Thomas Gilmore | Profiles RNS

Thomas Gilmore, PhD

Professor

Boston University Chobanian & Avedisian School of Medicine

Biochemistry & Cell Biology

PhD, University of California, Berkeley
AB, Princeton University

Websites

	Biology Faculty
	Google Scholar
	LinkedIn

ORCID : 0000-0002-1910-768X

Thomas D. Gilmore, PhD is a Biologist with extensive experience in the fields of signal transduction, cancer, molecular ecology, and cell biology. He has received many awards for his research and teaching including the Metcalf Cup and Prize, Boston University's highest award for excellence in teaching.Over the course of his career, Dr. Gilmore has received hundreds of thousands of dollars in funding from the NIH for his research.

Member
Boston University
Genome Science Institute

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Member
Boston University
BU-BMC Cancer Center

BU Research

REU Site: Control of Gene Expression for Biological Effect
03/01/2022 - 02/28/2025 (PI)
National Science Foundation
DBI-2150124

Transcription Factors in Cnidarian Immunity, Symbiosis, and Bleaching
03/01/2020 - 02/28/2025 (Multi-PI)
PI: Thomas Gilmore, PhD
National Science Foundation
IOS-1937650

REU Site: Control of Gene Expression for Biological Effect
04/01/2017 - 06/30/2024 (PI)
National Science Foundation
DBI-1659605

RAPID: Transcription Factor Profiling for SARS-CoV2 Tolerance/Symbiosis Regulation
06/01/2020 - 05/31/2023 (Multi-PI)
PI: Thomas Gilmore, PhD
National Science Foundation
IOS-2031624

NF-kappaB in Cnidarian Development
08/01/2014 - 07/31/2021 (Multi-PI)
PI: Thomas Gilmore, PhD
National Science Foundation
IOS-1354935

Molecular Mechanism of the NFkappaB Essential Modulator (NEMO) Scaffold Protein Mutated in Human Immunodeficiencies
08/15/2016 - 06/30/2021 (Co-Investigator)
PI: Adrian Whitty, PhD
NIH/National Institute of General Medical Sciences
5R01GM117350-04

Beckman Scholars Program 2017
05/01/2017 - 08/31/2020 (PI)
The Arnold and Mabel Beckman Foundation

Glycan recognition and the role of innate immunity in cnidarian-dinoflagellate symbioses
02/01/2016 - 01/31/2020 (Subcontract PI)
Oregon State University National Science Fdn

REU Site: Interplay Between Genes and the Environment
03/01/2013 - 02/28/2018 (PI)
National Science Foundation
DBI-1262934

Beckman Scholars Program 2014
06/01/2014 - 08/31/2017 (PI)
The Arnold and Mabel Beckman Foundation

Showing 10 of 14 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Inge MM, Miller R, Hook H, Bray D, Keenan JL, Zhao R, Gilmore TD, Siggers T. Rapid profiling of transcription factor-cofactor interaction networks reveals principles of epigenetic regulation. Nucleic Acids Res. 2024 Sep 23; 52(17):10276-10296. PMID: 39166482; PMCID: PMC11417405; DOI: 10.1093/nar/gkae706;

Wang M, Valadez-Ingersoll M, Gilmore TD. Control of nuclear localization of the nucleocapsid protein of SARS-CoV-2. Virology. 2024 Dec; 600:110232. PMID: 39265446

Valadez-Ingersoll M, Aguirre Carrión PJ, Bodnar CA, Desai NA, Gilmore TD, Davies SW. Starvation differentially affects gene expression, immunity and pathogen susceptibility across symbiotic states in a model cnidarian. Proc Biol Sci. 2024 Feb 28; 291(2017):20231685. PMID: 38412969; PMCID: PMC10898965; DOI: 10.1098/rspb.2023.1685;

DiRusso CJ, DeMaria AM, Wong J, Wang W, Jordanides JJ, Whitty A, Allen KN, Gilmore TD. A conserved core region of the scaffold NEMO is essential for signal-induced conformational change and liquid-liquid phase separation. J Biol Chem. 2023 Dec; 299(12):105396.View Related Profiles.

Whitty, Adrian
Gilmore, Thomas

PMID: 37890781; PMCID: PMC10694592; DOI: 10.1016/j.jbc.2023.105396;

Carrión PJA, Desai N, Brennan JJ, Fifer JE, Siggers T, Davies SW, Gilmore TD. Starvation decreases immunity and immune regulatory factor NF-?B in the starlet sea anemone Nematostella vectensis. Commun Biol. 2023 Jul 07; 6(1):698. PMID: 37420095; PMCID: PMC10329013; DOI: 10.1038/s42003-023-05084-7;

DiRusso CJ, DeMaria AM, Wong J, Jordanides JJ, Whitty A, Allen KN, Gilmore TD. A Conserved Core Region of the Scaffold NEMO is Essential for Signal-induced Conformational Change and Liquid-liquid Phase Separation. bioRxiv. 2023 May 25.View Related Profiles.

