Adrian Oblak

Postdoctoral Fellow (previously held)

Boston University Chobanian & Avedisian School of Medicine

Anatomy & Neurobiology

Publications
Contact Info

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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De La Cruz P, Gomes M, Lockett A, Fisher A, Cook T, Smith P, Lloyd C, Twigg HL, Oblak A, Aldaz CM, Machado RF. Partial Wwox Loss of Function Increases Severity of Murine Sepsis and Neuroinflammation. bioRxiv. 2025 Jan 18. PMID: 39868255; PMCID: PMC11761808; DOI: 10.1101/2025.01.17.633677;

Abhyankar SD, Luo Q, Hartman GD, Mahajan N, Corson TW, Oblak AL, Lamb BT, Bhatwadekar AD. Retinal dysfunction in APOE4 knock-in mouse model of Alzheimer's disease. Alzheimers Dement. 2025 Feb; 21(2):e14433. PMID: 39749840; PMCID: PMC11848189; DOI: 10.1002/alz.14433;

Soni DM, Lin PB, Lee-Gosselin A, Lloyd CD, Mason E, Ingraham CM, Perkins A, Moutinho M, Lamb BT, Chu S, Oblak AL. Inpp5d haplodeficiency alleviates tau pathology in the PS19 mouse model of Tauopathy. Alzheimers Dement. 2024 Jul; 20(7):4985-4998. PMID: 38923171; PMCID: PMC11247686; DOI: 10.1002/alz.14078;

Dabin LC, Kersey H, Kim B, Acri DJ, Sharify D, Lee-Gosselin A, Lasagna-Reeves CA, Oblak AL, Lamb BT, Kim J. Loss of Inpp5d has disease-relevant and sex-specific effects on glial transcriptomes. Alzheimers Dement. 2024 Aug; 20(8):5311-5323. PMID: 38923164; PMCID: PMC11350029; DOI: 10.1002/alz.13901;

Ramos Solis N, Cannon A, Dilday T, Abt M, Oblak AL, Soloff AC, Kaplan MH, Yeh ES. HUNK as a key regulator of tumor-associated macrophages in triple negative breast cancer. Oncoimmunology. 2024; 13(1):2364382. PMID: 38846083; PMCID: PMC11155704; DOI: 10.1080/2162402X.2024.2364382;

Ahat E, Shi Z, Chu S, Bui HH, Mason ER, Soni DM, Roth KD, Chalmers MJ, Oblak AL, Zhang J, Gutierrez JA, Richardson T. SHIP1 modulation and proteome characterization of microglia. J Proteomics. 2024 Jun 30; 302:105198. PMID: 38777089

Kotredes KP, Pandey RS, Persohn S, Elderidge K, Burton CP, Miner EW, Haynes KA, Santos DFS, Williams SP, Heaton N, Ingraham CM, Lloyd C, Garceau D, O'Rourke R, Herrick S, Rangel-Barajas C, Maharjan S, Wang N, Sasner M, Lamb BT, Territo PR, Sukoff Rizzo SJ, Carter GW, Howell GR, Oblak AL. Characterizing molecular and synaptic signatures in mouse models of late-onset Alzheimer's disease independent of amyloid and tau pathology. Alzheimers Dement. 2024 Jun; 20(6):4126-4146. PMID: 38735056; PMCID: PMC11180851; DOI: 10.1002/alz.13828;

Senkpeil L, Bhardwaj J, Little MR, Holla P, Upadhye A, Fusco EM, Swanson PA, Wiegand RE, Macklin MD, Bi K, Flynn BJ, Yamamoto A, Gaskin EL, Sather DN, Oblak AL, Simpson E, Gao H, Haining WN, Yates KB, Liu X, Murshedkar T, Richie TL, Sim BKL, Otieno K, Kariuki S, Xuei X, Liu Y, Polidoro RB, Hoffman SL, Oneko M, Steinhardt LC, Schmidt NW, Seder RA, Tran TM. Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine. JCI Insight. 2024 Apr 30; 9(11). PMID: 38687615; PMCID: PMC11382880; DOI: 10.1172/jci.insight.167408;

Sasner M, Preuss C, Pandey RS, Uyar A, Garceau D, Kotredes KP, Williams H, Oblak AL, Lin PB, Perkins B, Soni D, Ingraham C, Lee-Gosselin A, Lamb BT, Howell GR, Carter GW. In vivo validation of late-onset Alzheimer's disease genetic risk factors. Alzheimers Dement. 2024 Jul; 20(7):4970-4984. PMID: 38687251; PMCID: PMC11247676; DOI: 10.1002/alz.13840;

Ahmed C, Greve HJ, Garza-Lombo C, Malley JA, Johnson JA, Oblak AL, Block ML. Peripheral HMGB1 is linked to O3 pathology of disease-associated astrocytes and amyloid. Alzheimers Dement. 2024 May; 20(5):3551-3566. PMID: 38624088; PMCID: PMC11095433; DOI: 10.1002/alz.13825;

