Mapping and manipulating neural memory circuits in mice (SDL) to tackle brain disorders that disproportionally affect underrepresented groups by modifying neurons tied to memory
12/01/2022 - 11/30/2027 (PI)
Silicon Valley Community Foundation


Restoring the Brain with Activated Memories
07/12/2022 - 07/12/2027 (PI)
The Pew Charitable Trusts


The effect of adolescent drug-induced neuroimmune signaling in sex-specific social development and reward learning
07/01/2022 - 03/31/2027 (Subcontract PI)
Albany Medical College NIH NIDA
1R01DA052889-01A1

Characterizing the neural correlates of memory-guided conflict resolution
09/01/2022 - 08/31/2025 (Key Person / Mentor)
Howard Hughes Medical Institute


Neuron-Astrocyte Dynamics in Learning and Memory with Population- and Single-Cell Resolution
05/23/2023 - 05/22/2025 (PI)
Ludwig Family Foundation


Carol and Gene Ludwig Award for Neurodegeneration Research
09/24/2021 - 10/01/2024 (PI)
Ludwig Family Foundation


Restoring Access to Memories 'Lost' as a Result of Sleep Deprivation
09/01/2021 - 08/31/2024 (PI)
Department of Defense/AFOSR


2022 McKnight Matthew Pecot Fellowship
06/01/2022 - 05/31/2024 (PI)
The McKnight Foundation


Single-Cell and Target Specific Resolution of Multiple Memories Across the Brain
09/13/2019 - 08/31/2023 (Multi-PI)
PI: Steve Ramirez, PhD
Research Foundation for Mental Hygiene NIH NICHD
5R01HD101402-04

Artificially Modulating Memories to Alleviate Psychiatric Disease-Like Stress
07/01/2017 - 08/31/2023 (PI)
NIH/Office of the Director
5DP5OD023106-07

Showing 10 of 15 results. Show All Results

1. Surets M, Caban-Murillo A, Ramirez S. Prelimbic cortex ensembles promote appetitive learning-associated behavior. Learn Mem. 2024; 31(1-2). PMID: 38408863; PMCID: PMC10903945; DOI: 10.1101/lm.053892.123;
2. Suthard RL, Senne RA, Buzharsky MD, Diep AH, Pyo AY, Ramirez S. Engram reactivation mimics cellular signatures of fear. Cell Rep. 2024 Mar 26; 43(3):113850. PMID: 38401120
3. Dorst KE, Senne RA, Diep AH, de Boer AR, Suthard RL, Leblanc H, Ruesch EA, Pyo AY, Skelton S, Carstensen LC, Malmberg S, McKissick OP, Bladon JH, Ramirez S. Hippocampal Engrams Generate Variable Behavioral Responses and Brain-Wide Network States. J Neurosci. 2024 Jan 10; 44(2). PMID: 38050098; PMCID: PMC10860633; DOI: 10.1523/JNEUROSCI.0340-23.2023;
4. Rahsepar B, Norman JF, Noueihed J, Lahner B, Quick MH, Ghaemi K, Pandya A, Fernandez FR, Ramirez S, White JA. Theta-phase-specific modulation of dentate gyrus memory neurons. Elife. 2023 Jul 04; 12.View Related Profiles.

   Noueihed, Jad
   White, John
   Ramirez, Steve
   

   PMID: 37401757; PMCID: PMC10361715; DOI: 10.7554/eLife.82697;
5. Borzello M, Ramirez S, Treves A, Lee I, Scharfman H, Stark C, Knierim JJ, Rangel LM. Assessments of dentate gyrus function: discoveries and debates. Nat Rev Neurosci. 2023 Aug; 24(8):502-517. PMID: 37316588; PMCID: PMC10529488; DOI: 10.1038/s41583-023-00710-z;
6. Suthard RL, Senne RA, Buzharsky MD, Pyo AY, Dorst KE, Diep AH, Cole RH, Ramirez S. Basolateral Amygdala Astrocytes Are Engaged by the Acquisition and Expression of a Contextual Fear Memory. J Neurosci. 2023 Jul 05; 43(27):4997-5013. PMID: 37268419; PMCID: PMC10324998; DOI: 10.1523/JNEUROSCI.1775-22.2023;
7. Wilmerding LK, Kondratyev I, Ramirez S, Hasselmo ME. Route-dependent spatial engram tagging in mouse dentate gyrus. Neurobiol Learn Mem. 2023 Apr; 200:107738.View Related Profiles.

