Ali Guermazi, MD, PhD
Boston University School of Medicine
Dept of Radiology
Musculoskeletal Radiology

MD, University of Sfax
PhD, Jikei University School of Medicine

Dr. Guermazi is a French board-certified radiologist. Prior to joining Boston University, he was Director of the Osteoporosis and Arthritis Research Group (OARG) at University of California at San Francisco (UCSF) and then Director of Clinical Research at Synarc, Inc. in San Francisco. Dr. Guermazi interest is musculoskeletal diseases, in particular note are his scientific contributions in the diagnosis and disease progression assessment of osteoarthritis using MRI. His work has focused on identifying structural risk factors for developing and worsening osteoarthritis. Dr. Guermazi had been involved in developing several original and widely accepted radiological methods to assess osteoarthritis disease risk and progression, including the WORMS, BLOKS and MOAKS for the knee, HOAMS for the hip and fixed-flexion radiography for measuring joint space width. Dr. Guermazi has been involved as an MRI reader for the past 14 years in several large U.S. studies including the Health Aging and Body Composition (Health ABC) study, the Boston Osteoarthritis Knee study (BOKS), the Multi-center Osteoarthritis STudy (MOST), the Framingham study, Osteoarthritis Initiative (OAI), and other large NIH-funded studies, as well as several Pharmaceutical-sponsored clinical trials. He is author of over 275 peer-reviewed publications and Investigator on numerous research grants related to MRI reading for Osteoarthritis.

Section Chief
Boston University School of Medicine
Musculoskeletal Radiology

Assistant Dean
Boston University School of Medicine
Diversity & Inclusion

Boston University School of Medicine

Partial Meniscectomy vs. Nonoperative Mgmt. in Meniscal Tear with OA: an RCT
09/05/2020 - 08/31/2024 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NIAMS

Gadolinium Distribution in Rat Brain After Systemic Administration of Gadolinium-Based Contrast Agents
10/01/2016 - 10/01/2019 (Co-Investigator)
PI: Lee E. Goldstein, MD, PhD
GE Healthcare, Inc.

Characterizing Electrostatic Interactions Between Glycosaminoglycans and Cationic Small Molecules
03/05/2012 - 01/31/2017 (Multi-PI)
PI: Ali Guermazi, MD, PhD
NIH/National Institutes of Health

Evaluation of Feasibility of Volume Rad X-Ray Versus Conventional X-Ray and 3.0T MRI in Bi-Lateral Knees in With and Without Osteoarthritis
02/01/2009 - 04/30/2010 (PI)
General Electric Company

Tracking Treatable Tissues: Change in qMRI Biomarkers and Future Cartilage Loss
09/15/2017 - 06/30/2022 (PI)
University of Arizona NIH-NIAMS

Risk of Incident Knee OA and Clinical Outcomes Based on Imaging Biomarkers
09/15/2014 - 08/01/2019 (PI)
University of Arizona NIH-NIAMS

Partial Meniscectomy vs Nonoperative Management in Meniscal Tear with OA: a RCT
08/01/2012 - 07/31/2017 (PI)
Brigham & Women's NIH-NIAMS

Mechanisms and Clinical Importance of Hyperkyphosis: The Framingham Study
09/30/2011 - 08/31/2016 (PI)
Hebrew Rehab C Aged NIH-NIA

Partial meniscectomy vs. nonperative management in meniscal tear with OA: an RCT
09/28/2009 - 09/27/2013 (PI)
Brigham & Women's NIH-NIAMS

Central Reading of Knee MRI in Osteroarthritis Patients
11/01/2008 - 10/31/2011 (PI)
Arthritis Centre of Canada

Osteoartritis Initiave WORMS - BLOKS Comparison Study
04/01/2008 - 10/14/2009 (PI)
Univ of California, San Francisco NIH-NIAMS

Development for a model for the MRI progression of knee osteoarthritis
03/01/2007 - 02/28/2009 (PI)
Arthritis Centre of Canada University of Britis


