Ali Guermazi, MD, PhD
Boston University Chobanian & Avedisian School of Medicine
Dept of Radiology
Musculoskeletal Radiology

MD, University of Sfax
PhD, Jikei University School of Medicine

Dr. Guermazi is a French board-certified radiologist. Prior to joining Boston University, he was Director of the Osteoporosis and Arthritis Research Group (OARG) at University of California at San Francisco (UCSF) and then Director of Clinical Research at Synarc, Inc. in San Francisco. Dr. Guermazi interest is musculoskeletal diseases, in particular note are his scientific contributions in the diagnosis and disease progression assessment of osteoarthritis using MRI. His work has focused on identifying structural risk factors for developing and worsening osteoarthritis. Dr. Guermazi had been involved in developing several original and widely accepted radiological methods to assess osteoarthritis disease risk and progression, including the WORMS, BLOKS and MOAKS for the knee, HOAMS for the hip and fixed-flexion radiography for measuring joint space width. Dr. Guermazi has been involved as an MRI reader for the past 14 years in several large U.S. studies including the Health Aging and Body Composition (Health ABC) study, the Boston Osteoarthritis Knee study (BOKS), the Multi-center Osteoarthritis STudy (MOST), the Framingham study, Osteoarthritis Initiative (OAI), and other large NIH-funded studies, as well as several Pharmaceutical-sponsored clinical trials. He is author of over 275 peer-reviewed publications and Investigator on numerous research grants related to MRI reading for Osteoarthritis.

Section Chief
Boston University Chobanian & Avedisian School of Medicine
Musculoskeletal Radiology

Assistant Dean
Boston University Chobanian & Avedisian School of Medicine
Diversity & Inclusion

Boston University Chobanian & Avedisian School of Medicine

Partial Meniscectomy vs. Nonoperative Mgmt. in Meniscal Tear with OA: an RCT
09/05/2020 - 08/31/2024 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NIAMS

Effect of statin intake on Non-traumatic Generalized Knee Osteoarthritis
01/01/2022 - 08/31/2022 (Subcontract PI)
Johns Hopkins University NIH NIAMS

Gadolinium Distribution in Rat Brain After Systemic Administration of Gadolinium-Based Contrast Agents
10/01/2016 - 10/01/2019 (Co-Investigator)
PI: Lee E. Goldstein, MD, PhD
GE Healthcare, Inc.

Characterizing Electrostatic Interactions Between Glycosaminoglycans and Cationic Small Molecules
03/05/2012 - 01/31/2017 (Multi-PI)
PI: Ali Guermazi, MD, PhD
NIH/National Institutes of Health

Evaluation of Feasibility of Volume Rad X-Ray Versus Conventional X-Ray and 3.0T MRI in Bi-Lateral Knees in With and Without Osteoarthritis
02/01/2009 - 04/30/2010 (PI)
General Electric Company

Tracking Treatable Tissues: Change in qMRI Biomarkers and Future Cartilage Loss
09/15/2017 - 06/30/2022 (PI)
University of Arizona NIH-NIAMS

Risk of Incident Knee OA and Clinical Outcomes Based on Imaging Biomarkers
09/15/2014 - 08/01/2019 (PI)
University of Arizona NIH-NIAMS

Partial Meniscectomy vs Nonoperative Management in Meniscal Tear with OA: a RCT
08/01/2012 - 07/31/2017 (PI)
Brigham & Women's NIH-NIAMS

Mechanisms and Clinical Importance of Hyperkyphosis: The Framingham Study
09/30/2011 - 08/31/2016 (PI)
Hebrew Rehab C Aged NIH-NIA

Partial meniscectomy vs. nonperative management in meniscal tear with OA: an RCT
09/28/2009 - 09/27/2013 (PI)
Brigham & Women's NIH-NIAMS

Central Reading of Knee MRI in Osteroarthritis Patients
11/01/2008 - 10/31/2011 (PI)
Arthritis Centre of Canada

Osteoartritis Initiave WORMS - BLOKS Comparison Study
04/01/2008 - 10/14/2009 (PI)
Univ of California, San Francisco NIH-NIAMS

Development for a model for the MRI progression of knee osteoarthritis
03/01/2007 - 02/28/2009 (PI)
Arthritis Centre of Canada University of Britis