Showing 10 of 80 results. Show More

Benzow K, Karanjeet K, Oblak AL, Carter GW, Sasner M, Koob MD. Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice. Alzheimers Dement. 2024 Apr; 20(4):3080-3087. PMID: 38343132; PMCID: PMC11032548; DOI: 10.1002/alz.13730;

Margetts TJ, Wang HS, Karnik SJ, Plotkin LI, Movila A, Oblak AL, Fehrenbacher JC, Kacena MA. From the Mind to the Spine: The Intersecting World of Alzheimer's and Osteoporosis. Curr Osteoporos Rep. 2024 Feb; 22(1):152-164. PMID: 38334917; PMCID: PMC10912148; DOI: 10.1007/s11914-023-00848-w;

Dilday T, Abt M, Ramos-Solís N, Dayal N, Larocque E, Oblak AL, Sintim HO, Yeh ES. Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer. Cell Chem Biol. 2024 May 16; 31(5):989-999.e7. PMID: 38307028; PMCID: PMC11102337; DOI: 10.1016/j.chembiol.2024.01.001;

Karnik SJ, Margetts TJ, Wang HS, Movila A, Oblak AL, Fehrenbacher JC, Kacena MA, Plotkin LI. Mind the Gap: Unraveling the Intricate Dance Between Alzheimer's Disease and Related Dementias and Bone Health. Curr Osteoporos Rep. 2024 Feb; 22(1):165-176. PMID: 38285083; PMCID: PMC10912190; DOI: 10.1007/s11914-023-00847-x;

Yamada C, Ho A, Garcia C, Oblak AL, Bissel S, Porosencova T, Porosencov E, Uncuta D, Ngala B, Shepilov D, Skibo G, Mascarenhas AK, Akkaoui J, Lakshmana MK, Sankar U, Nichols F, Lamb BT, Groppa S, Movila A. Dementia exacerbates periodontal bone loss in females. J Periodontal Res. 2024 Jun; 59(3):512-520. PMID: 38243688

Baker KM, Abt M, Doud EH, Oblak AL, Yeh ES. Mapping the Anti-Cancer Activity of a-Connexin Carboxyl-Terminal (aCT1) Peptide in Resistant HER2+ Breast Cancer. Cancers (Basel). 2024 Jan 19; 16(2). PMID: 38275864; PMCID: PMC10814893; DOI: 10.3390/cancers16020423;

Yu M, Risacher SL, Nho KT, Wen Q, Oblak AL, Unverzagt FW, Apostolova LG, Farlow MR, Brosch JR, Clark DG, Wang S, Deardorff R, Wu YC, Gao S, Sporns O, Saykin AJ. Spatial transcriptomic patterns underlying amyloid-ß and tau pathology are associated with cognitive dysfunction in Alzheimer's disease. Cell Rep. 2024 Feb 27; 43(2):113691. PMID: 38244198; PMCID: PMC10926093; DOI: 10.1016/j.celrep.2024.113691;

Wang HS, Karnik SJ, Margetts TJ, Plotkin LI, Movila A, Fehrenbacher JC, Kacena MA, Oblak AL. Mind Gaps and Bone Snaps: Exploring the Connection Between Alzheimer's Disease and Osteoporosis. Curr Osteoporos Rep. 2024 Oct; 22(5):483-494. PMID: 38236512; PMCID: PMC11420299; DOI: 10.1007/s11914-023-00851-1;

Margetts TJ, Karnik SJ, Wang HS, Plotkin LI, Oblak AL, Fehrenbacher JC, Kacena MA, Movila A. Use of AI Language Engine ChatGPT 4.0 to Write a Scientific Review Article Examining the Intersection of Alzheimer's Disease and Bone. Curr Osteoporos Rep. 2024 Feb; 22(1):177-181. PMID: 38225472; PMCID: PMC10912103; DOI: 10.1007/s11914-023-00853-z;

Sasner M, Preuss C, Pandey RS, Uyar A, Garceau D, Kotredes KP, Williams H, Oblak AL, Lin PB, Perkins B, Soni D, Ingraham C, Lee-Gosselin A, Lamb BT, Howell GR, Carter GW. In vivo validation of late-onset Alzheimer's disease genetic risk factors. bioRxiv. 2023 Dec 24. PMID: 38187758; PMCID: PMC10769393; DOI: 10.1101/2023.12.21.572849;

Kotredes KP, Pandey RS, Persohn S, Elderidge K, Burton CP, Miner EW, Haynes KA, Santos DFS, Williams SP, Heaton N, Ingraham CM, Lloyd C, Garceau D, O'Rourke R, Herrick S, Rangel-Barajas C, Maharjan S, Wang N, Sasner M, Lamb BT, Territo PR, Sukoff Rizzo SJ, Carter GW, Howell GR, Oblak AL. Characterizing Molecular and Synaptic Signatures in mouse models of Late-Onset Alzheimer's Disease Independent of Amyloid and Tau Pathology. bioRxiv. 2023 Dec 20. PMID: 38187716; PMCID: PMC10769232; DOI: 10.1101/2023.12.19.571985;