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Hayashi D, Kompel AJ, Ventre J, Ducarouge A, Nguyen T, Regnard NE, Guermazi A. Automated detection of acute appendicular skeletal fractures in pediatric patients using deep learning. Skeletal Radiol. 2022 May 06.View Related Profiles. PMID: 35522332
  2. Takkal S, Diaz L, Manuel D, Huang Q, Guermazi A. Correction to: Concomitant lipoma arborescens and synovial osteochondromatosis of the knee. Skeletal Radiol. 2022 Apr 25.View Related Profiles. PMID: 35467130
  3. Tedeschi SK, Becce F, Pascart T, Guermazi A, Budzik JF, Dalbeth N, Filippou G, Iagnocco A, Kohler MJ, Laredo JD, Smith SE, Simeone FJ, Yinh J, Choi H, Abhishek A. Imaging features of calcium pyrophosphate deposition (CPPD) disease: consensus definitions from an international multidisciplinary working group. Arthritis Care Res (Hoboken). 2022 Apr 19. PMID: 35439343
  4. Takkal S, Diaz L, Manuel D, Huang Q, Guermazi A. Concomitant lipoma arborescens and synovial osteochondromatosis of the knee. Skeletal Radiol. 2022 Apr 13.View Related Profiles. PMID: 35416508
  5. Pishgar F, Ashraf-Ganjouei A, Dolatshahi M, Guermazi A, Zikria B, Cao X, Wan M, Roemer FW, Dam E, Demehri S. Conventional MRI-derived subchondral trabecular biomarkers and their association with knee cartilage volume loss as early as 1 year: a longitudinal analysis from Osteoarthritis Initiative. Skeletal Radiol. 2022 Apr 02. PMID: 35366094
  6. Neogi T, Hunter DJ, Churchill M, Shirinsky I, White A, Guermazi A, Omata M, Fountaine RJ, Pixton G, Viktrup L, Brown MT, West CR, Verburg KM. Observed efficacy and clinically important improvements in participants with osteoarthritis treated with subcutaneous tanezumab: results from a 56-week randomized NSAID-controlled study. Arthritis Res Ther. 2022 Mar 29; 24(1):78.View Related Profiles. PMID: 35351194; PMCID: PMC8966257; DOI: 10.1186/s13075-022-02759-0;
  7. Murphy MT, Wang N, Felson DT, Nevitt MC, Lewis CE, Frey-Law L, Guermazi A, Segal NA. Association between hamstring coactivation during isokinetic quadriceps strength testing and knee cartilage worsening over 24 months. Osteoarthritis Cartilage. 2022 Jun; 30(6):823-831.View Related Profiles. PMID: 35307535
  8. Collins JE, Shrestha S, Losina E, Marx RG, Guermazi A, Jarraya M, Jones MH, Levy BA, Mandl LA, Williams EE, Wright RW, Spindler KP, Katz JN. Five-Year Structural Changes in Patients with Meniscal Tear and Osteoarthritis: Data from an RCT of Arthroscopic Partial Meniscectomy vs. Physical Therapy. Arthritis Rheumatol. 2022 Mar 04.View Related Profiles. PMID: 35245416
  9. Messier SP, Newman JJ, Scarlett MJ, Mihalko SL, Miller GD, Nicklas BJ, DeVita P, Hunter DJ, Lyles MF, Eckstein F, Guermazi A, Loeser RF, Beavers DP. Changes in Body Weight and Knee Pain in Adults With Knee Osteoarthritis Three-and-a-Half Years After Completing Diet and Exercise Interventions: Follow-Up Study for a Single-Blind, Single-Center, Randomized Controlled Trial. Arthritis Care Res (Hoboken). 2022 04; 74(4):607-616. PMID: 34369105; PMCID: PMC8825890; DOI: 10.1002/acr.24765;
  10. Roemer FW, Felson DT, Stefanik JJ, Rabasa G, Wang N, Crema MD, Neogi T, Nevitt MC, Torner J, Lewis CE, Peloquin C, Guermazi A. Heterogeneity of cartilage damage in Kellgren and Lawrence grade 2 and 3 knees: the MOST study. Osteoarthritis Cartilage. 2022 May; 30(5):714-723.View Related Profiles. PMID: 35202808
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