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MD, University of Wisconsin Madison
BS, University of Wisconsin Madison

Websites

	Center for Transgender Medicine and Surgery
	Transgender Medicine Research Group
	BUMC Endocrinology Fellowship
	Department of Medicine Faculty

ORCID : 0000-0003-2497-8401

TransNet:Developing a Research Agenda in Transgender Health and Medicine
04/25/2015 - 03/31/2016 (Subcontract PI)
Regents of the University of Minnesota NIH NICHD
1R13HD084267-01

Thyroid Hormone Action On Skin
02/21/2001 - 02/21/2004 (PI)
Knoll Pharmaceutical Company with Thyroid Research Advisory Council

Central Resistance to Thyroid Hormone
06/15/1999 - 03/31/2001 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5 K08 DK02423 05

Multi Center, Open Label, Single Arm Phase IV Trial Evaluating the Diagnostic Utility of Thyrogen Stimulated Thyroglobulin Testing for the Surveillance of Patients with Treated Papillary or Follicular Thyroid Carcinoma at Risk for Recurrence
03/01/2000 - 12/31/2000 (PI)
Genzyme Corporation

A Pilot Program To Educate Physicians in Transgender Medicine
04/01/2014 - 03/31/2015 (PI)
Boston Foundation

Title

Yr	Title	Project-Sub Proj	Pubs
2015	TransNet: Developing a Research Agenda in Transgender Health and Medicine	1R13HD084267-01	6
2000	CENTRAL RESISTANCE TO THYROID HORMONE	5K08DK002423-05	4
1999	CENTRAL RESISTANCE TO THYROID HORMONE	7K08DK002423-04	4
1996	CENTRAL RESISTANCE TO THYROID HORMONE	1K08DK002423-01	4

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Chan KJ, Jolly D, Liang JJ, Weinand JD, Safer JD. ESTROGEN LEVELS DO NOT RISE WITH TESTOSTERONE TREATMENT FOR TRANSGENDER MEN. Endocr Pract. 2018 Apr; 24(4):329-333.View Related Profiles.

Jolly, Divya
Safer, Joshua

PMID: 29561193

Park JA, Safer JD. Clinical Exposure to Transgender Medicine Improves Students' Preparedness Above Levels Seen with Didactic Teaching Alone: A Key Addition to the Boston University Model for Teaching Transgender Healthcare. Transgend Health. 2018; 3(1):10-16. PMID: 29344576

Tangpricha V, Hannema SE, Irwig MS, Meyer WJ, Safer JD, Hembree WC. 2017 AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS/ENDOCRINE SOCIETY UPDATE ON TRANSGENDER MEDICINE: CASE DISCUSSIONS. Endocr Pract. 2017 Dec; 23(12):1430-1436. PMID: 29320643

Hembree WC, Cohen-Kettenis PT, Gooren L, Hannema SE, Meyer WJ, Murad MH, Rosenthal SM, Safer JD, Tangpricha V, T'Sjoen GG. ENDOCRINE TREATMENT OF GENDER-DYSPHORIC/GENDER-INCONGRUENT PERSONS: AN ENDOCRINE SOCIETY CLINICAL PRACTICE GUIDELINE. Endocr Pract. 2017 Dec; 23(12):1437. PMID: 29320642

Safer JD. Transgender Patients And Health Care Providers. Health Aff (Millwood). 2017 12; 36(12):2213. PMID: 29200359

Liang JJ, Jolly D, Chan KJ, Safer JD. TESTOSTERONE LEVELS ACHIEVED BY MEDICALLY TREATED TRANSGENDER WOMEN IN A UNITED STATES ENDOCRINOLOGY CLINIC COHORT. Endocr Pract. 2018 Feb; 24(2):135-142.View Related Profiles.

Jolly, Divya
Safer, Joshua

PMID: 29144822

Hembree WC, Cohen-Kettenis PT, Gooren L, Hannema SE, Meyer WJ, Murad MH, Rosenthal SM, Safer JD, Tangpricha V, T'Sjoen GG. Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2017 Nov 01; 102(11):3869-3903. PMID: 28945902

Liang JJ, Gardner IH, Walker JA, Safer JD. OBSERVED DEFICIENCIES IN MEDICAL STUDENT KNOWLEDGE OF TRANSGENDER AND INTERSEX HEALTH. Endocr Pract. 2017 Aug; 23(8):897-906. PMID: 28534684

Kailas M, Lu HMS, Rothman EF, Safer JD. PREVALENCE AND TYPES OF GENDER-AFFIRMING SURGERY AMONG A SAMPLE OF TRANSGENDER ENDOCRINOLOGY PATIENTS PRIOR TO STATE EXPANSION OF INSURANCE COVERAGE. Endocr Pract. 2017 Jul; 23(7):780-786.View Related Profiles.