Jesudason CD, Mason ER, Chu S, Oblak AL, Javens-Wolfe J, Moussaif M, Durst G, Hipskind P, Beck DE, Dong J, Amarasinghe O, Zhang ZY, Hamdani AK, Singhal K, Mesecar AD, Souza S, Jacobson M, Salvo JD, Soni DM, Kandasamy M, Masters AR, Quinney SK, Doolen S, Huhe H, Rizzo SJS, Lamb BT, Palkowitz AD, Richardson TI. SHIP1 therapeutic target enablement: Identification and evaluation of inhibitors for the treatment of late-onset Alzheimer's disease. Alzheimers Dement (N Y). 2023; 9(4):e12429. PMID: 38023622; PMCID: PMC10655782; DOI: 10.1002/trc2.12429;

Ho A, Ngala B, Yamada C, Garcia C, Duarte C, Akkaoui J, Ciolac D, Nusbaum A, Kochen W, Efremova D, Groppa S, Nathanson L, Bissel S, Oblak A, Kacena MA, Movila A. IL-34 exacerbates pathogenic features of Alzheimer's disease and calvaria osteolysis in triple transgenic (3x-Tg) female mice. Biomed Pharmacother. 2023 Oct; 166:115435. PMID: 37666180; PMCID: PMC10710767; DOI: 10.1016/j.biopha.2023.115435;

Tsai AP, Dong C, Lin PB, Oblak AL, Viana Di Prisco G, Wang N, Hajicek N, Carr AJ, Lendy EK, Hahn O, Atkins M, Foltz AG, Patel J, Xu G, Moutinho M, Sondek J, Zhang Q, Mesecar AD, Liu Y, Atwood BK, Wyss-Coray T, Nho K, Bissel SJ, Lamb BT, Landreth GE. Genetic variants of phospholipase C-?2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease. Immunity. 2023 Sep 12; 56(9):2121-2136.e6. PMID: 37659412; PMCID: PMC10564391; DOI: 10.1016/j.immuni.2023.08.008;

Yu M, Risacher SL, Nho KT, Wen Q, Oblak AL, Unverzagt FW, Apostolova LG, Farlow MR, Brosch JR, Clark DG, Wang S, Deardorff R, Wu YC, Gao S, Sporns O, Saykin AJ. Spatial transcriptomic patterns underlying regional vulnerability to amyloid-ß and tau pathologies and their relationships to cognitive dysfunction in Alzheimer's disease. medRxiv. 2023 Aug 16. PMID: 37645867; PMCID: PMC10462206; DOI: 10.1101/2023.08.12.23294017;

Lee-Gosselin A, Jury-Garfe N, You Y, Dabin L, Soni D, Dutta S, Rochet JC, Kim J, Oblak AL, Lasagna-Reeves CA. TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo. Cells. 2023 Jun 10; 12(12). PMID: 37371067; PMCID: PMC10296847; DOI: 10.3390/cells12121597;

Quinney SK, Murugesh K, Oblak A, Onos KD, Sasner M, Greenwood AK, Woo KH, Rizzo SJS, Territo PR. STOP-AD portal: Selecting the optimal pharmaceutical for preclinical drug testing in Alzheimer's disease. Alzheimers Dement. 2023 Nov; 19(11):5289-5295. PMID: 37157089

Wyatt-Johnson SK, Kersey HN, Codocedo JF, Newell KL, Landreth GE, Lamb BT, Oblak AL, Brutkiewicz RR. Control of the temporal development of Alzheimer's disease pathology by the MR1/MAIT cell axis. J Neuroinflammation. 2023 Mar 21; 20(1):78. PMID: 36944969; PMCID: PMC10029194; DOI: 10.1186/s12974-023-02761-6;

Osse AML, Pandey RS, Wirt RA, Ortiz AA, Salazar A, Kimmich M, Toledano Strom EN, Oblak A, Lamb B, Hyman JM, Carter GW, Kinney J. Reduction in GABAB on glia induce Alzheimer's disease related changes. Brain Behav Immun. 2023 May; 110:260-275. PMID: 36906075; PMCID: PMC10115139; DOI: 10.1016/j.bbi.2023.03.002;

Greve HJ, Dunbar AL, Lombo CG, Ahmed C, Thang M, Messenger EJ, Mumaw CL, Johnson JA, Kodavanti UP, Oblak AL, Block ML. The bidirectional lung brain-axis of amyloid-ß pathology: ozone dysregulates the peri-plaque microenvironment. Brain. 2023 Mar 01; 146(3):991-1005. PMID: 35348636; PMCID: PMC10169526; DOI: 10.1093/brain/awac113;

