/Reperfusion Injury in Type 1 Diabetes. Neurochem Res. 2022 Feb; 47(2):394-408. PMID: 34586586

Lee DJ, Xu H, Taylor AW. Editorial: Retinal Immunobiology and Retinopathy. Front Immunol. 2021; 12:758375. PMID: 34539681; PMCID: PMC8440985; DOI: 10.3389/fimmu.2021.758375;

Taylor AW, Hsu S, Ng TF. The Role of Retinal Pigment Epithelial Cells in Regulation of Macrophages/Microglial Cells in Retinal Immunobiology. Front Immunol. 2021; 12:724601.View Related Profiles.

Taylor, Andrew
Ng, Tatfong

PMID: 34484232; PMCID: PMC8414138; DOI: 10.3389/fimmu.2021.724601;

Showing 10 of 108 results. Show More

Taylor AW. Tailoring immune cell behavior to stop autoimmune disease. EBioMedicine. 2021 08; 70:103516. PMID: 34364167; PMCID: PMC8350449; DOI: 10.1016/j.ebiom.2021.103516;

Sanjiv N, Osathanugrah P, Fraser E, Ng TF, Taylor AW. Extracellular Soluble Membranes from Retinal Pigment Epithelial Cells Mediate Apoptosis in Macrophages. Cells. 2021 05 13; 10(5).View Related Profiles.

Taylor, Andrew
Ng, Tatfong

PMID: 34068205; PMCID: PMC8153131; DOI: 10.3390/cells10051193;

Ng TF, Manhapra A, Cluckey D, Choe Y, Vajram S, Taylor AW. Melanocortin 5 Receptor Expression and Recovery of Ocular Immune Privilege after Uveitis. Ocul Immunol Inflamm. 2022 May 19; 30(4):876-886.View Related Profiles.

Taylor, Andrew
Ng, Tatfong

PMID: 33617397; PMCID: PMC8380264; DOI: 10.1080/09273948.2020.1849735;

Lužnik Z, Sun Z, Nakagawa H, Taylor AW, Jurkunas UV, Yin J, Dana R. Association of a-Melanocyte-Stimulating Hormone With Corneal Endothelial Cell Survival During Oxidative Stress and Inflammation-Induced Cell Loss in Donor Tissue. JAMA Ophthalmol. 2020 11 01; 138(11):1192-1195. PMID: 32940642; PMCID: PMC7499243; DOI: 10.1001/jamaophthalmol.2020.3413;

Spana C, Taylor AW, Yee DG, Makhlina M, Yang W, Dodd J. Probing the Role of Melanocortin Type 1 Receptor Agonists in Diverse Immunological Diseases. Front Pharmacol. 2018; 9:1535. PMID: 30692924; PMCID: PMC6339910; DOI: 10.3389/fphar.2018.01535;

Benque IJ, Xia P, Shannon R, Ng TF, Taylor AW. The Neuropeptides of Ocular Immune Privilege, a-MSH and NPY, Suppress Phagosome Maturation in Macrophages. Immunohorizons. 2018 Nov; 2(10):314-323.View Related Profiles.

Taylor, Andrew
Xia, Pu
Ng, Tatfong

PMID: 30613828; PMCID: PMC6319950; DOI: 10.4049/immunohorizons.1800049;

Taylor AW, Ng TF. Negative regulators that mediate ocular immune privilege. J Leukoc Biol. 2018 Feb 12.View Related Profiles.

Taylor, Andrew
Ng, Tatfong

PMID: 29431864; PMCID: PMC6240388; DOI: 10.1002/JLB.3MIR0817-337R;

Wang E, Choe Y, Ng TF, Taylor AW. Retinal Pigment Epithelial Cells Suppress Phagolysosome Activation in Macrophages. Invest Ophthalmol Vis Sci. 2017 Feb 01; 58(2):1266-1273.View Related Profiles.

