Michael Hasselmo, DPH/DrPH
Professor
Boston University College of Arts and Sciences
Psychological and Brain Sciences

DPH/DrPH, University of Oxford
PhD, University of Oxford
AB, Harvard University



Michael E. Hasselmo graduated summa cum laude in 1984 from Harvard College with a Special Concentration in Behavioral Neuroscience. He was awarded the Detur Prize and inducted into Phi Beta Kappa in his junior year. He received a Rhodes scholarship to study at Oxford University, where he completed a D.Phil. from the Department of Experimental Psychology in 1988 based on unit recording of face-responsive neurons in monkey temporal lobe cortex. He completed a post-doctoral fellowship in the Division of Biology at the California Institute of Technology from 1988 to 1991 where he published work on modulatory mechanisms in cortical brain slice preparations. He was an Assistant and Associate Professor at Harvard University from 1991-1998 in the Department of Psychology and in the Mind, Brain and Behavior Interfaculty Initiative. He published work on cholinergic modulation of synaptic transmission and spike frequency accomodation in cortical structures, and demonstrated that acetylcholine sets appropriate cortical dynamics for encoding of new information.

He is the Director of the Center for Systems Neuroscience at Boston University and William Fairfield Warren Professor in the Department of Psychological and Brain Sciences. He is the principal investigator on two NIMH R01 grants and an ONR MURI award and participates on other grants. Research in the laboratory includes intracellular whole cell patch recordings to analyze modulatory effects and oscillatory dynamics in brain slice preparations of cortical structures, as well as extracellular recording of multiple single units in the entorhinal cortex (including grid cells and head direction cells) and place cells in the hippocampus. His modeling includes network level models and detailed biophysical models. Recent publications address the function of theta rhythm oscillations in generation of grid cell firing and encoding of information in the hippocampus and related cortical structures, building on his earlier models of the role of acetylcholine in regulating mechanisms of encoding and consolidation.

He has published over 120 articles in peer reviewed journals including Science, Nature, Neuron, Trends in Neurosciences, Trends in Cognitive Sciences, Journal of Neuroscience, Journal of Neurophysiology, Neural Computation and Hippocampus. He is the Editor-in-Chief at the journal Hippocampus and he is on the editorial board of Neurobiology of Learning and Memory, Behavioral Neuroscience, Journal of Computational Neuroscience, Neuroinformatics, Frontiers in Systems Neuroscience and Brain Structure and Function. He was elected as a member of the American Academy of Arts and Sciences, the American Association for the Advancement of Science and the Memory Disorders Research Society. He was on the Board of Reviewing Editors at Science and a former Associate Editor of the Journal of Neuroscience. He served as president of the International Neural Network Society in 2003 and on the board of governors for many years, and as program chair for the International Joint Conference on Neural Networks in Portland, Oregon, in July 2003, co-chair of the 1996 Computational Neuroscience conference and publications chair for the NeurIPS conference in 1995. He has served as a reviewer and program committee member for the CNS, NIPS, IJCNN and COSYNE conferences.

Professor
Boston University College of Arts and Sciences
Neuroscience


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Egocentric and Allocentric Spatial Coding in Cortex
08/20/2019 - 05/31/2025 (PI)
NIH/National Institute of Mental Health
5R01MH120073-05

Retrosplenial Cortex Circuit Interactions Supporting Spatial Cognition and Memory
07/15/2021 - 06/30/2023 (Key Person / Mentor)
NIH/National Institute of Neurological Disorders & Stroke
5K99NS119665-02

COMPARATIVE COGNITION AND HIPPOCAMPAL FUNCTION
09/23/2016 - 06/30/2023 (PI)
NIH/National Institute of Mental Health
5R01MH052090-25

Effects of Stress on Information Processing in the Hippocampal Formation
01/15/2021 - 01/14/2023 (Key Person / Mentor)
Brain & Behavior Research Foundation


Neural Circuits Underlying Symbolic Processing in Primate Cortex and Basal Ganglia
09/01/2016 - 11/30/2022 (PI)
Department of Defense/ONR


NRT UtB: Neurophotonics
09/01/2016 - 08/31/2022 (Multi-PI)
PI: Michael Hasselmo, DPH/DrPH
National Science Foundation
DGE-1633516

NEUROMODULATION AND CORTICAL MEMORY FUNCTION
02/01/2015 - 01/31/2022 (PI)
NIH/National Institute of Mental Health
5R01MH060013-20

Retrosplenial Cortex Interactions with Entorhinal Cortex and the Visual Anchoring of Spatial Representations
09/30/2017 - 03/31/2021 (Key Person / Mentor)
NIH/National Institute of Neurological Disorders & Stroke
5F32NS101836-04

HIPPOCAMPAL AND CORTICAL CODING IN MEMORY
07/15/2014 - 03/31/2020 (PI)
NIH/National Institute of Mental Health
5R01MH051570-22

