Ludy Chen Shih, MD, MMSc
Associate Professor (appointment pending)
Boston University School of Medicine
Dept of Neurology





Dr. Shih has research interests in gait and cognition in Parkinson's disease and related diseases and their digital signatures and innovation in deep brain stimulation for Parkinson’s disease, essential tremor and dystonia. Her work includes the use of wearable sensors and other objective methods to assess and characterize tremor, gait and related neurologic impairments and has been funded by the Michael J. Fox Foundation and the Consortia for Improving Medicine with Innovation and Technology (CIMIT). Her research interests also include clinical and translational research into novel methods of detection and management of gait, Parkinson’s disease and related disorders, including essential tremor, atypical parkinsonism and ataxia. She serves on the Medical Advisory Board for the International Essential Tremor Foundation, the International Parkinson's Disease and Movement Disorders Society Tremor Study Group and previously served on the Steering Committee for the Registry for Advancement of Deep Brain Stimulation Therapy for Parkinson’s Disease (RAD-PD). She is a member of the Parkinson Study Group (PSG), Tremor Research Group, Movement Disorder Society, American Academy of Neurology and American Neurological Association.

2002 Alpha Omega Alpha
2002 UCLA Department of Neurology: Richard D. Walter Award for Outstanding Neurology Student
2001 Alpha Omega Alpha Student Research Fellowship
2001 American Stroke Association Student Scholarship in Cerebrovascular Disease




Title

Study in Parkinson Disease of Exercise Phase 3 Clinical Trial (SPARX3)
01/01/2020 - 12/31/2023 (Site PI)
PI: Daniel Corcos
NIH NIH
1U01 NS102038-3

Department of Neurology Donors Fund
Gait analysis in parkinsonian disorders
01/01/2015 - 12/31/2017 (Co-PI)
PI: Ludy Chen Shih, MD, MMSc
BIDMC BIDMC

Department of Neurology Donor Fund
Transcranial stimulation for essential tremor
01/01/2014 - 12/31/2017 (PI)
BIDMC BIDMC


01/01/2013 - 12/31/2017 (Site PI)
PI: Hyder Jinnah
Dystonia Coalition NIH
1U54 NS065701-03

Connect.Parkinson: Connecting Individuals With Parkinson Disease to Specialists in Their Homes
01/01/2014 - 12/31/2016 (Site PI)
PI: Ludy Chen Shih, MD, MMSc
PCORI PCORI
AD-12-11-4701

Near Infrared Spectroscopy Measurements of Cerebral Oxygenation in DBS
01/01/2013 - 12/31/2015 (Co-Investigator)
PI: Ron Alterman
Medtronic, Inc Medtronic, Inc

Biomarker Development in Parkinson’s Disease
01/01/2011 - 12/31/2014 (Co-Investigator)
PI: Christopher Gibbons
Robert and Judy Goldberg Foundation

DaTscan Use and Impact in a Movement Disorder Center (Phase IV)
01/01/2011 - 01/01/2013 (Co-Investigator)
PI: David K. Simon
General Electric, Inc.

Non-invasive Compensation of Hand Tremor via Engineered Devices
01/01/2011 - 12/31/2012 (Co-Investigator)
PI: Rifat Sipahi
Center for Integration of Medicine and Innovative Technology

Use of wearable sensors to remotely assess tremor-related and parkinsonism-related disability in the home environment
01/01/2009 - 12/31/2010 (PI)
Center for Integration of Medicine and Innovative Technology

Showing 10 of 14 results. Show All Results

Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Schneider RB, Jimenez-Shahed J, Abraham DS, Thibault DP, Mantri S, Fullard M, Burack MA, Chou KL, Spindler M, Jermakowicz WJ, D'Haese PF, York MK, Kirk JC, Schwalb JM, Espay AJ, Shih LC, Simon DK, Hunter C, Crispo JAG, Willis AW. Acute readmission following deep brain stimulation surgery for Parkinson's disease: A nationwide analysis. Parkinsonism Relat Disord. 2020 01; 70:96-102. PMID: 31866156
     
  2. Joutsa J, Shih LC, Fox MD. Mapping holmes tremor circuit using the human brain connectome. Ann Neurol. 2019 12; 86(6):812-820. PMID: 31614012; DOI: 10.1002/ana.25618;
     