Taylor, Andrew
Ng, Tatfong

PMID: 28241314; PMCID: PMC5341620; DOI: 10.1167/iovs.16-21082;

Taylor AW. Reference Module in Neuroscience and Biobehavioral Psychology. Immunosuppressive and Anti-inflammatory Molecules That Maintain Immune Privilege of the Eye. 2017. View Publication

Lee DJ, Preble J, Lee S, Foster CS, Taylor AW. MC5r and A2Ar Deficiencies During Experimental Autoimmune Uveitis Identifies Distinct T cell Polarization Programs and a Biphasic Regulatory Response. Sci Rep. 2016 11 25; 6:37790. PMID: 27886238; PMCID: PMC5122918; DOI: 10.1038/srep37790;

Taylor AW. Ocular Immune Privilege and Transplantation. Front Immunol. 2016; 7:37. PMID: 26904026; PMCID: PMC4744940; DOI: 10.3389/fimmu.2016.00037;

Clemson CM, Yost J, Taylor AW. The Role of Alpha-MSH as a Modulator of Ocular Immunobiology Exemplifies Mechanistic Differences between Melanocortins and Steroids. Ocul Immunol Inflamm. 2017 Apr; 25(2):179-189. PMID: 26807874; PMCID: PMC5769144; DOI: 10.3109/09273948.2015.1092560;

Lee DJ, Taylor AW. Recovery from experimental autoimmune uveitis promotes induction of antiuveitic inducible Tregs. J Leukoc Biol. 2015 Jun; 97(6):1101-9. PMID: 25877928; PMCID: PMC6608001; DOI: 10.1189/jlb.3A1014-466RR;

Taylor AW, Dixit S, Yu J. Retinal Pigment Epithelial Cell Line Suppression of Phagolysosome Activation. Int J Ophthalmol Eye Sci. 2015 Jan 29; Suppl 2(1):1-6. PMID: 25905107; PMCID: PMC4403791

Taylor AW, Yee D, Lee DJ. Investigative Ophthalmology & Visual Science. Suppression of uveitis with melanocortin receptor specific agonists. 2015.

Bennett JL, Nickerson M, Costello F, Sergott RC, Calkwood JC, Galetta SL, Balcer LJ, Markowitz CE, Vartanian T, Morrow M, Moster ML, Taylor AW, Pace TW, Frohman T, Frohman EM. Re-evaluating the treatment of acute optic neuritis. J Neurol Neurosurg Psychiatry. 2015 Jul; 86(7):799-808. PMID: 25355373; PMCID: PMC4414747; DOI: 10.1136/jnnp-2014-308185;

Ma J, Mehta M, Lam G, Cyr D, Ng TF, Hirose T, Tawansy KA, Taylor AW, Lashkari K. Influence of subretinal fluid in advanced stage retinopathy of prematurity on proangiogenic response and cell proliferation. Mol Vis. 2014; 20:881-93.View Related Profiles.

Taylor, Andrew
Mehta, Manisha

PMID: 24966660; PMCID: PMC4067231

Hsu SM, Mathew R, Taylor AW, Stein-Streilein J. Ex-vivo tolerogenic F4/80? antigen-presenting cells (APC) induce efferent CD8? regulatory T cell-dependent suppression of experimental autoimmune uveitis. Clin Exp Immunol. 2014 Apr; 176(1):37-48. PMID: 24266626; PMCID: PMC3958152; DOI: 10.1111/cei.12243;

Lee DJ, Taylor AW. Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice. J Immunol. 2013 Oct 15; 191(8):4103-11.View Related Profiles.

Taylor, Andrew
Lee, Darren

PMID: 24043903; PMCID: PMC3796047; DOI: 10.4049/jimmunol.1300182;

Taylor AW. Alpha-melanocyte stimulating hormone (a-MSH) is a post-caspase suppressor of apoptosis in RAW 264.7 macrophages. PLoS One. 2013; 8(8):e74488. PMID: 24009773; PMCID: PMC3757010; DOI: 10.1371/journal.pone.0074488;

Phan TA, Taylor AW. The neuropeptides a-MSH and NPY modulate phagocytosis and phagolysosome activation in RAW 264.7 cells. J Neuroimmunol. 2013 Jul 15; 260(1-2):9-16. PMID: 23689030; PMCID: PMC3679250; DOI: 10.1016/j.jneuroim.2013.04.019;

