Elizabeth Bartolak-Suki, MD, DSc
Research Assistant Professor
Boston University College of Engineering
Dept of Biomedical Engineering
Albert Szent-Györgyi Medical University
Semmelweis University of Medicine
Dr. Elizabeth Bartolak-Suki is a Research Assistant Professor in Biomedical Engineering and a Senior Scientist at Boston University. Additionally, she is one of the Principal Investigators in the Cell & Tissue Mechanics Laboratory and interested in how the sensing is achieved via mechanosensitive channels and various transmembrane receptors such as integrins at focal adhesions. She is investigating at the molecular scale, how protein coupling at focal adhesions or cell-cell contacts lead to reorganization of focal adhesions as well as the cytoskeleton followed by molecular signaling cascades, turning genes on or off and eventually expressing various intra- and extracellular proteins. Moreover, these intracellular networks respond to mechanical stimuli not just at the molecular signaling scale but also as a whole at the organelle level, a new concept we introduced and study using live imaging. She developed novel techniques to manipulate and analyze cells and subcellular organelles in dynamic environments that mimic physiological rhythms in the human body. She utilized this stochastic nature of mechanical stimuli to regulate vascular smooth muscle cell contractility toward vascular tissue engineering and to develop new therapeutic strategies for alcohol related vascular malformations.
Publications listed below are automatically derived from MEDLINE/PubMed and other
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Showing 10 of 42 results.
Zeldich D, Bou Jawde S, Herrmann J, Arnaout L, Griffin M, Grunfeld N, Zhang Y, Krishnan R, Bartolák-Suki E, Suki B. Stabilizing breathing pattern using local mechanical vibrations: comparison of deterministic and stochastic stimulations in rodent models of apnea of prematurity. Biomed Eng Lett. 2021 Nov; 11(4):383-392.View Related Profiles. PMID: 34490067; PMCID: PMC8409477; DOI: 10.1007/s13534-021-00203-x;
Mondoñedo JR, Bartolák-Suki E, Bou Jawde S, Nelson K, Cao K, Sonnenberg A, Obrochta WP, Imsirovic J, Ram-Mohan S, Krishnan R, Suki B. A High-Throughput System for Cyclic Stretching of Precision-Cut Lung Slices During Acute Cigarette Smoke Extract Exposure. Front Physiol. 2020; 11:566.View Related Profiles. PMID: 32655401; PMCID: PMC7326018; DOI: 10.3389/fphys.2020.00566;
Li X, Xu J, Bartolák-Suki E, Jiang J, Tien J. Evaluation of 1-mm-diameter endothelialized dense collagen tubes in vascular microsurgery. J Biomed Mater Res B Appl Biomater. 2020 08; 108(6):2441-2449.View Related Profiles. PMID: 32017412; DOI: 10.1002/jbm.b.34576;
Mellenthin MM, Seong SA, Roy GS, Bartolák-Suki E, Hamlington KL, Bates JHT, Smith BJ. Using injury cost functions from a predictive single-compartment model to assess the severity of mechanical ventilator-induced lung injuries. J Appl Physiol (1985). 2019 07 01; 127(1):58-70. PMID: 31046518; PMCID: PMC6692741; DOI: 10.1152/japplphysiol.00770.2018;
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