Rothman, Emily
Safer, Joshua

PMID: 28448757

Berli JU, Knudson G, Fraser L, Tangpricha V, Ettner R, Ettner FM, Safer JD, Graham J, Monstrey S, Schechter L. What Surgeons Need to Know About Gender Confirmation Surgery When Providing Care for Transgender Individuals: A Review. JAMA Surg. 2017 Apr 01; 152(4):394-400. PMID: 28196182; DOI: 10.1001/jamasurg.2016.5549;

Showing 10 of 62 results. Show More

Safer JD. THE RECOGNITION THAT GENDER IDENTITY IS BIOLOGICAL COMPLICATES SOME PREVIOUSLY SETTLED CLINICAL DECISION MAKING. Endocr Pract. 2016 Dec 14. PMID: 27967232

Stevenson MO, Wixon N, Safer JD. Scalp Hair Regrowth in Hormone-Treated Transgender Woman. Transgend Health. 2016; 1(1):202-204. PMID: 28861534

Myers SC, Safer JD. INCREASED RATES OF SMOKING CESSATION OBSERVED AMONG TRANSGENDER WOMEN RECEIVING HORMONE TREATMENT. Endocr Pract. 2017 Jan; 23(1):32-36. PMID: 27682351; DOI: 10.4158/EP161438.OR;

Chan B, Skocylas R, Safer JD. Gaps in Transgender Medicine Content Identified Among Canadian Medical School Curricula. Transgend Health. 2016; 1(1):142-150. PMID: 29159305

Safer JD. THE LARGE GAPS IN TRANSGENDER MEDICAL KNOWLEDGE AMONG PROVIDERS MUST BE MEASURED AND ADDRESSED. Endocr Pract. 2016 Jul; 22(7):902-3. PMID: 27214166; DOI: 10.4158/EP161388.CO;

Mundluru SN, Safer JD, Larson AR. Unforeseen ethical challenges for isotretinoin treatment in transgender patients. Int J Womens Dermatol. 2016 Jun; 2(2):46-48.View Related Profiles.

Larson, Allison
Safer, Joshua

PMID: 28492004; PMCID: PMC5412105; DOI: 10.1016/j.ijwd.2016.03.002;

Eriksson SE, Safer JD. EVIDENCE-BASED CURRICULAR CONTENT IMPROVES STUDENT KNOWLEDGE AND CHANGES ATTITUDES TOWARDS TRANSGENDER MEDICINE. Endocr Pract. 2016 Jul; 22(7):837-41. PMID: 27042742; DOI: 10.4158/EP151141.OR;

Safer JD, Coleman E, Feldman J, Garofalo R, Hembree W, Radix A, Sevelius J. Barriers to healthcare for transgender individuals. Curr Opin Endocrinol Diabetes Obes. 2016 Apr; 23(2):168-71. PMID: 26910276; PMCID: PMC4802845; DOI: 10.1097/MED.0000000000000227;

Safer JD, Coleman E, Hembree W. There is reason for optimism: an introduction to the special issue on research needs in transgender health and medicine. Curr Opin Endocrinol Diabetes Obes. 2016 Apr; 23(2):165-7. PMID: 26910275; DOI: 10.1097/MED.0000000000000228;

Reisner SL, Deutsch MB, Bhasin S, Bockting W, Brown GR, Feldman J, Garofalo R, Kreukels B, Radix A, Safer JD, Tangpricha V, T'Sjoen G, Goodman M. Advancing methods for US transgender health research. Curr Opin Endocrinol Diabetes Obes. 2016 Apr; 23(2):198-207.View Related Profiles.