Whitty, Adrian
Gilmore, Thomas

PMID: 37292615; PMCID: PMC10245932; DOI: 10.1101/2023.05.25.542299;

Williams LM, Gilmore TD. An innate ability: How do basal invertebrates manage their chronic exposure to microbes? PLoS Pathog. 2022 Oct; 18(10):e1010897. PMID: 36315570; PMCID: PMC9621439; DOI: 10.1371/journal.ppat.1010897;

DiRusso CJ, Dashtiahangar M, Gilmore TD. Scaffold proteins as dynamic integrators of biological processes. J Biol Chem. 2022 Dec; 298(12):102628. PMID: 36273588; PMCID: PMC9672449; DOI: 10.1016/j.jbc.2022.102628;

Williams LM, Sridhar S, Samaroo J, Peart J, Adindu EK, Addanki A, DiRusso CJ, Aguirre Carrión PJ, Rodriguez-Sastre N, Siggers T, Gilmore TD. Comparison of NF-?B from the protists Capsaspora owczarzaki and Acanthoeca spectabilis reveals extensive evolutionary diversification of this transcription factor. Commun Biol. 2021 12 16; 4(1):1404. PMID: 34916615; PMCID: PMC8677719; DOI: 10.1038/s42003-021-02924-2;

Gilmore TD. NF-?B and Human Cancer: What Have We Learned over the Past 35 Years? Biomedicines. 2021 Jul 25; 9(8). PMID: 34440093; PMCID: PMC8389606; DOI: 10.3390/biomedicines9080889;

Showing 10 of 132 results. Show More

Aguirre Carrión PJ, Williams LM, Gilmore TD. Molecular and Biochemical Approaches to Study the Evolution of NF-?B Signaling in Basal Metazoans. Methods Mol Biol. 2021; 2366:67-91. PMID: 34236633

Williams LM, Gilmore TD. Looking Down on NF-?B. Mol Cell Biol. 2020 07 14; 40(15). PMID: 32393609; PMCID: PMC7364044; DOI: 10.1128/MCB.00104-20;

Williams LM, Inge MM, Mansfield KM, Rasmussen A, Afghani J, Agrba M, Albert C, Andersson C, Babaei M, Babaei M, Bagdasaryants A, Bonilla A, Browne A, Carpenter S, Chen T, Christie B, Cyr A, Dam K, Dulock N, Erdene G, Esau L, Esonwune S, Hanchate A, Huang X, Jennings T, Kasabwala A, Kehoe L, Kobayashi R, Lee M, LeVan A, Liu Y, Murphy E, Nambiar A, Olive M, Patel D, Pavesi F, Petty CA, Samofalova Y, Sanchez S, Stejskal C, Tang Y, Yapo A, Cleary JP, Yunes SA, Siggers T, Gilmore TD. Transcription factor NF-?B in a basal metazoan, the sponge, has conserved and unique sequences, activities, and regulation. Dev Comp Immunol. 2020 03; 104:103559. PMID: 31751628

Babaei M, Liu Y, Wuerzberger-Davis SM, McCaslin EZ, DiRusso CJ, Yeo AT, Kagermazova L, Miyamoto S, Gilmore TD. CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein. PLoS One. 2019; 14(9):e0222588. PMID: 31553754; PMCID: PMC6760803; DOI: 10.1371/journal.pone.0222588;

Shaffer R, DeMaria AM, Kagermazova L, Liu Y, Babaei M, Caban-Penix S, Cervantes A, Jehle S, Makowski L, Gilmore TD, Whitty A, Allen KN. A Central Region of NF-?B Essential Modulator Is Required for IKKß-Induced Conformational Change and for Signal Propagation. Biochemistry. 2019 07 02; 58(26):2906-2920.View Related Profiles.

Whitty, Adrian
Gilmore, Thomas

PMID: 31145594; PMCID: PMC9295417; DOI: 10.1021/acs.biochem.8b01316;

Mansfield KM, Gilmore TD. Innate immunity and cnidarian-Symbiodiniaceae mutualism. Dev Comp Immunol. 2019 01; 90:199-209. PMID: 30268783

Brennan JJ, Gilmore TD. Evolutionary Origins of Toll-like Receptor Signaling. Mol Biol Evol. 2018 07 01; 35(7):1576-1587. PMID: 29590394

Friedman LE, Gilmore TD, Finnerty JR. Intraspecific variation in oxidative stress tolerance in a model cnidarian: Differences in peroxide sensitivity between and within populations of Nematostella vectensis. PLoS One. 2018; 13(1):e0188265. PMID: 29373572; PMCID: PMC5786289; DOI: 10.1371/journal.pone.0188265;

Mansfield KM, Carter NM, Nguyen L, Cleves PA, Alshanbayeva A, Williams LM, Crowder C, Penvose AR, Finnerty JR, Weis VM, Siggers TW, Gilmore TD. Transcription factor NF-?B is modulated by symbiotic status in a sea anemone model of cnidarian bleaching. Sci Rep. 2017 11 22; 7(1):16025. PMID: 29167511; PMCID: PMC5700166; DOI: 10.1038/s41598-017-16168-w;

Brennan JJ, Messerschmidt JL, Williams LM, Matthews BJ, Reynoso M, Gilmore TD. Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-?B signal transduction, and development. Proc Natl Acad Sci U S A. 2017 11 21; 114(47):E10122-E10131. PMID: 29109290; PMCID: PMC5703304; DOI: 10.1073/pnas.1711530114;

Williams LM, Fuess LE, Brennan JJ, Mansfield KM, Salas-Rodriguez E, Welsh J, Awtry J, Banic S, Chacko C, Chezian A, Dowers D, Estrada F, Hsieh YH, Kang J, Li W, Malchiodi Z, Malinowski J, Matuszak S, McTigue T, Mueller D, Nguyen B, Nguyen M, Nguyen P, Nguyen S, Njoku N, Patel K, Pellegrini W, Pliakas T, Qadir D, Ryan E, Schiffer A, Thiel A, Yunes SA, Spilios KE, Pinzón C JH, Mydlarz LD, Gilmore TD. A conserved Toll-like receptor-to-NF-?B signaling pathway in the endangered coral Orbicella faveolata. Dev Comp Immunol. 2018 02; 79:128-136.View Related Profiles.

