Dr. Shih has research interests in gait and cognition in Parkinson's disease and related diseases and their digital signatures and innovation in deep brain stimulation for Parkinson’s disease, essential tremor and dystonia. Her work includes the use of wearable sensors and other objective methods to assess and characterize tremor, gait and related neurologic impairments and has been funded by the Michael J. Fox Foundation and the Consortia for Improving Medicine with Innovation and Technology (CIMIT). Her research interests also include clinical and translational research into novel methods of detection and management of gait, Parkinson’s disease and related disorders, including essential tremor, atypical parkinsonism and ataxia. She serves on the Medical Advisory Board for the International Essential Tremor Foundation, the International Parkinson's Disease and Movement Disorders Society Tremor Study Group and previously served on the Steering Committee for the Registry for Advancement of Deep Brain Stimulation Therapy for Parkinson’s Disease (RAD-PD). She is a member of the Parkinson Study Group (PSG), Tremor Research Group, Movement Disorder Society, American Academy of Neurology and American Neurological Association.
2002 UCLA Department of Neurology:
Richard D. Walter Award for Outstanding Neurology Student
2001 Alpha Omega Alpha Student Research Fellowship
2001 American Stroke Association Student Scholarship in Cerebrovascular Disease
Publications listed below are automatically derived from MEDLINE/PubMed and other
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Showing 10 of 35 results.
Schneider RB, Jimenez-Shahed J, Abraham DS, Thibault DP, Mantri S, Fullard M, Burack MA, Chou KL, Spindler M, Jermakowicz WJ, D'Haese PF, York MK, Kirk JC, Schwalb JM, Espay AJ, Shih LC, Simon DK, Hunter C, Crispo JAG, Willis AW. Acute readmission following deep brain stimulation surgery for Parkinson's disease: A nationwide analysis. Parkinsonism Relat Disord. 2020 01; 70:96-102. PMID: 31866156
Joutsa J, Shih LC, Fox MD. Mapping holmes tremor circuit using the human brain connectome. Ann Neurol. 2019 12; 86(6):812-820. PMID: 31614012; DOI: 10.1002/ana.25618;
Broom L, Worley A, Gao F, Hernandez LD, Ashton CE, Shih LC, VanderHorst VG. Translational methods to detect asymmetries in temporal and spatial walking metrics in parkinsonian mouse models and human subjects with Parkinson's disease. Sci Rep. 2019 02 21; 9(1):2437. PMID: 30792396
Joutsa J, Shih LC, Horn A, Reich MM, Wu O, Rost NS, Fox MD. Identifying therapeutic targets from spontaneous beneficial brain lesions. Ann Neurol. 2018 07; 84(1):153-157. PMID: 30014594; DOI: 10.1002/ana.25285;
Ondo W, Hashem V, LeWitt PA, Pahwa R, Shih L, Tarsy D, Zesiewicz T, Elble R. Comparison of the Fahn-Tolosa-Marin Clinical Rating Scale and the Essential Tremor Rating Assessment Scale. Mov Disord Clin Pract. 2018 Jan-Feb; 5(1):60-65. PMID: 30363460; DOI: 10.1002/mdc3.12560;
Beck CA, Beran DB, Biglan KM, Boyd CM, Dorsey ER, Schmidt PN, Simone R, Willis AW, Galifianakis NB, Katz M, Tanner CM, Dodenhoff K, Aldred J, Carter J, Fraser A, Jimenez-Shahed J, Hunter C, Spindler M, Reichwein S, Mari Z, Dunlop B, Morgan JC, McLane D, Hickey P, Gauger L, Richard IH, Mejia NI, Bwala G, Nance M, Shih LC, Singer C, Vargas-Parra S, Zadikoff C, Okon N, Feigin A, Ayan J, Vaughan C, Pahwa R, Dhall R, Hassan A, DeMello S, Riggare SS, Wicks P, Achey MA, Elson MJ, Goldenthal S, Keenan HT, Korn R, Schwarz H, Sharma S, Stevenson EA, Zhu W. National randomized controlled trial of virtual house calls for Parkinson disease. Neurology. 2017 Sep 12; 89(11):1152-1161. PMID: 28814455; DOI: 10.1212/WNL.0000000000004357;
Broom L, Ellison BA, Worley A, Wagenaar L, Sörberg E, Ashton C, Bennett DA, Buchman AS, Saper CB, Shih LC, Hausdorff JM, VanderHorst VG. A translational approach to capture gait signatures of neurological disorders in mice and humans. Sci Rep. 2017 06 12; 7(1):3225. PMID: 28607434; DOI: 10.1038/s41598-017-03336-1;
Shih LC, Pascual-Leone A. Non-invasive Brain Stimulation for Essential Tremor. Tremor Other Hyperkinet Mov (N Y). 2017; 7:458. PMID: 28373927; DOI: 10.7916/D8G44W01;
Horn A, Kühn AA, Merkl A, Shih L, Alterman R, Fox M. Probabilistic conversion of neurosurgical DBS electrode coordinates into MNI space. Neuroimage. 2017 04 15; 150:395-404. PMID: 28163141; DOI: 10.1016/j.neuroimage.2017.02.004;
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Available to Mentor as: (Review Mentor Role Definitions)
My clinical and research expertise is the phenotypic characterization of tremor and gait disorders and in the delivery of deep brain stimulation therapy for Parkinson's disease, essential tremor and dystonia. I have successfully mentored ~15 trainees and early career faculty members in movement disorders clinical research who now are independent investigators and/or movement disorders clinicians around the globe.
I have also had experience working in industry developing medicines for neurodegenerative diseases and can advise on the similarities and differences between a career in academic medicine and industry research and development.
I am committed to playing a role in faculty development and in mentoring trainees, early career clinicians and clinical researchers. I view being an empathetic listener and a connector of people and ideas to be one of the ways in which I can help trainees in various stages of their careers.
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Research / Scholarly Mentor