Wilson Wong, PhD
Associate Professor
Boston University College of Engineering
Dept of Biomedical Engineering

PhD, University of California, Los Angeles



Wilson Wong is an Assistant Professor for Biomedical Engineering at Boston University. He obtained his PhD in chemical engineering from the University of California, Los Angeles and his Bachelor's in chemical engineering from the University of California, Berkeley. His research interests are in applying metabolic engineering and immune cell engineering to rapidly and predictably engineer desired properties in human immune cells to treat diseases.

The Wong lab is a DESIGN driven lab where they apply synthetic biology to engineer desired properties in mammalian cells, with application in understanding cellular design principle and to treat diseases. One area that they are interested in is engineering genetic circuits to improve the efficacy and safety of adoptive T cell therapy. Here they are interested in using synthetic biology to design and construct novel signaling, transcription, and metabolic networks in cells for application in medicine and understanding design principles in living organisms. Specifically, they are interested in engineering human immune cells for adoptive cancer immunotherapy. Adoptive immunotherapy is a promising therapy for treatment of various cancers (1). Their goal at the Wong Lab is to engineer immune cells to enhance their disease fighting capability while minimizing adverse side effect. Also, by building novel networks inside immune cells, they can explore design principles by mapping network architecture to phenotype.


Precise tumor targeting with logic CAR circuits
09/17/2021 - 08/31/2026 (Multi-PI)
PI: Wilson Wong, PhD
NIH/National Cancer Institute
5U01CA265713-02

Precise targeting of T1D specific T cells using CAR and peptide-MHC chimeric antigen ligands
05/15/2022 - 04/30/2026 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
1R01DK132576-01

Targeting Fibroblast Discoidin Domain Receptor 2 for Immunotherapy to Pulmonary Fibrosis
12/01/2021 - 11/30/2025 (Subcontract PI)
Regents of the University of Michigan NIH NHLBI
1R01HL156998-01A1

Multiplexed and Logical Control of The Mammalian Transcriptome Using Cas13
09/20/2021 - 06/30/2025 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
5R01EB031904-02

Engineering Branching Networks Through Synthetic Turing Morphogen Circuits
12/10/2021 - 12/09/2024 (Multi-PI)
PI: Wilson Wong, PhD
Allen Institute d/b/a The Paul G. Allen Frontiers Group


Engineering CAR T Cells to Establish Stable Mixed Chimerism in Allogeneic Transplantation
09/01/2022 - 08/31/2024 (Key Person / Mentor)
NIH/National Heart, Lung, and Blood Institute
1F31HL162477-01A1

Synthetic toolkit for precision gene expression control and signal processing in mammalian cells
05/01/2020 - 01/31/2024 (Multi-PI)
PI: Wilson Wong, PhD
NIH/National Institute of Biomedical Imaging & Bioengineering
5R01EB029483-03

High-throughput chemical imaging for optimizing biofuel synthesis using synthetic biology
09/15/2018 - 09/14/2023 (Multi-PI)
PI: Wilson Wong, PhD
Department of Energy
DE-SC0019387

Design and in vivo comparison of alternative strategies for artificial Zinc Finger (aZnF) based regulatable gene therapies
03/04/2022 - 09/03/2023 (Multi-PI)
PI: Wilson Wong, PhD
Novartis Institutes for BioMedical Research


Signals that establish and maintain HIV latency
05/08/2018 - 04/30/2023 (Subcontract PI)
Boston Medical Center Corporation NIH NIAID
5R01AI138960-03

Showing 10 of 22 results. Show All Results

Disabling HIV provirus by promoting Chromatinization
07/01/2017 - 06/30/2019 (Activity-level PI)
PI: Andrew J. Henderson, PhD
American Foundation for AIDS Research


Title


Yr Title Project-Sub Proj Pubs
2022 Multiplexed and Logical Control of the Mammalian Transcriptome Using Cas13 5R01EB031904-02
2022 Advanced recombinase-based gene expression technology in mammalian cells 3R01GM129011-04S1
2022 Advanced recombinase-based gene expression technology in mammalian cells 5R01GM129011-04
2021 Multiplexed and Logical Control of the Mammalian Transcriptome Using Cas13 1R01EB031904-01
2021 Precise tumor targeting with logic CAR circuits 1U01CA265713-01
2021 Advanced recombinase-based gene expression technology in mammalian cells 5R01GM129011-03
2020 Advanced recombinase-based gene expression technology in mammalian cells 5R01GM129011-02
2020 Advanced recombinase-based gene expression technology in mammalian cells 3R01GM129011-02S1
2019 Engineering a smart CAR platform for human regulatory T cells 1R56EB027729-01A1
2019 Advanced recombinase-based gene expression technology in mammalian cells 1R01GM129011-01
Showing 10 of 11 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Wong NM, Frias E, Sigoillot FD, Letendre JH, Hild M, Wong WW. Engineering digitizer circuits for chemical and genetic screens in human cells. Nat Commun. 2021 10 22; 12(1):6150. PMID: 34686672; PMCID: PMC8536748; DOI: 10.1038/s41467-021-26359-9;
     
