Keywords
Last Name

Sharmila Masli, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentOphthalmology
Address72 E. Concord St Instructional (L)
Boston MA 02118
Phone(617) 638-4581
ORCID ORCID Icon0000-0001-8612-0617
 Research Expertise & Professional Interests
The major focus of research in the laboratory is the study of molecular mechanisms utilized by ocular antigen presenting cells (APCs) to regulate inflammatory ocular immune responses. Particular focus is on elucidating the role of thrombospondin-1 (TSP-1) in regulating ocular inflammation.

Resident ocular APCs in the posterior and anterior segment of the eye depend on TSP-1 for maintaining an anti-inflammatory phenotype. In the absence of TSP-1 these APCs acquire more immunogenic phenotype. These observations are examined further to determine their role in ocular inflammation.

Induction of regulatory T cells (Treg) subset by ocular APCs is known to be a key component of ocular immune privilege. The ability of ocular APCs to induce Treg and its correlation with their expression of TSP-1 is examined in the laboratory at the level of molecular mechanisms.

The laboratory has identified spontaneous development of autoimmune Sjögren’s syndrome and related ocular inflammation in TSP-1 deficient mice that closely resembles clinical symptoms in human Sjögren’s patients. Different projects in the laboratory address immunologic mechanisms underlying disease development in these mice.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Contreras-Ruiz L, Mir FA, Turpie B, Masli S. Thrombospondin derived peptide attenuates Sjögren's syndrome-associated ocular surface inflammation in mice. Clin Exp Immunol. 2016 Dec 29. PMID: 28033649.
    View in: PubMed
  2. Shatos MA, Hodges RR, Morinaga M, McNay DE, Islam R, Bhattacharya S, Li D, Turpie B, Makarenkova HP, Masli S, Utheim TP, Dartt DA. Alteration in cellular turnover and progenitor cell population in lacrimal glands from thrombospondin 1(-/-) mice, a model of dry eye. Exp Eye Res. 2016 Dec; 153:27-41. PMID: 27697548.
    View in: PubMed
  3. Smith RE, Reyes NJ, Khandelwal P, Schlereth SL, Lee HS, Masli S, Saban DR. Secondary allergic T cell responses are regulated by dendritic cell-derived thrombospondin-1 in the setting of allergic eye disease. J Leukoc Biol. 2016 Aug; 100(2):371-80. PMID: 26856994.
    View in: PubMed
  4. Contreras-Ruiz L, Mir FA, Turpie B, Krauss AH, Masli S. Sjögren's syndrome associated dry eye in a mouse model is ameliorated by topical application of integrin a4 antagonist GW559090. Exp Eye Res. 2016 Feb; 143:1-8. PMID: 26463157.
    View in: PubMed
  5. Mir FA, Contreras-Ruiz L, Masli S. Thrombospondin-1-dependent immune regulation by transforming growth factor-ß2-exposed antigen-presenting cells. Immunology. 2015 Dec; 146(4):547-56. PMID: 26458493.
    View in: PubMed
  6. Masli S. Matricellular Proteins in Ocular Diseases. J Ocul Pharmacol Ther. 2015 Sep; 31(7):365. PMID: 26192047.
    View in: PubMed
  7. Soriano-Romaní L, Contreras-Ruiz L, García-Posadas L, López-García A, Masli S, Diebold Y. Inflammatory Cytokine-Mediated Regulation of Thrombospondin-1 and CD36 in Conjunctival Cells. J Ocul Pharmacol Ther. 2015 Sep; 31(7):419-28. PMID: 26154920.
    View in: PubMed
  8. Regenfuß B, Dreisow ML, Hos D, Masli S, Bock F, Cursiefen C. The Naïve Murine Cornea as a Model System to Identify Novel Endogenous Regulators of Lymphangiogenesis: TRAIL and rtPA. Lymphat Res Biol. 2015 Jun; 13(2):76-84. PMID: 26091403.
    View in: PubMed
  9. Terzulli M, Contreras-Ruiz L, Ruiz LC, Kugadas A, Masli S, Gadjeva M. TSP-1 Deficiency Alters Ocular Microbiota: Implications for Sjögren's Syndrome Pathogenesis. J Ocul Pharmacol Ther. 2015 Sep; 31(7):413-8. PMID: 26352162.
    View in: PubMed
  10. Contreras-Ruiz L, Masli S. Immunomodulatory cross-talk between conjunctival goblet cells and dendritic cells. PLoS One. 2015; 10(3):e0120284. PMID: 25793763.
    View in: PubMed
  11. Dartt DA, Masli S. Conjunctival epithelial and goblet cell function in chronic inflammation and ocular allergic inflammation. Curr Opin Allergy Clin Immunol. 2014 Oct; 14(5):464-70. PMID: 25061855.
    View in: PubMed
  12. Nair KS, Barbay J, Smith RS, Masli S, John SW. Determining immune components necessary for progression of pigment dispersing disease to glaucoma in DBA/2J mice. BMC Genet. 2014; 15:42. PMID: 24678736.
