Michael Hasselmo, DPH/DrPH
Boston University College of Arts and Sciences
Dept of Psychological and Brain Sciences

DPH/DrPH, University of Oxford
PhD, University of Oxford

Michael E. Hasselmo graduated summa cum laude in 1984 from Harvard College with a Special Concentration in Behavioral Neuroscience. He was awarded the Detur Prize and inducted into Phi Beta Kappa in his junior year. He received a Rhodes scholarship to study at Oxford University, where he completed a D.Phil. from the Department of Experimental Psychology in 1988 based on unit recording of face-responsive neurons in monkey temporal lobe cortex. He completed a post-doctoral fellowship in the Division of Biology at the California Institute of Technology from 1988 to 1991 where he published work on modulatory mechanisms in cortical brain slice preparations. He was an Assistant and Associate Professor at Harvard University from 1991-1998 in the Department of Psychology and in the Mind, Brain and Behavior Interfaculty Initiative. He published work on cholinergic modulation of synaptic transmission and spike frequency accomodation in cortical structures, and demonstrated that acetylcholine sets appropriate cortical dynamics for encoding of new information.
He is the Director of the Center for Systems Neuroscience at Boston University. He is the principal investigator on two NIMH R01 grants an ONR MURI award and an NSF EAGER grant for the Initiative on Physics and Mathematics of Neural Systems. He is the Associate Director of the Center for Memory and Brain which is funded by a Silvio O. Conte P50 center grant. Research in the laboratory includes intracellular whole cell patch recordings to analyze modulatory effects and oscillatory dynamics in brain slice preparations of cortical structures, as well as extracellular recording of multiple single units in the entorhinal cortex (including grid cells and head direction cells) and place cells in the hippocampus. His modeling includes network level models and detailed biophysical models. Recent publications address the function of theta rhythm oscillations in generation of grid cell firing and encoding of information in the hippocampus and related cortical structures, building on his earlier models of the role of acetylcholine in regulating mechanisms of encoding and consolidation.

He has published over 120 articles in peer reviewed journals including Science, Nature, Neuron, Trends in Neurosciences, Trends in Cognitive Sciences, Journal of Neuroscience, Journal of Neurophysiology, Neural Computation and Hippocampus. He is a member of the Board of Reviewing Editors at Science, the Computational Neuroscience editor at Hippocampus, an Associate Editor of the Journal of Neuroscience and Frontiers in Systems Neuroscience, and he is on the editorial board of Neurobiology of Learning and Memory, Neural Networks, Network: Computation in Neural Systems, Neuroinformatics, and Brain Structure and Function. He served as president of the International Neural Network Society in 2003, and as program chair for the International Joint Conference on Neural Networks in Portland, Oregon, in July 2003. He is a current member of the board of governors of INNS. He was a co-chair of the 1996 Computational Neuroscience conference and publications chair for the NIPS conference in 1995. He has served as a reviewer and program committee member for the CNS, NIPS, IJCNN and COSYNE conferences.

Boston University College of Arts and Sciences

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

Egocentric and Allocentric Spatial Coding in Cortex
08/20/2019 - 05/31/2024 (PI)
NIH/National Institute of Mental Health

Neural Circuits Underlying Symbolic Processing in Primate Cortex and Basal Ganglia
09/01/2016 - 08/31/2021 (PI)
Department of Defense/ONR

NRT UtB: Neurophotonics
09/01/2016 - 08/31/2021 (Co-PI)
National Science Foundation

Comparative Cognition and Hippocampal Function
09/23/2016 - 06/30/2021 (PI)
NIH/National Institute of Mental Health

Neuromodulation and Cortical Memory Function
02/01/2015 - 01/31/2021 (PI)
NIH/National Institute of Mental Health

Hippocampal and Cortical Coding in Memory
07/15/2014 - 03/31/2020 (PI)
NIH/National Institute of Mental Health

Mechanisms of Entorhinal Cortex Function
04/01/2016 - 03/31/2019 (PI)
NIH/National Institute of Mental Health

NSF EAGER: Initiative for Physics and Mathematics of Neural Systems
09/01/2014 - 08/31/2017 (PI)
National Science Foundation