Taylor AW. Primary Open-Angle Glaucoma: A Transforming Growth Factor-ß Pathway-Mediated Disease. Am J Pathol. 2012 Jun; 180(6):2201-4. PMID: 22525463; PMCID: PMC3378912; DOI: 10.1016/j.ajpath.2012.03.011;

Lee DJ, Taylor AW. Following EAU recovery there is an associated MC5r-dependent APC induction of regulatory immunity in the spleen. Invest Ophthalmol Vis Sci. 2011; 52(12):8862-7.View Related Profiles.

Taylor, Andrew
Lee, Darren

PMID: 21989727; PMCID: PMC3231841; DOI: 10.1167/iovs.11-8153;

Taylor AW, Lee DJ. The alpha-melanocyte stimulating hormone induces conversion of effector T cells into treg cells. J Transplant. 2011; 2011:246856.View Related Profiles.

Taylor, Andrew
Lee, Darren

PMID: 21941624; PMCID: PMC3175390; DOI: 10.1155/2011/246856;

Streilein JW, Taylor AW. Therapeutic Immunosuppression. Local Immunosuppression: The Eye. 2011; 275-321. View Publication

Taylor AW, Kaplan HJ. Ocular immune privilege in the year 2010: ocular immune privilege and uveitis. Ocul Immunol Inflamm. 2010 Dec; 18(6):488-92. PMID: 21091058; PMCID: PMC3329254; DOI: 10.3109/09273948.2010.525730;

Kawanaka N, Taylor AW. Localized retinal neuropeptide regulation of macrophage and microglial cell functionality. J Neuroimmunol. 2011 Mar; 232(1-2):17-25. PMID: 20965575; PMCID: PMC3030990; DOI: 10.1016/j.jneuroim.2010.09.025;

Ly LV, Bronkhorst IH, van Beelen E, Vrolijk J, Taylor AW, Versluis M, Luyten GP, Jager MJ. Inflammatory cytokines in eyes with uveal melanoma and relation with macrophage infiltration. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5445-51. PMID: 20538984; PMCID: PMC3261048; DOI: 10.1167/iovs.10-5526;

Taylor AW, Lee D. Applications of the role of a-MSH in ocular immune privilege. Adv Exp Med Biol. 2010; 681:143-9. PMID: 21222267; PMCID: PMC3329275; DOI: 10.1007/978-1-4419-6354-3_12;

Lee DJ, Taylor AW. Characterization of Naturally Emerging Post-EAU Regulatory T Cells. Clinical Immunology. 2010; 135. View Publication
Jager MJ, Ly LV, Van Beelen E, Bronkhorst IHG, Versluis M, Taylor AW, Luyten GPM. Cytokines in enucleated eyes. Acta ophthalmologica. 2010; 88(s246). View Publication

Lau CH, Taylor AW. The immune privileged retina mediates an alternative activation of J774A.1 cells. Ocul Immunol Inflamm. 2009 Nov-Dec; 17(6):380-9. PMID: 20001256; PMCID: PMC4698149; DOI: 10.3109/09273940903118642;

Hamrah P, Haskova Z, Taylor AW, Zhang Q, Ksander BR, Dana MR. Local treatment with alpha-melanocyte stimulating hormone reduces corneal allorejection. Transplantation. 2009 Jul 27; 88(2):180-7. PMID: 19623012; PMCID: PMC2735785; DOI: 10.1097/TP.0b013e3181ac11ea;

Lee DJ, Biros DJ, Taylor AW. Injection of an alpha-melanocyte stimulating hormone expression plasmid is effective in suppressing experimental autoimmune uveitis. Int Immunopharmacol. 2009 Aug; 9(9):1079-86.View Related Profiles.