Dowers, Donovan
Gilmore, Thomas

PMID: 29080785

Cotter KA, Nacci D, Champlin D, Yeo AT, Gilmore TD, Callard GV. Adaptive Significance of ERa Splice Variants in Killifish (Fundulus heteroclitus) Resident in an Estrogenic Environment. Endocrinology. 2016 06; 157(6):2294-308. PMID: 27070100

Haery L, Mussakhan S, Waxman DJ, Gilmore TD. Evidence for an oncogenic modifier role for mutant histone acetyltransferases in diffuse large B-cell lymphoma. Leuk Lymphoma. 2016 11; 57(11):2661-71.View Related Profiles.

Waxman, David
Gilmore, Thomas

PMID: 27003102; PMCID: PMC5045243; DOI: 10.3109/10428194.2016.1160083;

Haery L, Thompson RC, Gilmore TD. Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy. Genes Cancer. 2015 May; 6(5-6):184-213. PMID: 26124919; PMCID: PMC4482241; DOI: 10.18632/genesandcancer.65;

Yeo AT, Chennamadhavuni S, Whitty A, Porco JA, Gilmore TD. Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines. Molecules. 2015; 20(5):7474-94.View Related Profiles.

Whitty, Adrian
Porco, John
Gilmore, Thomas

PMID: 25915462; PMCID: PMC4863944; DOI: 10.3390/molecules20057474;

Finnerty JR, Gilmore TD. Methods for analyzing the evolutionary relationship of NF-?B proteins using free, web-driven bioinformatics and phylogenetic tools. Methods Mol Biol. 2015; 1280:631-46. PMID: 25736776

Siggers T, Gilmore TD, Barron B, Penvose A. Characterizing the DNA binding site specificity of NF-?B with protein-binding microarrays (PBMs). Methods Mol Biol. 2015; 1280:609-30. PMID: 25736775

Gilmore TD, Gélinas C. Methods for assessing the in vitro transforming activity of NF-?B transcription factor c-Rel and related proteins. Methods Mol Biol. 2015; 1280:427-46. PMID: 25736765

Zhou L, Yeo AT, Ballarano C, Weber U, Allen KN, Gilmore TD, Whitty A. Disulfide-mediated stabilization of the I?B kinase binding domain of NF-?B essential modulator (NEMO). Biochemistry. 2014 Dec 23; 53(50):7929-44.View Related Profiles.

Whitty, Adrian
Allen, Karen
Gilmore, Thomas

PMID: 25400026; PMCID: PMC4278678; DOI: 10.1021/bi500920n;

Tarrant AM, Gilmore TD, Reitzel AM, Levy O, Technau U, Martindale MQ. Current directions and future perspectives from the third Nematostella research conference. Zoology (Jena). 2015 Apr; 118(2):135-40. PMID: 25450665; PMCID: PMC4786491; DOI: 10.1016/j.zool.2014.06.005;

Haery L, Lugo-Picó JG, Henry RA, Andrews AJ, Gilmore TD. Histone acetyltransferase-deficient p300 mutants in diffuse large B cell lymphoma have altered transcriptional regulatory activities and are required for optimal cell growth. Mol Cancer. 2014 Feb 15; 13:29. PMID: 24529102; PMCID: PMC3930761; DOI: 10.1186/1476-4598-13-29;

Cote SM, Gilmore TD, Shaffer R, Weber U, Bollam R, Golden MS, Glover K, Herscovitch M, Ennis T, Allen KN, Whitty A. Mutation of nonessential cysteines shows that the NF-?B essential modulator forms a constitutive noncovalent dimer that binds I?B kinase-ß with high affinity. Biochemistry. 2013 Dec 23; 52(51):9141-54.View Related Profiles.

Whitty, Adrian
Allen, Karen
Gilmore, Thomas

PMID: 24266532; PMCID: PMC4417627; DOI: 10.1021/bi401368r;

Thompson RC, Vardinogiannis I, Gilmore TD. Identification of an NF-?B p50/p65-responsive site in the human MIR155HG promoter. BMC Mol Biol. 2013 Sep 23; 14:24. PMID: 24059932; PMCID: PMC3849010; DOI: 10.1186/1471-2199-14-24;

Thompson RC, Vardinogiannis I, Gilmore TD. The sensitivity of diffuse large B-cell lymphoma cell lines to histone deacetylase inhibitor-induced apoptosis is modulated by BCL-2 family protein activity. PLoS One. 2013; 8(5):e62822. PMID: 23667527; PMCID: PMC3647059; DOI: 10.1371/journal.pone.0062822;

Layden MJ, Röttinger E, Wolenski FS, Gilmore TD, Martindale MQ. Microinjection of mRNA or morpholinos for reverse genetic analysis in the starlet sea anemone, Nematostella vectensis. Nat Protoc. 2013 May; 8(5):924-34. PMID: 23579781; PMCID: PMC4805419; DOI: 10.1038/nprot.2013.009;