   Hasselmo, Michael
   Ramirez, Steve
   

   PMID: 36822466; PMCID: PMC10106405; DOI: 10.1016/j.nlm.2023.107738;
8. Suthard RL, Jellinger AL, Surets M, Shpokayte M, Pyo AY, Buzharsky MD, Senne RA, Dorst K, Leblanc H, Ramirez S. Chronic Gq activation of ventral hippocampal neurons and astrocytes differentially affects memory and behavior. Neurobiol Aging. 2023 May; 125:9-31. PMID: 36801699
9. Linghu C, An B, Shpokayte M, Celiker OT, Shmoel N, Zhang R, Zhang C, Park D, Park WM, Ramirez S, Boyden ES. Recording of cellular physiological histories along optically readable self-assembling protein chains. Nat Biotechnol. 2023 May; 41(5):640-651. PMID: 36593405; PMCID: PMC10188365; DOI: 10.1038/s41587-022-01586-7;
10. Shpokayte M, McKissick O, Guan X, Yuan B, Rahsepar B, Fernandez FR, Ruesch E, Grella SL, White JA, Liu XS, Ramirez S. Hippocampal cells segregate positive and negative engrams. Commun Biol. 2022 Sep 26; 5(1):1009.View Related Profiles.

    Fernandez, Fernando
    White, John
    Ramirez, Steve
    

    PMID: 36163262; PMCID: PMC9512908; DOI: 10.1038/s42003-022-03906-8;

Showing 10 of 33 results. Show More

Sheena Josselyn and memories lost, found and created

Pew Scholar Investigates How Good and Bad Memories Impact Brain Health

Can You Rewrite Bad Memories as Good Ones? Scientists Believe This Brave New World Is Near

Boston University Study Sheds New Light on Fear Memories and Behavior

Good and bad memories are stored in different neurons, study finds

Memory: a revolutionary treatment for mental health disorders and neurodegeneration?

Steve Ramirez Reshapes Memories in the Brains of Mice

Unlocking the Power of Our Emotional Memory To Cure Mental Health Disorders Like Depression and PTSD

Good and bad memories have their own real estate in the brain, raising the possibility of memory manipulation

Can we rewrite fearful memories to treat anxiety?

Can We "Turn Down the Volume" on Negative Memories?

Rewriting negative memories by activating positive ones

Research team shines light on how the brain stores positive and negative memories

Unlocking the power of our emotional memory

BU neuroscientists hope to uncover new ways to treat memory-related disorders

Sniffing Out the Science of Smelling

Using optogenetics, scientists pinpoint the location and timing of memory formation in mice

The People’s Picks for Best Posts

Brain Cell DNA Refolds Itself to Aid Memory Recall

Study Suggests Scents Alter How Memories Are Processed In The Brain

Smell May Shape How Brains Process Memories

Study suggests power of scents can alter how memories are processed in brain

Study: Scents Alter How Memories Are Processed in the Brain

Linking scents to memories

Scents alter how memories are processed in the brain, new study suggests

New research reveals that scents alter how memories are processed in the brain

The Scents That Spark Our Memories

What a Memory Looks Like

The pill that ‘deletes painful memories’: Memory-altering drug could dull painful experiences after trial of 60 heartbroken volunteers helps them ‘turn the page’ and overcome ‘obsessions’

If you could erase the worst memory of your life, would you? Scientists working on a pill for that

How To Manipulate Memories

Can We Manipulate Memory To Fight Anxiety?

Will It Ever Be Possible to Understand the Human Brain?

Can we turn down the emotion on traumatic memories?

Study: Stimulating different parts of the brain can dial up or down a specific memory’s emotional oomph, study shows — (Details)

The incredible science exploring how to edit our memories

Study reveals possibility to enhance or suppress memories

Stimulating Parts Of The Brain May Enhance Or Suppress Memories

Proof It’s Possible to Enhance or Suppress Memories: Mice Study

Manipulating memories could become a reality one day: study (BU research featured)

WIll you be able to manipulate your memory? New study gives hope of breakthrough

Researchers figure out way to edit, enhance, suppress memories

Can We Turn Down The Emotion On Traumatic Memories?

Eternal Sunshine of the Spotless Mind: Scientists Discover How to Enhance and Suppress Memories with Uncanny Accuracy

Scientists Find a Volume Knob for Emotional Memories

Proof it's possible to enhance or suppress memories

Traumatic memories pit two neuron groups against each other

This neuroscientist makes memories—and suppresses them