Wang N, Maharjan S, Tsai AP, Lin PB, Qi Y, Wallace A, Jewett M, Liu F, Landreth GE, Oblak AL. Integrating multimodality magnetic resonance imaging to the Allen Mouse Brain Common Coordinate Framework. NMR Biomed. 2023 May; 36(5):e4887. PMID: 36454009; PMCID: PMC10106385; DOI: 10.1002/nbm.4887;

El Jordi O, Fischer KD, Meyer TB, Atwood BK, Oblak AL, Pan RW, McKinzie DL. Microglial knockdown does not affect acute withdrawal but delays analgesic tolerance from oxycodone in male and female C57BL/6J mice. Adv Drug Alcohol Res. 2022; 2:10848. PMID: 38390615; PMCID: PMC10880796; DOI: 10.3389/adar.2022.10848;

Lin PB, Tsai AP, Soni D, Lee-Gosselin A, Moutinho M, Puntambekar SS, Landreth GE, Lamb BT, Oblak AL. INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease. Alzheimers Dement. 2023 Jun; 19(6):2528-2537. PMID: 36524682

Maharjan S, Tsai AP, Lin PB, Ingraham C, Jewett MR, Landreth GE, Oblak AL, Wang N. Corrigendum: Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging. Front Neurosci. 2022; 16:1025457. PMID: 36312018; PMCID: PMC9611773; DOI: 10.3389/fnins.2022.1025457;

Onos KD, Quinney SK, Jones DR, Masters AR, Pandey R, Keezer KJ, Biesdorf C, Metzger IF, Meyers JA, Peters J, Persohn SC, McCarthy BP, Bedwell AA, Figueiredo LL, Cope ZA, Sasner M, Howell GR, Williams HM, Oblak AL, Lamb BT, Carter GW, Rizzo SJS, Territo PR. Pharmacokinetic, pharmacodynamic, and transcriptomic analysis of chronic levetiracetam treatment in 5XFAD mice: A MODEL-AD preclinical testing core study. Alzheimers Dement (N Y). 2022; 8(1):e12329. PMID: 36016830; PMCID: PMC9398229; DOI: 10.1002/trc2.12329;

Maharjan S, Tsai AP, Lin PB, Ingraham C, Jewett MR, Landreth GE, Oblak AL, Wang N. Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging. Front Neurosci. 2022; 16:964654. PMID: 36061588; PMCID: PMC9428354; DOI: 10.3389/fnins.2022.964654;

Oblak AL, Cope ZA, Quinney SK, Pandey RS, Biesdorf C, Masters AR, Onos KD, Haynes L, Keezer KJ, Meyer JA, Peters JS, Persohn SA, Bedwell AA, Eldridge K, Speedy R, Little G, Williams SP, Noarbe B, Obenaus A, Sasner M, Howell GR, Carter GW, Williams H, Lamb BT, Territo PR, Sukoff Rizzo SJ. Prophylactic evaluation of verubecestat on disease- and symptom-modifying effects in 5XFAD mice. Alzheimers Dement (N Y). 2022; 8(1):e12317. PMID: 35846156; PMCID: PMC9281365; DOI: 10.1002/trc2.12317;

Puntambekar SS, Moutinho M, Lin PB, Jadhav V, Tumbleson-Brink D, Balaji A, Benito MA, Xu G, Oblak A, Lasagna-Reeves CA, Landreth GE, Lamb BT. CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer's disease. Mol Neurodegener. 2022 Jun 28; 17(1):47. PMID: 35764973; PMCID: PMC9241248; DOI: 10.1186/s13024-022-00545-9;

Oblak AL, Kotredes KP, Pandey RS, Reagan AM, Ingraham C, Perkins B, Lloyd C, Baker D, Lin PB, Soni DM, Tsai AP, Persohn SA, Bedwell AA, Eldridge K, Speedy R, Meyer JA, Peters JS, Figueiredo LL, Sasner M, Territo PR, Sukoff Rizzo SJ, Carter GW, Lamb BT, Howell GR. Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer's Disease-Relevant Phenotypes in Mice. Front Aging Neurosci. 2022; 14:886575. PMID: 35813947; PMCID: PMC9263289; DOI: 10.3389/fnagi.2022.886575;

Moutinho M, Puntambekar SS, Tsai AP, Coronel I, Lin PB, Casali BT, Martinez P, Oblak AL, Lasagna-Reeves CA, Lamb BT, Landreth GE. The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease. Sci Transl Med. 2022 03 23; 14(637):eabl7634. PMID: 35320002; PMCID: PMC10161396; DOI: 10.1126/scitranslmed.abl7634;

Tsai AP, Dong C, Lin PB, Messenger EJ, Casali BT, Moutinho M, Liu Y, Oblak AL, Lamb BT, Landreth GE, Bissel SJ, Nho K. PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer's disease. Genome Med. 2022 02 18; 14(1):17. PMID: 35180881; PMCID: PMC8857783; DOI: 10.1186/s13073-022-01022-0;