Taylor, Andrew
Lee, Darren

PMID: 19426838; PMCID: PMC2754155; DOI: 10.1016/j.intimp.2009.05.001;

Taylor AW. Ocular immune privilege. Eye (Lond). 2009 Oct; 23(10):1885-9. PMID: 19136922; PMCID: PMC4698145; DOI: 10.1038/eye.2008.382;

Taylor AW. Review of the activation of TGF-beta in immunity. J Leukoc Biol. 2009 Jan; 85(1):29-33. PMID: 18818372; PMCID: PMC3188956; DOI: 10.1189/jlb.0708415;

Li D, Taylor AW. Diminishment of alpha-MSH anti-inflammatory activity in MC1r siRNA-transfected RAW264.7 macrophages. J Leukoc Biol. 2008 Jul; 84(1):191-8. PMID: 18388300; PMCID: PMC3178503; DOI: 10.1189/jlb.0707463;

Taylor AW, Kitaichi N. The diminishment of experimental autoimmune encephalomyelitis (EAE) by neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH) therapy. Brain Behav Immun. 2008 Jul; 22(5):639-46. PMID: 18171609; PMCID: PMC3337335; DOI: 10.1016/j.bbi.2007.11.001;

Taylor AW, Ku NO, Mortensen RF. Both human IL-1 and IL-6 induce synthesis of C-reactive protein (CRP) by the PLC/PRF/5 hepatoma cell line. Annals of the New York Academy of Sciences. 2008; 557(1):532-533. View Publication

Ng TF, Kitaichi N, Taylor AW. In vitro generated autoimmune regulatory T cells enhance intravitreous allogeneic retinal graft survival. Invest Ophthalmol Vis Sci. 2007 Nov; 48(11):5112-7.View Related Profiles.

Taylor, Andrew
Ng, Tatfong

PMID: 17962463

Shen L, Barabino S, Taylor AW, Dana MR. Effect of the ocular microenvironment in regulating corneal dendritic cell maturation. Arch Ophthalmol. 2007 Jul; 125(7):908-15. PMID: 17620569; PMCID: PMC4698151; DOI: 10.1001/archopht.125.7.908;

Ng TF, Lavik E, Keino H, Taylor AW, Langer RS, Young MJ. Creating an immune-privileged site using retinal progenitor cells and biodegradable polymers. Stem Cells. 2007 Jun; 25(6):1552-9.View Related Profiles.

Taylor, Andrew
Ng, Tatfong

PMID: 17548532

Zamiri P, Masli S, Kitaichi N, Taylor AW, Streilein JW. Thrombospondin plays a vital role in the immune privilege of the eye. 2005. Ocul Immunol Inflamm. 2007 May-Jun; 15(3):279-94.View Related Profiles.

Taylor, Andrew
Masli, Sharmila

PMID: 17613842

Taylor AW, Alard P, Yee DG, Streilein JW. Aqueous humor induces transforming growth factor-beta (TGF-beta)-producing regulatory T-cells. 1997. Ocul Immunol Inflamm. 2007 May-Jun; 15(3):215-24. PMID: 17613836

Taylor AW. Ocular immunosuppressive microenvironment. Chem Immunol Allergy. 2007; 92:71-85. PMID: 17264484

Stein-Streilein J, Taylor AW. An eye's view of T regulatory cells. J Leukoc Biol. 2007 Mar; 81(3):593-8. PMID: 17194735

Zamiri P, Masli S, Streilein JW, Taylor AW. Pigment epithelial growth factor suppresses inflammation by modulating macrophage activation. Invest Ophthalmol Vis Sci. 2006 Sep; 47(9):3912-8.View Related Profiles.

Taylor, Andrew
Masli, Sharmila

PMID: 16936104

Biros DJ, Namba K, Taylor AW. Alpha-MSH regulates protein ubiquitination in T cells. Cell Mol Biol (Noisy-le-grand). 2006; 52(2):33-8. PMID: 16914084; PMCID: PMC4698146

Taylor AW, Kitaichi N, Biros D. Melanocortin 5 receptor and ocular immunity. Cell Mol Biol (Noisy-le-grand). 2006; 52(2):53-9. PMID: 16914087

Taylor AW. Alpha-melanocyte stimulating hormone and the melanocortin receptors. Cellular and molecular biology. 2006; 52(2). View Publication

Taylor AW. The immunomodulating neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) suppresses LPS-stimulated TLR4 with IRAK-M in macrophages. J Neuroimmunol. 2005 May; 162(1-2):43-50. PMID: 15833358; PMCID: PMC4698338; DOI: 10.1016/j.jneuroim.2005.01.008;

Zamiri P, Masli S, Kitaichi N, Taylor AW, Streilein JW. Thrombospondin plays a vital role in the immune privilege of the eye. Invest Ophthalmol Vis Sci. 2005 Mar; 46(3):908-19.View Related Profiles.