Stefanik DJ, Wolenski FS, Friedman LE, Gilmore TD, Finnerty JR. Isolation of DNA, RNA and protein from the starlet sea anemone Nematostella vectensis. Nat Protoc. 2013 May; 8(5):892-9. PMID: 23579778

Wolenski FS, Layden MJ, Martindale MQ, Gilmore TD, Finnerty JR. Characterizing the spatiotemporal expression of RNAs and proteins in the starlet sea anemone, Nematostella vectensis. Nat Protoc. 2013 May; 8(5):900-15. PMID: 23579779; PMCID: PMC4792812; DOI: 10.1038/nprot.2013.014;

Gilmore TD, Tarrant AM, Finnerty JR. A report from the second Nematostella vectensis research conference. Dev Genes Evol. 2013 May; 223(3):207-11. PMID: 23314922

Wolenski FS, Bradham CA, Finnerty JR, Gilmore TD. NF-?B is required for cnidocyte development in the sea anemone Nematostella vectensis. Dev Biol. 2013 Jan 01; 373(1):205-15.View Related Profiles.

Bradham, Cynthia
Gilmore, Thomas

PMID: 23063796

Gilmore TD, Wolenski FS. NF-?B: where did it come from and why? Immunol Rev. 2012 Mar; 246(1):14-35. PMID: 22435545

Wolenski FS, Chandani S, Stefanik DJ, Jiang N, Chu E, Finnerty JR, Gilmore TD. Two polymorphic residues account for the differences in DNA binding and transcriptional activation by NF-?B proteins encoded by naturally occurring alleles in Nematostella vectensis. J Mol Evol. 2011 Dec; 73(5-6):325-36. PMID: 22198650

Yeo AT, Porco JA, Gilmore TD. Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide-induced apoptosis. Cancer Lett. 2012 May 1; 318(1):53-60.View Related Profiles.

Porco, John
Gilmore, Thomas

PMID: 22155272; PMCID: PMC3288124; DOI: 10.1016/j.canlet.2011.11.035;

Gilmore TD, Gerondakis S. The c-Rel Transcription Factor in Development and Disease. Genes Cancer. 2011 Jul; 2(7):695-711. PMID: 22207895; PMCID: PMC3218406; DOI: 10.1177/1947601911421925;

Garbati MR, Thompson RC, Haery L, Gilmore TD. A rearranged EP300 gene in the human B-cell lymphoma cell line RC-K8 encodes a disabled transcriptional co-activator that contributes to cell growth and oncogenicity. Cancer Lett. 2011 Mar 01; 302(1):76-83. PMID: 21232847; PMCID: PMC3042717; DOI: 10.1016/j.canlet.2010.12.018;

Gilmore TD, Garbati MR. Inhibition of NF-?B signaling as a strategy in disease therapy. Curr Top Microbiol Immunol. 2011; 349:245-63. PMID: 21113699

Wolenski FS, Garbati MR, Lubinski TJ, Traylor-Knowles N, Dresselhaus E, Stefanik DJ, Goucher H, Finnerty JR, Gilmore TD. Characterization of the core elements of the NF-?B signaling pathway of the sea anemone Nematostella vectensis. Mol Cell Biol. 2011 Mar; 31(5):1076-87. PMID: 21189285; PMCID: PMC3067825; DOI: 10.1128/MCB.00927-10;

Thompson RC, Herscovitch M, Zhao I, Ford TJ, Gilmore TD. NF-kappaB down-regulates expression of the B-lymphoma marker CD10 through a miR-155/PU.1 pathway. J Biol Chem. 2011 Jan 21; 286(3):1675-82. PMID: 20947507; PMCID: PMC3023462; DOI: 10.1074/jbc.M110.177063;

Gilmore TD, Thompson RC, Faber AC. Cyclins D3 and E go hand in hand with Cdk4/6 in diffuse large B-cell lymphoma. Cell Cycle. 2010 Feb 01; 9(3):448-9. PMID: 20130454

Garbati MR, Alço G, Gilmore TD. Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8. Cancer Lett. 2010 May 28; 291(2):237-45. PMID: 19948376; PMCID: PMC2849871; DOI: 10.1016/j.canlet.2009.10.018;

Sullivan JC, Wolenski FS, Reitzel AM, French CE, Traylor-Knowles N, Gilmore TD, Finnerty JR. Two alleles of NF-kappaB in the sea anemone Nematostella vectensis are widely dispersed in nature and encode proteins with distinct activities. PLoS One. 2009 Oct 06; 4(10):e7311. PMID: 19806194; PMCID: PMC2751831; DOI: 10.1371/journal.pone.0007311;

Chin M, Herscovitch M, Zhang N, Waxman DJ, Gilmore TD. Overexpression of an activated REL mutant enhances the transformed state of the human B-lymphoma BJAB cell line and alters its gene expression profile. Oncogene. 2009 May 21; 28(20):2100-11.View Related Profiles.

