Sudhir Kumar, PhD
Assistant Professor
Boston University School of Medicine
Dept of Nephrology
Nephrology

PhD, Ludwig-Maximilians-Universität München
MVSc, Haryana Agricultural University (HAU)




My long-term research goal is to elucidate the cells and signals in the kidney contributing to renal fibrosis. Specifically, I am interested in kidney pericyte biology and its role in kidney homeostasis and injury. I have extensive training in kidney developmental biology, mouse models for human diseases, molecular biology, molecular genetics and veterinary medicine. I completed my PhD in mouse genetics from LMU Munich Germany. I did my postdoctoral training in Dr. Weining Lu’s lab at the Renal Section, Boston University Medical Campus. Currently I am involved in different interdisciplinary research projects, which include: (1) Role of Slit-Robo signaling in kidney development and podocyte biology and injury and (2) Role of transcription factor ZEB2 in kidney development and disease. In addition, I am also actively participating in mentoring and training of Boston University graduate and undergraduate students.

2021 CTSI, Boston University: Pilot Grant Award
2011 LMU Munich, Germany: Magna Cum Laude, Doctoral thesis
2008 Bavarian Research Foundation Munich, Germany: PhD scholarship
2007 Industrial training award, Dept. of Biotechnology
2006 University scholarship during M.V.Sc. programme
1998 Distinction, Senior Secondary examination
1996 Merit Award, High School examination

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Pisarek-Horowitz A, Fan X, Kumar S, Rasouly HM, Sharma R, Chen H, Coser K, Bluette CT, Hirenallur-Shanthappa D, Anderson SR, Yang H, Beck LH, Bonegio RG, Henderson JM, Berasi SP, Salant DJ, Lu W. Loss of Roundabout Guidance Receptor 2 (Robo2) in Podocytes Protects Adult Mice from Glomerular Injury by Maintaining Podocyte Foot Process Structure. Am J Pathol. 2020 04; 190(4):799-816.View Related Profiles. PMID: 32220420; PMCID: PMC7217334; DOI: 10.1016/j.ajpath.2019.12.009;
     
  2. Kumar S, Rathkolb B, Sabrautzki S, Krebs S, Kemter E, Becker L, Beckers J, Bekeredjian R, Brommage R, Calzada-Wack J, Garrett L, Hölter SM, Horsch M, Klingenspor M, Klopstock T, Moreth K, Neff F, Rozman J, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Wolf E, Aigner B. Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice. J Biomed Sci. 2017 Aug 17; 24(1):57. PMID: 28818080; PMCID: PMC5559776; DOI: 10.1186/s12929-017-0365-5;
     
  3. Fan X, Yang H, Kumar S, Tumelty KE, Pisarek-Horowitz A, Rasouly HM, Sharma R, Chan S, Tyminski E, Shamashkin M, Belghasem M, Henderson JM, Coyle AJ, Salant DJ, Berasi SP, Lu W. SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion. JCI Insight. 2016 11 17; 1(19):e86934.View Related Profiles. PMID: 27882344; PMCID: PMC5111509; DOI: 10.1172/jci.insight.86934;
     
  4. Rasouly HM, Kumar S, Chan S, Pisarek-Horowitz A, Sharma R, Xi QJ, Nishizaki Y, Higashi Y, Salant DJ, Maas RL, Lu W. Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease. Kidney Int. 2016 Dec; 90(6):1262-1273.View Related Profiles. PMID: 27591083; PMCID: PMC5123919; DOI: 10.1016/j.kint.2016.06.037;
     
  5. Rieger A, Kemter E, Kumar S, Popper B, Aigner B, Wolf E, Wanke R, Blutke A. Missense Mutation of POU Domain Class 3 Transcription Factor 3 in Pou3f3L423P Mice Causes Reduced Nephron Number and Impaired Development of the Thick Ascending Limb of the Loop of Henle. PLoS One. 2016; 11(7):e0158977. PMID: 27420727; PMCID: PMC4946790; DOI: 10.1371/journal.pone.0158977;
     
  6. Kumar S, Rathkolb B, Kemter E, Sabrautzki S, Michel D, Adler T, Becker L, Beckers J, Busch DH, Garrett L, Hans W, Hölter SM, Horsch M, Klingenspor M, Klopstock T, Rácz I, Rozman J, Vargas Panesso IL, Vernaleken A, Zimmer A, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Wolf E, Aigner B. Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice. PLoS One. 2016; 11(3):e0150472. PMID: 27003440; PMCID: PMC4803225; DOI: 10.1371/journal.pone.0150472;
     
  7. Kumar S, Rathkolb B, Budde BS, Nürnberg P, de Angelis MH, Aigner B, Schneider MR. Gsdma3(I359N) is a novel ENU-induced mutant mouse line for studying the function of Gasdermin A3 in the hair follicle and epidermis. J Dermatol Sci. 2012 Sep; 67(3):190-2. PMID: 22682752; DOI: 10.1016/j.jdermsci.2012.05.001;
     

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 7 publications over 4 distinct years, with a maximum of 4 publications in 2016

YearPublications
20121
20164
20171
20201
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Kidney development, Pericyte biology, Kidney fibrosis, Podocyte Biology, SLIT-ROBO signaling, ZEB2
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