  2. Kiwimagi KA, Letendre JH, Weinberg BH, Wang J, Chen M, Watanabe L, Myers CJ, Beal J, Wong WW, Weiss R. Quantitative characterization of recombinase-based digitizer circuits enables predictable amplification of biological signals. Commun Biol. 2021 07 15; 4(1):875. PMID: 34267310; PMCID: PMC8282836; DOI: 10.1038/s42003-021-02325-5;
     
  3. Lin H, Lee HJ, Tague N, Lugagne JB, Zong C, Deng F, Shin J, Tian L, Wong W, Dunlop MJ, Cheng JX. Microsecond fingerprint stimulated Raman spectroscopic imaging by ultrafast tuning and spatial-spectral learning. Nat Commun. 2021 05 24; 12(1):3052.View Related Profiles. PMID: 34031374; PMCID: PMC8144602; DOI: 10.1038/s41467-021-23202-z;
     
  4. Kim T, Weinberg B, Wong W, Lu TK. Scalable recombinase-based gene expression cascades. Nat Commun. 2021 05 11; 12(1):2711. PMID: 33976199; PMCID: PMC8113245; DOI: 10.1038/s41467-021-22978-4;
     
  5. Tan X, Letendre JH, Collins JJ, Wong WW. Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics. Cell. 2021 02 18; 184(4):881-898. PMID: 33571426; PMCID: PMC7897318; DOI: 10.1016/j.cell.2021.01.017;
     
  6. Cho JH, Okuma A, Sofjan K, Lee S, Collins JJ, Wong WW. Engineering advanced logic and distributed computing in human CAR immune cells. Nat Commun. 2021 02 04; 12(1):792. PMID: 33542232; PMCID: PMC7862674; DOI: 10.1038/s41467-021-21078-7;
     
  7. Bowyer JE, Ding C, Weinberg BH, Wong WW, Bates DG. A mechanistic model of the BLADE platform predicts performance characteristics of 256 different synthetic DNA recombination circuits. PLoS Comput Biol. 2020 12; 16(12):e1007849. PMID: 33338034; PMCID: PMC7781486; DOI: 10.1371/journal.pcbi.1007849;
     
  8. Lee S, Wong WW. The Most Logical Approach to Improve CAR T Cell Therapy. Cell Syst. 2020 11 18; 11(5):421-423. PMID: 33212015; DOI: 10.1016/j.cels.2020.10.008;
     
  9. Olson A, Basukala B, Lee S, Gagne M, Wong WW, Henderson AJ. Targeted Chromatinization and Repression of HIV-1 Provirus Transcription with Repurposed CRISPR/Cas9. Viruses. 2020 10 12; 12(10).View Related Profiles. PMID: 33053801; PMCID: PMC7600714; DOI: 10.3390/v12101154;
     
  10. Sheets MB, Wong WW, Dunlop MJ. Correction to Light-Inducible Recombinases for Bacterial Optogenetics. ACS Synth Biol. 2020 Oct 16; 9(10):2857-2859.View Related Profiles. PMID: 33001633; DOI: 10.1021/acssynbio.0c00477;
     
Showing 10 of 29 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 29 publications over 8 distinct years, with a maximum of 7 publications in 2020

YearPublications
20121
20152
20162
20173
20184
20194
20207
20216

2022 Allen Distinguished Investigator Award
2021 National Academy of Engineering: German-American Frontiers of Engineering Invitee
2018 ACS Synthetic Biology: Young Investigator Award
2018 BU College of Engineering: Early Career Research Excellence Award
2016 NSF: CAREER Award
2015-2018 Boston University: Ignition Award
2013 NIH: Director’s New Innovator Award
2013 BU Engineering: Dean’s Catalyst Award
2009 American Cancer Society: Postdoctoral Fellowship
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