Waxman, David
Gilmore, Thomas

PMID: 19377508; PMCID: PMC2796798; DOI: 10.1038/onc.2009.74;

Gilmore TD, Perkins ND, Franzoso G. Getting away from it all in Capri: the 2008 EMBO workshop on NF-kappaB. Cell Death Differ. 2009 Apr; 16(4):651-4. PMID: 19287453; PMCID: PMC2827876; DOI: 10.1038/cdd.2009.3;

Leeman JR, Weniger MA, Barth TF, Gilmore TD. Deletion analysis and alternative splicing define a transactivation inhibitory domain in human oncoprotein REL. Oncogene. 2008 Dec 04; 27(53):6770-81. PMID: 18695674; PMCID: PMC2832920; DOI: 10.1038/onc.2008.284;

Leeman JR, Gilmore TD. Alternative splicing in the NF-kappaB signaling pathway. Gene. 2008 Nov 01; 423(2):97-107. PMID: 18718859; PMCID: PMC2624576; DOI: 10.1016/j.gene.2008.07.015;

Garbati MR, Gilmore TD. Ser484 and Ser494 in REL are the major sites of IKK phosphorylation in vitro: evidence that IKK does not directly enhance GAL4-REL transactivation. Gene Expr. 2008; 14(4):195-205. PMID: 19110719; PMCID: PMC2822992; DOI: 10.3727/105221608786883807;

Herscovitch M, Comb W, Ennis T, Coleman K, Yong S, Armstead B, Kalaitzidis D, Chandani S, Gilmore TD. Intermolecular disulfide bond formation in the NEMO dimer requires Cys54 and Cys347. Biochem Biophys Res Commun. 2008 Feb 29; 367(1):103-8. PMID: 18164680; PMCID: PMC2277332; DOI: 10.1016/j.bbrc.2007.12.123;

Gilmore TD. Multiple myeloma: lusting for NF-kappaB. Cancer Cell. 2007 Aug; 12(2):95-7. PMID: 17692798

Sullivan JC, Kalaitzidis D, Gilmore TD, Finnerty JR. Rel homology domain-containing transcription factors in the cnidarian Nematostella vectensis. Dev Genes Evol. 2007 Jan; 217(1):63-72. PMID: 17120026

Starczynowski DT, Trautmann H, Pott C, Harder L, Arnold N, Africa JA, Leeman JR, Siebert R, Gilmore TD. Mutation of an IKK phosphorylation site within the transactivation domain of REL in two patients with B-cell lymphoma enhances REL's in vitro transforming activity. Oncogene. 2007 Apr 26; 26(19):2685-94. PMID: 17072339

Courtois G, Gilmore TD. Mutations in the NF-kappaB signaling pathway: implications for human disease. Oncogene. 2006 Oct 30; 25(51):6831-43. PMID: 17072331

Gilmore TD. Introduction to NF-kappaB: players, pathways, perspectives. Oncogene. 2006 Oct 30; 25(51):6680-4. PMID: 17072321

Gilmore TD, Herscovitch M. Inhibitors of NF-kappaB signaling: 785 and counting. Oncogene. 2006 Oct 30; 25(51):6887-99. PMID: 17072334

Perkins ND, Gilmore TD. Good cop, bad cop: the different faces of NF-kappaB. Cell Death Differ. 2006 May; 13(5):759-72. PMID: 16410803

Liang MC, Bardhan S, Pace EA, Rosman D, Beutler JA, Porco JA, Gilmore TD. Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity. Biochem Pharmacol. 2006 Feb 28; 71(5):634-45.View Related Profiles.

Porco, John
Gilmore, Thomas

PMID: 16360644

Liang MC, Bardhan S, Porco JA, Gilmore TD. The synthetic epoxyquinoids jesterone dimer and epoxyquinone A monomer induce apoptosis and inhibit REL (human c-Rel) DNA binding in an IkappaBalpha-deficient diffuse large B-cell lymphoma cell line. Cancer Lett. 2006 Sep 8; 241(1):69-78.View Related Profiles.

Porco, John
Gilmore, Thomas

PMID: 16289774

Starczynowski DT, Reynolds JG, Gilmore TD. Mutations of tumor necrosis factor alpha-responsive serine residues within the C-terminal transactivation domain of human transcription factor REL enhance its in vitro transforming ability. Oncogene. 2005 Nov 10; 24(49):7355-68. PMID: 16027730

Gapuzan ME, Schmah O, Pollock AD, Hoffmann A, Gilmore TD. Immortalized fibroblasts from NF-kappaB RelA knockout mice show phenotypic heterogeneity and maintain increased sensitivity to tumor necrosis factor alpha after transformation by v-Ras. Oncogene. 2005 Sep 29; 24(43):6574-83. PMID: 16027734

Kalaitzidis D, Gilmore TD. Transcription factor cross-talk: the estrogen receptor and NF-kappaB. Trends Endocrinol Metab. 2005 Mar; 16(2):46-52. PMID: 15734144

Kalaitzidis D, Ok J, Sulak L, Starczynowski DT, Gilmore TD. Characterization of a human REL-estrogen receptor fusion protein with a reverse conditional transforming activity in chicken spleen cells. Oncogene. 2004 Sep 30; 23(45):7580-7. PMID: 15326488

Gilmore TD, Starczynowski DT, Kalaitzidis D. RELevant gene amplification in B-cell lymphomas? Blood. 2004 Apr 15; 103(8):3243-4; author reply 3244-5. PMID: 15070712

Gilmore TD, Kalaitzidis D, Liang MC, Starczynowski DT. The c-Rel transcription factor and B-cell proliferation: a deal with the devil. Oncogene. 2004 Mar 25; 23(13):2275-86. PMID: 14755244

Gilmore TD, Jean-Jacques J, Richards R, Cormier C, Kim J, Kalaitzidis D. Stable expression of the avian retroviral oncoprotein v-Rel in avian, mouse, and dog cell lines. Virology. 2003 Nov 10; 316(1):9-16. PMID: 14599786