Taylor, Andrew
Masli, Sharmila

PMID: 15728547

Kitaichi N, Namba K, Taylor AW. Inducible immune regulation following autoimmune disease in the immune-privileged eye. J Leukoc Biol. 2005 Apr; 77(4):496-502. PMID: 15647326; PMCID: PMC1363364; DOI: 10.1189/jlb.0204114;

Lau CH, Taylor AW. Clinical Immunology. Mechanisms of retinal immune privilege. 2005.

Nishida T, Miyata S, Itoh Y, Mizuki N, Ohgami K, Shiratori K, Ilieva IB, Ohno S, Taylor AW. Anti-inflammatory effects of alpha-melanocyte-stimulating hormone against rat endotoxin-induced uveitis and the time course of inflammatory agents in aqueous humor. Int Immunopharmacol. 2004 Aug; 4(8):1059-66. PMID: 15222980

Taylor AW, Yee DG. Somatostatin is an immunosuppressive factor in aqueous humor. Invest Ophthalmol Vis Sci. 2003 Jun; 44(6):2644-9. PMID: 12766068

Taylor AW. Modulation of regulatory T cell immunity by the neuropeptide alpha-melanocyte stimulating hormone. Cell Mol Biol (Noisy-le-grand). 2003 Mar; 49(2):143-9. PMID: 12887097

Kitaichi N, Kotake S, Morohashi T, Onoé K, Ohno S, Taylor AW. Diminution of experimental autoimmune uveoretinitis (EAU) in mice depleted of NK cells. J Leukoc Biol. 2002 Dec; 72(6):1117-21. PMID: 12488492

Namba K, Kitaichi N, Nishida T, Taylor AW. Induction of regulatory T cells by the immunomodulating cytokines alpha-melanocyte-stimulating hormone and transforming growth factor-beta2. J Leukoc Biol. 2002 Nov; 72(5):946-52. PMID: 12429716

Streilein JW, Ohta K, Mo JS, Taylor AW. Ocular immune privilege and the impact of intraocular inflammation. DNA Cell Biol. 2002 May-Jun; 21(5-6):453-9. PMID: 12167248

Liu Y, Hamrah P, Zhang Q, Taylor AW, Dana MR. Draining lymph nodes of corneal transplant hosts exhibit evidence for donor major histocompatibility complex (MHC) class II-positive dendritic cells derived from MHC class II-negative grafts. J Exp Med. 2002 Jan 21; 195(2):259-68. PMID: 11805152; PMCID: PMC2193609

Taylor AW. Neuroimmunomodulation and immune privilege: the role of neuropeptides in ocular immunosuppression. Neuroimmunomodulation. 2002-2003; 10(4):189-98. PMID: 12584406

Liu Y, Taylor AW, Dana MR. Corneal dendritic cells that migrate from corneal explants and mediate alloreactivity. Clinical Immunology. 2002; 103(3):S14.
Hamrah P, Haskova Z, Zhang Q, Taylor AW, Ksander BR, Dana MR. Investigative Ophthalmology & Visual Science. Treatment with alpha-MSH reduces corneal allorejection. 2002.