MECHANISMS OF ENTORHINAL CORTEX FUNCTION
04/01/2016 - 03/31/2019 (PI)
NIH/National Institute of Mental Health
5R01MH061492-15

Showing 10 of 20 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2023 Egocentric and Allocentric Spatial Coding in Cortex 5R01MH120073-05
2022 Egocentric and Allocentric Spatial Coding in Cortex 5R01MH120073-04
2021 Egocentric and Allocentric Spatial Coding in Cortex 5R01MH120073-03
2020 Egocentric and Allocentric Spatial Coding in Cortex 5R01MH120073-02
2020 Comparative Cognition and Hippocampal Function 5R01MH052090-25 45
2019 Egocentric and Allocentric Spatial Coding in Cortex 1R01MH120073-01
2019 Neuromodulation and Cortical Memory Function 5R01MH060013-20 117
2019 Comparative Cognition and Hippocampal Function 5R01MH052090-24 45
2018 Neuromodulation and Cortical Memory Function 5R01MH060013-19 117
2018 Hippocampal and Cortical Coding in Memory 5R01MH051570-22 49
Showing 10 of 67 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Robinson JC, Ying J, Hasselmo ME, Brandon MP. Optogenetic silencing of medial septal GABAergic neurons disrupts grid cell spatial and temporal coding in the medial entorhinal cortex. Cell Rep. 2024 Aug 27; 43(8):114590. PMID: 39163200
     
  2. Robinson JC, Ying J, Hasselmo ME, Brandon MP. Optogenetic Silencing of Medial Septal GABAergic Neurons Disrupts Grid Cell Spatial and Temporal Coding in the Medial Entorhinal Cortex. bioRxiv. 2023 Nov 09. PMID: 37986986; PMCID: PMC10659309; DOI: 10.1101/2023.11.08.566228;
     
  3. Chapman GW, Hasselmo ME. Predictive learning by a burst-dependent learning rule. Neurobiol Learn Mem. 2023 Nov; 205:107826. PMID: 37696414
     
  4. Lowet E, Sheehan DJ, Chialva U, De Oliveira Pena R, Mount RA, Xiao S, Zhou SL, Tseng HA, Gritton H, Shroff S, Kondabolu K, Cheung C, Wang Y, Piatkevich KD, Boyden ES, Mertz J, Hasselmo ME, Rotstein HG, Han X. Theta and gamma rhythmic coding through two spike output modes in the hippocampus during spatial navigation. Cell Rep. 2023 Aug 29; 42(8):112906.View Related Profiles. PMID: 37540599; PMCID: PMC10530698; DOI: 10.1016/j.celrep.2023.112906;
     
  5. Robinson JC, Wilmot JH, Hasselmo ME. Septo-hippocampal dynamics and the encoding of space and time. Trends Neurosci. 2023 Sep; 46(9):712-725.View Related Profiles. PMID: 37479632; PMCID: PMC10538955; DOI: 10.1016/j.tins.2023.06.004;
     
  6. Lian Y, Williams S, Alexander AS, Hasselmo ME, Burkitt AN. Learning the Vector Coding of Egocentric Boundary Cells from Visual Data. J Neurosci. 2023 Jul 12; 43(28):5180-5190. PMID: 37286350; PMCID: PMC10342228; DOI: 10.1523/JNEUROSCI.1071-22.2023;
     
  7. Alexander AS, Robinson JC, Stern CE, Hasselmo ME. Gated transformations from egocentric to allocentric reference frames involving retrosplenial cortex, entorhinal cortex, and hippocampus. Hippocampus. 2023 May; 33(5):465-487. PMID: 36861201; PMCID: PMC10403145; DOI: 10.1002/hipo.23513;
     
  8. Wilmerding LK, Kondratyev I, Ramirez S, Hasselmo ME. Route-dependent spatial engram tagging in mouse dentate gyrus. Neurobiol Learn Mem. 2023 Apr; 200:107738.View Related Profiles. PMID: 36822466; PMCID: PMC10106405; DOI: 10.1016/j.nlm.2023.107738;
     
  9. Cao R, Bladon JH, Charczynski SJ, Hasselmo ME, Howard MW. Internally generated time in the rodent hippocampus is logarithmically compressed. Elife. 2022 Oct 17; 11.View Related Profiles. PMID: 36250631; PMCID: PMC9651951; DOI: 10.7554/eLife.75353;
     
  10. Stern CE, Hasselmo ME. Mechanisms for maintaining information in working memory. Cogn Neurosci. 2022 Jul; 13(3-4):218-219. PMID: 36214597; PMCID: PMC10121215; DOI: 10.1080/17588928.2022.2131750;
     
Showing 10 of 240 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 240 publications over 36 distinct years, with a maximum of 16 publications in 2005

YearPublications
19891
19902
19911
19922
19931
19944
19954
19965
19976
19984
19995
20006
20015
20026
20035
20046
200516
200610
200710
200812
20099
20105
20115
201214
201315
201413
20159
20166
201710
201810
20193
202013
20212
20227
20237
20241
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