  3. Broom L, Worley A, Gao F, Hernandez LD, Ashton CE, Shih LC, VanderHorst VG. Translational methods to detect asymmetries in temporal and spatial walking metrics in parkinsonian mouse models and human subjects with Parkinson's disease. Sci Rep. 2019 02 21; 9(1):2437. PMID: 30792396
     
  4. Joutsa J, Shih LC, Horn A, Reich MM, Wu O, Rost NS, Fox MD. Identifying therapeutic targets from spontaneous beneficial brain lesions. Ann Neurol. 2018 07; 84(1):153-157. PMID: 30014594; DOI: 10.1002/ana.25285;
     
  5. Elble RJ, Shih L, Cozzens JW. Surgical treatments for essential tremor. Expert Rev Neurother. 2018 04; 18(4):303-321. PMID: 29475371; DOI: 10.1080/14737175.2018.1445526;
     
  6. Ondo W, Hashem V, LeWitt PA, Pahwa R, Shih L, Tarsy D, Zesiewicz T, Elble R. Comparison of the Fahn-Tolosa-Marin Clinical Rating Scale and the Essential Tremor Rating Assessment Scale. Mov Disord Clin Pract. 2018 Jan-Feb; 5(1):60-65. PMID: 30363460; DOI: 10.1002/mdc3.12560;
     
  7. Beck CA, Beran DB, Biglan KM, Boyd CM, Dorsey ER, Schmidt PN, Simone R, Willis AW, Galifianakis NB, Katz M, Tanner CM, Dodenhoff K, Aldred J, Carter J, Fraser A, Jimenez-Shahed J, Hunter C, Spindler M, Reichwein S, Mari Z, Dunlop B, Morgan JC, McLane D, Hickey P, Gauger L, Richard IH, Mejia NI, Bwala G, Nance M, Shih LC, Singer C, Vargas-Parra S, Zadikoff C, Okon N, Feigin A, Ayan J, Vaughan C, Pahwa R, Dhall R, Hassan A, DeMello S, Riggare SS, Wicks P, Achey MA, Elson MJ, Goldenthal S, Keenan HT, Korn R, Schwarz H, Sharma S, Stevenson EA, Zhu W. National randomized controlled trial of virtual house calls for Parkinson disease. Neurology. 2017 Sep 12; 89(11):1152-1161. PMID: 28814455; DOI: 10.1212/WNL.0000000000004357;
     
  8. Broom L, Ellison BA, Worley A, Wagenaar L, Sörberg E, Ashton C, Bennett DA, Buchman AS, Saper CB, Shih LC, Hausdorff JM, VanderHorst VG. A translational approach to capture gait signatures of neurological disorders in mice and humans. Sci Rep. 2017 06 12; 7(1):3225. PMID: 28607434; DOI: 10.1038/s41598-017-03336-1;
     
  9. Shih LC, Pascual-Leone A. Non-invasive Brain Stimulation for Essential Tremor. Tremor Other Hyperkinet Mov (N Y). 2017; 7:458. PMID: 28373927; DOI: 10.7916/D8G44W01;
     
  10. Horn A, Kühn AA, Merkl A, Shih L, Alterman R, Fox M. Probabilistic conversion of neurosurgical DBS electrode coordinates into MNI space. Neuroimage. 2017 04 15; 150:395-404. PMID: 28163141; DOI: 10.1016/j.neuroimage.2017.02.004;
     
Showing 10 of 35 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 35 publications over 13 distinct years, with a maximum of 5 publications in 2016 and 2017

YearPublications
20031
20071
20092
20103
20113
20121
20134
20142
20153
20165
20175
20182
20193

My clinical and research expertise is the phenotypic characterization of tremor and gait disorders and in the delivery of deep brain stimulation therapy for Parkinson's disease, essential tremor and dystonia. I have successfully mentored ~15 trainees and early career faculty members in movement disorders clinical research who now are independent investigators and/or movement disorders clinicians around the globe.

I have also had experience working in industry developing medicines for neurodegenerative diseases and can advise on the similarities and differences between a career in academic medicine and industry research and development.

I am committed to playing a role in faculty development and in mentoring trainees, early career clinicians and clinical researchers. I view being an empathetic listener and a connector of people and ideas to be one of the ways in which I can help trainees in various stages of their careers.

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')
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