Liu Y, Dana MR, Tewari V, Taylor AW. Immune response to intragraft antigen in draining lymph nodes after corneal transplantation is mediated by interleukin-12. J Interferon Cytokine Res. 2001 Oct; 21(10):813-9. PMID: 11710993

Taylor A, Namba K. In vitro induction of CD25+ CD4+ regulatory T cells by the neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH). Immunol Cell Biol. 2001 Aug; 79(4):358-67. PMID: 11488983; DOI: 10.1046/j.1440-1711.2001.01022.x;

Ohta K, Yamagami S, Taylor AW, Streilein JW. IL-6 antagonizes TGF-beta and abolishes immune privilege in eyes with endotoxin-induced uveitis. Invest Ophthalmol Vis Sci. 2000 Aug; 41(9):2591-9. PMID: 10937571

Ohta K, Wiggert B, Yamagami S, Taylor AW, Streilein JW. Analysis of immunomodulatory activities of aqueous humor from eyes of mice with experimental autoimmune uveitis. J Immunol. 2000 Feb 1; 164(3):1185-92. PMID: 10640729

Taylor AW, Yee DG, Nishida T, Namba K. Neuropeptide regulation of immunity. The immunosuppressive activity of alpha-melanocyte-stimulating hormone (alpha-MSH). Ann N Y Acad Sci. 2000; 917:239-47. PMID: 11268350

Namba K, Stein-Streilein J, Taylor AW. Innate immune regulation of ocular autoimmune disease. Journal of Leukocyte Biology. 2000.

Streilein JW, Okamoto S, Sano Y, Taylor AW. Neural control of ocular immune privilege. Ann N Y Acad Sci. 2000; 917:297-306. PMID: 11268357

Taylor AW. Mediators of inflammatory innate immunity antagonize alpha-MSH induction of regulatory T cells. Journal of Leukocyte Biology. 2000.
Doherty JM, Mellon J, Taylor AW, Streilein JW. Modulation of corneal endothelial cell function by pro-inflammatory factors and innate immune cells. Journal of Leukocyte Biology. 2000.
Taylor AW. Principles of Molecular Regulation. T Cells and Immunosuppression. 2000; 429-436. View Publication

Nishida T, Taylor AW. Specific aqueous humor factors induce activation of regulatory T cells. Invest Ophthalmol Vis Sci. 1999 Sep; 40(10):2268-74. PMID: 10476792

Ohta K, Wiggert B, Taylor AW, Streilein JW. Effects of experimental ocular inflammation on ocular immune privilege. Invest Ophthalmol Vis Sci. 1999 Aug; 40(9):2010-8. PMID: 10440255

Yamada J, Yoshida M, Taylor AW, Streilein JW. Mice with Th2-biased immune systems accept orthotopic corneal allografts placed in "high risk" eyes. J Immunol. 1999 May 1; 162(9):5247-55. PMID: 10227999

Pena JD, Taylor AW, Ricard CS, Vidal I, Hernandez MR. Transforming growth factor beta isoforms in human optic nerve heads. Br J Ophthalmol. 1999 Feb; 83(2):209-18. PMID: 10396201; PMCID: PMC1722920

Taylor AW. Ocular immunosuppressive microenvironment. Chem Immunol. 1999; 73:72-89. PMID: 10590575

Taylor AW, Yee DG, Streilein JW. Suppression of nitric oxide generated by inflammatory macrophages by calcitonin gene-related peptide in aqueous humor. Invest Ophthalmol Vis Sci. 1998 Jul; 39(8):1372-8. PMID: 9660485

Goslings WR, Prodeus AP, Streilein JW, Carroll MC, Jager MJ, Taylor AW. A small molecular weight factor in aqueous humor acts on C1q to prevent antibody-dependent complement activation. Invest Ophthalmol Vis Sci. 1998 May; 39(6):989-95. PMID: 9579478

Taylor AW, Alard P, Yee DG, Streilein JW. Aqueous humor induces transforming growth factor-beta (TGF-beta)-producing regulatory T-cells. Curr Eye Res. 1997 Sep; 16(9):900-8. PMID: 9288451

Streilein JW, Ksander BR, Taylor AW. Immune deviation in relation to ocular immune privilege. J Immunol. 1997 Apr 15; 158(8):3557-60. PMID: 9103414

Streilein JW, Takeuchi M, Taylor AW. Immune privilege, T-cell tolerance, and tissue-restricted autoimmunity. Hum Immunol. 1997 Feb; 52(2):138-43. PMID: 9077562

Nishida T, Yee DG, Streilein JW, Taylor AW. Effect of aqueous humor treated t-cells on delayed type hyper sensitivity response. 1997.
Taylor AW. Aqueous humor induces regulatory T-cells through a time-dependent interaction of alpha-MSH and TGF-beta 2. Investigative Ophthalmology & Visual Science. 1997; 38(4):3272.