Starczynowski DT, Reynolds JG, Gilmore TD. Deletion of either C-terminal transactivation subdomain enhances the in vitro transforming activity of human transcription factor REL in chicken spleen cells. Oncogene. 2003 Oct 09; 22(44):6928-36. PMID: 14534540

Gapuzan ME, Pitoc GA, Gilmore TD. Mutations within a conserved protein kinase A recognition sequence confer temperature-sensitive and partially defective activities onto mouse c-Rel. Biochem Biophys Res Commun. 2003 Jul 18; 307(1):92-9. PMID: 12849986

Liang MC, Bardhan S, Li C, Pace EA, Porco JA, Gilmore TD. Jesterone dimer, a synthetic derivative of the fungal metabolite jesterone, blocks activation of transcription factor nuclear factor kappaB by inhibiting the inhibitor of kappaB kinase. Mol Pharmacol. 2003 Jul; 64(1):123-31.View Related Profiles.

Porco, John
Gilmore, Thomas

PMID: 12815168

Wang Y, Gilmore TD. Zyxin and paxillin proteins: focal adhesion plaque LIM domain proteins go nuclear. Biochim Biophys Acta. 2003 Feb 17; 1593(2-3):115-20. PMID: 12581855

Gilmore TD. The Re1/NF-kappa B/I kappa B signal transduction pathway and cancer. Cancer Treat Res. 2003; 115:241-65. PMID: 12613200

Kalaitzidis D, Davis RE, Rosenwald A, Staudt LM, Gilmore TD. The human B-cell lymphoma cell line RC-K8 has multiple genetic alterations that dysregulate the Rel/NF-kappaB signal transduction pathway. Oncogene. 2002 Dec 12; 21(57):8759-68. PMID: 12483529

Li C, Bardhan S, Pace EA, Liang MC, Gilmore TD, Porco JA. Angiogenesis inhibitor epoxyquinol a: total synthesis and inhibition of transcription factor NF-kappaB. Org Lett. 2002 Sep 19; 4(19):3267-70.View Related Profiles.

Porco, John
Gilmore, Thomas

PMID: 12227765

Gilmore T, Gapuzan ME, Kalaitzidis D, Starczynowski D. Rel/NF-kappa B/I kappa B signal transduction in the generation and treatment of human cancer. Cancer Lett. 2002 Jul 08; 181(1):1-9. PMID: 12430173

Kalaitzidis D, Gilmore TD. Genomic organization and expression of the rearranged REL proto-oncogene in the human B-cell lymphoma cell line RC-K8. Genes Chromosomes Cancer. 2002 May; 34(1):129-35. PMID: 11921291

Gapuzan ME, Yufit PV, Gilmore TD. Immortalized embryonic mouse fibroblasts lacking the RelA subunit of transcription factor NF-kappaB have a malignantly transformed phenotype. Oncogene. 2002 Apr 11; 21(16):2484-92. PMID: 11971183

Li C, Pace EA, Liang MC, Lobkovsky E, Gilmore TD, Porco JA. Total synthesis of the NF-kappa B inhibitor (-)-cycloepoxydon: utilization of tartrate-mediated nucleophilic epoxidation. J Am Chem Soc. 2001 Nov 14; 123(45):11308-9.View Related Profiles.

Porco, John
Gilmore, Thomas

PMID: 11697981

Gilmore TD, Cormier C, Jean-Jacques J, Gapuzan ME. Malignant transformation of primary chicken spleen cells by human transcription factor c-Rel. Oncogene. 2001 Oct 25; 20(48):7098-103. PMID: 11704834

Piffat KA, Hrdlicková R, Nehyba J, Ikeda T, Liss A, Huang S, Sif S, Gilmore TD, Bose HR. The chicken RelB transcription factor has transactivation sequences and a tissue-specific expression pattern that are distinct from mammalian RelB. Mol Cell Biol Res Commun. 2001 Sep; 4(5):266-75. PMID: 11529676

Wang Y, Gilmore TD. LIM domain protein Trip6 has a conserved nuclear export signal, nuclear targeting sequences, and multiple transactivation domains. Biochim Biophys Acta. 2001 Apr 23; 1538(2-3):260-72. PMID: 11336797

Barkett M, Dooher JE, Lemonnier L, Simmons L, Scarpati JN, Wang Y, Gilmore TD. Three mutations in v-Rel render it resistant to cleavage by cell-death protease caspase-3. Biochim Biophys Acta. 2001 Apr 03; 1526(1):25-36. PMID: 11287119

Epinat JC, Dvorin EL, Gilmore TD. Envelope-dependent transactivation by the retroviral oncoprotein v-Rel is required for efficient malignant transformation of chicken spleen cells. Oncogene. 2000 Jun 29; 19(28):3131-7. PMID: 10918567

Epinat JC, Kazandjian D, Harkness DD, Petros S, Dave J, White DW, Gilmore TD. Mutant envelope residues confer a transactivation function onto N-terminal sequences of the v-Rel oncoprotein. Oncogene. 2000 Feb 03; 19(5):599-607. PMID: 10698504

Gilmore TD. The Rel/NF-kappaB signal transduction pathway: introduction. Oncogene. 1999 Nov 22; 18(49):6842-4. PMID: 10602459

Gilmore TD. Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel. Oncogene. 1999 Nov 22; 18(49):6925-37. PMID: 10602467

Epinat JC, Gilmore TD. Diverse agents act at multiple levels to inhibit the Rel/NF-kappaB signal transduction pathway. Oncogene. 1999 Nov 22; 18(49):6896-909. PMID: 10602465

