Ludy Shih, MD, MMSc, FAAN, FANA
Associate Professor
Boston University Chobanian & Avedisian School of Medicine

MD, University of California, Los Angeles School of Medicine
MMS/MMSc, Massachusetts Institute of Technology
BS, Stanford University

Dr. Shih is a neurologist focused on movement disorders and neurodegenerative diseases like Parkinson's disease (PD), dementia, and essential tremor (ET). She is also a Framingham Heart Study and BU Alzheimer's Disease Research Center investigator with research interests in how PD, dementia, ET and related disorders intersect with cognitive impairment and aging. Her work includes using neuroimaging analytic techniques, wearable sensors, and other methods to assess and characterize neurologic impairment in order to develop clinical and translational tools for diagnosis and management of disease among diverse populations. Her investigator-initiated work has been funded by the Michael J. Fox Foundation, the Consortia for Improving Medicine with Innovation and Technology (CIMIT), and the Tremor Research Group (TRG).

She completed a Master's degree in Clinical Investigation from the Harvard-MIT Health Sciences and Technology Clinical Investigator Training Program in collaboration with Pfizer and Merck & Co. Her clinical practice and interests have focused on taking care of patients in all stages of PD and related disorders, including those before, during and after deep brain stimulation (DBS) and heavily centered upon the interdisciplinary nature of assessing and managing motor, cognitive, and behavioral aspects of individuals with PD, as well as those with ET and dystonia.

Currently, her group is interested in four main areas:

1. Developing digital motor and cognitive signatures of brain aging in community-based and clinical populations to improve detection of PD, PD dementia and other forms of dementia.
2. The use of technology to improve care for vulnerable aging individuals with PD, on motor, cognitive and behavioral aspects
3. ET epidemiology, investigational treatments and outcomes research
4. Improving education and career development pathways for physician-scholars

Additional Experiences:

While working in biotech and pharma, she has worked on multi-disciplinary teams on biomarker (fluid, imaging and wearable sensors), epidemiology, and natural history studies. Primarily focused on research and early development, she led clinical study design for several phase 1 and phase 2 studies, including the evaluation and selection of outcome assessments, including biomarker assessments and biostatistical innovation into protocol development, and was responsible for overall study execution and oversight. In addition, she has experience with both US and EU regulatory agency interactions, academic-industry partnerships through scientific collaborations, and evaluated external assets for in-licensing.

She currently serves as Associate Editor for Annals of Clinical and Translational Neurology (ACTN), and on the Board of the American Society for Experimental Neurotherapeutics (ASENT). She also sits on the International Parkinson's Disease and Movement Disorders Society (MDS) Tremor Study Group and Epidemiology Study Group, and Medical Advisory Board for the International Essential Tremor Foundation (IETF). She is a member of the Parkinson Study Group (PSG), Tremor Research Group (TRG), and is fellow of the American Academy of Neurology (AAN) and of the American Neurological Association (ANA).

Diversity, Equity, Inclusion and Accessibility

I am dedicated to helping clinicians interested in careers in academic medicine navigate the hidden curriculum for success in the academic arena. I serve as a mentor for the BUSM school-wide PROF (Propelling Rise of Faculty) Initiative. I organize the Department of Neurology Research and Scholarly Activity Series open to students, residents, fellows and all faculty to help foster scholarly productivity. I have mentored undergraduates who have been first-generation college students as they navigate application to medical school. In addition, I lead efforts to provide innovative care to all patients in our Parkinson's Disease and Movement Disorders Center, but with a focus on immigrants and people of diverse racial and ethnic groups seen in our center to help them navigate the challenges of living with neurological disease.

02/16/2022 - 02/15/2025 (PI)
Praxis Precision Medicines

Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3
08/01/2021 - 07/31/2024 (PI)
Boston University National Institute o

The Essential Tremor Rating Assessment Scale Patient-Reported Outcome
07/01/2022 - 12/31/2023 (PI)
Tremor Research Group

Feasibility of Remote Measures and Assessments for Deep Brain Stimulation (FoRMA-DBS)
08/01/2021 - 07/31/2023 (PI)
Abbott Neuromodulation

Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3
08/21/2021 - 08/20/2022 (PI)
Northwestern University National Institute o


Study in Parkinson Disease of Exercise Phase 3 Clinical Trial (SPARX3)
01/01/2020 - 12/31/2023 (Site PI)
PI: Daniel Corcos
1U01 NS102038-3

Department of Neurology Donors Fund
01/01/2015 - 12/31/2017 (Co-PI)
PI: Ludy Shih, MD, MMSc, FAAN, FANA

Department of Neurology Donor Fund
01/01/2014 - 12/31/2017 (PI)

01/01/2013 - 12/31/2017 (Site PI)
PI: Hyder Jinnah
Dystonia Coalition NIH
1U54 NS065701-03

Connect.Parkinson: Connecting Individuals With Parkinson Disease to Specialists in Their Homes
01/01/2014 - 12/31/2016 (Site PI)
PI: Ludy Shih, MD, MMSc, FAAN, FANA

Near Infrared Spectroscopy Measurements of Cerebral Oxygenation in DBS
01/01/2013 - 12/31/2015 (Co-Investigator)
PI: Ron Alterman
Medtronic, Inc Medtronic, Inc

Biomarker Development in Parkinson’s Disease
01/01/2011 - 12/31/2014 (Co-Investigator)
PI: Christopher Gibbons
Robert and Judy Goldberg Foundation

DaTscan Use and Impact in a Movement Disorder Center (Phase IV)
01/01/2011 - 01/01/2013 (Co-Investigator)
PI: David K. Simon
General Electric, Inc.