Safer, Joshua
Bhasin, Shalender

PMID: 26845331; PMCID: PMC4916925; DOI: 10.1097/MED.0000000000000229;

Feldman J, Brown GR, Deutsch MB, Hembree W, Meyer W, Meyer-Bahlburg HF, Tangpricha V, T'Sjoen G, Safer JD. Priorities for transgender medical and healthcare research. Curr Opin Endocrinol Diabetes Obes. 2016 Apr; 23(2):180-7. PMID: 26825469; PMCID: PMC4821501; DOI: 10.1097/MED.0000000000000231;

Thomas DD, Safer JD. A SIMPLE INTERVENTION RAISED RESIDENT-PHYSICIAN WILLINGNESS TO ASSIST TRANSGENDER PATIENTS SEEKING HORMONE THERAPY. Endocr Pract. 2015 Oct; 21(10):1134-42. PMID: 26151424; DOI: 10.4158/EP15777.OR;

Weinand JD, Safer JD. Hormone therapy in transgender adults is safe with provider supervision; A review of hormone therapy sequelae for transgender individuals. J Clin Transl Endocrinol. 2015 Jun; 2(2):55-60. PMID: 28090436; DOI: 10.1016/j.jcte.2015.02.003;

Saraswat A, Weinand JD, Safer JD. Evidence supporting the biologic nature of gender identity. Endocr Pract. 2015 Feb; 21(2):199-204. PMID: 25667367; DOI: 10.4158/EP14351.RA;

Gardner IH, Safer JD. Progress on the road to better medical care for transgender patients. Curr Opin Endocrinol Diabetes Obes. 2013 Dec; 20(6):553-8. PMID: 24468757; DOI: 10.1097/01.med.0000436188.95351.4d;

Safer JD, Pearce EN. A simple curriculum content change increased medical student comfort with transgender medicine. Endocr Pract. 2013 Jul-Aug; 19(4):633-7.View Related Profiles.

Pearce, Elizabeth
Safer, Joshua

PMID: 23425656; DOI: 10.4158/EP13014.OR;

Safer JD. Transgender medical research, provider education, and patient access are overdue. Endocr Pract. 2013 Jul-Aug; 19(4):575-6. PMID: 23337168; DOI: 10.4158/EP13013.ED;

Safer JD. Thyroid hormone and wound healing. J Thyroid Res. 2013; 2013:124538. PMID: 23577275; PMCID: PMC3616354; DOI: 10.1155/2013/124538;

Safer JD. Thyroid hormone action on skin. Curr Opin Endocrinol Diabetes Obes. 2012 Oct; 19(5):388-93. PMID: 22914563; DOI: 10.1097/MED.0b013e328357b45e;

Kannan S, Safer JD. Finding the right balance between resistance and sensitivity: a review of the cardiac manifestations of the syndrome of resistance to thyroid hormone and the implications for treatment. Endocr Pract. 2012 Mar-Apr; 18(2):252-5. PMID: 22068246; DOI: 10.4158/EP11075.RA;

Toraldo G, Bhasin S, Bakhit M, Guo W, Serra C, Safer JD, Bhawan J, Jasuja R. Topical androgen antagonism promotes cutaneous wound healing without systemic androgen deprivation by blocking ß-catenin nuclear translocation and cross-talk with TGF-ß signaling in keratinocytes. Wound Repair Regen. 2012 Jan-Feb; 20(1):61-73.View Related Profiles.

Toraldo, Gianluca
Bhawan, Jag
Safer, Joshua
Bhasin, Shalender
Guo, Wen

PMID: 22276587; PMCID: PMC5461922; DOI: 10.1111/j.1524-475X.2011.00757.x;

Leung AM, Safer JD. Thyrotoxicosis of extra thyroid origin. Werner and Ingbar's The Thyroid. Lippincott Williams and Williams. Philadelphia. 2012; 429-433.

Huang MP, Rodgers KA, O'Mara R, Mehta M, Abuzahra HS, Tannenbaum AD, Persons K, Holick MF, Safer JD. The thyroid hormone degrading type 3 deiodinase is the primary deiodinase active in murine epidermis. Thyroid. 2011 Nov; 21(11):1263-8.View Related Profiles.