    View in: PubMed
  13. Contreras-Ruiz L, Ryan DS, Sia RK, Bower KS, Dartt DA, Masli S. Polymorphism in THBS1 gene is associated with post-refractive surgery chronic ocular surface inflammation. Ophthalmology. 2014 Jul; 121(7):1389-97. PMID: 24679443.
    View in: PubMed
  14. Masli S, Sheibani N, Cursiefen C, Zieske J. Matricellular protein thrombospondins: influence on ocular angiogenesis, wound healing and immuneregulation. Curr Eye Res. 2014 Aug; 39(8):759-74. PMID: 24559320.
    View in: PubMed
  15. Contreras-Ruiz L, Ghosh-Mitra A, Shatos MA, Dartt DA, Masli S. Modulation of conjunctival goblet cell function by inflammatory cytokines. Mediators Inflamm. 2013; 2013:636812. PMID: 24453426.
    View in: PubMed
  16. Contreras-Ruiz L, Regenfuss B, Mir FA, Kearns J, Masli S. Conjunctival inflammation in thrombospondin-1 deficient mouse model of Sjögren's syndrome. PLoS One. 2013; 8(9):e75937. PMID: 24086667.
    View in: PubMed
  17. Cursiefen C, Maruyama K, Bock F, Saban D, Sadrai Z, Lawler J, Dana R, Masli S. Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes. J Exp Med. 2011 May 9; 208(5):1083-92. PMID: 21536744.
    View in: PubMed
  18. Hos D, Saban DR, Bock F, Regenfuss B, Onderka J, Masli S, Cursiefen C. Suppression of inflammatory corneal lymphangiogenesis by application of topical corticosteroids. Arch Ophthalmol. 2011 Apr; 129(4):445-52. PMID: 21482870.
    View in: PubMed
  19. Masli S, Vega JL. Ocular immune privilege sites. Methods Mol Biol. 2011; 677:449-58. PMID: 20941626.
    View in: PubMed
  20. Hori J, Vega JL, Masli S. Review of ocular immune privilege in the year 2010: modifying the immune privilege of the eye. Ocul Immunol Inflamm. 2010 Oct; 18(5):325-33. PMID: 20849282.
    View in: PubMed
  21. Vega JL, Saban D, Carrier Y, Masli S, Weiner HL. Retinal pigment epithelial cells induce foxp3(+) regulatory T cells via membrane-bound TGF-ß. Ocul Immunol Inflamm. 2010 Dec; 18(6):459-69. PMID: 20887202.
    View in: PubMed
  22. Saban DR, Bock F, Chauhan SK, Masli S, Dana R. Thrombospondin-1 derived from APCs regulates their capacity for allosensitization. J Immunol. 2010 Oct 15; 185(8):4691-7. PMID: 20844200.
    View in: PubMed
  23. Turpie B, Yoshimura T, Gulati A, Rios JD, Dartt DA, Masli S. Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice. Am J Pathol. 2009 Sep; 175(3):1136-47. PMID: 19700744.
    View in: PubMed
  24. Vega JL, Keino H, Masli S. Surgical denervation of ocular sympathetic afferents decreases local transforming growth factor-beta and abolishes immune privilege. Am J Pathol. 2009 Sep; 175(3):1218-25. PMID: 19700755.
    View in: PubMed
  25. Ng TF, Turpie B, Masli S. Thrombospondin-1-mediated regulation of microglia activation after retinal injury. Invest Ophthalmol Vis Sci. 2009 Nov; 50(11):5472-8. PMID: 19494207.
    View in: PubMed
  26. Masli S, Turpie B. Anti-inflammatory effects of tumour necrosis factor (TNF)-alpha are mediated via TNF-R2 (p75) in tolerogenic transforming growth factor-beta-treated antigen-presenting cells. Immunology. 2009 May; 127(1):62-72. PMID: 18795974.
    View in: PubMed
  27. Ghafoori P, Yoshimura T, Turpie B, Masli S. Increased IkappaB alpha expression is essential for the tolerogenic property of TGF-beta-exposed APCs. FASEB J. 2009 Jul; 23(7):2226-34. PMID: 19237504.
    View in: PubMed
  28. Yang K, Vega JL, Hadzipasic M, Schatzmann Peron JP, Zhu B, Carrier Y, Masli S, Rizzo LV, Weiner HL. Deficiency of thrombospondin-1 reduces Th17 differentiation and attenuates experimental autoimmune encephalomyelitis. J Autoimmun. 2009 Mar; 32(2):94-103. PMID: 19181483.
    View in: PubMed
  29. Saban DR, Cornelius J, Masli S, Schwartzkopff J, Doyle M, Chauhan SK, Peck AB, Grant MB. The role of ACAID and CD4+CD25+FOXP3+ regulatory T cells on CTL function against MHC alloantigens. Mol Vis. 2008; 14:2435-42. PMID: 19104677.