Non-invasive Compensation of Hand Tremor via Engineered Devices
01/01/2011 - 12/31/2012 (Co-Investigator)
PI: Rifat Sipahi
Center for Integration of Medicine and Innovative Technology

Use of wearable sensors to remotely assess tremor-related and parkinsonism-related disability in the home environment
01/01/2009 - 12/31/2010 (PI)
Center for Integration of Medicine and Innovative Technology

Showing 10 of 14 results. Show All Results

Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Romano MF, Shih LC, Paschalidis IC, Au R, Kolachalama VB. Large Language Models in Neurology Research and Future Practice. Neurology. 2023 Dec 04; 101(23):1058-1067.View Related Profiles. PMID: 37816646
  2. Adam O, Shih L, Molho E, Hanspal E, Zurbenko I. Time to initiation of symptomatic treatment in untreated Parkinson disease in the Parkinson progression marker initiative cohort: A 10-year follow up. Parkinsonism Relat Disord. 2023 Sep; 114:105796. PMID: 37549586
  3. Bruce HJ, Tripodis Y, McClean M, Korell M, Tanner CM, Contreras B, Gottesman J, Kirsch L, Karim Y, Martin B, Palmisano J, Abdolmohammadi B, Shih LC, Stein TD, Stern RA, Adler CH, Mez J, Nowinski C, McKee AC, Alosco ML. American Football Play and Parkinson Disease Among Men. JAMA Netw Open. 2023 Aug 01; 6(8):e2328644.View Related Profiles. PMID: 37566412; PMCID: PMC10422187; DOI: 10.1001/jamanetworkopen.2023.28644;
  4. Miller MI, Shih LC, Kolachalama VB. Machine Learning in Clinical Trials: A Primer with Applications to Neurology. Neurotherapeutics. 2023 Jul; 20(4):1066-1080.View Related Profiles. PMID: 37249836; PMCID: PMC10228463; DOI: 10.1007/s13311-023-01384-2;
  5. Wang R, Shih LC. Parkinson's disease - current treatment. Curr Opin Neurol. 2023 Aug 01; 36(4):302-308. PMID: 37366218
  6. O'Shea SA, Shih LC. Global Epidemiology of Movement Disorders: Rare or Underdiagnosed? Semin Neurol. 2023 Feb; 43(1):4-16.View Related Profiles. PMID: 36893797
  7. Mahajan A, Shih LC. Introduction to Diagnostic Challenges in Movement Disorders. Semin Neurol. 2023 Feb; 43(1):2-3. PMID: 36807281
  8. Qiu S, Miller MI, Joshi PS, Lee JC, Xue C, Ni Y, Wang Y, De Anda-Duran I, Hwang PH, Cramer JA, Dwyer BC, Hao H, Kaku MC, Kedar S, Lee PH, Mian AZ, Murman DL, O'Shea S, Paul AB, Saint-Hilaire MH, Alton Sartor E, Saxena AR, Shih LC, Small JE, Smith MJ, Swaminathan A, Takahashi CE, Taraschenko O, You H, Yuan J, Zhou Y, Zhu S, Alosco ML, Mez J, Stein TD, Poston KL, Au R, Kolachalama VB. Multimodal deep learning for Alzheimer's disease dementia assessment. Nat Commun. 2022 Jun 20; 13(1):3404.View Related Profiles. PMID: 35725739; PMCID: PMC9209452; DOI: 10.1038/s41467-022-31037-5;
  9. Cosentino S, Shih LC. Does essential tremor increase risk of cognitive impairment and dementia? Yes. Int Rev Neurobiol. 2022; 163:195-231. PMID: 35750363
  10. Fehlings MG, Chen Y, Aarabi B, Ahmad F, Anderson KD, Dumont T, Fourney DR, Harrop JS, Kim KD, Kwon BK, Lingam HK, Rizzo M, Shih LC, Tsai EC, Vaccaro A, McKerracher L. A Randomized Controlled Trial of Local Delivery of a Rho Inhibitor (VX-210) in Patients with Acute Traumatic Cervical Spinal Cord Injury. J Neurotrauma. 2021 08 01; 38(15):2065-2072. PMID: 33559524; PMCID: PMC8309435; DOI: 10.1089/neu.2020.7096;
Showing 10 of 45 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 45 publications over 16 distinct years, with a maximum of 7 publications in 2023


2002 Alpha Omega Alpha
2002 UCLA Department of Neurology: Richard D. Walter Award for Outstanding Neurology Student
2001 Alpha Omega Alpha Student Research Fellowship
2001 American Stroke Association Student Scholarship in Cerebrovascular Disease

My clinical and research expertise is the phenotypic characterization of tremor and gait disorders and in the delivery of deep brain stimulation therapy for Parkinson's disease, essential tremor and dystonia. I have successfully mentored ~15 trainees and early career faculty members in movement disorders clinical research who are independent investigators and/or movement disorders clinicians around the globe.

I have also had experience working in industry developing medicines for neurodegenerative diseases and can advise on the similarities and differences between a career in academic medicine and industry research and development.

I am committed to playing a role in faculty development and in mentoring trainees and early career clinicians. I view being an empathetic listener and a connector of people and ideas to be one of the ways in which I can help trainees in various stages of their careers. I have participated in mentor training such as the Boston University Provost Mentor Fellows Program.

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')
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