Safer, Joshua
Holick, Michael

PMID: 21936673; DOI: 10.1089/thy.2011.0105;

Safer JD. Thyroid hormone action on skin. Dermatoendocrinol. 2011 Jul; 3(3):211-5. PMID: 22110782; PMCID: PMC3219173; DOI: 10.4161/derm.3.3.17027;

Choong K, Safer JD. Graves disease and gynecomastia in 2 roommates. Endocr Pract. 2011 Jul-Aug; 17(4):647-50. PMID: 21613048; DOI: 10.4158/EP11082.CO;

Abraham TM, de las Morenas A, Lee SL, Safer JD. In thyroid fine-needle aspiration, use of bedside-prepared slides significantly increased diagnostic adequacy and specimen cellularity relative to solution-based samples. Thyroid. 2011 Mar; 21(3):237-42.View Related Profiles.

De Las Morenas, Antonio
Safer, Joshua
Lee, Stephanie

PMID: 21323589; DOI: 10.1089/thy.2010.0211;

Ariza MA, Loken WM, Pearce EN, Safer JD. Male sex, African American race or ethnicity, and triiodothyronine levels at diagnosis predict weight gain after antithyroid medication and radioiodine therapy for hyperthyroidism. Endocr Pract. 2010 Jul-Aug; 16(4):609-16.View Related Profiles.

Pearce, Elizabeth
Safer, Joshua

PMID: 20350916; DOI: 10.4158/EP09374.OR;

Bhasin S, Safer J, Tangpricha V. The Hormone Foundation’s patient guide to the endocrine treatment of transsexual persons. Journal of Clinical Endocrinology and Metabolism. 2009; 94(9).

Safer JD, Persons K, Holick MF. A thyroid hormone deiodinase inhibitor can decrease cutaneous cell proliferation in vitro. Thyroid. 2009 Feb; 19(2):181-5.View Related Profiles.

Safer, Joshua
Holick, Michael

PMID: 19191748; DOI: 10.1089/thy.2008.0227;

Feldman J, Safer J. Hormone therapy in adults: Suggested revisions to the sixth version of the Standards of Care. International Journal of Transgenderism. 2009; 3(11):146-182.

Pietras SM, Safer JD. Diagnostic confusion attributable to spurious elevation of both total thyroid hormone and thyroid hormone uptake measurements in the setting of autoantibodies: case report and review of related literature. Endocr Pract. 2008 Sep; 14(6):738-42.View Related Profiles.

Safer, Joshua
Alexanian, Sara

PMID: 18996795

Safer JD, Tangpricha V. Out of the shadows: it is time to mainstream treatment for transgender patients. Endocr Pract. 2008 Mar; 14(2):248-50. PMID: 18308667; PMCID: PMC3105355

Safer JD, Holick MF. Potential therapeutic uses of thyroid hormone. Thyroid Disorders with Cutaneous Manifestations, Heymann WR, ed. Springer-Verlag. London, UK. 2008; 181-186.

Safer JD, Ray S, Holick MF. A topical parathyroid hormone/parathyroid hormone-related peptide receptor antagonist stimulates hair growth in mice. Endocrinology. 2007 Mar; 148(3):1167-70.View Related Profiles.

Safer, Joshua
Holick, Michael

PMID: 17170098

Saha AK, Persons K, Safer JD, Luo Z, Holick MF, Ruderman NB. AMPK regulation of the growth of cultured human keratinocytes. Biochem Biophys Res Commun. 2006 Oct 20; 349(2):519-24.View Related Profiles.

Saha, Asish
Safer, Joshua
Holick, Michael
Ruderman, Neil
Luo, Zhijun

PMID: 16949049

Safer JD, Crawford TM, Holick MF. Topical thyroid hormone accelerates wound healing in mice. Endocrinology. 2005 Oct; 146(10):4425-30.View Related Profiles.

Safer, Joshua
Holick, Michael

PMID: 15976059

Safer JD. The skin and connective tissue in hypothyroidism. Werner and Ingbar’s The Thyroid, 9th Edition, Braverman LE and Utiger RD, eds. Lippincott Williams and Williams. Philadelphia, PA. 2005; 769-773.
Safer JD, Hennessey JV, Braverman LE. Substituting brand name levothyroxine preparations with generics would increase treatment cost. Annals of Internal Medicine. 2005. View Publication
Safer JD. The skin in thyrotoxicosis. Werner and Ingbar’s The Thyroid, 9th Edition, Braverman LE and Utiger RD, eds. Lippincott Williams and Williams. Philadelphia, PA. 2005; 553-558.

Safer JD, Crawford TM, Holick MF. A role for thyroid hormone in wound healing through keratin gene expression. Endocrinology. 2004 May; 145(5):2357-61.View Related Profiles.