Barkett M, Gilmore TD. Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene. 1999 Nov 22; 18(49):6910-24. PMID: 10602466

Epinat JC, Gilmore TD. In vitro-translated diphtheria toxin A chain inhibits translation in wheat germ extracts: analysis of biologically active, caspase-3-resistant diphtheria toxin mutants. Biochim Biophys Acta. 1999 Oct 18; 1472(1-2):34-41. PMID: 10572923; DOI: 10.1016/s0304-4165(99)00101-4;

Wang Y, Dooher JE, Koedood Zhao M, Gilmore TD. Characterization of mouse Trip6: a putative intracellular signaling protein. Gene. 1999 Jul 08; 234(2):403-9. PMID: 10395914

Zhao MK, Wang Y, Murphy K, Yi J, Beckerle MC, Gilmore TD. LIM domain-containing protein trip6 can act as a coactivator for the v-Rel transcription factor. Gene Expr. 1999; 8(4):207-17. PMID: 10794523

Sylla BS, Hung SC, Davidson DM, Hatzivassiliou E, Malinin NL, Wallach D, Gilmore TD, Kieff E, Mosialos G. Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappaB through a pathway that includes the NF-kappaB-inducing kinase and the IkappaB kinases IKKalpha and IKKbeta. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):10106-11. PMID: 9707608

Gilmore TD. Clinically relevant findings. J Clin Invest. 1997 Dec 15; 100(12):2935-6. PMID: 9399935; PMCID: PMC508501; DOI: 10.1172/JCI119843;

Barkett M, Xue D, Horvitz HR, Gilmore TD. Phosphorylation of IkappaB-alpha inhibits its cleavage by caspase CPP32 in vitro. J Biol Chem. 1997 Nov 21; 272(47):29419-22. PMID: 9367996

White DW, Gilmore TD. Transcription factors, oncogenes, and apoptosis. Science. 1997 Apr 11; 276(5310):185. PMID: 9132938

Gilmore TD. Introduction: The Rel/NF-kappaB signal transduction pathway Semin Cancer Biol. 1997 Apr; 8(2):61-2. PMID: 9299583; DOI: 10.1006/scbi.1997.0056;

Gilmore TD, Koedood M, Piffat KA, White DW. Rel/NF-kappaB/IkappaB proteins and cancer. Oncogene. 1996 Oct 03; 13(7):1367-78. PMID: 8875974

White DW, Gilmore TD. Bcl-2 and CrmA have different effects on transformation, apoptosis and the stability of I kappa B-alpha in chicken spleen cells transformed by temperature-sensitive v-Rel oncoproteins. Oncogene. 1996 Sep 05; 13(5):891-9. PMID: 8806678

White DW, Pitoc GA, Gilmore TD. Interaction of the v-Rel oncoprotein with NF-kappaB and IkappaB proteins: heterodimers of a transformation-defective v-Rel mutant and NF-2 are functional in vitro and in vivo. Mol Cell Biol. 1996 Mar; 16(3):1169-78. PMID: 8622661

Morin PJ, Downs JA, Snodgrass AM, Gilmore TD. Genetic analysis of growth inhibition by GAL4-L kappa B-alpha in Saccharomyces cerevisiae. Cell Growth Differ. 1995 Jul; 6(7):789-98. PMID: 7547500

White DW, Roy A, Gilmore TD. The v-Rel oncoprotein blocks apoptosis and proteolysis of I kappa B-alpha in transformed chicken spleen cells. Oncogene. 1995 Mar 02; 10(5):857-68. PMID: 7898928

Sif S, Gilmore TD. Interaction of the v-Rel oncoprotein with cellular transcription factor Sp1. J Virol. 1994 Nov; 68(11):7131-8. PMID: 7933095

Feinstein R, Bolton WK, Quinones JN, Mosialos G, Sif S, Huff JL, Capobianco AJ, Gilmore TD. Characterization of a chicken cDNA encoding the retinoblastoma gene product. Biochim Biophys Acta. 1994 May 17; 1218(1):82-6. PMID: 8193168; DOI: 10.1016/0167-4781(94)90103-1;

Sif S, Gilmore TD. NF-kappa B p100 is one of the high-molecular-weight proteins complexed with the v-Rel oncoprotein in transformed chicken spleen cells. J Virol. 1993 Dec; 67(12):7612-7. PMID: 8230480

Gilmore TD, Morin PJ. The I kappa B proteins: members of a multifunctional family. Trends Genet. 1993 Dec; 9(12):427-33. PMID: 8122310

White DW, Gilmore TD. Temperature-sensitive transforming mutants of the v-rel oncogene. J Virol. 1993 Nov; 67(11):6876-81. PMID: 8411392

Sif S, Capobianco AJ, Gilmore TD. The v-Rel oncoprotein increases expression from Sp1 site-containing promoters in chicken embryo fibroblasts. Oncogene. 1993 Sep; 8(9):2501-9. PMID: 8361761

Sarkar S, Gilmore TD. Transformation by the vRel oncoprotein requires sequences carboxy-terminal to the Rel homology domain. Oncogene. 1993 Aug; 8(8):2245-52. PMID: 8336947

Morin PJ, Subramanian GS, Gilmore TD. GAL4-I kappa B alpha and GAL4-I kappa B gamma activate transcription by different mechanisms. Nucleic Acids Res. 1993 May 11; 21(9):2157-63. PMID: 8502557