Kotredes KP, Oblak A, Pandey RS, Lin PB, Garceau D, Williams H, Uyar A, O'Rourke R, O'Rourke S, Ingraham C, Bednarczyk D, Belanger M, Cope Z, Foley KE, Logsdon BA, Mangravite LM, Sukoff Rizzo SJ, Territo PR, Carter GW, Sasner M, Lamb BT, Howell GR. Corrigendum: Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEe4 and Trem2*R47H. Front Aging Neurosci. 2022; 14:857628. PMID: 35197847; PMCID: PMC8859544; DOI: 10.3389/fnagi.2022.857628;

Nieder C, Rosene DL, Mortazavi F, Oblak AL, Ketten DR. Morphology and unbiased stereology of the lateral superior olive in the short-beaked common dolphin, Delphinus delphis (Cetacea, Delphinidae). J Morphol. 2022 04; 283(4):446-461.View Related Profiles.

Oblak, Adrian
Rosene, Douglas
Mortazavi, Farzad

PMID: 35066941

Tsai AP, Lin PB, Dong C, Moutinho M, Liu Y, Bissel SJ, Oblak AL, Nho K, Lamb BT, Landreth GE. Impact of PLCG2 expression on Microglial Biology and Disease Pathogenesis in Alzheimer's Disease. Alzheimers Dement. 2021 Dec; 17 Suppl 2:e058740. PMID: 34971198

Lin PB, Tsai AP, Nho K, Lamb BT, Oblak AL. INPP5D regulates the amyloid pathology in Alzheimer's disease. Alzheimers Dement. 2021 Dec; 17 Suppl 2:e058724. PMID: 34971187

Karahan H, Smith DC, Kim B, Dabin LC, Al-Amin MM, Wijeratne HRS, Pennington T, Viana di Prisco G, McCord B, Lin PB, Li Y, Peng J, Oblak AL, Chu S, Atwood BK, Kim J. Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer's disease in a mouse model of Aß amyloidosis. Sci Adv. 2021 Nov 05; 7(45):eabe3954. PMID: 34731000; PMCID: PMC8565913; DOI: 10.1126/sciadv.abe3954;

Kotredes KP, Oblak A, Pandey RS, Lin PB, Garceau D, Williams H, Uyar A, O'Rourke R, O'Rourke S, Ingraham C, Bednarycek D, Belanger M, Cope Z, Foley KE, Logsdon BA, Mangravite LM, Sukoff Rizzo SJ, Territo PR, Carter GW, Sasner M, Lamb BT, Howell GR. Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEe4 and Trem2*R47H. Front Aging Neurosci. 2021; 13:735524. PMID: 34707490; PMCID: PMC8544520; DOI: 10.3389/fnagi.2021.735524;

Oblak AL, Lin PB, Kotredes KP, Pandey RS, Garceau D, Williams HM, Uyar A, O'Rourke R, O'Rourke S, Ingraham C, Bednarczyk D, Belanger M, Cope ZA, Little GJ, Williams SG, Ash C, Bleckert A, Ragan T, Logsdon BA, Mangravite LM, Sukoff Rizzo SJ, Territo PR, Carter GW, Howell GR, Sasner M, Lamb BT. Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study. Front Aging Neurosci. 2021; 13:713726. PMID: 34366832; PMCID: PMC8346252; DOI: 10.3389/fnagi.2021.713726;

Lin PB, Wang PK, Pang CY, Hu WF, Tsai AP, Oblak AL, Liew HK. Moderate Ethanol Pre-treatment Mitigates ICH-Induced Injury via ER Stress Modulation in Rats. Front Mol Neurosci. 2021; 14:682775. PMID: 34248500; PMCID: PMC8267178; DOI: 10.3389/fnmol.2021.682775;

Tsai AP, Lin PB, Dong C, Moutinho M, Casali BT, Liu Y, Lamb BT, Landreth GE, Oblak AL, Nho K. INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia. Neurobiol Dis. 2021 06; 153:105303. PMID: 33631273; PMCID: PMC8082515; DOI: 10.1016/j.nbd.2021.105303;

Oblak AL, Forner S, Territo PR, Sasner M, Carter GW, Howell GR, Sukoff-Rizzo SJ, Logsdon BA, Mangravite LM, Mortazavi A, Baglietto-Vargas D, Green KN, MacGregor GR, Wood MA, Tenner AJ, LaFerla FM, Lamb BT. Model organism development and evaluation for late-onset Alzheimer's disease: MODEL-AD. Alzheimers Dement (N Y). 2020; 6(1):e12110. PMID: 33283040; PMCID: PMC7683958; DOI: 10.1002/trc2.12110;

Preuss C, Pandey R, Piazza E, Fine A, Uyar A, Perumal T, Garceau D, Kotredes KP, Williams H, Mangravite LM, Lamb BT, Oblak AL, Howell GR, Sasner M, Logsdon BA, Carter GW. A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease. Mol Neurodegener. 2020 11 10; 15(1):67. PMID: 33172468; PMCID: PMC7656729; DOI: 10.1186/s13024-020-00412-5;