    View in: PubMed
  30. Almulki L, Noda K, Amini R, Schering A, Garland RC, Nakao S, Nakazawa T, Hisatomi T, Thomas KL, Masli S, Hafezi-Moghadam A. Surprising up-regulation of P-selectin glycoprotein ligand-1 (PSGL-1) in endotoxin-induced uveitis. FASEB J. 2009 Mar; 23(3):929-39. PMID: 19050046.
    View in: PubMed
  31. Anderson MG, Nair KS, Amonoo LA, Mehalow A, Trantow CM, Masli S, John SW. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet. 2008; 9:30. PMID: 18402690.
    View in: PubMed
  32. Miyahara S, Almulki L, Noda K, Nakazawa T, Hisatomi T, Nakao S, Thomas KL, Schering A, Zandi S, Frimmel S, Tayyari F, Garland RC, Miller JW, Gragoudas ES, Masli S, Hafezi-Moghadam A. In vivo imaging of endothelial injury in choriocapillaris during endotoxin-induced uveitis. FASEB J. 2008 Jun; 22(6):1973-80. PMID: 18216288.
    View in: PubMed
  33. Zamiri P, Masli S, Kitaichi N, Taylor AW, Streilein JW. Thrombospondin plays a vital role in the immune privilege of the eye. 2005. Ocul Immunol Inflamm. 2007 May-Jun; 15(3):279-94. PMID: 17613842.
    View in: PubMed
  34. Zamiri P, Masli S, Streilein JW, Taylor AW. Pigment epithelial growth factor suppresses inflammation by modulating macrophage activation. Invest Ophthalmol Vis Sci. 2006 Sep; 47(9):3912-8. PMID: 16936104.
    View in: PubMed
  35. Keino H, Masli S, Sasaki S, Streilein JW, Stein-Streilein J. CD8+ T regulatory cells use a novel genetic program that includes CD103 to suppress Th1 immunity in eye-derived tolerance. Invest Ophthalmol Vis Sci. 2006 Apr; 47(4):1533-42. PMID: 16565389.
    View in: PubMed
  36. Masli S, Turpie B, Streilein JW. Thrombospondin orchestrates the tolerance-promoting properties of TGFbeta-treated antigen-presenting cells. Int Immunol. 2006 May; 18(5):689-99. PMID: 16569680.
    View in: PubMed
  37. Kim CY, Masli S, Streilein JW. Qa-1, a nonclassical MHC molecule with immunomodulatory functions, is ubiquitously expressed in the immune-privileged anterior chamber of the eye. Ocul Immunol Inflamm. 2005 Jul-Aug; 13(4):271-7. PMID: 16159717.
    View in: PubMed
  38. Zamiri P, Masli S, Kitaichi N, Taylor AW, Streilein JW. Thrombospondin plays a vital role in the immune privilege of the eye. Invest Ophthalmol Vis Sci. 2005 Mar; 46(3):908-19. PMID: 15728547.
    View in: PubMed
  39. Cursiefen C, Masli S, Ng TF, Dana MR, Bornstein P, Lawler J, Streilein JW. Roles of thrombospondin-1 and -2 in regulating corneal and iris angiogenesis. Invest Ophthalmol Vis Sci. 2004 Apr; 45(4):1117-24. PMID: 15037577.
    View in: PubMed
  40. Streilein JW, Masli S, Takeuchi M, Kezuka T. The eye's view of antigen presentation. Hum Immunol. 2002 Jun; 63(6):435-43. PMID: 12039518.
    View in: PubMed
  41. Masli S, Turpie B, Hecker KH, Streilein JW. Expression of thrombospondin in TGFbeta-treated APCs and its relevance to their immune deviation-promoting properties. J Immunol. 2002 Mar 1; 168(5):2264-73. PMID: 11859114.
    View in: PubMed
  42. Masli S, De Fazio SR, Gozzo JJ. Requirement for early donor cell chimerism during prolonged survival of murine skin allografts. Transplantation. 2000 Apr 27; 69(8):1667-75. PMID: 10836379.
    View in: PubMed
  43. Gozzo J, Masli S, De Fazio S. Extension of graft survival with pulsed administration of donor dendritic cells. Transplant Proc. 1999 Feb-Mar; 31(1-2):1196. PMID: 10083534.
    View in: PubMed
  44. Masli S, De Fazio SR, Gozzo JJ. Expression of dendritic cell markers on bone marrow cells in a fraction enriched for the ability to prolong skin allograft survival in ALS-treated murine recipients. Transplant Proc. 1997 Feb-Mar; 29(1-2):1147-8. PMID: 9123242.
    View in: PubMed
  45. De Fazio SR, Masli S, Gozzo JJ. Effect of monoclonal anti-CD4 and anti-CD8 on skin allograft survival in mice treated with donor bone marrow cells. Transplantation. 1996 Jan 15; 61(1):104-10. PMID: 8560547.
    View in: PubMed
  46. Khouri W, Masli S, De Fazio SR, Gozzo JJ. Effect of asialofetuin on prolongation of skin allograft survival by donor bone marrow cells. Transplantation. 1994 Feb; 57(3):440-6. PMID: 7509090.
    View in: PubMed
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