Capobianco AJ, Gilmore TD. A conditional mutant of vRel containing sequences from the human estrogen receptor. Virology. 1993 Mar; 193(1):160-70. PMID: 8438564

Mosialos G, Gilmore TD. v-Rel and c-Rel are differentially affected by mutations at a consensus protein kinase recognition sequence. Oncogene. 1993 Mar; 8(3):721-30. PMID: 8437855

Morin PJ, Subramanian GS, Gilmore TD. AAT1, a gene encoding a mitochondrial aspartate aminotransferase in Saccharomyces cerevisiae. Biochim Biophys Acta. 1992 Dec 29; 1171(2):211-4. PMID: 1482685

Capobianco AJ, Chang D, Mosialos G, Gilmore TD. p105, the NF-kappa B p50 precursor protein, is one of the cellular proteins complexed with the v-Rel oncoprotein in transformed chicken spleen cells. J Virol. 1992 Jun; 66(6):3758-67. PMID: 1533881

Morin PJ, Gilmore TD. The C terminus of the NF-kappa B p50 precursor and an I kappa B isoform contain transcription activation domains. Nucleic Acids Res. 1992 May 25; 20(10):2453-8. PMID: 1598203

Gilmore TD. Role of rel family genes in normal and malignant lymphoid cell growth. Cancer Surv. 1992; 15:69-87. PMID: 1451115

Mosialos G, Hamer P, Capobianco AJ, Laursen RA, Gilmore TD. A protein kinase-A recognition sequence is structurally linked to transformation by p59v-rel and cytoplasmic retention of p68c-rel. Mol Cell Biol. 1991 Dec; 11(12):5867-77. PMID: 1944267

Capobianco AJ, Gilmore TD. Repression of the chicken c-rel promoter by vRel in chicken embryo fibroblasts is not mediated through a consensus NF-kappa B binding site. Oncogene. 1991 Dec; 6(12):2203-10. PMID: 1766669

Gilmore TD. Malignant transformation by mutant Rel proteins. Trends Genet. 1991 Oct; 7(10):318-22. PMID: 1781029

Richardson PM, Gilmore TD. vRel is an inactive member of the Rel family of transcriptional activating proteins. J Virol. 1991 Jun; 65(6):3122-30. PMID: 1903456

Dailey D, Schieven GL, Lim MY, Marquardt H, Gilmore T, Thorner J, Martin GS. Novel yeast protein kinase (YPK1 gene product) is a 40-kilodalton phosphotyrosyl protein associated with protein-tyrosine kinase activity. Mol Cell Biol. 1990 Dec; 10(12):6244-56. PMID: 1701015

Gilmore TD. NF-kappa B, KBF1, dorsal, and related matters. Cell. 1990 Sep 07; 62(5):841-3. PMID: 2203533

Kamens J, Richardson P, Mosialos G, Brent R, Gilmore T. Oncogenic transformation by vrel requires an amino-terminal activation domain. Mol Cell Biol. 1990 Jun; 10(6):2840-7. PMID: 2111443

Delwart EL, Mosialos G, Gilmore T. Retroviral envelope glycoproteins contain a "leucine zipper"-like repeat. AIDS Res Hum Retroviruses. 1990 Jun; 6(6):703-6. PMID: 2364015

Capobianco AJ, Simmons DL, Gilmore TD. Cloning and expression of a chicken c-rel cDNA: unlike p59v-rel, p68c-rel is a cytoplasmic protein in chicken embryo fibroblasts. Oncogene. 1990 Mar; 5(3):257-65. PMID: 2179815

Gilmore TD, Temin HM. v-rel oncoproteins in the nucleus and in the cytoplasm transform chicken spleen cells. J Virol. 1988 Mar; 62(3):703-14. PMID: 2828665

Luk KC, Gilmore TD, Panganiban AT. The spleen necrosis virus int gene product expressed in Escherichia coli has DNA binding activity and mediates att and U5-specific DNA multimer formation in vitro. Virology. 1987 Mar; 157(1):127-36. PMID: 3548033

Gilmore TD, Temin HM. Different localization of the product of the v-rel oncogene in chicken fibroblasts and spleen cells correlates with transformation by REV-T. Cell. 1986 Mar 14; 44(5):791-800. PMID: 3004745

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 132 publications over 38 distinct years, with a maximum of 8 publications in 1993

Bar chart showing 132 publications over 38 distinct years, with a maximum of 8 publications in 1993

Year	Publications
1986	1
1987	1
1988	1
1990	5
1991	4
1992	4
1993	8
1994	2
1995	2
1996	3
1997	4
1998	1
1999	7
2000	2
2001	5
2002	5
2003	6
2004	3
2005	5
2006	6
2007	2
2008	3
2009	4
2010	3
2011	5
2012	2
2013	7
2014	3
2015	5
2016	2
2017	3
2018	3
2019	3
2020	1
2021	3
2022	2
2023	3
2024	3

Media Mentions

From Lab to Lifeguard Chair

BU Today 7/31/2023

2014 Boston University: Boston Univ Scholar/Teacher of the Year Award

2009 Boston University: Metcalf Cup & Prize for Excellence in Teaching

1992-1996 American Cancer Society Faculty Research Award

1989-1991 American Cancer Society Junior Faculty Research Award

1981-1982 University of California: Chancellor's Patent Fund Award for Research

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

molecular biology
cell biology
signal transduction
cancer
molecular ecology

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