Jadhav VS, Lin PBC, Pennington T, Di Prisco GV, Jannu AJ, Xu G, Moutinho M, Zhang J, Atwood BK, Puntambekar SS, Bissel SJ, Oblak AL, Landreth GE, Lamb BT. Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice. Mol Neurodegener. 2020 10 28; 15(1):62. PMID: 33115519; PMCID: PMC7594478; DOI: 10.1186/s13024-020-00409-0;

Reilly AM, Tsai AP, Lin PB, Ericsson AC, Oblak AL, Ren H. Metabolic Defects Caused by High-Fat Diet Modify Disease Risk through Inflammatory and Amyloidogenic Pathways in a Mouse Model of Alzheimer's Disease. Nutrients. 2020 Sep 29; 12(10). PMID: 33003412; PMCID: PMC7600118; DOI: 10.3390/nu12102977;

Sukoff Rizzo SJ, Masters A, Onos KD, Quinney S, Sasner M, Oblak A, Lamb BT, Territo PR. Improving preclinical to clinical translation in Alzheimer's disease research. Alzheimers Dement (N Y). 2020; 6(1):e12038. PMID: 32548237; PMCID: PMC7293992; DOI: 10.1002/trc2.12038;

Xu C, Apostolova LG, Oblak AL, Gao S. Association of Hypercholesterolemia with Alzheimer's Disease Pathology and Cerebral Amyloid Angiopathy. J Alzheimers Dis. 2020; 73(4):1305-1311. PMID: 31929164; PMCID: PMC7489304; DOI: 10.3233/JAD-191023;

Gondim DD, Oblak A, Murrell JR, Richardson R, Epperson F, Ross OA, Ghetti B. Diffuse Lewy Body Disease and Alzheimer Disease: Neuropathologic Phenotype Associated With the PSEN1 p.A396T Mutation. J Neuropathol Exp Neurol. 2019 07 01; 78(7):585-594. PMID: 31165862; PMCID: PMC6581554; DOI: 10.1093/jnen/nlz039;

Orczykowski ME, Calderazzo SM, Shobin E, Pessina MA, Oblak AL, Finklestein SP, Kramer BC, Mortazavi F, Rosene DL, Moore TL. Cell based therapy reduces secondary damage and increases extent of microglial activation following cortical injury. Brain Res. 2019 08 15; 1717:147-159.View Related Profiles.

Oblak, Adrian
Rosene, Douglas
Mortazavi, Farzad
Orczykowski, Mary
Pessina, Monica
Calderazzo, Samantha
Moore, Tara

PMID: 30998931; PMCID: PMC6530569; DOI: 10.1016/j.brainres.2019.04.015;

You Y, Perkins A, Cisternas P, Muñoz B, Taylor X, You Y, Garringer HJ, Oblak AL, Atwood BK, Vidal R, Lasagna-Reeves CA. Tau as a mediator of neurotoxicity associated to cerebral amyloid angiopathy. Acta Neuropathol Commun. 2019 02 26; 7(1):26. PMID: 30808415; PMCID: PMC6390363; DOI: 10.1186/s40478-019-0680-z;

Pottier C, Zhou X, Perkerson RB, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, Sánchez-Valle R, Antonell A, Lladó A, Parsons TM, Finch NA, Finger EC, Lippa CF, Huey ED, Neumann M, Heutink P, Synofzik M, Wilke C, Rissman RA, Slawek J, Sitek E, Johannsen P, Nielsen JE, Ren Y, van Blitterswijk M, DeJesus-Hernandez M, Christopher E, Murray ME, Bieniek KF, Evers BM, Ferrari C, Rollinson S, Richardson A, Scarpini E, Fumagalli GG, Padovani A, Hardy J, Momeni P, Ferrari R, Frangipane F, Maletta R, Anfossi M, Gallo M, Petrucelli L, Suh E, Lopez OL, Wong TH, van Rooij JGJ, Seelaar H, Mead S, Caselli RJ, Reiman EM, Noel Sabbagh M, Kjolby M, Nykjaer A, Karydas AM, Boxer AL, Grinberg LT, Grafman J, Spina S, Oblak A, Mesulam MM, Weintraub S, Geula C, Hodges JR, Piguet O, Brooks WS, Irwin DJ, Trojanowski JQ, Lee EB, Josephs KA, Parisi JE, Ertekin-Taner N, Knopman DS, Nacmias B, Piaceri I, Bagnoli S, Sorbi S, Gearing M, Glass J, Beach TG, Black SE, Masellis M, Rogaeva E, Vonsattel JP, Honig LS, Kofler J, Bruni AC, Snowden J, Mann D, Pickering-Brown S, Diehl-Schmid J, Winkelmann J, Galimberti D, Graff C, Öijerstedt L, Troakes C, Al-Sarraj S, Cruchaga C, Cairns NJ, Rohrer JD, Halliday GM, Kwok JB, van Swieten JC, White CL, Ghetti B, Murell JR, Mackenzie IRA, Hsiung GR, Borroni B, Rossi G, Tagliavini F, Wszolek ZK, Petersen RC, Bigio EH, Grossman M, Van Deerlin VM, Seeley WW, Miller BL, Graff-Radford NR, Boeve BF, Dickson DW, Biernacka JM, Rademakers R. Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. Lancet Neurol. 2018 06; 17(6):548-558. PMID: 29724592; PMCID: PMC6237181; DOI: 10.1016/S1474-4422(18)30126-1;