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Takkal S, Diaz L, Manuel D, Huang Q, Guermazi A. Correction to: Concomitant lipoma arborescens and synovial osteochondromatosis of the knee. Skeletal Radiol. 2022 Sep; 51(9):1907.View Related Profiles. PMID: 35467130
  2. Su W, Liu G, Mohajer B, Wang J, Shen A, Zhang W, Liu B, Guermazi A, Gao P, Cao X, Demehri S, Wan M. Senescent preosteoclast secretome promotes metabolic syndrome associated osteoarthritis through cyclooxygenase 2. Elife. 2022 Jul 26; 11. PMID: 35881544; PMCID: PMC9365389; DOI: 10.7554/eLife.79773;
  3. Collins JE, Shrestha S, Losina E, Marx RG, Guermazi A, Jarraya M, Jones MH, Levy BA, Mandl LA, Williams EE, Wright RW, Spindler KP, Katz JN. Five-Year Structural Changes in the Knee Among Patients With Meniscal Tear and Osteoarthritis: Data From a Randomized Controlled Trial of Arthroscopic Partial Meniscectomy Versus Physical Therapy. Arthritis Rheumatol. 2022 Aug; 74(8):1333-1342.View Related Profiles. PMID: 35245416; PMCID: PMC9339455; DOI: 10.1002/art.42105;
  4. Mohajer B, Dolatshahi M, Moradi K, Najafzadeh N, Eng J, Zikria B, Wan M, Cao X, Roemer FW, Guermazi A, Demehri S. Role of Thigh Muscle Changes in Knee Osteoarthritis Outcomes: Osteoarthritis Initiative Data. Radiology. 2022 Oct; 305(1):169-178. PMID: 35727152; PMCID: PMC9524577; DOI: 10.1148/radiol.212771;
  5. MacKay J, Guermazi A, Kwoh CK, See PLP, Jarraya M, Li L, Hannon MJ, Fuji T, Roemer FW. Magnetic Resonance Imaging-Defined Osteophyte Presence and Concomitant Cartilage Damage in Knees With Incident Tibiofemoral Osteoarthritis: Data From the Pivotal Osteoarthritis Initiative Magnetic Resonance Imaging Analyses Study. Arthritis Care Res (Hoboken). 2022 Sep; 74(9):1513-1519. PMID: 33770420
  6. Macri EM, Neogi T, Jarraya M, Guermazi A, Roemer F, Lewis CE, Torner JC, Lynch JA, Tolstykh I, Jafarzadeh SR, Stefanik JJ. Magnetic Resonance Imaging-Defined Osteoarthritis Features and Anterior Knee Pain in Individuals With, or at Risk for, Knee Osteoarthritis: A Multicenter Study on Osteoarthritis. Arthritis Care Res (Hoboken). 2022 Sep; 74(9):1533-1540.View Related Profiles. PMID: 33768706; PMCID: PMC8463633; DOI: 10.1002/acr.24604;
  7. Heiss DMR, Guermazi A, Janka PDMR, Uder PDMM, Li X, Hayashi D, Roemer FW. Update: Posttreatment Imaging of the Knee after Cartilage Repair. Semin Musculoskelet Radiol. 2022 Jun; 26(3):216-229. PMID: 35654091
  8. Li J, Fu S, Gong Z, Zhu Z, Zeng D, Cao P, Lin T, Chen T, Wang X, Lartey R, Kwoh CK, Guermazi A, Roemer FW, Hunter DJ, Ma J, Ding C. MRI-based Texture Analysis of Infrapatellar Fat Pad to Predict Knee Osteoarthritis Incidence. Radiology. 2022 Sep; 304(3):611-621. PMID: 35638929; PMCID: PMC9434820; DOI: 10.1148/radiol.212009;
  9. Roemer FW, Guermazi A, Hannon MJ, Fujii T, Omoumi P, Hunter DJ, Eckstein F, Kwoh CK. Presence of Magnetic Resonance Imaging-Defined Inflammation Particularly in Overweight and Obese Women Increases Risk of Radiographic Knee Osteoarthritis: The POMA Study. Arthritis Care Res (Hoboken). 2022 Aug; 74(8):1391-1398. PMID: 33527736; PMCID: PMC8326300; DOI: 10.1002/acr.24568;
  10. MacFarlane LA, Yang H, Collins JE, Brophy RH, Cole BJ, Spindler KP, Guermazi A, Jones MH, Mandl LA, Martin S, Marx RG, Levy BA, Stuart M, Safran-Norton C, Wright J, Wright RW, Losina E, Katz JN. Association Between Baseline Meniscal Symptoms and Outcomes of Operative and Nonoperative Treatment of Meniscal Tear in Patients With Osteoarthritis. Arthritis Care Res (Hoboken). 2022 Aug; 74(8):1384-1390.View Related Profiles. PMID: 33650303; PMCID: PMC8408275; DOI: 10.1002/acr.24588;
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