Taylor AW. Neuroimmunomodulation in immune privilege: role of neuropeptides in ocular immunosuppression. Neuroimmunomodulation. 1996 Jul-Aug; 3(4):195-204. PMID: 9094440

Taylor AW, Streilein JW. Inhibition of antigen-stimulated effector T cells by human cerebrospinal fluid. Neuroimmunomodulation. 1996 Mar-Jun; 3(2-3):112-8. PMID: 8945726

Taylor AW, Streilein JW. Aqueous humor induces effector T-cells to mediate immunosuppression. 1996.
Taylor AW, Streilein JW. Alpha-melanocyte stimulating hormone prevents induction of effector t-cell inflammatory activity. 1996.

Cagliero E, Roth T, Taylor AW, Lorenzi M. The effects of high glucose on human endothelial cell growth and gene expression are not mediated by transforming growth factor-beta. Lab Invest. 1995 Nov; 73(5):667-73. PMID: 7474940

Taylor AW, Streilein JW, Cousins SW. Immunoreactive vasoactive intestinal peptide contributes to the immunosuppressive activity of normal aqueous humor. J Immunol. 1994 Aug 1; 153(3):1080-6. PMID: 8027541

Taylor AW, Streilein JW, Cousins SW. Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon. Neuroimmunomodulation. 1994 May-Jun; 1(3):188-94. PMID: 7489333

Taylor AW, Streilein JW, Cousins SW. Identification of alpha-melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humor. Curr Eye Res. 1992 Dec; 11(12):1199-206. PMID: 1490338

Streilein JW, Wilbanks GA, Taylor A, Cousins S. Eye-derived cytokines and the immunosuppressive intraocular microenvironment: a review. Curr Eye Res. 1992; 11 Suppl:41-7. PMID: 1424750

Taylor AW, Mortensen RF. Effect of alpha-2-macroglobulin on cytokine-mediated human C-reactive protein production. Inflammation. 1991 Feb; 15(1):61-70. PMID: 1711512

Taylor AW, Ku NO, Mortensen RF. Regulation of cytokine-induced human C-reactive protein production by transforming growth factor-beta. J Immunol. 1990 Oct 15; 145(8):2507-13. PMID: 2170518

Jones LR, Taylor AW, Hines HC. Characteristics of frozen colostrum thawed in a microwave oven. J Dairy Sci. 1987 Sep; 70(9):1941-5. PMID: 3668051

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 108 publications over 34 distinct years, with a maximum of 8 publications in 2000

Bar chart showing 108 publications over 34 distinct years, with a maximum of 8 publications in 2000

Year	Publications
1987	1
1990	1
1991	1
1992	2
1994	2
1995	1
1996	4
1997	5
1998	2
1999	5
2000	8
2001	2
2002	7
2003	2
2004	1
2005	4
2006	5
2007	6
2008	4
2009	4
2010	6
2011	3
2012	1
2013	3
2014	3
2015	3
2016	3
2017	2
2018	2
2019	1
2020	1
2021	7
2022	3
2023	3

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2019-2024 Association for Research In Vision and Ophthalmology (ARVO): Elected Immunology Member of the Board of Trustees

2019 Association of American Medical Colleges (AAMC): GRAND Steering Committee Member

2015 Association for Research In Vision and Ophthalmology (ARVO): Gold Fellow, an honor to recognize individual members accomplishments, and leadership

2014-2018 NIH: DPVS Study Section Member

2011-2011 Association for Research In Vision and Ophthalmology (ARVO): Elected position for 3 years on the Annual Program Committee for the ARVO annual meeting representin

2010-2015 Association for Research In Vision and Ophthalmology (ARVO): Silver Fellow, an honor to recognize individual members accomplishments, and leadership