Mortazavi F, Oblak AL, Morrison WZ, Schmahmann JD, Stanley HE, Wedeen VJ, Rosene DL. Geometric Navigation of Axons in a Cerebral Pathway: Comparing dMRI with Tract Tracing and Immunohistochemistry. Cereb Cortex. 2018 04 01; 28(4):1219-1232.View Related Profiles.

Oblak, Adrian
Rosene, Douglas
Mortazavi, Farzad
Stanley, H.

PMID: 28203748; PMCID: PMC6074943; DOI: 10.1093/cercor/bhx034;

Orczykowski ME, Arndt KR, Palitz LE, Kramer BC, Pessina MA, Oblak AL, Finklestein SP, Mortazavi F, Rosene DL, Moore TL. Cell based therapy enhances activation of ventral premotor cortex to improve recovery following primary motor cortex injury. Exp Neurol. 2018 07; 305:13-25.View Related Profiles.

Oblak, Adrian
Rosene, Douglas
Mortazavi, Farzad
Orczykowski, Mary
Pessina, Monica
Moore, Tara

PMID: 29540323; PMCID: PMC5955823; DOI: 10.1016/j.expneurol.2018.03.010;

Rasmussen J, Mahler J, Beschorner N, Kaeser SA, Häsler LM, Baumann F, Nyström S, Portelius E, Blennow K, Lashley T, Fox NC, Sepulveda-Falla D, Glatzel M, Oblak AL, Ghetti B, Nilsson KPR, Hammarström P, Staufenbiel M, Walker LC, Jucker M. Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease. Proc Natl Acad Sci U S A. 2017 12 05; 114(49):13018-13023. PMID: 29158413; PMCID: PMC5724274; DOI: 10.1073/pnas.1713215114;

Saijo E, Ghetti B, Zanusso G, Oblak A, Furman JL, Diamond MI, Kraus A, Caughey B. Ultrasensitive and selective detection of 3-repeat tau seeding activity in Pick disease brain and cerebrospinal fluid. Acta Neuropathol. 2017 May; 133(5):751-765. PMID: 28293793; DOI: 10.1007/s00401-017-1692-z;

McEwan WA, Falcon B, Vaysburd M, Clift D, Oblak AL, Ghetti B, Goedert M, James LC. Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation. Proc Natl Acad Sci U S A. 2017 01 17; 114(3):574-579. PMID: 28049840; PMCID: PMC5255578; DOI: 10.1073/pnas.1607215114;

Garringer HJ, Sammeta N, Oblak A, Ghetti B, Vidal R. Amyloid and intracellular accumulation of BRI2. Neurobiol Aging. 2017 Apr; 52:90-97. PMID: 28131015; PMCID: PMC5359036; DOI: 10.1016/j.neurobiolaging.2016.12.018;

Galimberti D, Cioffi SM, Fenoglio C, Serpente M, Oblak AL, Rodriguez-Porcel F, Oldoni E, Hagen MC, Arcaro M, Scarpini E, Ghetti B, Espay AJ. Rapidly progressive primary progressive aphasia and parkinsonism with novel GRN mutation. Mov Disord. 2017 03; 32(3):476-478. PMID: 27859661; DOI: 10.1002/mds.26872;

Liachko NF, Saxton AD, McMillan PJ, Strovas TJ, Currey HN, Taylor LM, Wheeler JM, Oblak AL, Ghetti B, Montine TJ, Keene CD, Raskind MA, Bird TD, Kraemer BC. The phosphatase calcineurin regulates pathological TDP-43 phosphorylation. Acta Neuropathol. 2016 Oct; 132(4):545-61. PMID: 27473149; PMCID: PMC5026939; DOI: 10.1007/s00401-016-1600-y;

Umeh CC, Kalakoti P, Greenberg MK, Notari S, Cohen Y, Gambetti P, Oblak AL, Ghetti B, Mari Z. Clinicopathological Correlates in a PRNP P102L Mutation Carrier with Rapidly Progressing Parkinsonism-dystonia. Mov Disord Clin Pract. 2016 Jul-Aug; 3(4):355-358. PMID: 27617269; PMCID: PMC5015693; DOI: 10.1002/mdc3.12307;

