G. Graham Shipley, PhD, DSc
Emeritus Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

PhD, University of Nottingham
BSc, University of Nottingham

Dr. Shipley is Emeritus Professor of Physiology and Biophysics at Chobanian and Avedisian School of Medicine. His research interests center around the structure and function of cell membranes, receptor-ligand interactions and transmembrane signaling mechanisms. A combination of biochemical, chemical and biophysical approaches are used to probe: (1) membrane lipid conformation, structure, properties and interactions, (2) membrane receptor-lipid interactions and (3) membrane receptor-ligand interactions. Current approaches involve the isolation of membrane-associated proteins and lipids (e.g. low density lipoprotein (LDL) receptor, insulin receptor, integrins, gangliosides), their reconstitution with well characterized lipid monolayer and bilayer matrices and structural studies of the protein-lipid assemblies. Ligand binding studes include LDL receptor/LDL, insulin receptor/insulin, and ganglioside/toxin interactions. The biochemical methods involved include lipid and protein isolation, gel/affinity chromatography, antibody techniques, immunoblotting, detergent solubilization, lipid-protein reconstitution, etc. Chemical methods include lipid sythesis, TLC, HPLC, IR and NMR. The biophysical approach involves x-ray diffraction, protein crystallography, electron microscopy/image reconstruction, surface chemistry and calorimetric and spectroscopic (CD, NMR) methods.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Boston University Chobanian & Avedisian School of Medicine
Biochemistry & Cell Biology

Glycosphingolipids and GM1-Cholera Toxin Interactions
01/01/1997 - 12/31/2002 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL57405 04


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Shipley GG, Tall AR, Atkinson D. In Memoriam: Donald MacFarland Small (1931-2019). J Lipid Res. 2019 May; 60(5):911-912.View Related Profiles. PMID: 33722375
  2. Doyle DA, Shipley GG. Membranes: editorial overview. Curr Opin Struct Biol. 2009 Aug; 19(4):369-71. PMID: 19709877; DOI: 10.1016/j.sbi.2009.07.011;
  3. Jeon H, Shipley GG. Localization of the N-terminal domain of the low density lipoprotein receptor. J Biol Chem. 2000 Sep 29; 275(39):30465-70. PMID: 10889195
  4. Jeon H, Shipley GG. Vesicle-reconstituted low density lipoprotein receptor. Visualization by cryoelectron microscopy. J Biol Chem. 2000 Sep 29; 275(39):30458-64. PMID: 10889196
  5. Shipley GG. Bilayers and nonbilayers: structure, forces and protein crystallization. Curr Opin Struct Biol. 2000 Aug; 10(4):471-3. PMID: 10981637
  6. Saxena K, Duclos RI, Sripada PK, Shipley GG. Unusual hydration properties of C16:0 sulfatide bilayer membranes. Biophys J. 2000 Jul; 79(1):385-93. PMID: 10866964; PMCID: PMC1300942
  7. Saxena K, Zimmermann P, Schmidt RR, Shipley GG. Bilayer properties of totally synthetic C16:0-lactosyl-ceramide. Biophys J. 2000 Jan; 78(1):306-12. PMID: 10620294; PMCID: PMC1300638
  8. Woldin CN, Hing FS, Lee J, Pilch PF, Shipley GG. Structural studies of the detergent-solubilized and vesicle-reconstituted insulin receptor. J Biol Chem. 1999 Dec 3; 274(49):34981-92.View Related Profiles. PMID: 10574975
  9. Saxena K, Duclos RI, Zimmermann P, Schmidt RR, Shipley GG. Structure and properties of totally synthetic galacto- and gluco-cerebrosides. J Lipid Res. 1999 May; 40(5):839-49. PMID: 10224153
  10. Saxena K, Shipley GG. Structural studies of detergent-solubilized and vesicle-reconstituted low-density lipoprotein (LDL) receptor. Biochemistry. 1997 Dec 16; 36(50):15940-8. PMID: 9398328
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This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 62 publications over 22 distinct years, with a maximum of 9 publications in 1987


2014 Boston University School of Medicine: Educator of the Year in Graduate Medical Sciences, Doctoral Degree Programs
Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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