Safer, Joshua
Holick, Michael

PMID: 14736740

Santini F, Vitti P, Chiovato L, Ceccarini G, Macchia M, Montanelli L, Gatti G, Rosellini V, Mammoli C, Martino E, Chopra IJ, Safer JD, Braverman LE, Pinchera A. Role for inner ring deiodination preventing transcutaneous passage of thyroxine. J Clin Endocrinol Metab. 2003 Jun; 88(6):2825-30.View Related Profiles.

Safer, Joshua
Braverman, Lewis

PMID: 12788895

Safer JD, Crawford TM, Fraser LM, Hoa M, Ray S, Chen TC, Persons K, Holick MF. Thyroid hormone action on skin: diverging effects of topical versus intraperitoneal administration. Thyroid. 2003 Feb; 13(2):159-65.View Related Profiles.

Safer, Joshua
Holick, Michael
Chen, Tai

PMID: 12699590

Safer JD. Resistance to Thyroid Hormone. Contemporary Endocrinology: Diseases of the Thyroid, 2nd Edition, Braverman LE, ed. Humana Press Inc. Totowa, NJ. 2003; 199-216.

Koutkia P, Safer JD. Adrenal metastasis secondary to papillary thyroid carcinoma. Thyroid. 2001 Nov; 11(11):1077-9. PMID: 11762719

Tangpricha V, Chen BJ, Swan NC, Sweeney AT, de las Morenas A, Safer JD. Twenty-one-gauge needles provide more cellular samples than twenty-five-gauge needles in fine-needle aspiration biopsy of the thyroid but may not provide increased diagnostic accuracy. Thyroid. 2001 Oct; 11(10):973-6.View Related Profiles.

Sweeney, Ann
De Las Morenas, Antonio
Safer, Joshua

PMID: 11716046

Safer JD, Fraser LM, Ray S, Holick MF. Topical triiodothyronine stimulates epidermal proliferation, dermal thickening, and hair growth in mice and rats. Thyroid. 2001 Aug; 11(8):717-24.View Related Profiles.

Safer, Joshua
Holick, Michael

PMID: 11525263

Safer JD, Colan SD, Fraser LM, Wondisford FE. A pituitary tumor in a patient with thyroid hormone resistance: a diagnostic dilemma. Thyroid. 2001 Mar; 11(3):281-91. PMID: 11327621

Safer JD, O'Connor MG, Colan SD, Srinivasan S, Tollin SR, Wondisford FE. The thyroid hormone receptor-beta gene mutation R383H is associated with isolated central resistance to thyroid hormone. J Clin Endocrinol Metab. 1999 Sep; 84(9):3099-109. PMID: 10487671

Safer JD, Cohen RN, Hollenberg AN, Wondisford FE. Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone. J Biol Chem. 1998 Nov 13; 273(46):30175-82.View Related Profiles.

Hollenberg, Anthony
Safer, Joshua

PMID: 9804773

Langlois MF, Zanger K, Monden T, Safer JD, Hollenberg AN, Wondisford FE. A unique role of the beta-2 thyroid hormone receptor isoform in negative regulation by thyroid hormone. Mapping of a novel amino-terminal domain important for ligand-independent activation. J Biol Chem. 1997 Oct 3; 272(40):24927-33.View Related Profiles.

Hollenberg, Anthony
Safer, Joshua

PMID: 9312095

Safer JD, Wondisford FE. TSH, Normal Physiology. Contemporary Endocrinology: Diseases of the Pituitary, Wierman ME, ed. Humana Press Inc. Totowa, NJ. 1997; 283-293.

Safer JD, Langlois MF, Cohen R, Monden T, John-Hope D, Madura J, Hollenberg AN, Wondisford FE. Isoform variable action among thyroid hormone receptor mutants provides insight into pituitary resistance to thyroid hormone. Mol Endocrinol. 1997 Jan; 11(1):16-26.View Related Profiles.

Hollenberg, Anthony
Safer, Joshua

PMID: 8994184

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 9 publications over 6 distinct years, with a maximum of 3 publications in 2005

Bar chart showing 9 publications over 6 distinct years, with a maximum of 3 publications in 2005

Year	Publications
1997	1
2003	1
2005	3
2008	1
2009	2
2012	1

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