Deters KD, Risacher SL, Yoder KK, Oblak AL, Unverzagt FW, Murrell JR, Epperson F, Tallman EF, Quaid KA, Farlow MR, Saykin AJ, Ghetti B. [(11)C]PiB PET in Gerstmann-Sträussler-Scheinker disease. Am J Nucl Med Mol Imaging. 2016; 6(1):84-93. PMID: 27069768; PMCID: PMC4749507

Ehrlich M, Hallmann AL, Reinhardt P, Araúzo-Bravo MJ, Korr S, Röpke A, Psathaki OE, Ehling P, Meuth SG, Oblak AL, Murrell JR, Ghetti B, Zaehres H, Schöler HR, Sterneckert J, Kuhlmann T, Hargus G. Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein. Stem Cell Reports. 2015 Jul 14; 5(1):83-96. PMID: 26143746; PMCID: PMC4618448; DOI: 10.1016/j.stemcr.2015.06.001;

Ghetti B, Oblak AL, Boeve BF, Johnson KA, Dickerson BC, Goedert M. Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging. Neuropathol Appl Neurobiol. 2015 Feb; 41(1):24-46. PMID: 25556536; PMCID: PMC4329416; DOI: 10.1111/nan.12213;

Boyd CD, Tierney M, Wassermann EM, Spina S, Oblak AL, Ghetti B, Grafman J, Huey E. Visuoperception test predicts pathologic diagnosis of Alzheimer disease in corticobasal syndrome. Neurology. 2014 Aug 5; 83(6):510-9. PMID: 24991033; PMCID: PMC4142003; DOI: 10.1212/WNL.0000000000000667;

Oblak AL, Hagen MC, Sweadner KJ, Haq I, Whitlow CT, Maldjian JA, Epperson F, Cook JF, Stacy M, Murrell JR, Ozelius LJ, Brashear A, Ghetti B. Rapid-onset dystonia-parkinsonism associated with the I758S mutation of the ATP1A3 gene: a neuropathologic and neuroanatomical study of four siblings. Acta Neuropathol. 2014 Jul; 128(1):81-98. PMID: 24803225; PMCID: PMC4059967; DOI: 10.1007/s00401-014-1279-x;

Oblak A, Gibbs TT, Blatt GJ. Reduced serotonin receptor subtypes in a limbic and a neocortical region in autism. Autism Res. 2013 Dec; 6(6):571-83.View Related Profiles.

Oblak, Adrian
Blatt, Gene
Gibbs, Terrell

PMID: 23894004; PMCID: PMC3859849; DOI: 10.1002/aur.1317;

Koo BB, Oblak AL, Zhao Y, Farris CW, Bowley B, Rosene DL, Killiany RJ. Hippocampal network connections account for differences in memory performance in the middle-aged rhesus monkey. Hippocampus. 2013 Dec; 23(12):1179-88.View Related Profiles.

Oblak, Adrian
Koo, Bang-bon
Farris, Chad
Rosene, Douglas
Killiany, Ronald

PMID: 23780752; PMCID: PMC4113965; DOI: 10.1002/hipo.22156;

Oblak AL, Rosene DL, Kemper TL, Bauman ML, Blatt GJ. Altered posterior cingulate cortical cyctoarchitecture, but normal density of neurons and interneurons in the posterior cingulate cortex and fusiform gyrus in autism. Autism Res. 2011 Jun; 4(3):200-11.View Related Profiles.

Oblak, Adrian
Rosene, Douglas
Blatt, Gene
Bauman, Margaret
Kemper, Thomas

PMID: 21360830; PMCID: PMC3110607; DOI: 10.1002/aur.188;

Oblak AL, Gibbs TT, Blatt GJ. Reduced GABAA receptors and benzodiazepine binding sites in the posterior cingulate cortex and fusiform gyrus in autism. Brain Res. 2011 Mar 22; 1380:218-28.View Related Profiles.

Oblak, Adrian
Blatt, Gene
Gibbs, Terrell

PMID: 20858465; PMCID: PMC3020259; DOI: 10.1016/j.brainres.2010.09.021;

Oblak AL, Gibbs TT, Blatt GJ. Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism. J Neurochem. 2010 Sep 1; 114(5):1414-23.View Related Profiles.

Oblak, Adrian
Blatt, Gene
Gibbs, Terrell

PMID: 20557420; PMCID: PMC2923229; DOI: 10.1111/j.1471-4159.2010.06858.x;

Oblak A, Gibbs TT, Blatt GJ. Decreased GABAA receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism. Autism Res. 2009 Aug; 2(4):205-19.View Related Profiles.

Oblak, Adrian
Blatt, Gene
Gibbs, Terrell

PMID: 19650112; PMCID: PMC2762426; DOI: 10.1002/aur.88;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 80 publications over 16 distinct years, with a maximum of 17 publications in 2024

Bar chart showing 80 publications over 16 distinct years, with a maximum of 17 publications in 2024

Year	Publications
2009	1
2010	2
2011	1
2013	2
2014	2
2015	2
2016	5
2017	3
2018	3
2019	3
2020	6
2021	7
2022	13
2023	11
2024	17
2025	2

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