Prefrontal and Medial-Temporal Interactions in Memory
09/06/2011 - 06/30/2017 (Multi-PI)
NIH/National Institutes of Health

08/01/2010 - 07/31/2016 (PI)
Department of Defense/Navy

Showing 10 of 16 results. Show All Results


Yr Title Project-Sub Proj Pubs
2019 Egocentric and Allocentric Spatial Coding in Cortex 1R01MH120073-01
2019 Neuromodulation and Cortical Memory Function 5R01MH060013-20 117
2019 Comparative Cognition and Hippocampal Function 5R01MH052090-24 45
2018 Neuromodulation and Cortical Memory Function 5R01MH060013-19 117
2018 Hippocampal and Cortical Coding in Memory 5R01MH051570-22 49
2018 Comparative Cognition and Hippocampal Function 5R01MH052090-23 45
2017 Mechanisms of Entorhinal Cortex Function 5R01MH061492-15 120
2017 Neuromodulation and Cortical Memory Function 5R01MH060013-18 117
2017 Hippocampal and Cortical Coding in Memory 5R01MH051570-21 49
2017 Comparative Cognition and Hippocampal Function 5R01MH052090-22 45
Showing 10 of 62 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Sherfey J, Ardid S, Miller EK, Hasselmo ME, Kopell NJ. Prefrontal oscillations modulate the propagation of neuronal activity required for working memory. Neurobiol Learn Mem. 2020 Sep; 173:107228.View Related Profiles. PMID: 32561459
  2. Kinsky NR, Mau W, Sullivan DW, Levy SJ, Ruesch EA, Hasselmo ME. Trajectory-modulated hippocampal neurons persist throughout memory-guided navigation. Nat Commun. 2020 05 15; 11(1):2443.View Related Profiles. PMID: 32415083
  3. Liu Y, Brincat SL, Miller EK, Hasselmo ME. A Geometric Characterization of Population Coding in the Prefrontal Cortex and Hippocampus during a Paired-Associate Learning Task. J Cogn Neurosci. 2020 Aug; 32(8):1455-1465. PMID: 32379002
  4. Hasselmo ME, Alexander AS, Hoyland A, Robinson JC, Bezaire MJ, Chapman GW, Saudargiene A, Carstensen LC, Dannenberg H. The Unexplored Territory of Neural Models: Potential Guides for Exploring the Function of Metabotropic Neuromodulation. Neuroscience. 2020 Apr 08. PMID: 32278058
  5. Hasselmo ME, Alexander AS, Dannenberg H, Newman EL. Overview of computational models of hippocampus and related structures: Introduction to the special issue. Hippocampus. 2020 Apr; 30(4):295-301. PMID: 32119171
  6. Alexander AS, Carstensen LC, Hinman JR, Raudies F, Chapman GW, Hasselmo ME. Egocentric boundary vector tuning of the retrosplenial cortex. Sci Adv. 2020 02; 6(8):eaaz2322. PMID: 32128423
  7. Zhu H, Paschalidis IC, Chang A, Stern CE, Hasselmo ME. A neural circuit model for a contextual association task inspired by recommender systems. Hippocampus. 2020 Apr; 30(4):384-395. PMID: 32057161
  8. Issa JB, Tocker G, Hasselmo ME, Heys JG, Dombeck DA. Navigating Through Time: A Spatial Navigation Perspective on How the Brain May Encode Time. Annu Rev Neurosci. 2020 Jul 08; 43:73-93. PMID: 31961765
  9. Dannenberg H, Alexander AS, Robinson JC, Hasselmo ME. The Role of Hierarchical Dynamical Functions in Coding for Episodic Memory and Cognition. J Cogn Neurosci. 2019 09; 31(9):1271-1289. PMID: 31251890
  10. Hinman JR, Chapman GW, Hasselmo ME. Neuronal representation of environmental boundaries in egocentric coordinates. Nat Commun. 2019 06 24; 10(1):2772. PMID: 31235693
Showing 10 of 218 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 218 publications over 32 distinct years, with a maximum of 16 publications in 2005

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